Special Issue "p53 Signaling in Cancers"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 April 2018)
Dr. Natalia Issaeva
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Interests: p53, DNA damage, head and neck cancer; HPV
This Special Issue is about the unique tumor suppressor p53. The exclusivity of this gene begins from its discovery—it was originally believed to be an oncogene, but genetic and functional data obtained ten years after its discovery showed it to be a powerful natural tumor suppressor. The most commonly-mutated gene in cancer, a major responder to stress conditions, and a potent regulator of transcription and a strong player in signaling to apoptosis, p53 became one of the most attractive molecular targets in cancer therapy; together with p53 animal models, p53 reactivating molecules, in turn, appeared to be a great tool to study p53 cellular functions. Recently-discovered p53 activities in metabolism, immunity, epigenetic regulation and non-apoptotic cell death evidently showed that we are still far away from a clear understanding of how p53 exerts its tumors suppressor functions. Here, we welcome papers outlining mechanisms of p53 control and p53 roles in cancer and normal tissues.
Dr. Natalia Issaeva
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor suppressor
- cell death