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616 Results Found

  • Review
  • Open Access
5 Citations
3,395 Views
19 Pages

Advances and Mechanisms of RNA–Ligand Interaction Predictions

  • Chen Zhuo,
  • Chengwei Zeng,
  • Haoquan Liu,
  • Huiwen Wang,
  • Yunhui Peng and
  • Yunjie Zhao

15 January 2025

The diversity and complexity of RNA include sequence, secondary structure, and tertiary structure characteristics. These elements are crucial for RNA’s specific recognition of other molecules. With advancements in biotechnology, RNA–ligan...

  • Article
  • Open Access
1 Citations
2,218 Views
16 Pages

Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes

  • Shengzhou Jin,
  • Lanfen Wang,
  • Yinggang Jia,
  • Wenbo Ma and
  • Dingyi Wang

10 September 2024

Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method...

  • Article
  • Open Access
17 Citations
4,996 Views
18 Pages

30 December 2022

Within the current context of climate emergency, the topic of climate change has become more prominent in secondary education in Spain. However, in general, conceptual confusions arise which should be clarified due to the social importance of climate...

  • Article
  • Open Access
14 Citations
4,842 Views
19 Pages

Algerian Olive Germplasm and Its Relationships with the Central-Western Mediterranean Varieties Contributes to Clarify Cultivated Olive Diversification

  • Kamel Atrouz,
  • Ratiba Bousba,
  • Francesco Paolo Marra,
  • Annalisa Marchese,
  • Francesca Luisa Conforti,
  • Benedetta Perrone,
  • Hamza Harkat,
  • Amelia Salimonti and
  • Samanta Zelasco

1 April 2021

Olive tree with its main final product, olive oil, is an important element of Mediterranean history, considered the emblematic fruit of a civilization. Despite its wide diffusion and economic and cultural importance, its evolutionary and phylogenetic...

  • Article
  • Open Access
1,431 Views
11 Pages

Comparative Study of Blood Neopterin and Biopterins in Patients with COVID-19 and Secondary Bacterial Infection

  • Tomohiro Eguchi,
  • Shuhei Niiyama,
  • Chinatsu Kamikokuryo,
  • Yutaro Madokoro,
  • Kenshin Shimono,
  • Satoshi Hara,
  • Hiroshi Ichinose and
  • Yasuyuki Kakihana

26 July 2024

Background/Objectives: As COVID-19 can be severe, early predictive markers of both severity and onset of secondary bacterial infections are needed. This study first examined changes over time in the levels of plasma neopterin (NP) and biopterins (BPs...

  • Article
  • Open Access
7 Citations
2,568 Views
9 Pages

Secondary-Heteroatom-Doping-Derived Synthesis of N, S Co-Doped Graphene Nanoribbons for Enhanced Oxygen Reduction Activity

  • Bing Li,
  • Tingting Xiang,
  • Yuqi Shao,
  • Fei Lv,
  • Chao Cheng,
  • Jiali Zhang,
  • Qingchao Zhu,
  • Yifan Zhang and
  • Juan Yang

23 September 2022

The rareness and weak durability of Pt-based electrocatalysts for oxygen reduction reactions (ORRs) have hindered the large-scale application of fuel cells. Here, we developed an efficient metal-free catalyst consisting of N, S co-doped graphene nano...

  • Article
  • Open Access
26 Citations
12,061 Views
12 Pages

Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

  • Chang-Chun Wu,
  • Lee-Chin Wong,
  • Chia-Jui Hsu,
  • Chianne-Wen Yang,
  • Ying-Chieh Tsai,
  • Feng-Shiang Cheng,
  • Hsiao-Yun Hu and
  • Wang-Tso Lee

21 October 2021

Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics Lactobacillus p...

  • Review
  • Open Access
4 Citations
3,835 Views
20 Pages

Resistance to Antiangiogenic Therapy in Hepatocellular Carcinoma: From Molecular Mechanisms to Clinical Impact

  • Piera Federico,
  • Emilio Francesco Giunta,
  • Andrea Tufo,
  • Francesco Tovoli,
  • Angelica Petrillo and
  • Bruno Daniele

18 December 2022

Antiangiogenic drugs were the only mainstay of advanced hepatocellular carcinoma (HCC) treatment from 2007 to 2017. However, primary or secondary resistance hampered their efficacy. Primary resistance could be due to different molecular and/or geneti...

  • Article
  • Open Access
8 Citations
5,068 Views
15 Pages

25 August 2020

Chitosan is a polysaccharide admitted in winemaking as clarifying, antimicrobial and chelating agent. In addition, evidence about its antioxidant and radical scavenging activities have been recently reported in wine conditions. As an insoluble adjuva...

  • Review
  • Open Access
161 Citations
10,800 Views
23 Pages

12 December 2018

Caspase-3, onto which there is a convergence of the intrinsic and extrinsic apoptotic pathways, is the main executioner of apoptosis. We here review the current literature on the intervention of the protease in the execution of naturally occurring ne...

  • Perspective
  • Open Access
9 Citations
4,255 Views
10 Pages

Although functional impairment is required for a diagnosis in the DSM 5, the time frame and definition of functional impairment is ambiguous. We present a conceptual review clarifying the difference between functional impairment as a stable trait rep...

  • Article
  • Open Access
42 Citations
5,797 Views
35 Pages

Blockchain Enhanced Construction Waste Information Management: A Conceptual Framework

  • Zhen Liu,
  • Tzuhui Wu,
  • Fenghong Wang,
  • Mohamed Osmani and
  • Peter Demian

26 September 2022

Despite the large quantities of secondary materials flowing within the built environment, their actual volume and respective waste management processes are not accurately known and recorded. Consequently, various sustainability and material efficienc...

  • Article
  • Open Access
7 Citations
2,255 Views
20 Pages

6 April 2023

The Pile-beam-arch (PBA) method is a new and effective construction method for the urban metro station. It is the key to ensuring the safe construction of the station to clarify the influence of PBA method construction on surface deformation under un...

  • Article
  • Open Access
3 Citations
2,786 Views
8 Pages

31 August 2019

Background and objectives: Psychological distress (PD) is associated with continuous sedentary behaviors (CSB; based on the ratio of 1.5 metabolic equivalents (METs) sessions or more continuing for over 30 min) in older adults, but the long-term rela...

  • Article
  • Open Access
1 Citations
3,334 Views
23 Pages

The friction/adhesion between the tool and chip is generally large in metal cutting, and it causes many problems such as high cutting energy/rough surface finish. To suppress this, cutting fluid and tool coating are used in practice, but they are hig...

  • Review
  • Open Access
2 Citations
1,759 Views
27 Pages

Influencing Factors and Regulatory Mechanisms of Fresh Tea Leaf Quality: A Review

  • Tianyu Wu,
  • Junjie He,
  • Xiujuan Deng,
  • Xiaohua Wang,
  • Wenxia Yuan,
  • Qiaomei Wang,
  • Xinya Chen,
  • Man Zou,
  • Hongmei An and
  • Raoqiong Che

20 September 2025

The contents of secondary metabolites such as tea polyphenols, amino acids, caffeine, and volatile metabolites in fresh tea leaves are key factors determining the unique flavor and health attributes of finished tea products. However, differences in v...

  • Review
  • Open Access
32 Citations
6,780 Views
16 Pages

16 August 2021

Collaboration is problematic in the public sector, yet many smart city theorists advocate relationships fully dependent upon collaboration to address the intense complexity encountered by city governments and achieve city objectives of quality of lif...

  • Article
  • Open Access
14 Citations
6,902 Views
12 Pages

Intra-Population Variation of Secondary Metabolites in Cistus ladanifer L.

  • Cristina Valares Masa,
  • Juan Carlos Alías Gallego,
  • Natividad Chaves Lobón and
  • Teresa Sosa Díaz

In previous studies, secondary metabolites in the leaf exudate of Cistus ladanifer, specifically aglycone flavonoids and diterpenes, were demonstrated to play an ecophysiological role. They protect against ultraviolet radiation, have antiherbivore ac...

  • Article
  • Open Access
5 Citations
5,162 Views
11 Pages

13 October 2019

It has been a long-standing topic how the lattice misfit is cancelled at a semi-coherent interphase boundary consisting of terraces and steps. Apart from a set of misfit dislocations separating the coherent patches, the role of steps (which is freque...

  • Article
  • Open Access
5 Citations
2,163 Views
16 Pages

24 May 2024

Monascus pigments (MPs), a class of secondary metabolites produced by Monascus spp., can be classified into yellow, orange, and red MPs according to their differences in the wavelength of the maximum absorption. However, the biosynthetic sequence and...

  • Article
  • Open Access
14 Citations
3,921 Views
15 Pages

Comparative Metabolomics Reveals Fungal Conversion of Co-Existing Bacterial Metabolites within a Synthetic Aspergillus-Streptomyces Community

  • Yutong Shi,
  • Yihan Ma,
  • Jihua Wei,
  • Yichao Ge,
  • Wei Jiang,
  • Shan He,
  • Xiaodan Wu,
  • Xiaoqin Zhang and
  • Bin Wu

19 September 2021

In nature, secondary metabolites have been proven to be the essential communication media between co-occurring microorganisms and to influence their relationship with each other. In this study, we conducted a metabolomics survey of the secondary meta...

  • Article
  • Open Access
2 Citations
3,946 Views
19 Pages

21 December 2022

In the context of social transformation, the needs of society and individuals for information technology are changing, and discussions on the value and function of information technology are getting more and more attention. The purpose of this resear...

  • Article
  • Open Access
7 Citations
3,124 Views
11 Pages

Pituitary Enlargement and Hypopituitarism in Patients Treated with Immune Checkpoint Inhibitors: Two Sides of the Same Coin?

  • Sabrina Chiloiro,
  • Antonella Giampietro,
  • Antonio Bianchi,
  • Sara Menotti,
  • Flavia Angelini,
  • Tommaso Tartaglione,
  • Gian Carlo Antonini Cappellini,
  • Federica De Galitiis,
  • Ernesto Rossi and
  • Maria Fleseriu
  • + 3 authors

26 February 2023

Background: Immune checkpoint inhibitor hypophysitis (IIHs) is an emerging problem in cancer patients treated with immune checkpoint inhibitors (ICIs). We aimed to describe the clinical and molecular features of a multicenter series of IIHs. Methods:...

  • Article
  • Open Access
1 Citations
5,074 Views
13 Pages

Evaluating Digital Map Utilization and Interpretation Skills of Students

  • Hiroyuki Yamauchi,
  • Jiali Song,
  • Takashi Oguchi,
  • Takuro Ogura and
  • Kotaro Iizuka

In recent years, secondary schools and university departments related to geography have begun to teach various topics using Geographic Information Systems (GIS). In particular, WebGIS, available online without installing additional software, is recog...

  • Review
  • Open Access
12 Citations
13,528 Views
17 Pages

Diagnostic Approach to Lower Limb Entrapment Neuropathies: A Narrative Literature Review

  • Nicu Cătălin Drăghici,
  • Vitalie Văcăraș,
  • Roxana Bolchis,
  • Atamyrat Bashimov,
  • Diana Maria Domnița,
  • Silvina Iluț,
  • Livia Livinț Popa,
  • Tudor Dimitrie Lupescu and
  • Dafin Fior Mureșanu

4 November 2023

Entrapment neuropathies of the lower limb are a misunderstood and underdiagnosed group of disorders, characterized by pain and dysesthesia, muscular weakness, and specific provoking movements on physical examination. The most frequent of these syndro...

  • Article
  • Open Access
6 Citations
1,103 Views
7 Pages

Management of coronary artery disease patients in Latvia compared with practice in Central-Eastern Europe and globally: Analysis of the CLARIFY registry

  • Andrejs Erglis,
  • Iveta Mintale,
  • Gustavs Latkovskis,
  • Inga Balode,
  • Sanda Jegere,
  • Iveta Bajare,
  • Aldis Rozenbergs,
  • Nicola Greenlaw,
  • Roberto Ferrari and
  • For the CLARIFY registry investigators

4 August 2015

Background and objective: Management of outpatients with stable coronary artery disease (CAD) is important in secondary prevention. The objective was to describe differences in the characteristics of CAD patients in Latvia compared with other countri...

  • Article
  • Open Access
14 Citations
3,372 Views
10 Pages

Machine Learning Algorithms: Prediction and Feature Selection for Clinical Refracture after Surgically Treated Fragility Fracture

  • Hirokazu Shimizu,
  • Ken Enda,
  • Tomohiro Shimizu,
  • Yusuke Ishida,
  • Hotaka Ishizu,
  • Koki Ise,
  • Shinya Tanaka and
  • Norimasa Iwasaki

5 April 2022

Background: The number of patients with fragility fracture has been increasing. Although the increasing number of patients with fragility fracture increased the rate of fracture (refracture), the causes of refracture are multifactorial, and its predi...

  • Article
  • Open Access
32 Citations
9,245 Views
11 Pages

7 December 2016

The community of whole microbes and antibiotic resistance bacteria (ARB) in hospital wastewater treatment plants (WWTP) receiving domestic wastewater (DWW) and hospital wastewater (HWW) was investigated. Samples from an influent of a secondary clarif...

  • Article
  • Open Access
11 Citations
2,909 Views
10 Pages

18 January 2023

Background: There is a high prevalence of diabetes mellitus (DM) in patients with pancreatic ductal adenocarcinoma (PDAC). An inflammatory response is considered as a potential mechanism involved in the process. The systemic immune-inflammation (SII)...

  • Article
  • Open Access
2 Citations
2,616 Views
18 Pages

Identification of Black Cumin (Nigella sativa) MicroRNAs by Next-Generation Sequencing and Their Implications in Secondary Metabolite Biosynthesis

  • Andrea G. Uriostegui-Pena,
  • Almendra Reyes-Calderón,
  • Claudia Gutiérrez-García,
  • Aashish Srivastava,
  • Ashutosh Sharma and
  • Sujay Paul

8 October 2024

Secondary metabolites are bioactive compounds believed to contribute to the pharmacological properties of plants. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in post-transcriptional regulation and are thought to play an important r...

  • Article
  • Open Access
27 Citations
6,643 Views
15 Pages

Carbon Storage Dynamics of Secondary Forest Succession in the Central Loess Plateau of China

  • Bin Yang,
  • Wenhui Zhang,
  • Yanlei Lu,
  • Weiwei Zhang and
  • Yanan Wang

17 April 2019

Research Highlights: This study comprehensively revealed the carbon sequestration characteristics of secondary forests in the central Loess Plateau during vegetation succession. Background and Objectives: The secondary succession of Loess Plateau for...

  • Article
  • Open Access
4 Citations
2,110 Views
25 Pages

GhMYB52 Like: A Key Factor That Enhances Lint Yield by Negatively Regulating the Lignin Biosynthesis Pathway in Fibers of Upland Cotton (Gossypium hirsutum L.)

  • Yang Yang,
  • Xue Zhou,
  • Xi Zhu,
  • Bo Ding,
  • Linzhu Jiang,
  • Huiming Zhang,
  • Silu Li,
  • Shuyan Cao,
  • Mi Zhang and
  • Lei Hou

In the context of sustainable agriculture and biomaterial development, understanding and enhancing plant secondary cell wall formation are crucial for improving crop fiber quality and biomass conversion efficiency. This is especially critical for eco...

  • Article
  • Open Access
4 Citations
1,004 Views
23 Pages

CO2 Geothermal Power Generation: Laboratory Experiment on the Interaction Between Carbonated Water and Rishiri Island Basalt in the Vicinity of Injection Wells

  • Sakurako Satake,
  • Heejun Yang,
  • Koji Mori,
  • Yukiko Hoshino,
  • Akira Ueda,
  • Hideki Kuramitz,
  • Kentaro Masuoka,
  • Hisako Enomoto and
  • Amane Terai

28 April 2025

Novel geothermal power generation systems are being developed that use supercritical CO2 as the heat transfer medium. In this technology, some CO2 injected into the underground reacts with surrounding water and rocks to form secondary minerals, such...

  • Article
  • Open Access
1 Citations
1,222 Views
22 Pages

27 November 2024

Southeast Asia is suffering from extreme weather, and its carbon emissions are increasing rapidly. For efficient emission reduction, clarifying the complex sources behind is necessary. This study takes a new perspective of incorporating multiple GHGs...

  • Article
  • Open Access
555 Views
11 Pages

Systematic Notchplasty in Primary ACL Reconstruction Using Hamstring Autografts: A Prospective Cohort Study on the Rate of Secondary Arthrolysis

  • Adrien Saint-Etienne,
  • Alexandre Hardy,
  • Antonio Miele,
  • Nicolas Lefevre,
  • Olivier Grimaud,
  • Alain Meyer and
  • Yoann Bohu

15 October 2025

Background: Arthrofibrosis requiring arthrolysis is a relevant complication after anterior cruciate ligament (ACL) reconstruction. It has been suggested that intercondylar notch impingement may contribute to this outcome. The aim of this study was to...

  • Article
  • Open Access
12 Citations
3,493 Views
15 Pages

Enhancement Mechanism of Stibnite Dissolution Mediated by Acidithiobacillus ferrooxidans under Extremely Acidic Condition

  • Can Wang,
  • Jin-Lan Xia,
  • Hong-Chang Liu,
  • Yu-Hang Zhou,
  • Zhen-Yuan Nie,
  • Lu Chen and
  • Wen-Sheng Shu

Oxidative dissolution of stibnite (Sb2S3), one of the most prevalent geochemical processes for antimony (Sb) release, can be promoted by Sb-oxidizing microbes, which were studied under alkaline and neutral conditions but rarely under acidic condition...

  • Article
  • Open Access
23 Citations
3,243 Views
19 Pages

Investigating Dynamics of the Spinal Cord Injury Adjustment Model: Mediation Model Analysis

  • Ashley Craig,
  • Yvonne Tran,
  • Mohit Arora,
  • Ilaria Pozzato and
  • James W. Middleton

4 August 2022

Spinal cord injury (SCI) is a severe neurological injury that results in damage to multiple bodily systems. SCI rehabilitation requires a significant focus on improving adjustment to the injury. This paper presents a detailed description of the Spina...

  • Article
  • Open Access
1,394 Views
20 Pages

Multiomic Analysis Provided Insights into the Responses of Carbon Sources by Wood-Rotting Fungi Daldinia carpinicola

  • Peng Yang,
  • Xingchi Ma,
  • Yu Zhang,
  • Yanan Sun,
  • Hao Yu,
  • Jiandong Han,
  • Meng Ma,
  • Luzhang Wan and
  • Fansheng Cheng

4 February 2025

Daldinia carpinicola is a newly identified species of wood-rotting fungi, with substantial aspects of its biology and ecological function yet to be clarified. A Nanopore third-generation sequencer was employed for de novo genome assembly to examine t...

  • Article
  • Open Access
3 Citations
2,125 Views
12 Pages

10 December 2023

The study focuses on investigating the relationship between the ultrasonic effect and microstructure of ultrasonic-assisted gas tungsten arc welding (UA-GTAW) Inconel690 alloy joints. The influence of ultrasonic vibrations on Inconel690 plates was ex...

  • Article
  • Open Access
4 Citations
2,672 Views
15 Pages

An Invisible Boundary between Geographic Ranges of Cryptic Species of Narrow-Headed Voles (Stenocranius, Lasiopodomys, Cricetidae) in Transbaikalia

  • Tatyana V. Petrova,
  • Ivan A. Dvoyashov,
  • Yury A. Bazhenov,
  • Ekaterina V. Obolenskaya and
  • Andrey A. Lissovsky

16 March 2023

The narrow-headed vole species complex is represented by Lasiopodomys gregalis and L. raddei, which probably diverged at the beginning of the Middle Pleistocene and came into secondary contact in the Transbaikal region. The current study analyzed mit...

  • Article
  • Open Access
5 Citations
3,405 Views
15 Pages

From AI Knowledge to AI Usage Intention in the Managerial Accounting Profession and the Role of Personality Traits—A Decision Tree Regression Approach

  • Lavinia Denisia Cuc,
  • Dana Rad,
  • Teodor Florin Cilan,
  • Bogdan Cosmin Gomoi,
  • Cristina Nicolaescu,
  • Robert Almași,
  • Simona Dzitac,
  • Florin Lucian Isac and
  • Ionut Pandelica

This study examines the key drivers behind the adoption of artificial intelligence (AI) in the accounting profession, emphasizing the influence of AI-related knowledge, personality traits, and professional roles. By applying Decision Tree Regression...

  • Review
  • Open Access
124 Citations
7,957 Views
16 Pages

Microbiota-Derived Metabolites in Tumor Progression and Metastasis

  • Tania Rossi,
  • Daniele Vergara,
  • Francesca Fanini,
  • Michele Maffia,
  • Sara Bravaccini and
  • Francesca Pirini

12 August 2020

Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the produ...

  • Review
  • Open Access
21 Citations
3,195 Views
28 Pages

Dendrimers as Antiamyloid Agents

  • Svetlana A. Sorokina and
  • Zinaida B. Shifrina

Dendrimer–protein conjugates have significant prospects for biological applications. The complexation changes the biophysical behavior of both proteins and dendrimers. The dendrimers could influence the secondary structure of proteins, zeta-pot...

  • Review
  • Open Access
28 Citations
35,973 Views
13 Pages

Osgood-Schlatter Disease: Appearance, Diagnosis and Treatment: A Narrative Review

  • Francisco Corbi,
  • Sergi Matas,
  • Jesús Álvarez-Herms,
  • Sebastian Sitko,
  • Ernest Baiget,
  • Joaquim Reverter-Masia and
  • Isaac López-Laval

Osgood-Schlatter disease is the most common osteochondritis of the lower limb in sport-practicing children and adolescents. Its manifestation usually coincides with the appearance of the secondary ossification center of the tibia and is linked to the...

  • Article
  • Open Access
845 Views
17 Pages

The deep-water area of the Qiongdongnan basin is currently a hot topic for exploration. The discovery of gas fields in the Baodao sag confirms its abundant oil and gas resources and potential, making it of significant economic and strategic importanc...

  • Article
  • Open Access
19 Citations
3,713 Views
17 Pages

Dysphagia refers to swallowing difficulty, which impacts patients’ quality of life. Dysphagia influences clinical outcomes, including mortality rates and length of hospital stay of older hospitalized patients. Dysphagia may affect the current a...

  • Article
  • Open Access
574 Views
22 Pages

Genome-Wide Characterization of the MDS Gene Family in Gossypium Reveals GhMDS11 as a Key Mediator of Cold Stress Response

  • Xuehan Zhu,
  • Ahmad Haris Khan,
  • Yihao Liu,
  • Allah Madad,
  • Faren Zhu,
  • Junwei Wang,
  • Ganggang Zhang,
  • Fei Wang,
  • Zihan Li and
  • Hongbin Li

18 October 2025

Cotton’s susceptibility to low temperatures makes it a crucial raw resource for the world’s textile industry, yet its cultivation in temperate regions is severely limited. Although plant growth and stress responses depend on receptor-like...

  • Article
  • Open Access
1,127 Views
13 Pages

27 August 2024

The floodplain transverse slope is a significant parameter reflecting the degree of development of a secondary suspended river, as well as a crucial index of the flood risk in the river channel. Clarifying the factors that influence the evolution of...

  • Article
  • Open Access
8 Citations
6,426 Views
11 Pages

Ultrasound-Guided Dorsal Penile Nerve Block in Children: An Anatomical-Based Observational Study of a New Anesthesia Technique

  • Markus Zadrazil,
  • Georg Feigl,
  • Philipp Opfermann,
  • Peter Marhofer,
  • Daniela Marhofer and
  • Werner Schmid

29 December 2023

Dorsal penile nerve block stands out as one of the commonly employed regional anesthetic techniques in children. Despite the large body of experience, failure rates are still significant. We included 20 children (median (SD) age of 73 (31) months) sc...

  • Article
  • Open Access
584 Views
22 Pages

9 September 2025

Owing to the differences in crystallographic orientations among individual grains, dislocation structures in polycrystals are inherently inhomogeneous from grain to grain. Since intergranular incompatibility is inevitable during plastic deformation,...

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