Announcements

We are delighted to share some of the highly cited papers from the Section “Metabolomic Profiling Technology” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. In addition, some Special Issues related to this topic are currently open for submission.

The following is a list of articles and Special Issues that we believe will be interest of you:

1. “Challenges in the Metabolomics-Based Biomarker Validation Pipeline”
by Shenghan Li, Nikita Looby, Vinod Chandran and Vathany Kulasingam
Metabolites 2024, 14(4), 200; https://doi.org/10.3390/metabo14040200
Available Online: https://www.mdpi.com/2218-1989/14/4/200

2. “An Overview of Pre-Analytical Factors Impacting Metabolomics Analyses of Blood Samples”
by Amy Thachil, Li Wang, Rupasri Mandal, David Wishart and Tom Blydt-Hansen
Metabolites 2024, 14(9), 474; https://doi.org/10.3390/metabo14090474
Available Online: https://www.mdpi.com/2218-1989/14/9/474

3. “Advances in Mass Spectrometry-Based Blood Metabolomics Profiling for Non-Cancer Diseases: A Comprehensive Review”
by Ekaterina Demicheva, Vladislav Dordiuk, Fernando Polanco Espino, Konstantin Ushenin, Saied Aboushanab, Vadim Shevyrin, Aleksey Buhler, Elena Mukhlynina, Olga Solovyova, Irina Danilova et al.
Metabolites 2024, 14(1), 54; https://doi.org/10.3390/metabo14010054
Available Online: https://www.mdpi.com/2218-1989/14/1/54

4. “Accurate Prediction of ¹H NMR Chemical Shifts of Small Molecules Using Machine Learning”
by Tanvir Sajed, Zinat Sayeeda, Brian L. Lee, Mark Berjanskii, Fei Wang, Vasuk Gautam and David S. Wishart
Metabolites 2024, 14(5), 290; https://doi.org/10.3390/metabo14050290
Available Online: https://www.mdpi.com/2218-1989/14/5/290

5. “Metabolic Connectome and Its Role in the Prediction, Diagnosis, and Treatment of Complex Diseases”
by Weiyu Meng, Hongxin Pan, Yuyang Sh, Xiaobing Zhai, Abao Xing, Sai Sachin Lingampelly, Srinivasa R. Sripathi, Yuefei Wang and Kefeng Li
Metabolites 2024, 14(2), 93; https://doi.org/10.3390/metabo14020093
Available Online: https://www.mdpi.com/2218-1989/14/2/93

6. “Salicylic Acid Modulates Volatile Organic Compound Profiles During CEVd Infection in Tomato Plants”
by Marc Balanzá, Francisco Vázquez-Prol, Ismael Rodrigo, José María Bellés, Francisco Vera-Sirera, Maria Pilar López-Gresa and Purificación Lisón
Metabolites 2025, 15(2), 102; https://doi.org/10.3390/metabo15020102
Available Online: https://www.mdpi.com/2218-1989/15/2/102

Special Issues:

“Mass Spectrometry Imaging and Spatial Metabolomics—2nd Edition”
Guest Editors: Dr. Zhonghua Wang and Dr. Zhonghua Wang
Submission deadline: 20 July 2026 

“Women’s Special Issue Series: Metabolomic Profiling Technology”
Guest Editors: Dr. Thusitha W. Rupasinghe and Dr. RuAngelie Edrada-Ebel
Submission deadline: 31 October 2026

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of feature papers from the Section “Animal Metabolism” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. Many of these papers are published by our Editorial Board Members and Guest Editors, and they are expected to attract readers’ interest and provide valuable opportunities for follow-up research.

The following is a list of articles that we believe will be of interest to you:

1. “Metabolomic Changes in Rat Serum after Chronic Exposure to Glyphosate-Based Herbicide”
by Oluwatosin Daramola, Cristian D. Gutierrez Reyes, Jesús Chávez-Reyes, Bruno A. Marichal-Cancino, Judith Nwaiwu, Sherifdeen Onigbinde, Moyinoluwa Adeniyi, Joy Solomon, Md Mostofa Al Amin Bhuiyan and Yehia Mechref
Metabolites 2024, 14(1), 50; https://doi.org/10.3390/metabo14010050
Available online: https://www.mdpi.com/2218-1989/14/6/314

2. “Identifying Predictive Biomarkers of Subclinical Mastitis in Dairy Cows through Urinary Metabotyping”
by Grzegorz Zwierzchowski, Klevis Haxhiaj, Roman Wójcik, David S. Wishart and Burim N. Ametaj
Metabolites 2024, 14(4), 205; https://doi.org/10.3390/metabo14040205
Available online: https://www.mdpi.com/2218-1989/14/4/205

3. “Impact of Substance Use Disorder on Tryptophan Metabolism Through the Kynurenine Pathway: A Narrative Review”
by Lindsey Contella, Christopher L. Farrell, Luigi Boccuto, Alain H. Litwin and Marion L. Snyder
Metabolites 2024, 14(11), 611; https://doi.org/10.3390/metabo14110611
Available online: https://www.mdpi.com/2218-1989/14/11/611

4. “Temperament Upregulates Mitochondrial Enzymes and Negatively Affects Myofibrillar Fragmentation in Beef of Excitable Bos taurus indicus Cattle”
by Patricia Maloso Ramos, Eduardo Francisquine Delgado, Ana Cláudia da Silva, Nara Regina Brandão Cônsolo, Vinicius Laerte Silva Herreira, João Marcos Bovetto de Campos Valim, Fernanda Maria Marins Ocampos, Luiz Alberto Colnago and Saulo da Luz e Silva
Metabolites 2025, 15(1), 24; https://doi.org/10.3390/metabo15010024
Available online: https://www.mdpi.com/2218-1989/15/1/24

5. “Depth of Interbreed Difference in Postmortem Bovine Muscle Determined by CE-FT/MS and LC-FT/MS Metabolomics”
by Susumu Muroya, Yuta Horiuchi, Kazuki Iguchi, Takuma Higuchi, Shuji Sakamoto, Koichi Ojima and Kazutsugu Matsukawa
Metabolites 2024, 14(5), 261; https://doi.org/10.3390/metabo14050261
Available online: https://www.mdpi.com/2218-1989/14/5/261

6. “Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment”
by Fulvio Laus, Marilena Bazzano, Andrea Spaterna, Luca Laghi and Andrea Marchegiani
Metabolites 2024, 14(5), 269; https://doi.org/10.3390/metabo14050269
Available online: https://www.mdpi.com/2218-1989/14/5/269

7. “Mitochondrial Abundance and Function Differ Across Muscle Within Species”
by Con-Ning Yen, Jocelyn S. Bodmer, Jordan C. Wicks, Morgan D. Zumbaugh, Michael E. Persia, Tim H. Shi and David E. Gerrard
Metabolites 2024, 14(10), 269; https://doi.org/10.3390/metabo14100553
Available online: https://www.mdpi.com/2218-1989/14/10/553

8. “Artemia Nauplii Enriched with Soybean Lecithin Enhances Growth Performance, Intestine Morphology, and Desiccation Stress Resistance in Yellow Drum (Nibea albiflora) Larvae”
by Zhenya Zhou, Pian Zhang, Peng Tan, Ruiyi Chen, Weihua Hu, Ligai Wang, Yuming Zhang and
Dongdong Xu
Metabolites 2025, 15(1), 63; https://doi.org/10.3390/metabo15010063
Available online: https://www.mdpi.com/2218-1989/15/1/63

9. “Mycotoxins in Feed: Hazards, Toxicology, and Plant Extract-Based Remedies”
by Xiangnan Zhang, Jiashun Chen, Xiaokang Ma, Xiongzhuo Tang, Bie Tan, Peng Liao, Kang Yao and Qian Jiang
Metabolites 2025, 15(4), 219; https://doi.org/10.3390/metabo15040219
Available online: https://www.mdpi.com/2218-1989/15/4/219

10. “Non-Alcoholic Fatty Liver Disease Induced by Feeding Medium-Chain Fatty Acids Upregulates Cholesterol and Lipid Homeostatic Genes in Skeletal Muscle of Neonatal Pigs”
by Samuel D. Gerrard, Fernando H. Biase, Joseph A. Yonke, Ravi Yadav, Anthony J. Shafron, Nishanth E. Sunny, David E. Gerrard and Samer W. El-Kadi
Metabolites 2024, 14(7), 384; https://doi.org/10.3390/metabo14070384
Available online: https://www.mdpi.com/2218-1989/14/7/384

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of the highly cited papers from the Section “Nutrition and Metabolism” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. In addition, some Special Issues related to this topic are currently open for submission.

The following is a list of articles and Special Issues that we believe will be of interest to you:

1. “Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health”
by Eugenio Caradonna, Federico Abate, Elisabetta Schiano, Francesca Paparella, Fulvio Ferrara, Emilio Vanoli, Rossana Difruscolo, Vito Maria Goffredo, Bruno Amato, Carlo Setacci et al.
Metabolites 2025, 15(4), 220; https://doi.org/10.3390/metabo15040220
Available Online: https://www.mdpi.com/2218-1989/15/4/220

2. “Iron Absorption: Molecular and Pathophysiological Aspects”
by Margherita Correnti, Elena Gammella, Gaetano Cairo and Stefania Recalcati
Metabolites 2024, 14(4), 228; https://doi.org/10.3390/metabo14040228
Available Online: https://www.mdpi.com/2218-1989/14/4/228

3. “The Role of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Livestock and Poultry Gut Health: A Review”
by Taojing Yue, Yanan Lu, Wenli Ding, Bowen Xu, Cai Zhang, Lei Li, Fuchun Jian and Shucheng Huang
Metabolites 2025, 15(7), 478; https://doi.org/10.3390/metabo15070478
Available Online: https://www.mdpi.com/2218-1989/15/7/478

4. “Obesity, Dietary Fats, and Gastrointestinal Cancer Risk-Potential Mechanisms Relating to Lipid Metabolism and Inflammation”
by Kathleen A. J. Mitchelson, Fiona O’Connell, Jacintha O’Sullivan and Helen M. Roche
Metabolites 2024, 14(1), 42; https://doi.org/10.3390/metabo14010042
Available Online: https://www.mdpi.com/2218-1989/14/1/42

5. “Research Progress on Antioxidant Peptides from Fish By-Products: Purification, Identification, and Structure–Activity Relationship”
by Xinru Liu, Qiuyue Hu, Yafang Shen, Yuxin Wu, Lu Gao, Xuechao Xu and Guijie Hao
Metabolites 2024, 14(10), 561; https://doi.org/10.3390/metabo14100561
Available Online: https://www.mdpi.com/2218-1989/14/10/561

6. “Physiological Perturbations in Combat Sports: Weight Cycling and Metabolic Function—A Narrative Review”
by Modesto A. Lebron, Jeffrey R. Stout and David H. Fukuda
Metabolites 2024, 14(2), 83; https://doi.org/10.3390/metabo14020083
Available Online: https://www.mdpi.com/2218-1989/14/2/83

7. “The Role of Olive Oil in Cardiometabolic Risk”
by Andrea Salvo and Antonino Tuttolomondo
Metabolites 2025, 15(3), 190; https://doi.org/10.3390/metabo15030190
Available Online: https://www.mdpi.com/2218-1989/15/3/190 

8. “Effects of the Menstrual Cycle and Hormonal Contraceptive Use on Metabolic Outcomes, Strength Performance, and Recovery: A Narrative Review”
by Hannah E. Cabre, Lacey M. Gould, Leanne M. Redman and Abbie E. Smith-Ryan
Metabolites 2024, 14(7), 347; https://doi.org/10.3390/metabo14070347
Available Online: https://www.mdpi.com/2218-1989/14/7/347

9. “Machine Learning-Driven Insights in Cancer Metabolomics: From Subtyping to Biomarker Discovery and Prognostic Modeling”
by Amr Elguoshy, Hend Zedan and Suguru Saito
Metabolites 2025, 15(8), 514; https://doi.org/10.3390/metabo15080514
Available Online: https://www.mdpi.com/2218-1989/15/8/514

10. “Bile Acids in Pancreatic Carcinogenesis”
by Bharti Sharma, Kate Twelker, Cecilia Nguyen, Scott Ellis, Navin D. Bhatia, Zachary Kuschner, Andrew Agriantonis, George Agriantonis, Monique Arnold, Jasmine Dave et al.
Metabolites 2024, 14(7), 348; https://doi.org/10.3390/metabo14070348
Available Online: https://www.mdpi.com/2218-1989/14/7/348

Special Issues:

“Nutrition and Metabolic Diseases: Mechanistic Insights and Personalized Dietary Strategies”
Guest Editors: Dr. Silvia Tagliamonte and Prof. Dr. Marcelo Macedo Rogero
Submission deadline: 15 July 2026

“Vitamin D Metabolism: Implications in Metabolic Health and Disease”
Guest Editors: Dr. Gar Yee Koh and Prof. Dr. Elena Planells
Submission deadline: 15 July 2026

“The Impact of Diet on the Metabolism and Body Composition of Patients with Skin Diseases”
Guest Editors: Dr. Giuseppe Annunziata, Prof. Dr. Luigi Barrea and Prof. Dr. Matteo Megna
Submission deadline: 20 July 2026

“Nutritional Metabolism and Biomarkers in Patients with Inflammatory Bowel Disease”
Guest Editor: Dr. Małgorzata Godala
Submission deadline: 25 July 2026

“Nutrition and Dietary Supplementation in the Context of Health, Disease, and Physical Performance”
Guest Editors: Dr. Magdalena Górnicka and Dr. Ewa Niedźwiedzka
Submission deadline: 25 July 2026

“Nutritional Intervention and Metabolic Health: Carbohydrates and Keto Diet”
Guest Editor: Dr. Louise Lu
Submission deadline: 30 July 2026

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of the highly cited papers from the Section “Microbiology and Ecological Metabolomics” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. In addition, some Special Issues related to this topic are currently open for submission.

The following is a list of articles and Special Issues that we believe will be interest of you:

1. “Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway”
by Huan-Huan Li, Xian Liu, Yu-Ping Wang, Xi Xu, Lin Zhu, Wei Zhang and Kun Ren
Metabolites 2025, 15(5), 329; https://doi.org/10.3390/metabo15050329
Full text available online: https://www.mdpi.com/2218-1989/15/5/329

2. “Meta-Analysis of Abiotic Conditions Affecting Exopolysaccharide Production in Cyanobacteria”
by Shijie Wu, Fuwen Wang, Hong Wang, Cong Shen and Kaiqiang Yu
Metabolites 2025, 15(2), 131; https://doi.org/10.3390/metabo15020131
Full text available online: https://www.mdpi.com/2218-1989/15/2/131

3. “In Vivo Effectiveness of Pleurotus ostreatus in Degradation of Toxic Metabolites of Filamentous Fungi Such as Aflatoxin B1 and Zearalenone”
by Agnieszka Zapaśnik, Marcin Bryła, Adrian Wojtczak and Barbara Sokołowska
Metabolites 2025, 15(1), 20; https://doi.org/10.3390/metabo15010020
Full text available online: https://www.mdpi.com/2218-1989/15/1/20

4. “Untargeted GC-MS Metabolic Profiling of Anaerobic Gut Fungi Reveals Putative Terpenoids and Strain-Specific Metabolites”
by Lazarina V. Butkovich, Candice L. Swift, Chaevien S. Clendinen, Heather M. Olson, Samuel O. Purvine, Oliver B. Vining and Michelle A. O’Malley
Metabolites 2025, 15(9), 578; https://doi.org/10.3390/metabo15090578
Full text available online: https://www.mdpi.com/2218-1989/15/9/578

5. “Exogenous γ-Aminobutyric Acid (GABA) Enhanced Response to Abiotic Stress in Hypsizygus marmoreus by Improving Mycelial Growth and Antioxidant Capacity”
by Zhi Cao, Hongyu Chen, Chenli Zhou, Ming Gong, Yan Li, Youran Shao, Yingying Wu and Dapeng Bao
Metabolites 2024, 14(2), 94; https://doi.org/10.3390/metabo14020094
Full text available online: https://www.mdpi.com/2218-1989/14/2/94

6. “Impact of Microplastic Exposure on Blood Glucose Levels and Gut Microbiota: Differential Effects under Normal or High-Fat Diet Conditions”
by Manjin Xu, Huixia Niu, Lizhi Wu, Mingluan Xing, Zhe Mo, Zhijian Chen, Xueqing Li and Xiaoming Lou
Metabolites 2024, 14(9), 504; https://doi.org/10.3390/metabo14090504
Full text available online: https://www.mdpi.com/2218-1989/14/9/504

7. “HMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses”
by Danica Bajic, Frank Wiens, Eva Wintergerst, Stef Deyaert, Aurélien Baudot and Pieter Van den Abbeele
Metabolites 2024, 14(4), 239; https://doi.org/10.3390/metabo14040239
Full text available online: https://www.mdpi.com/2218-1989/14/4/239

8. “Genetic Circuits for Feedback Control of Gamma-Aminobutyric Acid Biosynthesis in Probiotic Escherichia coli Nissle 1917”
by Matthew Lebovich, Marcos A. Lora, Jared Gracia-David and Lauren B. Andrews
Metabolites 2024, 14(1), 44; https://doi.org/10.3390/metabo14010044
Full text available online: https://www.mdpi.com/2218-1989/14/1/44

9. “MS2Lipid: A Lipid Subclass Prediction Program Using Machine Learning and Curated Tandem Mass Spectral Data”
by Nami Sakamoto, Takaki Oka, Yuki Matsuzawa, Kozo Nishida, Jayashankar Jayaprakash, Aya Hori, Makoto Arita and Hiroshi Tsugawa
Metabolites 2024, 14(11), 602; https://doi.org/10.3390/metabo14110602
Full text available online: https://www.mdpi.com/2218-1989/14/11/602

Special Issues:

“New Findings on Microbial Metabolism and Its Effects on Human Health”
Guest Editors: Dr. Ulrike E. Rolle-Kampczyk, Dr. Beatrice Engelmann and Dr. Sven-Bastiaan Haange
Submission deadline: 15 September 2026

“Metabolomics Approaches in Chemical Ecology: Decoding Interspecies Interactions Through Metabolic Profiling”
Guest Editors: Dr. Remington X. Poulin and Dr. C. Benjamin Naman
Submission deadline: 31 August 2026

“Dysbiosis and Metabolic Disorders of the Microbiota”
Guest Editor: Dr. Guozhu Ye
Submission deadline: 1 July 2026

“Microbial Metabolites and Host Health”
Guest Editor: Dr. Weilan Wang
Submission deadline: 30 June 2026

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are pleased to share some of the highly cited papers from the Section “Bioinformatics and Data Analysis” published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. In addition, some Special Issues related to this topic are currently open for submission.

The following is a list of notable articles and Special Issues:

1. “A Comprehensive LC–MS Metabolomics Assay for Quantitative Analysis of Serum and Plasma”
by Lun Zhang, Jiamin Zheng, Mathew Johnson, Rupasri Mandal, Meryl Cruz, Miriam Martínez-Huélamo, Cristina Andres-Lacueva and David S. Wishart
Metabolites 2024, 14(11), 622; https://doi.org/10.3390/metabo14110622
Available online: https://www.mdpi.com/2218-1989/14/11/622

2. “Explainable AI to Facilitate Understanding of Neural Network-Based Metabolite Profiling Using NMR Spectroscopy”
by Hayden Johnson and Aaryani Tipirneni-Sajja
Metabolites 2024, 14(6), 332; https://doi.org/10.3390/metabo14060332
Available online: https://www.mdpi.com/2218-1989/14/6/332

3. “Implementation of FAIR Practices in Computational Metabolomics Workflows—A Case Study”
by Mahnoor Zulfiqar, Michael R. Crusoe, Birgitta König-Ries, Christoph Steinbeck, Kristian Peters and Luiz Gadelha
Metabolites 2024, 14(2), 118; https://doi.org/10.3390/metabo14020118
Available online: https://www.mdpi.com/2218-1989/14/2/118

4. “Integrating TCGA and Single-Cell Sequencing Data for Hepatocellular Carcinoma: A Novel Glycosylation (GLY)/Tumor Microenvironment (TME) Classifier to Predict Prognosis and Immunotherapy Response”
by Yun Wu, Jiaru Chen, Riting Zhu, Guoliang Huang, Jincheng Zeng, Hongbing Yu, Zhiwei He and Cuifang Han
Metabolites 2024, 14(1), 51; https://doi.org/10.3390/metabo14010051
Available online: https://www.mdpi.com/2218-1989/14/1/51

5. “Temperature Dependence of Platelet Metabolism”
by Freyr Jóhannsson, James T. Yurkovich, Steinn Guðmundsson, Ólafur E. Sigurjónsson and Óttar Rolfsson
Metabolites 2024, 14(2), 91; https://doi.org/10.3390/metabo14020091
Available online: https://www.mdpi.com/2218-1989/14/2/91

6. “Analysis of In Vivo Plant Volatiles Using Active Sampling and TD-GC×GC-TOFMS”
by Sheri A. Schmidt, Ewenet Yemane Mesfin, Chaminda De Silva Weeraddana, A. Paulina de la Mata, Alejandro C. Costamagna and James J. Harynuk
Metabolites 2024, 14(11), 623; https://doi.org/10.3390/metabo14110623
Available online: https://www.mdpi.com/2218-1989/14/11/623

7. “Advanced Machine Learning for Comparative Synovial Fluid Analysis in Osteoarthritis and Rheumatoid Arthritis”
by Karolina Krystyna Kopeć, Gabrieleanselmo Uccheddu, Paweł Chodnicki, Antonio Noto, Cristina Piras, Martina Spada, Luigi Atzori and Vassilios Fanos
Metabolites 2025, 15(2), 112; https://doi.org/10.3390/metabo15020112  
Available online: https://www.mdpi.com/2218-1989/15/2/112

8. “A Comprehensive Comparison between Primary Liver Cancer and Liver Metastases through scRNA-Seq Data Analysis”
by Shuang Hao, Liqun Chen, Wenhui Du and Huiyan Sun
Metabolites 2024, 14(2), 90; https://doi.org/10.3390/metabo14020090
Available online: https://www.mdpi.com/2218-1989/14/2/90

9. “A Deep Mining Strategy for Peptide Rapid Identification in Lactobacillus reuteri Based on LC–MS/MS Integrated with FBMN and De Novo Sequencing”
by Yilang Zuo, Shilin Gong, Li Zhang, Jie Zhou, Jian-Lin Wu and Na Li
Metabolites 2024, 14(9), 467; https://doi.org/10.3390/metabo14090467
Available online: https://www.mdpi.com/2218-1989/14/9/467

10. “Intra-Individual Variations in How Insulin Sensitivity Responds to Long-Term Exercise: Predictions by Machine Learning Based on Large-Scale Serum Proteomics”
by Jonas Krag Viken, Thomas Olsen, Christian André Drevon, Marit Hjorth, Kåre Inge Birkeland, Frode Norheim and Sindre Lee-Ødegård
Metabolites 2024, 14(6), 335; https://doi.org/10.3390/metabo14060335
Available online: https://www.mdpi.com/2218-1989/14/6/335

Special Issues:

1. “Mechanism-Aware Machine Learning in Metabolomics and Clinical Translation: Signatures, Pathways, and Patient Impact”
Guest Editor: Dr. Vasuk Gautam
Submission deadline: 31 July 2026

2. “Machine Learning in Metabolomics: Unlocking the Future of Data Analysis”
Guest Editors: Dr. Boryana Petrova and Dr. Arzu Tugce Guler
Submission deadline: 31 May 2026

3. “Open-Source Software in Metabolomics, 2nd Edition”
Guest Editor: Prof. Dr. Seongho Kim
Submission deadline: 10 May 2026

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of feature papers from the Section “Bioinformatics and Data Analysis” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. Many of these papers are published by our Editorial Board Members and Guest Editors, and they are expected to attract readers’ interest and provide valuable opportunities for follow-up research.

The following is a list of articles that we believe will be of interest to you:

1. “The Omics Dashboard for Interactive Exploration of Metabolomics and Multi-Omics Data”
by Suzanne Paley and Peter D. Karp
Metabolites 2024, 14(1), 65; https://doi.org/10.3390/metabo14010065
Available online: https://www.mdpi.com/2218-1989/14/1/65

2. “Predicting the Pathway Involvement of Metabolites Based on Combined Metabolite and Pathway Features”
by Erik D. Huckvale and Hunter N. B. Moseley
Metabolites 2024, 14(5), 266; https://doi.org/10.3390/metabo14050266
Available online: https://www.mdpi.com/2218-1989/14/5/266

3. “A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation”
by Mario Lovrić, Tingting Wang, Mads Rønnow Staffe, Iva Šunić, Kristina Časni, Jessica Lasky-Su, Bo Chawes and Morten Arendt Rasmussen
Metabolites 2024, 14(5), 278; https://doi.org/10.3390/metabo14050278
Available online: https://www.mdpi.com/2218-1989/14/5/278

4. “Predicting the Association of Metabolites with Both Pathway Categories and Individual Pathways”
by Erik D. Huckvale and Hunter N. B. Moseley
Metabolites 2024, 14(9), 510; https://doi.org/10.3390/metabo14090510
Available online: https://www.mdpi.com/2218-1989/14/9/510

5. “Predicting the Pathway Involvement of All Pathway and Associated Compound Entries Defined in the Kyoto Encyclopedia of Genes and Genomes”
by Erik D. Huckvale and Hunter N. B. Moseley
Metabolites 2024, 14(11), 582; https://doi.org/10.3390/metabo14110582
Available online: https://www.mdpi.com/2218-1989/14/11/582

6. “Global Lipidomics Reveals the Lipid Composition Heterogeneity of Extracellular Vesicles from Drug-Resistant Leishmania”
by Sehyeon (Erica) Kim, Ana Victoria Ibarra-Meneses, Christopher Fernandez-Prada and Tao Huan
Metabolites 2024, 14(12), 658; https://doi.org/10.3390/metabo14120658
Available online: https://www.mdpi.com/2218-1989/14/12/658

7. “Comprehensive Blood Metabolome and Exposome Analysis, Annotation, and Interpretation in E-Waste Workers”
by Zhiqiang Pang, Charles Viau, Julius N. Fobil, Niladri Basu and Jianguo Xia
Metabolites 2024, 14(12), 671; https://doi.org/10.3390/metabo14120671
Available online: https://www.mdpi.com/2218-1989/14/12/671

8. “Matrix Linear Models for Connecting Metabolite Composition to Individual Characteristics”
by Gregory Farage, Chenhao Zhao, Hyo Young Choi, Timothy J. Garrett, Marshall B. Elam, Katerina Kechris and Śaunak Sen
Metabolites 2025, 15(2), 140; https://doi.org/10.3390/metabo15020140
Available online: https://www.mdpi.com/2218-1989/15/2/140

9. “Predicting the Pathway Involvement of Compounds Annotated in the Reactome Knowledgebase”
by Erik D. Huckvale and Hunter N. B. Moseley
Metabolites 2025, 15(3), 161; https://doi.org/10.3390/metabo15030161
Available online: https://www.mdpi.com/2218-1989/15/3/161

10. “Cytokine-Based Insights into Bloodstream Infections and Bacterial Gram Typing in ICU COVID-19 Patients”
by Rúben Araújo, Luís Ramalhete, Cristiana P. Von Rekowski, Tiago A. H. Fonseca, Cecília R. C. Calado and Luís Bento
Metabolites 2025, 15(3), 204; https://doi.org/10.3390/metabo15030204
Available online: https://www.mdpi.com/2218-1989/15/3/204

11. “Integrative Modeling of Urinary Metabolomics and Metal Exposure Reveals Systemic Impacts of Electronic Waste in Exposed Populations”
by Fiona Hui, Zhiqiang Pang, Charles Viau, Gerd U. Balcke, Julius N. Fobil, Niladri Basu and Jianguo Xia
Metabolites 2025, 15(7), 456; https://doi.org/10.3390/metabo15070456
Available online: https://www.mdpi.com/2218-1989/15/7/456

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of the highly cited papers from the Section “Food Metabolomics” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. In addition, some Special Issues related to the scope of this section are currently open for submission.

The following is a list of articles and Special Issues that we believe will be of interest to you:

1. “Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions”
by Giovanni Martemucci, Mohamad Khalil, Alessio Di Luca, Hala Abdallah and Angela Gabriella D’Alessandro
Metabolites 2024, 14(6), 327; https://doi.org/10.3390/metabo14060327
Available online: https://www.mdpi.com/2218-1989/14/6/327

2. “Nutritional Modulation of the Gut–Brain Axis: A Comprehensive Review of Dietary Interventions in Depression and Anxiety Management”
by Mariana Merino del Portillo, Vicente Javier Clemente-Suárez, Pablo Ruisoto, Manuel Jimenez, Domingo Jesús Ramos-Campo, Ana Isabel Beltran-Velasco, Ismael Martínez-Guardado, Alejandro Rubio-Zarapuz, Eduardo Navarro-Jiménez and José Francisco Tornero-Aguilera
Metabolites 2024, 14(10), 549; https://doi.org/10.3390/metabo14100549
Available online: https://www.mdpi.com/2218-1989/14/10/549

3. “Explorative Study on Volatile Organic Compounds of Cinnamon Based on GC-IMS”
by Yu Pan, Liya Qiao, Shanshuo Liu, Ye He, Danna Huang, Wuwei Wu, Yingying Liu, Lu Chen and Dan Huang
Metabolites 2024, 14(5), 274; https://doi.org/10.3390/metabo14050274
Available online: https://www.mdpi.com/2218-1989/14/5/274

4. “Investigation of the Functional Components in Health Beverages Made from Polygonatum cyrtonema Rhizomes Provides Primary Evidence to Support Their Claimed Health Benefits”
by Qiyan Song, Youwu Chen, Ye Shao, Weiting Pu, Bihuan Ye, Xiaoxiao Shi, Jianjun Shen and Haibo Li
2024, 14(7), 376; https://doi.org/10.3390/metabo14070376
Available online: https://www.mdpi.com/2218-1989/14/7/376

5. “The Effect of Maternal Overweight/Obesity on Serum and Breastmilk Leptin, and Its Associations with Body Composition, Cardiometabolic Health Indices, and Maternal Diet: The BLOOM Study”
by Monika A. Zielinska-Pukos, Łukasz Kopiasz and Jadwiga Hamulka
Metabolites 2024, 14(4), 221; https://doi.org/10.3390/metabo14040221
Available online: https://www.mdpi.com/2218-1989/14/4/221

6. “Changes in Metabolite Profiles of Chinese Soy Sauce at Different Time Durations of Fermentation Studied by ¹H-NMR-Based Metabolomics”
by Jalal Uddin, Samra Yasmin, Ghulam Mustafa Kamal, Mufarreh Asmari, Muhammad Saqib and Heyu Chen
Metabolites 2024, 14(5), 285; https://doi.org/10.3390/metabo14050285
Available online: https://www.mdpi.com/2218-1989/14/5/285

7. “Non-Targeted Metabolomics Analysis Reveals Metabolite Profiles Change During Whey Fermentation with Kluyveromyces marxianus”
by Yansong Gao, Lei Gao, You Kang, Ge Yang, Zijian Zhao, Yujuan Zhao and Shengyu Li
Metabolites 2024, 14(12), 694; https://doi.org/10.3390/metabo14120694
Available online: https://www.mdpi.com/2218-1989/14/12/694

8. “Metabolomics Reveals the Effects of Nitrogen/Phosphorus/Potassium (NPK) Fertilizer Levels on Cucumber Fruit Raised in Different Nutrient Soils”
by Na-Rae Lee, Yangmin X. Kim, Yerim Lee, Chanwook Lee, Yosung Song, Hyejin Park, Choong Hwan Lee and Yejin Lee
Metabolites 2024, 14(2), 102; https://doi.org/10.3390/metabo14020102
Available online: https://www.mdpi.com/2218-1989/14/2/102

9. “Metabolomics Analysis Reveals Characteristic Functional Components in Pigeon Eggs”
by Rui Zhang, Lingling Chang, Xinyue Shen, Qingping Tang, Chunyu Mu, Shengyong Fu and Zhu Bu
Metabolites 2025, 15(2), 122; https://doi.org/10.3390/metabo15020122
Available online: https://www.mdpi.com/2218-1989/15/2/122

10. “Role of Dietary Ceramide 2-Aminoethylphosphonate on Aberrant Crypt Foci Formation and Colon Inflammation in 1,2-Dimethylhydrazine-Treated Mice: A Comparison with the Role of Sphingomyelin”
by Shinji Yamashita, Wakaba Yutani, Maho Sugimoto, Kazuo Miyashita and Mikio Kinoshita
Metabolites 2025, 15(3), 147; https://doi.org/10.3390/metabo15030147
Available online: https://www.mdpi.com/2218-1989/15/3/147

11. “Effects of Roasting Process on Sensory Qualities, Color, Physicochemical Components, and Identification of Key Aroma Compounds in Hubei Strip-Shaped Green Tea”
by Fei Ye, Anhui Gui, Xiaoyan Qiao, Panpan Liu, Xueping Wang, Shengpeng Wang, Lin Feng, Jin Teng, Jinjin Xue, Xun Chen et al.
Metabolites 2025, 15(3), 155; https://doi.org/10.3390/metabo15030155
Available online: https://www.mdpi.com/2218-1989/15/3/155

12. “Identification and Evaluation of Colour Change in Rosemary and Biluochun Tea Infusions”
by Yuan Yuan, Caochuang Fang, Chaohan Li, Jiaqi You and Kun Ma
Metabolites 2025, 15(4), 265; https://doi.org/10.3390/metabo15040265
Available online: https://www.mdpi.com/2218-1989/15/4/265

Special Issues:

1. “Foodomics: Advanced Molecular Profiling for Future Nutrition and Sustainable Food Systems”
Guest Editors: Dr. Sung-Tong Chin and Dr. Suwimol Chockchaisawasdee
Submission deadline: 15 August 2026

2. “Effects of Micronutrients on Human Metabolism”
Guest Editor: Dr. Lin Xiao
Submission deadline: 17 April 2026

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of the feature papers from the Section “Food Metabolomics” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. Many of the papers are from our Editorial Board Members and Guest Editors; they are expected to attract readers’ interest and provide valuable opportunities for follow-up research.

The following is a list of articles that we believe will be of interest to you:

1. “Integrative Genomic and Metabolomic Analysis Identifies mQTLs Associated with Genetic Selection for Tenderness in Nellore Cattle”
by Joao Marcos Bovetto de Campos Valim, Vinicius Laerte Silva Herreira, Ana Laura dos Santos Munhoz Gôngora, Lauro César Ferreira Beltrão, Eduardo Solano Pina dos Santos, Brenda Santos de Oliveira, Guilherme Pugliesi, Miguel Henrique de Almeida Santana, Guilherme Henrique Gebim Polizel, Luiz Alberto Colnago et al.
Metabolites 2025, 15(12), 760; https://doi.org/10.3390/metabo15120760
Available online: https://www.mdpi.com/2218-1989/15/12/760

2. “Metabolomic Variation in Sugarcane Maturation Under a Temperate Climate”
by Yasuhiro Date, Chiaki Ishikawa and Hiroshi Ono
Metabolites 2025, 15(8), 558; https://doi.org/10.3390/metabo15080558
Available online: https://www.mdpi.com/2218-1989/15/8/558

3. “Tracking Metabolite Variations during the Degradation of Vegetables in Rice Bran Bed with Intact-State Nuclear Magnetic Resonance Spectroscopy”
by Kengo Ito, Ryusei Yamamoto and Yasuyo Sekiyama
Metabolites 2024, 14(7), 391; https://doi.org/10.3390/metabo14070391
Available online: https://www.mdpi.com/2218-1989/14/7/391

4. “A Data-Driven Approach to Link GC-MS and LC-MS with Sensory Attributes of Chicken Bouillon with Added Yeast-Derived Flavor Products in a Combined Prediction Model”
by Simon Leygeber, Carmen Diez-Simon, Justus L. Großmann, Anne-Charlotte Dubbelman, Amy C. Harms, Johan A. Westerhuis, Doris M. Jacobs, Peter W. Lindenburg, Margriet M. W. B. Hendriks, Brenda C. H. Ammerlaan et al.
Metabolites 2025, 15(5), 317; https://doi.org/10.3390/metabo15050317
Available online: https://www.mdpi.com/2218-1989/15/5/317

5. “Effect of Thermal Processing by Spray Drying on Key Ginger Compounds”
by Alina Warren-Walker, Manfred Beckmann, Alison Watson, Steffan McAllister and Amanda J. Lloyd
Metabolites 2025, 15(6), 350; https://doi.org/10.3390/metabo15060350
Available online: https://www.mdpi.com/2218-1989/15/6/350

6. “Single-Nucleus RNA Sequencing Reveals Muscle-Region-Specific Differences in Fibro-Adipogenic Progenitors Driving Intramuscular Fat Accumulation”
by Shuji Ueda, Chiaki Kitamura, Yuka Tateoka, Akinori Kanai, Yutaka Suzuki, Itsuko Fukuda
and Yasuhito Shirai
Metabolites 2025, 15(4), 231; https://doi.org/10.3390/metabo15040231
Available online: https://www.mdpi.com/2218-1989/15/4/231

7. “Dose-Dependent Effects of Turmeric (Curcuma aromatica S.) Starch on Colonic Fermentation in Rats”
by Ekanayake Mudiyanselage Asanka Chamara Ekanayake, Ryota Ishii, Ryuji Nagata, Ken-ichiro Shimada, Kyu-Ho Han and Michihiro Fukushima
Metabolites 2024, 14(11), 572; https://doi.org/10.3390/metabo14110572
Available online: https://www.mdpi.com/2218-1989/14/11/572

8. “A Data-Driven Approach to Sugarcane Breeding Programs with Agronomic Characteristics and Amino Acid Constituent Profiling”
by Chiaki Ishikawa, Yasuhiro Date, Makoto Umeda, Yusuke Tarumoto, Megumi Okubo, Yasujiro Morimitsu, Yasuaki Tamura, Yoichi Nishiba and Hiroshi Ono
Metabolites 2024, 14(4), 243; https://doi.org/10.3390/metabo14040243
Available online: https://www.mdpi.com/2218-1989/14/4/243

9. “Chromatography-Based Metabolomics as a Tool in Bioorganic Research of Honey”
by Marina Kranjac, Piotr Marek Kuś, Saša Prđun, Renata Odžak and Carlo Ignazio Giovanni Tuberoso
Metabolites 2024, 14(11), 606; https://doi.org/10.3390/metabo14110606
Available online: https://www.mdpi.com/2218-1989/14/11/606

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of the highly cited papers from the Section “Integrative Metabolomics” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. In addition, some Special Issues related to this topic are currently open for submission.

The following is a list of articles and Special Issues that we believe will be of interest to you:

1. “Integrated Transcriptomics and Metabolomics Analysis Reveals the Effects of Cutting on the Synthesis of Flavonoids and Saponins in Chinese Herbal Medicine Astragalus mongholious”
by Xu Guo, Xiang Yan, Yuanyuan Wang, Zhiyong Shi, Jingping Niu, Jianping Liang and Xiaoyun Jia
Metabolites 2024, 14(2), 97; https://doi.org/10.3390/metabo14020097
Available online: https://www.mdpi.com/2218-1989/14/2/97

2. “Underlying Mechanisms of Chromatographic H/D, H/F, cis/trans and Isomerism Effects in GC-MS”
by Dimitrios Tsikas
Metabolites 2025, 15(1), 43; https://doi.org/10.3390/metabo15010043
Available online: https://www.mdpi.com/2218-1989/15/1/43

3. “LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling”
by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis and Helen Gika
Metabolites 2025, 15(1), 62; https://doi.org/10.3390/metabo15010062  
Available online: https://www.mdpi.com/2218-1989/15/1/62

4. “Metabolomics and Lipidomics Analyses Aid Model Classification of Type 2 Diabetes in Non-Human Primates”
by Peining Tao, Stacey Conarello, Thomas P. Wyche, Nanyan Rena Zhang, Keefe Chng, John Kang and Theodore R. Sana
Metabolites 2024, 14(3), 159; https://doi.org/10.3390/metabo14030159
Available online: https://www.mdpi.com/2218-1989/14/3/159

5. “From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes”
by Lente Blok, Nordin Hanssen, Max Nieuwdorp and Elena Rampanelli
Metabolites 2025, 15(2), 138; https://doi.org/10.3390/metabo15020138
Available online: https://www.mdpi.com/2218-1989/15/2/138

Special Issues:

“Integrating Metabolism and Molecular Biology in Cancer Research and Therapeutics”
Guest Editor: Dr. Susmita Barman
Submission deadline: 30 June 2026

“Metabolomic Strategies for Deep Systems Profiling Towards Biomarker Discovery and Precision Medicine”
Guest Editors: Dr. Silvia Valentinuzzi and Dr. Troy D. Wood
Submission deadline: 25 July 2026

“Integrative Metabolomics: Pathway Dynamics, Exposure Analysis and Precision Health”
Guest Editors: Dr. Soundara Viveka Thangaraj and Prof. Dr. Wei Sha
Submission deadline: 31 August 2026

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).

We are delighted to share some of feature papers from the Section “Integrative Metabolomics” that were published in Metabolites (ISSN: 2218-1989) in 2024 and 2025. Some of these papers are authored by our Editorial Board Members and Guest Editors; they are expected to attract readers’ interest and provide valuable opportunities for follow-up research.

The following is a list of articles that we believe will be of interest to you:

1. “LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling”
by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis and Helen Gika
Metabolites 2025, 15(1), 62; https://doi.org/10.3390/metabo15010062  
Available online: https://www.mdpi.com/2218-1989/15/1/62

2. “Multifluid Metabolomics Identifies Novel Biomarkers for Irritable Bowel Syndrome”
by Daniel Kirk, Panayiotis Louca, Ilias Attaye, Xinyuan Zhang, Kari E. Wong, Gregory A. Michelotti, Mario Falchi, Ana M. Valdes, Frances M. K. Williams and Cristina Menni
Metabolites 2025, 15(2), 121; https://doi.org/10.3390/metabo15020121
Available online: https://www.mdpi.com/2218-1989/15/2/121

3. “Metabolomic Profiling of Hepatitis B-Associated Liver Disease Progression: Chronic Hepatitis B, Cirrhosis, and Hepatocellular Carcinoma”
by Junsang Oh, Kei-Anne Garcia Baritugo, Jayoung Kim, Gyubin Park, Ki Jun Han, Sangheun Lee and Gi-Ho Sung
Metabolites 2025, 15(8), 504; https://doi.org/10.3390/metabo15080504
Available online: https://www.mdpi.com/2218-1989/15/8/504

4. “Herbal Weight Loss Supplements Induce Metabolomic In Vitro Changes Indicative of Oxidative Stress”
by Emily C. Davies, Garth L. Maker, Ian F. Musgrave and Samantha Lodge
Metabolites 2025, 15(9), 587; https://doi.org/10.3390/metabo15090587
Available online: https://www.mdpi.com/2218-1989/15/9/587

5. “NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance”
by Adam Varga, Adam Attila Matrai, Barbara Bedocs-Barath, Laszlo Adam Fazekas, Felipe Salignac Brasil, Aashna Mehta, Erzsebet Vanyolos, Adam Deak, Tamas Lesznyak, Katalin Peto et al.
Metabolites 2025, 15(9), 607; https://doi.org/10.3390/metabo15090607
Available online: https://www.mdpi.com/2218-1989/15/9/607

If you are an active researcher in the field and are passionate about participating in cutting-edge research publications, please do not hesitate to contact the Metabolites Editorial Office (metabolites@mdpi.com).