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Metabolites
Special Issues
Effects of Nutrition Intake on Pet Metabolism
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Effects of Nutrition Intake on Pet Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: 1 September 2025 | Viewed by 675

Special Issue Editor

Dr. Giulia Pignataro

E-Mail Website
Guest Editor
Department of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy
Interests: nutrition; gut microbiota; nutraceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The focus on animal nutrition is the trend of the moment, not only for the scientific community but also for pet owners who are increasingly curious and well versed in nutrition.

Healthy dietary patterns and specific nutrients have been shown to be beneficial for promoting health and prolonging life among pets.

Various nutrients and substances and their effect on the body that takes them up are already known, and there is increasing attention on the search for new substances including phytotherapeutic ones.

Given the importance of this issue, the journal Metabolites is planning a Special Issue, titled “Effects of Nutrition Intake on Pet Metabolism”, with the aim of providing a source for accurate, up-to-date scientific information on this topic.

This Special Issue aims to investigate the growing attention of the scientific world but also of the feed industry in pet food and nutraceuticals.

The submitted manuscripts should focus on nutrition epidemiology, the direct impact of specific food components, dietary patterns, energy intake, macro- and micro-nutrients, food insecurity, innovative foods, malnourishment, and appetite on the health status of pets. We also welcome manuscripts that focus on nutrition intervention studies (i.e., protein diet and diet quality) and nutrient intake effects on pet morbility (i.e., multimorbidity, well-being, and frailty).

Dr. Giulia Pignataro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pet nutrition
  • pet food
  • nutraceuticals
  • clinical dietetics
  • metabolomics

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Published Papers (1 paper)

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Research

14 pages, 1761 KiB  
Article
Ergosterol Protects Canine MDCK Cells from Gentamicin-Induced Damage by Modulating Autophagy and Apoptosis
by Zhipeng Qin, Liuwei Xie, Yao Wang, Na Zhang, Hailong Bi, Mingqiang Song and Chao Xu
Metabolites 2025, 15(6), 373; https://doi.org/10.3390/metabo15060373 - 5 Jun 2025
Viewed by 436
Abstract
Background: Renal injury is a critical health issue in pet dogs, often exacerbated by drug-induced nephrotoxicity such as gentamicin (GM). This study investigated the protective effects of ergosterol (Erg), a natural compound from edible mushrooms, against GM-induced damage in Madin–Darby canine kidney (MDCK) [...] Read more.
Background: Renal injury is a critical health issue in pet dogs, often exacerbated by drug-induced nephrotoxicity such as gentamicin (GM). This study investigated the protective effects of ergosterol (Erg), a natural compound from edible mushrooms, against GM-induced damage in Madin–Darby canine kidney (MDCK) cells. Methods: MDCK cells were treated with GM (0.5–3 mmol/L) for 12 h to establish injury. Erg (1 to 32 μg/mL) was pretreated for 12 h before GM exposure (2 mmol/L). Cell viability, nitric oxide (NO), lactate dehydrogenase (LDH), oxidative stress markers (SOD, GSH, CAT, MDA), inflammatory cytokines (IL-1β, IL-6, TNF-α), renal function indicators (Scr, BUN), and autophagy/apoptosis-related proteins (ATG5, Beclin1, P62, BAX, BCL-2) were assessed via CCK-8, ELISA, fluorescence staining, and Western blot. Statistical significance (p < 0.05) was determined by ANOVA and LSD post hoc tests. Results: GM (2 mmol/L) significantly reduced cell viability (p < 0.01) and elevated NO and LDH levels (p < 0.01). Erg pretreatment (4–8 μg/mL) restored cell viability (p < 0.01), suppressed NO (p < 0.01) and LDH release (p < 0.01), and enhanced antioxidant enzyme activities (SOD, GSH, CAT; p < 0.01). Erg attenuated GM-induced reactive oxygen species (ROS) overproduction (p < 0.01) and decreased pro-inflammatory cytokines (IL-1β, IL-6, TNF-α; p < 0.01). Renal markers Scr and BUN were reduced (p < 0.01). Mechanistically, Erg upregulated autophagy proteins ATG5 and Beclin1 (p < 0.01), reduced P62 accumulation (p < 0.01), and lowered the BAX/BCL-2 ratio (p < 0.01). Conclusions: Erg protects MDCK cells from GM-induced nephrotoxicity by restoring autophagy flux, suppressing mitochondrial apoptosis, and mitigating oxidative stress and inflammation. These findings highlight Erg’s potential as a natural therapeutic agent for canine renal injury. Further in vivo studies are needed to validate its clinical efficacy. Full article
(This article belongs to the Special Issue Effects of Nutrition Intake on Pet Metabolism)
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