Proceedings, Volume 41, 2019

A magnetic composite consisting of iron oxide and a cobalt–aluminum-layered double hydroxide, Fe₂O₃@Co-Al-layered double hydroxide was prepared through linking of Fe₂O₃ to Co-Al layered double hydroxide (LDH) by sodium acetate. Layered double hydroxi...

C*-BODIPYs, that is, boron dipyrromethenes (BODIPYs) which have chiral carbons attached directly to the boron center, are introduced for the first time. These novel chiral BODIPYs mean a new strategy for the chiral perturbation of the inherently achi...

In recent years, heterogeneous semiconductor photocatalysts have attracted great attention in the arena of environmental remediation and solar energy conversion; because, sunlight energy is a renewable, cheap, and accessible source of energy and also...

A series of isoxazole based (E)-1-(isoxazole-5-yl)-3-(substituted phenyl)-prop-2-en-1-ones (chalcones, 3a-3o) and 3-(isoxazol-5-yl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide (dihydropyrazoles, 4a-4o) were synthesized, characterized...

Six 1,3-oxazoles were synthetized in moderate to good yields by Van Leusen reaction in a pressure reactor. The methodology allowed to decrease the reaction times reported in the literature from hours to 20 min. In addition, preliminary qualitative re...

The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts of Annona reticulata with Allium fistolisum and Brassica oleraceaeand correlate cytotoxicity results with known pharmacologi...

A series of six new alkyne-2-chloroquinolines were synthesized in moderate yields (40%–65%) via the Passerini three-component reaction (P-3CR) under mild green conditions. The P-3CR takes place when a carboxylic acid, an oxo compound (aldehyde or ket...

The present study was conducted to test for in vivo Brine Shrimp Lethality Assay (BSLA) of the Aqueous and ethanolic extracts Annona reticulate Linn. and Allium sativumand correlate cytotoxicity results with known pharmacological activities of the pl...

The isolation of water-soluble polysaccharides and proteins solubilized during the treatment of rye flour in an isotonic aqueous medium is described. Protein and polysaccharide assays of the aqueous fractions showed the high extraction performance of...

Noble metallic nanoparticles, silver (AgNPs) and gold (AuNPs) mainly, exhibit good antimicrobial, antibacterial, and antifungal properties and, therefore, have a significant contribution to the constant growing field of nanomedicine. They can be synt...

The Ugi four-component reaction is versatile multicomponent reaction for generation of complex diversity, herein, we developed a novel methodology by using 4-((1-((tetrahydrofuran-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde as one of the...

A series of imidazo[1,2-a]pyridine-chromones were synthesized by microwave-assisted Groebke–Blackburn–Bienaymé reaction (GBBR) under eco-friendly conditions (20 mol% ammonium chloride catalyst in EtOH). Chromones and imidazo[1,2-a]pyridines are a pr...

A series of six fused bis-heterocycles having imidazo[1,2-a]pyridine bound with quinoline were synthesized by microwave-assisted Groebke-Blackburn-Bienaymé reaction (GBBR) under green catalysis. The GBB products are privileged scaffolds and their syn...

Currently, the plastic packaging industry in Brazil is the second largest producer in the packaging sector, with approximately 35% of the total packaging produced per year. Out of this total, 572 thousand tons are composed of polyethylene terephthala...

The essential oils (EOs) from the leaves of Schinus areira and one of its components, globulol, were studied for their antioxidant, antimutagenic and antipromutagenic activities. The chemical composition of the EOs obtained using hydrodistillation w...

Isosorbide is a competitive starting material for various valuable derivatives by functionalization and/or substitution since it is a renewable and carbon neutral material that is produced on an industrial scale from sorbitol. A set of O-alkyl- or O-...

Monoterpenes are optically active compounds which occur in nature. This fact makes them interesting precursors for the synthesis of optically active ligands, which can be applied in various asymmetric reactions. In this work, we present the synthesis...

Tetralactam macrocycles are suitable candidates to be employed as synthetic receptors for charged or neutral guests. In the sensing of neutral molecules, nonpolar solvents such as chloroform or dichloromethane are usually employed so the hydrogen-bon...

Plants have been used for centuries to treat diseases and are considered an important source of new antimicrobial agents. Plant extracts can be obtained and their composition determined, being widely employed in the pharmaceutical and cosmetic indust...

We investigated electrochemical sensors based on graphite oxide (GrO) and oxidized carbon black (CbO). GrO and CbO were synthesized by the modified Hummers method. Single-stranded DNA (ssDNA) probes were synthesized with a 5′ primary amine for attach...

In the present work, our objective is to take advantage of the property presented by Ionic Liquids (ILs) based on 1-alkyl-3-methylimidazolium cations by having amphiphilic character when the alkyl group is a long hydrocarbon chain. These ILs can act...

The composition of the repugnatorial secretion of some populations of the Cuban endemic millipede Rhinocricus inhabiting in the western region of the Cuban archipelago has been developed. Several quinonoids metabolites were identified. From some indi...

In this plan, we use Praseodymium metal-doped copper indium disulfide (Pr-doped CIS) heterostructure as hole-transporting materials (HTMs) in the FTO/TiO2/Perovskite absorber/HTM/ Au device. And photovoltaic performance of these Pr-doped CIS heterost...

Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble to form different types...

The sensors modified carbon nanotubes and molecularly imprinted polymers are an excellent choice for the determination of D-arabinose, because they have high selectivity and sensitivity for analysis. This allows the control and optimization of the se...

Ionic liquids (ILs) are mostly composed of organic cations and organic/inorganic anions. One of the most important class of ILs are imidazolium ILs. The hydrophilicity and hydrophobicity of ILs are regularly influenced by length of alkyl side chain o...

In certain countries, many of the reagents used to transform carboxylic acids to acyl halides such as phosphorus trichloride, phosphorus tribromide, phosphorus pentachloride, phosphoryl chloride, thionyl chloride and sulfuryl chloride are difficult t...

Activated alkenes such as cinnamates and chalcones can easily be converted to 2,3-dideuterio-arylpropionates and dideuteriochalcones, respectively, by the action of NaBD₄, AcOD in the presence of Pd on carbon. Toluene or benzene was used as solvent....

An eco-friendly methodology for the synthesis of novel Schiff base analogs of Raltegravir, an Integrase inhibitor drug is described. Pertinence of these imine derivatives is related to Medicinal Chemistry to develop new anti-VIH compounds. To our kno...

We have developed a new idea to synthesize key intermediate molecule by utilizing deep eutectic solvent (DES) and ultrasound in a multistep reaction to ensure process cost-effective. Key intermediate (3) and final compounds (4a–n) were synthesized in...

Although the wide arsenal of drugs available to treat bacterial infections, emerging drug-resistant bacterial pathogens have recently highlighted an urgent need to find new more effective and less toxic therapeutic agents. Fluoroquinolones, includin...

A new series of 5-acetylbarbituric based thiosemicarbazones named 5-acetylbarbituric hydrazine-1-carbothioamide (Acb4NDH, 1), N-methyl-(5-acetylbarbituric)hydrazine- 1-carbothioamide (Acb4NM, 2), N-ethyl-(5-acetylbarbituric)hydrazine-1-carbothioamide...

A series of six di- and tri-halogenated N-arylcinnamanilides designed as anti-inflammatory and antimicrobial agents was prepared and characterized. Since it is known that lipophilicity significantly influences the biological activity of compounds, th...

Several synthetic routes have been achieved to synthesize pyrane fused systems. As a follow up of earlier work, we hereby report the microwave assisted synthesis of key intermediate, pyrane fused acridine compounds 3a–f. It was obtained by treating α...

Chalcones are a group of compounds that belong to the flavonoid family and have a wide variety of uses, including a high therapeutic potential for multiple diseases, such as, anticancer, antifungal or antibacterial agents. As is well known, chalcones...

Currently, constructing solid acid catalysts with well-defined structures, environmentally benign, with high catalytic activity, easy separation, and high chemical stability is the most important area of industrial and environmental concern. Over the...

New coumarin namely 2-(3-(7-methylcoumarin)acetamido)benzoic acid (MAB) was successfully synthesized by reaction of ethyl 2-(7-methylcoumarin)acetate with anthranilic acid. The chemical structure of MAB was confirmed by FT-IR, NMR spectroscopies and...

A series of 1,3,5-triazine derivatives, incorporating aminobenzenesulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step by step nucle...

In this study, a novel porphyrin-based metal–organic framework (Co-Por MOF) was successfully synthesized by a simple one-step solvothermal method. We report a metal–organic framework based on the covalent interaction of an organic linker, 5,10,15,20-...

Metal-organic frameworks are a class of attractive materials for fluorescent sensing. Here, we report the exploration of fluorescent Zn-based amine/azine-functionalized MOF, TMU-17-NH₂, ([Zn(NH₂-BDC)(4-bpdb)].2DMF; NH₂-BDC = amino-1,4-benzenedicarbox...

A serie of 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines were synthesized via a one pot Ugi-azide/Pictet–Spengler process under mild ultrasound-assisted conditions. The products containing two privileged heterocyclic frameworks: 1,5-disubstit...

A serie of novel 3-tetrazolylmethyl-4H-chromen-4-ones were synthesized via Ugi-azide reaction under mild ultrasound-assisted conditions (room temperature, EtOH, 10% mol ZnO nanoparticles). The products containing two privileged heterocyclic framework...

Adenine complexes were prepared with some of the first series transition metals in a stoichiometric ratio of 1: 2 (Mⁿ⁺: L), where Mⁿ⁺ = Mn²⁺, Fe³⁺, Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, and Cd²⁺ ions. The Complexes were characterized by the physicochemical and sp...

Herein, we describe the synthetic route to access a red-emitting BODIPY from its α-diformylated precursor. The photophysical signatures of this dye are sensitive to the presence of thiol-containing amino acids (like cysteine, homocysteine, and glutat...

In recent years, the many alluring methods to prepare inorganic-organic hybrid nanomaterials have garnered great interest. The in-situ growth phenomenon is the most straightforward way to form these compounds with multiply dimensions. Here in, we dem...

Prostaglandins (PGs) with cytoprotective activity were studied for a long time, and a few PGE₁ and PGE₂ stable analogues were promoted as drugs: arbaprostil, enprostil, misoprostol, and rioptostol. Similarly, nocloprost, a 9β-chlorine prostaglandin a...

Different activity of compounds with the same molecular formula but possessing alternative bonding arrangement or orientation of atoms in space is a very important issue when constructing molecules that can selectively interact with certain domains o...

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by the reaction of Meldrum’s acid with triethyl orthoformate and aniline, reacts with active methylene nitriles to afford 2-oxo-1,2-dihydropyridine-3-carboxylic acid derivatives,...

Derivatives of boron-dipyrromethene (BODIPY) constitute an important class of chromophores. [...]

The synthesis and characterization of three new bis 1-substituted 1H-tetrazoles are described. Two products were synthesized in a single step via a direct heterocyclization of primary amines, methyl orthoester (trymethyl orthoformate), and sodium azi...