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Proceeding Paper

Synthesis of Novel Schiff Base Derivates Containing a Fragment of the HIV Integrase Inhibitor Drug Raltegravir †

by
Jairo J. Rojas-Ortiz
1,
Claudia Contreras-Celedón
1,
Mario A. Gómez-Hurtado
2,
Luis Chacón-García
1 and
Carlos J. Cortes-García
1,*
1
Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, C.P. 58033 Morelia, Michoacán, Mexico
2
Laboratorio de Productos Naturales, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria, C.P. 58033 Morelia, Michoacán, Mexico
*
Author to whom correspondence should be addressed.
†
Presented at the 23rd International Electronic Conference on Synthetic Organic Chemistry, 15 November 2019–15 December 2019; Available online: https://ecsoc-23.sciforum.net/.
Proceedings 2019, 41(1), 5; https://doi.org/10.3390/ecsoc-23-06462
Published: 14 November 2019
(This article belongs to the Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry)
Versions Notes

Abstract

An eco-friendly methodology for the synthesis of novel Schiff base analogs of Raltegravir, an Integrase inhibitor drug is described. Pertinence of these imine derivatives is related to Medicinal Chemistry to develop new anti-VIH compounds. To our knowledge, this is the first report of the synthesis of Schiff base using a Raltegravir drug fragment as amino component. In addition, these Imines will be used as a synthetic precursor to prepare other nitrogen heterocycles of biological relevance such as 1,5-disubstituted Tetrazoles.
Keywords: Raltegravir; Schiff base; complex imines Raltegravir; Schiff base; complex imines

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MDPI and ACS Style

Rojas-Ortiz, J.J.; Contreras-Celedón, C.; Gómez-Hurtado, M.A.; Chacón-García, L.; Cortes-García, C.J. Synthesis of Novel Schiff Base Derivates Containing a Fragment of the HIV Integrase Inhibitor Drug Raltegravir. Proceedings 2019, 41, 5. https://doi.org/10.3390/ecsoc-23-06462

AMA Style

Rojas-Ortiz JJ, Contreras-Celedón C, Gómez-Hurtado MA, Chacón-García L, Cortes-García CJ. Synthesis of Novel Schiff Base Derivates Containing a Fragment of the HIV Integrase Inhibitor Drug Raltegravir. Proceedings. 2019; 41(1):5. https://doi.org/10.3390/ecsoc-23-06462

Chicago/Turabian Style

Rojas-Ortiz, Jairo J., Claudia Contreras-Celedón, Mario A. Gómez-Hurtado, Luis Chacón-García, and Carlos J. Cortes-García. 2019. "Synthesis of Novel Schiff Base Derivates Containing a Fragment of the HIV Integrase Inhibitor Drug Raltegravir" Proceedings 41, no. 1: 5. https://doi.org/10.3390/ecsoc-23-06462

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