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2,346 Results Found

  • Article
  • Open Access
17 Citations
8,863 Views
15 Pages

1 January 2020

The Therapeutic Community (TC) model is considered an effective treatment for substance dependence, particularly for individuals with complex presentations. While a popular approach for this cohort across a number of countries, few studies have focus...

  • Article
  • Open Access
8 Citations
3,222 Views
9 Pages

28 January 2023

A series of behavioral detection paradigms have been developed for zebrafish (Danio rerio) to examine anxiety-like behavioral responses. Among them, the novel tank diving test is rapidly gaining popularity in translational neuroscience and behavioral...

  • Article
  • Open Access
9 Citations
2,697 Views
21 Pages

28 June 2023

Temperature-dependent IR spectroscopy capable of revealing specific changes in the band intensities, positions, and shape was used to increase the information on humic substances (HS) from soils. Temperature dependences of IR spectra of HS isolated f...

  • Article
  • Open Access
16 Citations
5,153 Views
11 Pages

Prevalence of, Factors Associated with and Level of Dependence of Psychoactive Substance Use among Mekelle University Students, Ethiopia

  • Azeb Gebresilassie Tesema,
  • Znabu Hadush Kahsay,
  • Gebrezgi Gidey Lemma,
  • Welday Hagos Gebretsadik,
  • Mamuye Mussie Weldemaryam,
  • Gebrecherkos Gebregiorgis Alemayohu and
  • Maree L Hackett

Background: Psychoactive substance use is a major public health concern globally. Though youth attending higher education institutions are considered particularly vulnerable to psychoactive substances, there is a paucity of evidence in Ethiopia. We a...

  • Article
  • Open Access
3 Citations
2,586 Views
11 Pages

Substance Use/Dependence in Psychiatric Emergency Setting Leading to Hospitalization: Predictors of Continuity of Care

  • Angelo Giovanni Icro Maremmani,
  • Mirella Aglietti,
  • Guido Intaschi and
  • Silvia Bacciardi

Background: Poor adherence to treatment is a common clinical problem in individuals affected by mental illness and substance use/dependence. In Italy, mental care is organized in a psychiatric service and addiction unit (SERD), characterized by dual...

  • Review
  • Open Access
173 Citations
27,490 Views
19 Pages

Food Addiction in the Light of DSM-5

  • Adrian Meule and
  • Ashley N. Gearhardt

16 September 2014

The idea that specific kind of foods may have an addiction potential and that some forms of overeating may represent an addicted behavior has been discussed for decades. In recent years, the interest in food addiction is growing and research on this...

  • Article
  • Open Access
2 Citations
2,912 Views
17 Pages

20 November 2021

Substance abuse or drug dependence is a prevalent phenomenon, and is on the rise in United States. Important contributing factors for the prevalence are the addictive nature of certain medicinal/prescriptive drugs, individual dispositions (biological...

  • Review
  • Open Access
2 Citations
6,022 Views
21 Pages

Psychodynamic Therapies for the Treatment of Substance Addictions: A PRISMA Meta-Analysis

  • Marco Zuccon,
  • Eleonora Topino,
  • Alessandro Musetti and
  • Alessio Gori

7 October 2023

The aim of this meta-analysis was to compare psychodynamic with other treatments in studies of substance addiction. The literature search was conducted using the PubMed, Web of Science, Cohcrane library, SCOPUS, and Onesearch databases. All studies c...

  • Article
  • Open Access
21 Citations
9,070 Views
15 Pages

Integrated Exposure-Based Therapy for Co-Occurring Post Traumatic Stress Disorder (PTSD) and Substance Dependence: Predictors of Change in PTSD Symptom Severity

  • Katherine L. Mills,
  • Emma L. Barrett,
  • Sabine Merz,
  • Julia Rosenfeld,
  • Philippa L. Ewer,
  • Claudia Sannibale,
  • Amanda L. Baker,
  • Sally Hopwood,
  • Sudie E. Back and
  • Kathleen T. Brady
  • + 1 author

15 November 2016

This paper examines factors associated with change in PTSD symptom severity among individuals randomised to receive an integrated exposure-based psychotherapy for PTSD and substance dependence–Concurrent Treatment of PTSD and Substance Use Disorders...

  • Article
  • Open Access
6 Citations
22,558 Views
13 Pages

Identifying and Exploring Jean Watson’s Theory of Human Caring in Nursing Approaches for Patients with Psychoactive Substance Dependence in Medical and Surgical Acute Wards

  • Felice Curcio,
  • Marzia Lommi,
  • Rosa Nury Zambrano Bermeo,
  • Ana Alejandra Esteban-Burgos,
  • Gianluca Pucciarelli and
  • Cesar Iván Avilés González

28 August 2024

Patients with substance use disorders may view healthcare professionals as capable of supporting them through their suffering and experience. Although numerous studies have focused on the roles, approaches, and attitudes of healthcare professionals,...

  • Article
  • Open Access
1 Citations
642 Views
26 Pages

Assessment of Postural Stability in Semi-Open Prisoners: A Pilot Study

  • Michalina Błażkiewicz,
  • Jacek Wąsik,
  • Justyna Kędziorek,
  • Wiktoria Bandura,
  • Jakub Kacprzak,
  • Kamil Radecki,
  • Karolina Kowalewska and
  • Dariusz Mosler

10 September 2025

Background/Objectives: This study investigated postural stability in male inmates of a semi-open correctional facility, with a specific focus on comparing individuals with and without a history of substance dependence. The aim was to identify how add...

  • Review
  • Open Access
1 Citations
2,197 Views
37 Pages

Molecular and Environmental Determinants of Addictive Substances

  • Małgorzata Lorek,
  • Piotr Kamiński,
  • Jędrzej Baszyński,
  • Tadeusz Tadrowski,
  • Edward Jacek Gorzelańczyk,
  • Julia Feit,
  • Natalia Kurhaluk,
  • Alina Woźniak and
  • Halina Tkaczenko

5 November 2024

Knowledge about determinants of addiction in people taking addictive substances is poor and needs to be supplemented. The novelty of this paper consists in the analysis of innovative aspects of current research about relationships between determinant...

  • Article
  • Open Access
2,769 Views
18 Pages

Background: research shows that university students’ academic engagement and performance can be usefully predicted by academic behavioural confidence (ABC), a set of self-beliefs in study-focused behaviours. While demographic and institutional...

  • Article
  • Open Access
29 Citations
6,578 Views
17 Pages

In the past twenty years, the consumption of opioid medications has reached significant proportions, leading to a rise in drug misuse and abuse and increased opioid dependence and related fatalities. Thus, the purpose of this study was to determine w...

  • Review
  • Open Access
9 Citations
12,475 Views
16 Pages

29 February 2024

Cannabis is a widely used substance among the youth population, with an estimated 2.8% currently smoking cannabis. Its popularity is growing due to the perception of its harmless nature and lack of dependence. However, this increase in use has been l...

  • Article
  • Open Access
8 Citations
5,936 Views
15 Pages

Differences between Female and Male Inmates in Animal Assisted Therapy (AAT) in Austria: Do We Need Treatment Programs Specific to the Needs of Females in AAT?

  • Birgit U. Stetina,
  • Christine Krouzecky,
  • Lisa Emmett,
  • Armin Klaps,
  • Nora Ruck,
  • Zuzana Kovacovsky,
  • Anastasiya Bunina and
  • Jan Aden

4 February 2020

With the growth of female inmates worldwide, research regarding specific treatment of these has become more important. Although new programs have been started, the lack of scientific results is startling. The goal of the current study was to identify...

  • Feature Paper
  • Article
  • Open Access
44 Citations
9,485 Views
14 Pages

1 May 2021

Novel per- and polyfluoroalkyl substances (PFAS) were recently identified in drinking water sources throughout North Carolina. These include the perfluoroether acids (PFEAs) perfluoro-2-methoxyacetic acid (PFMOAA), perfluoro-2-methoxypropanoic acid (...

  • Feature Paper
  • Article
  • Open Access
1 Citations
743 Views
19 Pages

Eco-Friendly Biotechnological Approaches to Enhance Germination Efficiency in Lavandula angustifolia Mill.

  • Ioan-Adrian Georgiu,
  • Elena Adriana Ciulca,
  • Giancarla Velicevici,
  • Radu E. Sestras,
  • Monica Boscaiu,
  • Oscar Vicente and
  • Adriana F. Sestras

The improvement of Lavandula angustifolia Mill. seed germination represents a crucial step towards the development of eco-biotechnological solutions for the sustainable propagation of aromatic plants. This study evaluated the effects of four biostimu...

  • Review
  • Open Access
6 Citations
7,753 Views
14 Pages

6 January 2015

A series of in vivo and in vitro studies using animal and human models in the past 15 years have demonstrated that approximately 55% (~66% in humans) of the glucose disposal effect of an i.v. injection of insulin in the fed state is dependent on the...

  • Brief Report
  • Open Access
3 Citations
6,142 Views
13 Pages

Whole-Exome Sequencing to Identify Potential Genetic Risk in Substance Use Disorders: A Pilot Feasibility Study

  • P. V. AshaRani,
  • Syidda Amron,
  • Noor Azizah Bte Zainuldin,
  • Sumanty Tohari,
  • Alvin Y. J. Ng,
  • Guo Song,
  • Byrappa Venkatesh and
  • Ajay S. Mathuru

25 June 2021

Genetics intersects with environmental, cultural, and social factors in the development of addictive disorders. This study reports the feasibility of whole-exome sequencing of trios (subject and two family members) to discover potential genetic varia...

  • Review
  • Open Access
2,934 Views
21 Pages

The escalating challenges of climate change, soil degradation, and the need to ensure global food security are driving the transition towards more sustainable agricultural practices. Biostimulants, a diverse category of substances and microorganisms,...

  • Article
  • Open Access
7 Citations
2,828 Views
28 Pages

12 July 2023

This study addresses the challenge of assessing the carcinogenic potential of hazardous chemical mixtures, such as per- and polyfluorinated substances (PFASs), which are known to contribute significantly to cancer development. Here, we propose a nove...

  • Article
  • Open Access
49 Citations
6,959 Views
26 Pages

Temperature Dependences of IR Spectra of Humic Substances of Brown Coal

  • Dmitry S. Volkov,
  • Olga B. Rogova and
  • Mikhail A. Proskurnin

11 September 2021

The capabilities of temperature-monitored IR spectroscopy for studying the organic matter and mineral composition of humic substances (HS) were tested. Temperature dependences of the mid-IR spectra of humic substances heated in the air in the range 2...

  • Review
  • Open Access
13 Citations
5,384 Views
20 Pages

17 September 2020

Long-term memory formation requires coordinated regulation of gene expression and persistent changes in cell function. For decades, research has implicated histone modifications in regulating chromatin compaction necessary for experience-dependent ch...

  • Review
  • Open Access
13 Citations
10,978 Views
16 Pages

Recreational Drug Misuse and Its Potential Contribution to Male Fertility Levels’ Decline: A Narrative Review

  • Nicolò Schifano,
  • Stefania Chiappini,
  • Alessio Mosca,
  • Andrea Miuli,
  • Maria Chiara Santovito,
  • Mauro Pettorruso,
  • Paolo Capogrosso,
  • Federico Dehò,
  • Giovanni Martinotti and
  • Fabrizio Schifano

19 November 2022

Recreational drug intake may be associated with a range of medical untoward consequences, including male infertility. However, as the related evidence is still limited, the main outcome of this review is to provide a better understanding of the exist...

  • Review
  • Open Access
12 Citations
7,366 Views
15 Pages

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, drug-free, neural-circuit-based therapeutic tool that was recently cleared by the United States Food and Drug Associate for the treatment of smoking cessation. TMS has been investi...

  • Article
  • Open Access
1 Citations
1,086 Views
16 Pages

Immunotoxicity of Four Per- and Polyfluoroalkyl Substances Following 28-Day Oral Repeat Dosing in Rats Assessed by the Anti-Sheep Red Blood Cell IgM Response

  • Michael F. Hughes,
  • Michael J. DeVito,
  • Grace Patlewicz,
  • Russell S. Thomas,
  • Linda D. Adams,
  • Jeffrey L. Ambroso,
  • Xi Yang,
  • Bindu G. Upadhyay,
  • Stefanie C. M. Burleson and
  • Elaina M. Kenyon

10 June 2025

Some PFASs are immunotoxic in rodent models and associated with diminished vaccine response in exposed humans. This study assessed the immunotoxicity of four PFASs via the T cell-dependent IgM antibody response (TDAR) to sheep red blood cells (SRBCs)...

  • Article
  • Open Access
8 Citations
4,165 Views
18 Pages

Trihexyphenidyl Alters Its Host’s Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop—The Modulating Role of Anacyclus pyrethrum

  • Abdelmounaim Baslam,
  • Hajar Azraida,
  • Rachida Aboufatima,
  • Mohamed Ait-El-Mokhtar,
  • Ilham Dilagui,
  • Samia Boussaa,
  • Abderrahman Chait and
  • Marouane Baslam

21 December 2023

Trihexyphenidyl (THP)—a synthetic anticholinergic medication used to manage parkinsonism and extrapyramidal symptoms—has gained significant clinical recognition. However, there is a critical gap in understanding its withdrawal effects. Th...

  • Article
  • Open Access
7 Citations
4,272 Views
10 Pages

Introduction: Advances in experimental psychology have led to a better understanding of automatic, unconscious processes, referred to as attentional biases. Despite the growing evidence from meta-analytical studies, we still do not understand why som...

  • Article
  • Open Access
15 Citations
3,012 Views
16 Pages

Organizational Factors Moderating Changes in Tobacco Use Dependence Care Delivery Following a Comprehensive Tobacco-Free Workplace Intervention in Non-Profit Substance Use Treatment Centers

  • Kathy Le,
  • Tzuan A. Chen,
  • Isabel Martinez Leal,
  • Virmarie Correa-Fernández,
  • Ezemenari M. Obasi,
  • Bryce Kyburz,
  • Teresa Williams,
  • Kathleen Casey,
  • Matthew Taing and
  • Daniel P. O’Connor
  • + 1 author

Although tobacco use is the leading preventable cause of death and is elevated among patients with substance use disorders, many substance use treatment centers (SUTCs) do not offer tobacco use interventions (i.e., screening and treatment). This stud...

  • Review
  • Open Access
430 Citations
40,243 Views
39 Pages

The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review

  • Kirrilly M. Pursey,
  • Peter Stanwell,
  • Ashley N. Gearhardt,
  • Clare E. Collins and
  • Tracy L. Burrows

21 October 2014

Obesity is a global issue and it has been suggested that an addiction to certain foods could be a factor contributing to overeating and subsequent obesity. Only one tool, the Yale Food Addiction Scale (YFAS) has been developed to specifically assess...

  • Article
  • Open Access
3 Citations
2,433 Views
32 Pages

Substance Detection and Identification Using Frequency Doubling of the THz Broadband Pulse

  • Vyacheslav A. Trofimov,
  • Svetlana A. Varentsova,
  • Yongqiang Yang and
  • Zihao Cai

We propose and discuss an effective tool for substance detection and identification using a broadband THz pulse that is based on frequency conversion near the substance absorption frequencies. With this aim, we analyze the evolution of spectral inten...

  • Article
  • Open Access
6 Citations
2,312 Views
13 Pages

The prevalence of tobacco use increases in times of stress; however, during the initial stage of the COVID-19 pandemic, tobacco use rates stayed the same in most populations. Previous work focused on the initial months of the pandemic, while this stu...

  • Hypothesis
  • Open Access
4 Citations
2,529 Views
6 Pages

23 April 2022

Previous studies in animals and humans have shown multiple types of interaction between alcohol (ethanol) intake and the catecholamine signaling molecules: dopamine, norepinephrine and epinephrine. This literature suggests that the administration of...

  • Article
  • Open Access
6 Citations
2,848 Views
12 Pages

COVID-19 Impact on Australian Patients with Substance Use Disorders: Emergency Department Admissions in Western Sydney before Vaccine Roll Out

  • Meryem Jefferies,
  • Harunor Rashid,
  • Robert Graham,
  • Scott Read,
  • Gouri R. Banik,
  • Thao Lam,
  • Gaitan F. Njiomegnie,
  • Mohammed Eslam,
  • Xiaojing Zhao and
  • Nausheen Ahmed
  • + 2 authors

Background: In this study, we determined the impact of the COVID-19 pandemic on Western Sydney patients with substance use disorders (SUD) by comparing emergency department (ED) admission rates before and after the onset of the COVID-19 pandemic and...

  • Systematic Review
  • Open Access
28 Citations
7,520 Views
10 Pages

Sexualized Drug Use and Chemsex among Men Who Have Sex with Men in Europe: A Systematic Review and Meta-Analysis

  • Marina Coronado-Muñoz,
  • Emilio García-Cabrera,
  • Angélica Quintero-Flórez,
  • Encarnación Román and
  • Ángel Vilches-Arenas

21 March 2024

Background: In recent years, in Europe, there has been a growing concern about the use of sexualized drugs among men who have sex with men (MSM), due to its possible link to an increase in sexually transmitted infections. The aim of this review is to...

  • Article
  • Open Access
1 Citations
2,379 Views
20 Pages

Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of Anacyclus pyrethrum

  • Abdelmounaim Baslam,
  • Hamid Kabdy,
  • Yassine Chait,
  • Hajar Azraida,
  • Loubna El Yazouli,
  • Rachida Aboufatima,
  • Abderrahman Chait and
  • Marouane Baslam

The escalating rates of morbidity and mortality associated with opioid use disorder (OUD) have spurred a critical need for improved treatment outcomes. This study aimed to investigate the impact of prolonged exposure to Fentanyl, a potent opioid, on...

  • Article
  • Open Access
7 Citations
7,555 Views
27 Pages

The Dynamic Universal Profiles of Spiritual Awareness: A Latent Profile Analysis

  • Simon Hanseung Choi,
  • Clayton Hoi-Yun McClintock,
  • Elsa Lau and
  • Lisa Miller

12 June 2020

The aim of the current investigation was to identify universal profiles of lived spirituality. A study on a large sample of participants (N = 5512) across three countries, India, China, and the United States, suggested there are at least five cross-c...

  • Review
  • Open Access
7 Citations
4,145 Views
21 Pages

21 August 2020

Alcohol use disorder is a pervasive healthcare issue with significant socioeconomic consequences. There is a plethora of neural imaging techniques available at the clinical and preclinical level, including magnetic resonance imaging and three-dimensi...

  • Review
  • Open Access
5 Citations
3,950 Views
36 Pages

18 February 2025

Introduction: Substance use disorder (SUD) is a significant global clinical issue marked by the excessive consumption of alcohol, nicotine, and various psychoactive substances, leading to impaired social, cognitive, and occupational functioning. Indi...

  • Review
  • Open Access
7,648 Views
13 Pages

Does Dexamphetamine Cause Addiction? A Narrative Review

  • Hazer Khalifa,
  • Emily J. Hibbert,
  • Natalie Gauci and
  • Alison Poulton

Dexamphetamine (DEX) is widely used in treatments, but concerns persist about its potential for addiction. This review aimed to assess the risks of DEX addiction by examining the existing literature. Originally planned as a systematic review, it was...

  • Article
  • Open Access
505 Views
18 Pages

Comparative Analysis of Psychological Profiles and Physical Functioning in Addicted and Non-Addicted Male Prisoners: A Pilot Study

  • Michalina Błażkiewicz,
  • Jacek Wąsik,
  • Justyna Kędziorek,
  • Wiktoria Bandura,
  • Jakub Kacprzak,
  • Kamil Radecki,
  • Karolina Radecka and
  • Dariusz Mosler

25 October 2025

Background/Objectives: The prison environment presents a unique context for examining the impact of addiction on physical and psychological functioning. Individuals with substance use disorders (SUDs) are overrepresented in correctional facilities an...

  • Article
  • Open Access
12 Citations
4,042 Views
16 Pages

The main objective of the research was to examine the associations between problematic alcohol use, tobacco use and cannabis use among Czech and Slovak university students during the early COVID-19 pandemic. The research sample consisted of 1422 part...

  • Article
  • Open Access
2 Citations
2,733 Views
16 Pages

27 May 2022

Deoxynivalenol (DON), the most naturally-occurring trichothecenes, may affect animal and human health by causing vomiting as a hallmark of food poisoning. Deoxynivalenol-3-glucoside (D3G) usually co-occurs with DON as its glucosylated form and is ano...

  • Article
  • Open Access
8 Citations
9,690 Views
15 Pages

The Design and Application of Game Rewards in Youth Addiction Care

  • Marierose M. M. van Dooren,
  • Valentijn T. Visch and
  • Renske Spijkerman

6 April 2019

Different types of rewards are applied in persuasive games to encourage play persistence of its users and facilitate the achievement of desired real-world goals, such as behavioral change. Persuasive games have successfully been applied in mental hea...

  • Article
  • Open Access
16 Citations
3,528 Views
14 Pages

Variability of Bioactive Substances in Potatoes (Solanum Tuberosum L.) Depending on Variety and Maturity

  • Hana Franková,
  • Janette Musilová,
  • Július Árvay,
  • Ľuboš Harangozo,
  • Marek Šnirc,
  • Alena Vollmannová,
  • Judita Lidiková,
  • Alžbeta Hegedűsová and
  • Edina Jaško

17 June 2022

Potatoes (Solanum tuberosum L.) are an essential food for the human diet and thus represent an important source of biologically active substances. This study aimed at investigating the content of bioactive substances (total anthocyanin and polyphenol...

  • Article
  • Open Access
8 Citations
3,201 Views
15 Pages

Do Individuals with Internet Gaming Disorder Share Personality Traits with Substance-Dependent Individuals?

  • Julie Giustiniani,
  • Magali Nicolier,
  • Madeline Pascard,
  • Caroline Masse,
  • Pierre Vandel,
  • Djamila Bennabi,
  • Sophia Achab,
  • Frédéric Mauny and
  • Emmanuel Haffen

(1) Background: Internet gaming disorder (IGD) shares many similarities with substance use disorder (SUD), contributing to its recognition as an addictive disorder. Nevertheless, no study has compared IGD to other addictive disorders in terms of pers...

  • Article
  • Open Access
51 Citations
27,594 Views
16 Pages

29 October 2015

Alcoholism and drug addiction have marked impacts on the ability of families to function. Much of the literature has been focused on adult members of a family who present with substance dependency. There is limited research into the effects of adoles...

  • Article
  • Open Access
38 Citations
6,705 Views
30 Pages

25 May 2015

We propose an effective method for the detection and identification of dangerous substances by using the broadband THz pulse. This pulse excites, for example, many vibrational or rotational energy levels of molecules simultaneously. By analyzing the...

  • Review
  • Open Access
113 Citations
13,787 Views
15 Pages

11 February 2017

Acute respiratory distress syndrome (ARDS) is caused by infectious insults, such as pneumonia from various pathogens or related to other noninfectious events. Clinical and histopathologic characteristics are similar across severely affected patients,...

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