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Article

Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
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Academic Editor: Michael Petriello
Toxics 2021, 9(5), 100; https://doi.org/10.3390/toxics9050100
Received: 18 March 2021 / Revised: 13 April 2021 / Accepted: 23 April 2021 / Published: 1 May 2021
Novel per- and polyfluoroalkyl substances (PFAS) were recently identified in drinking water sources throughout North Carolina. These include the perfluoroether acids (PFEAs) perfluoro-2-methoxyacetic acid (PFMOAA), perfluoro-2-methoxypropanoic acid (PFMOPrA), and perfluoro-4-methoxybutanioc acid (PFMOBA). Little toxicological data exist for these PFEAs. Therefore, the present study described signs of toxicity and immunotoxicity following oral exposure. Adult male and female C57BL/6 mice were exposed once/day for 30 days to PFMOAA (0, 0.00025, 0.025, or 2.5 mg/kg), PFMOPrA, or PFMOBA (0, 0.5, 5, or 50 mg/kg). A dose of 7.5 mg/kg of perfluorooctanoic acid (PFOA) was used as a positive control. Terminal body weights, and absolute liver, spleen, or thymus weights did not differ by dose for any compound; exposure to 50 mg/kg of PFMOBA increased relative liver weights in males. Changes in splenic cellularity were observed in males exposed to PFMOPrA and decreased numbers of B and natural killer (NK) cells were observed in males and females exposed to PFMOBA. Exposure did not alter NK cell cytotoxicity or T cell-dependent antibody responses at doses administered. Our results indicate that these “understudied” PFAS have toxicological potential but require additional investigation across endpoints and species, including humans, to understand health effects via drinking water exposure. View Full-Text
Keywords: PFAS: per- and polyfluoroalkyl substance; PFOA: perfluorooctanoic acid; PFOS: perfluorooctane sulfonic acid; PFMOAA: perfluoro-2-methoxyacetic acid; PFMOPrA: perfluoro-2-methoxypropanoic acid; PFMOBA: perfluoro-4-methoxybutanioc acid; NK: Natural Killer; TDAR: T cell-dependent antibody responses PFAS: per- and polyfluoroalkyl substance; PFOA: perfluorooctanoic acid; PFOS: perfluorooctane sulfonic acid; PFMOAA: perfluoro-2-methoxyacetic acid; PFMOPrA: perfluoro-2-methoxypropanoic acid; PFMOBA: perfluoro-4-methoxybutanioc acid; NK: Natural Killer; TDAR: T cell-dependent antibody responses
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MDPI and ACS Style

Woodlief, T.; Vance, S.; Hu, Q.; DeWitt, J. Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure. Toxics 2021, 9, 100. https://doi.org/10.3390/toxics9050100

AMA Style

Woodlief T, Vance S, Hu Q, DeWitt J. Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure. Toxics. 2021; 9(5):100. https://doi.org/10.3390/toxics9050100

Chicago/Turabian Style

Woodlief, Tracey, Samuel Vance, Qing Hu, and Jamie DeWitt. 2021. "Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure" Toxics 9, no. 5: 100. https://doi.org/10.3390/toxics9050100

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