To improve the physicochemical properties of valnemulin (VLM), different solid forms formed by VLM and organic acids, including tartaric acid (TAR), fumaric acid (FUM), and oxalic acid (OXA), were successfully prepared and characterized by using diff...
Material choice is a fundamental consideration when it comes to designing a solid dosage form. The matrix material will ultimately determine the rate of drug release since the physical properties (solubility, viscosity, and more) of the material cont...
Polyamides’ properties are greatly influenced by the polymerization process and the type of feedstock used. The solid forms of nylon salts play a significant role in determining the final characteristics of the material. This study focuses on t...
Background: Topical semi-solid dosage forms are crucial for treating inflammatory skin disorders, wounds, burns, and superficial infections. Despite their widespread clinical use, comprehensive pharmaceutical market analyses of registered topical med...
Drug delivery systems (DDS) often comprise biopharmaceuticals in aqueous form, making them susceptible to physical and chemical degradation, and therefore requiring low temperature storage in cold supply and distribution chains. Freeze-drying, spray-...
The safe administration of solid oral dose forms in hospital inpatients with swallowing difficulties is challenging. The aim of this study was to establish the prevalence of difficulties in swallowing solid oral dose forms in acute hospital inpatient...
Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-amorphous systems, are a result of the combination of an active pharmaceutical ingredient (API) with a pharmaceutically acceptable co-former. These solid for...
The mechanochemical synthesis of drug–drug solid forms containing metformin hydrochloride (MET·HCl) and thiazide diuretics hydrochlorothiazide (HTZ) or chlorothiazide (CTZ) is reported. Characterization of these new systems indicates formation of bin...
Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with hot-melt extrusio...
Background: The well-established biopharmaceutical advantages provided by nanosuspensions (NSs) make their conversion into solid oral dosage forms particularly appealing for improving both patients’ compliance and product stability. However, su...
3D printing technology in medicine is gaining great attention from researchers since the FDA approved the first 3D-printed tablet (Spritam®) on the market. This technique permits the fabrication of various types of dosage forms with different geo...
3D printing is a new emerging technology in the pharmaceutical manufacturing landscape. Its potential advantages for personalized medicine have been widely explored and commented on in the literature over recent years. More recently, the selective la...
Background/Objectives: Oral solid dosage (OSD) forms are historically categorized as low-risk vectors for leachables under the assumption that solid-state matrices impose severe kinetic barriers against migrant migration and reactivity. This study in...
In selective laser sintering (SLS), the heating temperature is a critical parameter for printability but can also be deleterious for the stability of active ingredients. This work aims to explore the plasticizing effect of di-carboxylic acids on redu...
A lack of effective intervention in addressing patient non-adherence and the acceptability of solid oral dosage forms combined with the clinical consequences of swallowing problems in an ageing world population highlight the need for developing metho...
Fused deposition modeling (FDM) three-dimensional (3D) printing is being increasingly explored as a direct manufacturing method to product pharmaceutical solid dosage forms. Despite its many advantages as a pharmaceutical formulation tool, it remains...
Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF depends on...
The aim of this work was to investigate the effect of process parameters on the printability of a formulation containing copovidone and paracetamol, and on the properties of solid oral forms 3D-printed through selective laser sintering. Firstly, the...
This study addresses the challenge of developing a cheap, patient-friendly alternative to antibiotics using bacteriophages for gastrointestinal applications. It explores the feasibility of manufacturing an enteric solid dosage form containing a salmo...
Emissivity is a parameter allowing the assessment of thermal/optical properties of active pharmaceutical ingredients (APIs). ε reflects radiative properties, changes with product aging, and correlates with surface characteristics. This study...
Near solidus forming (NSF) of steels is a novel process under the umbrella of semi-solid forming technologies midway between classical hot forging and semi-solid technologies. This article presents the work done at Mondragon Unibertsitatea to develop...
Suspended solids are an important part of lake ecosystems, and their nitrogen and phosphorus contents have a significant effect on water quality. However, information on nitrogen and phosphorus forms in suspended solids remains limited. Therefore, a...
The delivery of phages to epithelial surfaces for therapeutic outcomes is a realistic proposal, and indeed one which is being currently tested in clinical trials. This paper reviews some of the known research on formulation of phages into semi-solid...
TiNi shape memory alloy (SMA) prepared by laser solid forming (LSF) has wide application prospect and research value. In this work, LSF-Ti49.2Ni50.8 alloy was tested by X-ray diffraction (XRD), differential scanning calorimetry (DSC), and transmissio...
Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller dos...
To simulate sheet metal forming processes precisely, an in-house dynamic explicit code was developed to apply a new solid-shell element to sheet metal forming analyses, with a corotational coordinate system utilized to simplify the nonlinearity and t...
The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community. In this study, the ASD of ten-selec...
A threat to human health in developed and, in particular, in developing countries, counterfeit medicines represent the largest identified fraud market worldwide. 3D screen printing (3DSP), an additive manufacturing technology that enables large-scale...
The planar solid-state pulse-forming line (planar solid-state PFL) is an important solid-state device used in compact pulse power systems. Moreover, pulsed power systems constitute a crucial element within electroporation systems. In this paper, we p...
Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-4, used for the treatment of type 2 diabetes mellitus. The crystal structure of active pharmaceutical solids determines their physical and chemical properties. The polymorphism, solvates...
Bicalutamide (BCL), a clinically important non-steroidal antiandrogen, exhibits pronounced conformational polymorphism and complex solid-state behaviour that critically influence its physicochemical and biopharmaceutical properties. This review compr...
Glucomannan (GM)—a polysaccharide generally extracted from the tuber of Amorphophallus konjac—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity a...
Drug substance degradation kinetics in solid dosage forms is rarely mechanistically modeled due to several potential micro-environmental and manufacturing related effects that need to be integrated into rate laws. The aim of our work was to construct...
Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused b...
Fabricating an Inconel 718 superalloy using electromagnetic stirring assisted laser solid forming (EMS-LSF) is a novel method to modify its microstructure and mechanical properties by consuming the Nb element in the γ phase to alleviate interde...
Bergamot essential oil (BEO) possess antimicrobial, antiproliferative, anti-inflammatory, analgesic, neuroprotective, and cardiovascular effects. However, it is rich in volatile compounds, e.g., limonene, that are susceptible to conversion and degrad...
Antifriction alloys such as AlSn20Cu are key material options for sliding bearings used in machinery. Uniform distribution and a near-equiaxed granularity tin phase are generally considered to be ideal characteristics of an AlSn20Cu antifriction allo...
The traditional cement compaction process boasts notable advantages such as high strength, durability, and aesthetic appeal. However, compaction forming technology for cement products results in high carbon emissions. Consequently, it is imperative t...
In this paper, an activated bismuth layer formed in situ on a solid bismuth microelectrode, used as a working electrode for the electrochemical sensitive determination of Ga(III), based on anodic stripping voltammetry (ASV) is discussed. The new elec...
In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing...
Background/Objectives: Niclosamide, an anthelmintic drug included in the World Health Organization Model List of Essential Medicines, has recently attracted attention for drug repurposing applications. Its strong tendency to form solvates and hydrate...
As one of the key components of high-voltage pulse modulators, the pulse-forming lines (PFLs) are moving in the direction of compact, solid-state, and stable working for a relatively long time. In this paper, a long-lifetime PFL, based on a glass cer...
3D printing (3DP) can serve not only as an excellent platform for producing solid dosage forms tailored to individualized dosing regimens but can also be used as a tool for creating a suitable 3D model for drug screening, sensing, testing and organ-o...
Specific aspects of semi-solid dosage forms for topical application include the nature of the barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a greater influence of sensory perception. Advances in understan...
Aluminum alloys have been widely used in various engineering applications due to their excellent physical properties such as low density, high strength and good cutting capacity. In this paper, the semi-solid thixotropic extrusion forming process is...
Laser solid forming (LSF) is a promising additive manufacturing technology. In the LSF process, deformation behaviors dictate the accuracy of the produced parts. In this study, by using a laser displacement detector based on laser triangulation princ...
Oxymetholone [C21H32O3] and metribolone [C19H24O2] are synthetic anabolic-androgenic agents which are included in the steroid class. Their ability to form new solid forms and their possibility to be included in host-guest β-cyclodextrin complexe...
The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are dis...
TA15/Ti2AlNb multiple-layer samples and a dual-alloy sample were fabricated by laser solid forming (LSF) in this study. The formation mechanism of the dilute region and microstructure evolution of the dual alloy were analyzed. The results confirmed a...
The steep thermal gradient and complicated thermal cycle occur in the fabrication of Ti6Al4V alloy during laser solid forming (LSF). That leads to obvious anisotropic mechanical properties and requires essential heat treatments to improve its perform...
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