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Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA
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Processes 2013, 1(2), 67-127; https://doi.org/10.3390/pr1020067
Received: 31 May 2013 / Revised: 11 July 2013 / Accepted: 26 July 2013 / Published: 19 August 2013
(This article belongs to the Special Issue Feature Papers)
The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes. View Full-Text
Keywords: solids processing; reduced-order modeling; flowsheet simulation; pharmaceutical manufacturing solids processing; reduced-order modeling; flowsheet simulation; pharmaceutical manufacturing
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Rogers, A.J.; Hashemi, A.; Ierapetritou, M.G. Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms. Processes 2013, 1, 67-127.

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