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Processes 2013, 1(2), 67-127; doi:10.3390/pr1020067
Review
Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms
Received: 31 May 2013 / Revised: 11 July 2013 / Accepted: 26 July 2013 / Published: 19 August 2013
(This article belongs to the Special Issue Feature Papers)
Abstract: The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.
Keywords:
solids processing; reduced-order modeling; flowsheet simulation; pharmaceutical manufacturing
This is an open access article distributed under the
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MDPI and ACS Style
Rogers, A.J.; Hashemi, A.; Ierapetritou, M.G. Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms. Processes 2013, 1, 67-127.
AMA StyleRogers AJ, Hashemi A, Ierapetritou MG. Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms. Processes. 2013; 1(2):67-127.
Chicago/Turabian StyleRogers, Amanda J.; Hashemi, Amir; Ierapetritou, Marianthi G. 2013. "Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms." Processes 1, no. 2: 67-127.
Processes
EISSN 2227-9717
Published by MDPI AG, Basel, Switzerland
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