Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

doi:10.3390/pr1020067

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Processes 2013, 1(2), 67-127; doi:10.3390/pr1020067

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Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Amanda J. Rogers, Amir Hashemi and Marianthi G. Ierapetritou *

Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854, USA

* Author to whom correspondence should be addressed.

Received: 31 May 2013; in revised form: 11 July 2013 / Accepted: 26 July 2013 / Published: 19 August 2013

(This article belongs to the Special Issue Feature Papers)

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Abstract: The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.

Keywords: solids processing; reduced-order modeling; flowsheet simulation; pharmaceutical manufacturing

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MDPI and ACS Style

Rogers, A.J.; Hashemi, A.; Ierapetritou, M.G. Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms. Processes 2013, 1, 67-127.

AMA Style

Rogers AJ, Hashemi A, Ierapetritou MG. Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms. Processes. 2013; 1(2):67-127.

Chicago/Turabian Style

Rogers, Amanda J.; Hashemi, Amir; Ierapetritou, Marianthi G. 2013. "Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms." Processes 1, no. 2: 67-127.

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