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Article

Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Korea
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Pharmaceutics 2020, 12(8), 738; https://doi.org/10.3390/pharmaceutics12080738
Received: 30 June 2020 / Revised: 24 July 2020 / Accepted: 3 August 2020 / Published: 5 August 2020
(This article belongs to the Special Issue Hot-Melt Extrusion)
In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling. View Full-Text
Keywords: hot-melt extrusion; 3D printing; controlled release; immediate release; pharmaceutical manufacturing; personalized medication; ibuprofen; solid dispersion; solubilization; polyvinyl pyrrolidone hot-melt extrusion; 3D printing; controlled release; immediate release; pharmaceutical manufacturing; personalized medication; ibuprofen; solid dispersion; solubilization; polyvinyl pyrrolidone
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MDPI and ACS Style

Lee, J.; Song, C.; Noh, I.; Song, S.; Rhee, Y.-S. Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms. Pharmaceutics 2020, 12, 738. https://doi.org/10.3390/pharmaceutics12080738

AMA Style

Lee J, Song C, Noh I, Song S, Rhee Y-S. Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms. Pharmaceutics. 2020; 12(8):738. https://doi.org/10.3390/pharmaceutics12080738

Chicago/Turabian Style

Lee, Jaemin, Chanwoo Song, Inhwan Noh, Sangbyeong Song, and Yun-Seok Rhee. 2020. "Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms" Pharmaceutics 12, no. 8: 738. https://doi.org/10.3390/pharmaceutics12080738

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