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Open AccessArticle

Effect of Solid Forms on Physicochemical Properties of Valnemulin

State Key Laboratory for Nuclear Resources and Environment, East China University of Technology, Nanchang 330013, China
School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China
Author to whom correspondence should be addressed.
Crystals 2019, 9(12), 675;
Received: 14 November 2019 / Revised: 30 November 2019 / Accepted: 9 December 2019 / Published: 16 December 2019
(This article belongs to the Special Issue Pharmaceutical Crystals and Its Application)
To improve the physicochemical properties of valnemulin (VLM), different solid forms formed by VLM and organic acids, including tartaric acid (TAR), fumaric acid (FUM), and oxalic acid (OXA), were successfully prepared and characterized by using differential scanning calorimetry (DSC), scanning electron microscope (SEM), X-ray powder diffraction (XRPD), and Fourier-transform infrared spectroscopy (FT-IR). The excess enthalpy Hex between VLM and other organic acids was calculated by COSMOthermX software and was used to evaluate the probability of forming multi-component solids between VLM and organic acids. By thermal analysis, it was confirmed that multi-component solid forms of VLM were thermodynamically more stable than VLM itself. Through dynamic vapor sorption (DVS) experiments, it was found that three multi-component solid forms of VLM had lower hygroscopicity than VLM itself. Furthermore, the intrinsic dissolution rate of VLM and its multi-component forms was determined in one kind of acidic aqueous medium by using UV-vis spectrometry. It was found that the three multi-component solid forms of VLM dissolved faster than VLM itself. View Full-Text
Keywords: valnemulin; solid forms; dissolution rate; hygroscopicity valnemulin; solid forms; dissolution rate; hygroscopicity
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Ouyang, J.; Chen, J.; Zhou, L.; Han, F.; Huang, X. Effect of Solid Forms on Physicochemical Properties of Valnemulin. Crystals 2019, 9, 675.

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