Advances in Amorphous Drug Formulations
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (31 May 2020) | Viewed by 56804
Special Issue Editor
Interests: amorphous drugs and formulations; co-amorphous drug delivery; silica based drug delivery systems; functional excipients
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Amorphous drug delivery systems are one of the most promising technologies to tackle the issue of poor bioavailability of an increasing number of poorly soluble drugs in the development pipelines. Due to the poor physical stability of pure amorphous drugs, formulation scientists frequently use different types of excipients to stabilize the drug in its amorphous form, including different types of polymeric carriers, mesoporous materials or other low molecular weight excipients. The mechanism of stabilization has been attributed to the properties of the chosen excipient and the drug, such as drug-excipient miscibility, antiplasticization, molecular interactions, etc. However, whilst more and more products have reached the market in the past few years, the amorphous form and amorphous formulations still remain not fully understood. This Special Issue serves to capture the contemporary progress in the field of amorphous formulations, both from a fundamental understanding and their practical application.
Prof. Dr. Korbinian Löbmann
Guest Editor
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Keywords
- poorly soluble drugs
- high energy solids
- amorphous form
- relaxation
- glass solutions
- solid state miscibility
- amorphous solid dispersions (ASDs)
- polymeric carriers
- mesoporous silica
- co-amorphous
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