Special Issue "Phage Therapy and Phage-Mediated Biological Control"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: 31 January 2019
Bacteriophages or phages – the viruses of bacteria – are the most abundant and potentially most diverse organisms on Earth. The majority of these viruses are lytic, meaning that, upon producing new phages, they not only kill but also lyse their bacterial hosts. Most phages target these hosts with high precision, resulting in easily predicted pharmacodynamics. Phages, in other words, have been evolving for roughly three billion years to be extremely effective at killing bacteria but, properly chosen, have little potential to do much else, such as displaying toxicity towards bodies or environments.
Given these properties, phages have at least a potential to serve as antibacterial agents both within and outside of medicine. They have in fact been used as antibacterials clinically for nearly 100 years, longer even than chemical antibiotics have been known to science. Indeed, they represent highly diverse, easily discovered, readily characterized, inexpensively produced, low-toxicity antibacterial agents. Were we to include bacteriophages among ‘antibiotics’ then there arguably would be no antibiotic crisis.
In this Special Issue we seek submissions broadly pertaining to the subject of phage therapy, the clinical or veterinary use of bacterial viruses as antibacterial “drugs”, or, more generally, the use of phages as antibacterial biological control agents.
1. Phage therapy pharmacology
2. Ecology of Anti-Biofilm Agents I: Antibiotics versus Bacteriophages
3. Ecology of Anti-Biofilm Agents II: Bacteriophage Exploitation and Biocontrol of Biofilm Bacteria
Prof. Stephen T. Abedon
Dr. Diana R. Alves
Manuscripts should be pre-submitted directly Stephen Abedon (firstname.lastname@example.org) for initial editing. Research articles should strive to conform to the guidelines outlined in [editorial: “Phage Therapy Pharmacology: What Information Phage Therapy Studies Should Report”]. Following this initial editing, manuscripts should be submitted for peer review as follows:
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed Open Access quarterly journal published by MDPI.
experimental phage therapy
phage-mediated biocontrol of bacteria
plant disease biocontrol
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Creating Impact: The Challenges and Opportunities of Commercialisation in the Field of Bacteriophage Research
Article Type: Opinion
Authors: Martha R.J. Clokie 1, Craig R. Thomson 2
Affiliations: 1 Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, LE1 9HN, UK
2 HGF Limited, Patent and Trade Mark Attorneys, Delta House, 50 West Nile Street, Glasgow G1 2NP, UK
Title: Isolating and Characterizing Therapeutic Phages for Host Range Breadth
Article Type: Review
Authors: Paul Hyman
Affiliation: Ashland University, Ashland, OH
Title: Bacterial strains for the propagation of therapeutic phages
Article Type: Review
Authors: Malgorzata Lobocka, Aleksandra Glowacka
Affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; Autonomous Department of Microbial Biology, Warsaw University of Life Sciences-SGGW, Warsaw, Poland
Title: Millions of Doses: Quantifying the History of Phage Therapy Use, Worldwide
Authors: Elizabeth M. Kutter et al.
Affiliation: The Evergreen State College
Article Type: Review
Title: Phageome Pharmacokinetics: The Within-Body Movement of Naturally Occurring Bacteriophages
Authors: Krystyna Dąbrowska 1 and Stephen T. Abedon 2
Affiliations: 1. Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
2. The Ohio State University
Title: Bacteriophage encapsulation in solid dosage forms using spray drying and tablet production for oral delivery against enteric infections
Article Type: Article
Authors: Gurinder K. Vinner, Zahra Rezaie-Yazdie, Mark Leaper, Danish J Malik
Affiliations: Chemical Engineering Department, Loughborough University, Loughborough, United Kingdom