Emerging Strategies to Enhance Solubility of Poorly Soluble Drugs: From Nanosystems to Molecular Innovations

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 38

Special Issue Editor


E-Mail Website
Guest Editor
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA
Interests: hot-melt extrusion; colon-specific drug delivery; fast-dissolving tablets; formulation and pharmacokinetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The poor aqueous solubility of many APIs remains a major challenge in drug development, often restricting bioavailability and therapeutic effectiveness. This Special Issue will cover various innovative strategies developed over the past decade to improve the solubility and dissolution rate of poorly soluble drugs. New approaches include nanonization techniques such as those incorporating nanocrystals and solid lipid nanoparticles, the employment of amorphous solid dispersions, cyclodextrin complexation, co-crystallization, and the use of ionic liquids and deep eutectic solvents. Additionally, molecular-level innovations including those in prodrug design and salt formation will be discussed, alongside advances in formulation technologies such as 3D printing and hot-melt extrusion.

Dr. Sateesh Kumar Vemula
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • poorly soluble drugs
  • solubility enhancement
  • nanotechnology
  • amorphous solid dispersions
  • cyclodextrin complexation
  • co-crystallization
  • ionic liquids
  • deep eutectic solvents
  • prodrug design
  • formulation technologies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers

This special issue is now open for submission.
Back to TopTop