Emerging Strategies to Enhance Solubility of Poorly Soluble Drugs: From Nanosystems to Molecular Innovations
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 1022
Special Issue Editor
Interests: drug delivery systems; biodegradable polymers; nanomedicine; 3D printing in pharmaceutics; hot-melt extrusion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The poor aqueous solubility of many APIs remains a major challenge in drug development, often restricting bioavailability and therapeutic effectiveness. This Special Issue will cover various innovative strategies developed over the past decade to improve the solubility and dissolution rate of poorly soluble drugs. New approaches include nanonization techniques such as those incorporating nanocrystals and solid lipid nanoparticles, the employment of amorphous solid dispersions, cyclodextrin complexation, co-crystallization, and the use of ionic liquids and deep eutectic solvents. Additionally, molecular-level innovations including those in prodrug design and salt formation will be discussed, alongside advances in formulation technologies such as 3D printing and hot-melt extrusion.
Dr. Sateesh Kumar Vemula
Guest Editor
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Keywords
- poorly soluble drugs
- solubility enhancement
- nanotechnology
- amorphous solid dispersions
- cyclodextrin complexation
- co-crystallization
- ionic liquids
- deep eutectic solvents
- prodrug design
- formulation technologies
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