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Article

3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers

1
Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland
2
Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Piispankatu 8, 20500 Turku, Finland
3
Oulun Keskus Apteekki, Isokatu 45, 90100 Oulu, Finland
4
Nanoform Finland Oyj, Viikinkaari 4, 00790 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(12), 1239; https://doi.org/10.3390/pharmaceutics12121239
Received: 31 October 2020 / Revised: 8 December 2020 / Accepted: 14 December 2020 / Published: 19 December 2020
(This article belongs to the Special Issue Applications of Additive Manufacturing in Pharmaceutics)
Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller doses of veterinary medicines. This study aims to investigate the use of three semi-solid extrusion 3D printers in a pharmacy or animal clinic setting for the extemporaneous manufacturing of prednisolone containing orodispersible films for veterinary use. Orodispersible films with adequate content uniformity and acceptance values as defined by the European Pharmacopoeia were produced with one of the studied printers, namely the Allevi 2 bioprinter. Smooth and flexible films with high mechanical strength, neutral pH, and low moisture content were produced with a high correlation between the prepared design and the obtained drug amount, indicating that the Allevi 2 printer could successfully be used to extemporaneously manufacture personalized doses for animals at the point-of-care. View Full-Text
Keywords: 3D printing; semi-solid extrusion 3D printing; additive manufacturing; extemporaneous manufacturing; drug delivery; personalized dosage forms; veterinary medicine; prednisolone 3D printing; semi-solid extrusion 3D printing; additive manufacturing; extemporaneous manufacturing; drug delivery; personalized dosage forms; veterinary medicine; prednisolone
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MDPI and ACS Style

Sjöholm, E.; Mathiyalagan, R.; Rajan Prakash, D.; Lindfors, L.; Wang, Q.; Wang, X.; Ojala, S.; Sandler, N. 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers. Pharmaceutics 2020, 12, 1239. https://doi.org/10.3390/pharmaceutics12121239

AMA Style

Sjöholm E, Mathiyalagan R, Rajan Prakash D, Lindfors L, Wang Q, Wang X, Ojala S, Sandler N. 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers. Pharmaceutics. 2020; 12(12):1239. https://doi.org/10.3390/pharmaceutics12121239

Chicago/Turabian Style

Sjöholm, Erica, Rathna Mathiyalagan, Dhayakumar Rajan Prakash, Lisa Lindfors, Qingbo Wang, Xiaoju Wang, Samuli Ojala, and Niklas Sandler. 2020. "3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers" Pharmaceutics 12, no. 12: 1239. https://doi.org/10.3390/pharmaceutics12121239

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