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5,743 Results Found

  • Article
  • Open Access
9 Citations
6,152 Views
14 Pages

A Platform for Testing the Biocompatibility of Implants: Silicone Induces a Proinflammatory Response in a 3D Skin Equivalent

  • Rima Nuwayhid,
  • Torsten Schulz,
  • Frank Siemers,
  • Jeannine Schreiter,
  • Philipp Kobbe,
  • Gunther Hofmann,
  • Stefan Langer and
  • Olga Kurow

Biocompatibility testing of materials is carried out in 2D cell cultures or animal models despite serious limitations. 3D skin equivalents are advanced in vitro models for human skin. Silicone has been shown to be noncytotoxic but capable of elicitin...

(This article belongs to the Section Molecular and Translational Medicine)
  • Review
  • Open Access
50 Citations
10,446 Views
12 Pages

Galvanic Skin Response Features in Psychiatry and Mental Disorders: A Narrative Review

  • Renata Markiewicz,
  • Agnieszka Markiewicz-Gospodarek and
  • Beata Dobrowolska

This narrative review is aimed at presenting the galvanic skin response (GSR) Biofeedback method and possibilities for its application in persons with mental disorders as a modern form of neurorehabilitation. In the treatment of mental disorders of v...

(This article belongs to the Special Issue Advances in Neuropsychological and Neuropsychiatric Rehabilitation)
  • Article
  • Open Access
50 Citations
5,546 Views
18 Pages

Alteration of the Immune Response and the Microbiota of the Skin during a Natural Infection by Vibrio harveyi in European Seabass (Dicentrarchus labrax)

  • María Cámara-Ruiz,
  • Isabel M. Cerezo,
  • Francisco A. Guardiola,
  • José María García-Beltrán,
  • M. Carmen Balebona,
  • Miguel Ángel Moriñigo and
  • María Ángeles Esteban

Disease outbreaks continue to represent one of the main bottlenecks for the sustainable development of the aquaculture industry. In marine aquaculture, many species from the Vibrio genus are serious opportunistic pathogens responsible for significant...

(This article belongs to the Special Issue Feature Papers in Gut Microbiota)
  • Article
  • Open Access
19 Citations
8,850 Views
14 Pages

21 November 2024

Anxiety is a significant mental health concern that can be effectively monitored using physiological signals such as galvanic skin response (GSR). While the potential of machine learning (ML) algorithms to enhance the classification of anxiety based...

(This article belongs to the Special Issue Advanced Technologies and Applications of Emotion Recognition)
  • Article
  • Open Access
727 Views
12 Pages

Skin Temperature as a Marker of Vasomotor Response and Restoration of Blood Flow After Aesthetic Botulinum Toxin Therapy in the Forehead

  • Olesya Kytko,
  • Ekaterina Emelyanova,
  • Evgeniy Kutin,
  • Yulianna Enina,
  • Vasiliy Troitskiy,
  • Sergey Dydykin,
  • Alexander Moiseenko,
  • Amelia Popova and
  • Yuriy Vasil’ev

12 May 2026

Objective: The aim of the study was to evaluate the dynamics of skin temperature at the injection points of botulinum toxin type A in the forehead area at different time stages as a marker of the vasomotor response and restoration of microcirculation...

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition)
  • Article
  • Open Access
5 Citations
4,408 Views
10 Pages

Comparison of Sympathetic Skin Response (SSR) between Electrical and Acoustic Stimuli in a Healthy Pediatric Population

  • Sara Cavaliere,
  • Giovanna Bertini,
  • Cesarina Cossu,
  • Maria Bastianelli,
  • Simonetta Gabbanini,
  • Cristina Mei and
  • Silvia Lori

1 September 2021

Data in the literature report that latency and morphology in the cutaneous sympathetic skin response (SSR) do not change according to the type of stimulus delivered, unlike the amplitude which shows greater values in relation to the intensity of the...

(This article belongs to the Section Inborn Errors and Neonatal Screening)
  • Article
  • Open Access
1 Citations
2,139 Views
10 Pages

30 November 2023

The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing. Here, we evaluated the skin sen...

(This article belongs to the Special Issue Hazardous Effects of Pesticides on Human Health)
  • Review
  • Open Access
33 Citations
10,962 Views
21 Pages

The healing of deep skin wounds is a complex phenomenon evolving according with a fine spatiotemporal regulation of different biological events (hemostasis, inflammation, proliferation, remodeling). Due to the spontaneous evolution of damaged human d...

(This article belongs to the Topic Bioreactors for Advanced Cell Culture, (Nano)toxicity, Regenerative Medicine and Organ Bioengineering)
  • Article
  • Open Access
5 Citations
2,881 Views
20 Pages

A Proposed Method of Automating Data Processing for Analysing Data Produced from Eye Tracking and Galvanic Skin Response

  • Javier Sáez-García,
  • María Consuelo Sáiz-Manzanares and
  • Raúl Marticorena-Sánchez

8 November 2024

The use of eye tracking technology, together with other physiological measurements such as psychogalvanic skin response (GSR) and electroencephalographic (EEG) recordings, provides researchers with information about users’ physiological behavio...

(This article belongs to the Special Issue Smart Learning Environments)
  • Article
  • Open Access
54 Citations
18,343 Views
27 Pages

Correlation Analysis of Different Measurement Places of Galvanic Skin Response in Test Groups Facing Pleasant and Unpleasant Stimuli

  • Andres Sanchez-Comas,
  • Kåre Synnes,
  • Diego Molina-Estren,
  • Alexander Troncoso-Palacio and
  • Zhoe Comas-González

19 June 2021

The galvanic skin response (GSR; also widely known as electrodermal activity (EDA)) is a signal for stress-related studies. Given the sparsity of studies related to the GSR and the variety of devices, this study was conducted at the Human Health Acti...

(This article belongs to the Special Issue Emotion Recognition in Human-Machine Interaction)
  • Article
  • Open Access
33 Citations
6,305 Views
19 Pages

Stress Evaluation in Simulated Autonomous and Manual Driving through the Analysis of Skin Potential Response and Electrocardiogram Signals

  • Pamela Zontone,
  • Antonio Affanni,
  • Riccardo Bernardini,
  • Leonida Del Linz,
  • Alessandro Piras and
  • Roberto Rinaldo

28 April 2020

The evaluation of car drivers’ stress condition is gaining interest as research on Autonomous Driving Systems (ADS) progresses. The analysis of the stress response can be used to assess the acceptability of ADS and to compare the driving styles...

(This article belongs to the Special Issue Electromagnetic Sensors for Biomedical Applications)
  • Article
  • Open Access
50 Citations
14,241 Views
20 Pages

Galvanic Skin Response and Photoplethysmography for Stress Recognition Using Machine Learning and Wearable Sensors

  • Alina Nechyporenko,
  • Marcus Frohme,
  • Yaroslav Strelchuk,
  • Vladyslav Omelchenko,
  • Vitaliy Gargin,
  • Liudmyla Ishchenko and
  • Victoriia Alekseeva

21 December 2024

This study investigates stress recognition using galvanic skin response (GSR) and photoplethysmography (PPG) data and machine learning, with a new focus on air raid sirens as a stressor. It bridges laboratory and real-world conditions and highlights...

(This article belongs to the Section Biomedical Engineering)
  • Article
  • Open Access
9 Citations
3,184 Views
17 Pages

22 August 2024

Automatic emotion recognition using portable sensors is gaining attention due to its potential use in real-life scenarios. Existing studies have not explored Galvanic Skin Response and Photoplethysmography sensors exclusively for emotion recognition...

  • Article
  • Open Access
10 Citations
4,784 Views
12 Pages

The Effect of Age, Gender, and Job on Skin Conductance Response among Smartphone Users Who are Prohibited from Using Their Smartphone

  • Hsiu-Fen Hsieh,
  • Hsin-Tien Hsu,
  • Pei-Chao Lin,
  • Yu-Jen Yang,
  • Yu-Tung Huang,
  • Chih-Hung Ko and
  • Hsiu-Hung Wang

The smartphone is a widely used and rapidly growing phenomenon worldwide, and problematic smartphone use is common in our society. This study’s objective was to examine the gender difference of baseline and post-intervention skin conductance re...

(This article belongs to the Special Issue Technological Innovation in Clinical Healthcare and Health Management)
  • Article
  • Open Access
4 Citations
5,194 Views
18 Pages

25 August 2021

Emergency situations promote risk-taking behaviors associated with anxiety reactivity. A previous study using the Iowa Gambling Task (IGT) has demonstrated that prespecified state anxiety predicts moderate risk-taking (middle-risk/high-return) after...

(This article belongs to the Special Issue Neuropsychological Research of Risk Understanding and Decision Making: Normal and Pathological Profiles)
  • Article
  • Open Access
8 Citations
7,515 Views
14 Pages

Full Skin Equivalent Models for Simulation of Burn Wound Healing, Exploring Skin Regeneration and Cytokine Response

  • Patrick P. G. Mulder,
  • Rajiv S. Raktoe,
  • Marcel Vlig,
  • Anouk Elgersma,
  • Esther Middelkoop and
  • Bouke K. H. L. Boekema

Healing of burn injury is a complex process that often leads to the development of functional and aesthetic complications. To study skin regeneration in more detail, organotypic skin models, such as full skin equivalents (FSEs) generated from dermal...

(This article belongs to the Section Biomaterials for Tissue Engineering and Regenerative Medicine)
  • Article
  • Open Access
118 Citations
12,144 Views
15 Pages

Choline Chloride–Lactic Acid-Based NADES As an Extraction Medium in a Response Surface Methodology-Optimized Method for the Extraction of Phenolic Compounds from Hazelnut Skin

  • Chiara Fanali,
  • Valeria Gallo,
  • Susanna Della Posta,
  • Laura Dugo,
  • Leone Mazzeo,
  • Marco Cocchi,
  • Vincenzo Piemonte and
  • Laura De Gara

Deep eutectic solvents (DESs) are promising green solvents for the extraction of compounds from food byproducts. Hazelnut (Corylus avellana L.) is one of the most commonly cultivated tree nuts worldwide. The skin represents one of the major byproduct...

(This article belongs to the Special Issue Deep Eutectic Solvents in Analytical Chemistry)
  • Article
  • Open Access
10 Citations
4,883 Views
17 Pages

Being able to distinguish between safe and risky options is paramount in making functional choices. However, deliberate manipulation of decision-makers emotions can lead to risky behaviors. This study aims at understanding how affective reactions dri...

(This article belongs to the Special Issue How Emotions Guide Decision-Making: Behavioral and Brain Mechanisms)
  • Article
  • Open Access
25 Citations
10,625 Views
21 Pages

20 April 2024

Wearable health devices (WHDs) are rapidly gaining ground in the biomedical field due to their ability to monitor the individual physiological state in everyday life scenarios, while providing a comfortable wear experience. This study introduces a no...

(This article belongs to the Special Issue Current Accuracy and Advances in Wearable Sensors and Biosensors for Physiological Signals Measurement)
  • Article
  • Open Access
756 Views
18 Pages

19 May 2026

To identify candidate genes associated with skin tissue responses in Hu sheep raised under different regional rearing environments and to preliminarily explore their potential relevance to low-temperature-related environmental responses, this study u...

(This article belongs to the Section Animal Genetics and Genomics)
  • Review
  • Open Access
56 Citations
12,715 Views
20 Pages

26 February 2017

The growing incidence of non-melanoma skin cancer (NMSC) necessitates a thorough understanding of its primary risk factors, which include exposure to ultraviolet (UV) wavelengths of sunlight and age. Whereas UV radiation (UVR) has long been known to...

(This article belongs to the Special Issue Cancer Chemoprevention)
  • Article
  • Open Access
3 Citations
3,008 Views
21 Pages

Impact of Minimally Manipulated Cell Therapy on Immune Responses in Radiation-Induced Skin Wound Healing

  • Victoria A. Shestakova,
  • Ekaterina I. Smirnova,
  • Dmitrii A. Atiakshin,
  • Anastas A. Kisel,
  • Sergey N. Koryakin,
  • Evgeniy V. Litun,
  • Vyacheslav O. Saburov,
  • Grigory A. Demyashkin,
  • Tatyana S. Lagoda and
  • Ilya D. Klabukov
  • + 10 authors

25 February 2025

The current treatment of radiation-induced skin wounds utilizes mainly conventional therapies, including topical steroids, creams, ointments, and hydrogel dressings, which do not take into account the immunologic changes that occur in the skin after...

(This article belongs to the Section Molecular Immunology)
  • Review
  • Open Access
59 Citations
12,767 Views
29 Pages

Advances in Smart-Response Hydrogels for Skin Wound Repair

  • Yinuo Fan,
  • Han Wang,
  • Chunxiao Wang,
  • Yuanhao Xing,
  • Shuying Liu,
  • Linhan Feng,
  • Xinyu Zhang and
  • Jingdi Chen

5 October 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, as a result of their unique structural properties, highly tunable physicochemical properties, and excellent biocompatibility. The...

(This article belongs to the Section Polymer Applications)
  • Article
  • Open Access
43 Citations
8,205 Views
16 Pages

7 February 2018

One of the main reasons for fatal accidents on the road is distracted driving. The continuous attention of an individual driver is a necessity for the task of driving. While driving, certain levels of distraction can cause drivers to lose their atten...

(This article belongs to the Special Issue Sensing, Data Analysis and Platforms for Ubiquitous Intelligence)
  • Article
  • Open Access
15 Citations
4,718 Views
22 Pages

26 September 2023

Psoriasis is a chronic immune-mediated skin disease in which the symptom-free, uninvolved skin carries alterations in gene expression, serving as a basis for lesion formation. Histones and histone acetylation-related processes are key regulators of g...

(This article belongs to the Special Issue Autoimmune Diseases: A Swing Dance of the Immune Cells)
  • Article
  • Open Access
6 Citations
4,455 Views
14 Pages

15 January 2025

Skin Conductance Response (SCR) is a physiological index associated with arousing emotions. Previous studies have not explored the relationship between SCR signals and emotions in situations where multiple emotions dynamically fluctuate. Moreover, me...

(This article belongs to the Section Computer Science, Mathematics and AI)
  • Article
  • Open Access
7 Citations
5,808 Views
19 Pages

3 February 2018

The reference electronic skin is a sensor array based on PVDF (Polyvinylidene fluoride) piezoelectric polymers, coupled to a rigid substrate and covered by an elastomer layer. It is first evaluated how a distributed normal force (Hertzian distributio...

(This article belongs to the Special Issue Tactile Sensors and Sensing)
  • Article
  • Open Access
14 Citations
6,108 Views
11 Pages

Skin Conductance Responses Indicate Children are Physiologically Aroused by Their Favourite Branded Food and Drink Products

  • Rachel Smith,
  • Bridget Kelly,
  • Heather Yeatman,
  • Stuart Johnstone,
  • Louise Baur,
  • Lesley King,
  • Emma Boyland,
  • Kathy Chapman,
  • Clare Hughes and
  • Adrian Bauman

Children’s favourite food and beverage brands use various tactics to foster positive associations and loyalty. This brand-consumer dynamic is frequently influenced by the use of implicit techniques and emotional appeals. Few studies have used p...

(This article belongs to the Special Issue Marketing of Foods and Beverages: Impact and Potential Solutions for Children and Young People’s Health)
  • Article
  • Open Access
826 Views
16 Pages

20 May 2026

Skin temperature measurement is a complex issue. Skin tissue is one of the main thermoregulatory organs and takes major responsibility for heat exchange in the organism. Accurate skin temperature measurement may contribute to better estimation of dee...

(This article belongs to the Special Issue Metrology in Modern Measurement Systems and Sensors: Design, Application, Research and Challenges)
  • Article
  • Open Access
1 Citations
727 Views
16 Pages

A Device for Characterizing Skin Physiological Response to Mechanical Loading in Transtibial Prosthesis Users

  • Molly E. Baumann,
  • Mathew J. Weissinger,
  • Joseph L. Garbini,
  • Conor L. Lanahan,
  • Joseph C. Mertens,
  • Bailey Ramesh,
  • W. Lee Childers and
  • Joan E. Sanders

8 April 2026

The skin’s physiological response to repetitive stress is not well understood in prosthesis users. Improving this understanding could facilitate the design of a diagnostic tool to determine if the skin is adapting to tolerate stress from a pros...

(This article belongs to the Section Biomedical Sensors)
  • Review
  • Open Access
3 Citations
2,668 Views
35 Pages

13 September 2022

The goal of this review is to explain how to design a biomaterial approach to control the adaptive response to injury, with an emphasis on skin wounds. The strategies will be selected based on whether they have a reasonable probability of meeting the...

(This article belongs to the Section Biomaterials)
  • Article
  • Open Access
4 Citations
2,858 Views
16 Pages

Airborne fine dust pollution poses a significant threat to both respiratory and skin health, yet the skin’s physiological response to such exposure has been underexplored. This study investigates the impact of fine dust on skin cells, focusing...

(This article belongs to the Special Issue Air Quality, Health and Climate)
  • Article
  • Open Access
4 Citations
3,879 Views
16 Pages

In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. The response of major cell subpopulations in the draining lymph nodes to skin infection with Staphylococcus epidermidis was assessed using the r...

(This article belongs to the Special Issue Immune Response to Viruses and Bacteria)
  • Article
  • Open Access
490 Views
13 Pages

Influence of Time of Day on Skin Microvascular Response to Post-Occlusive Reactive Hyperemia

  • Kamil Gałęziok,
  • Krzysztof Fostiak,
  • Artur Terbalyan,
  • Michał Wilk and
  • Robert Trybulski

22 May 2026

Study aim: Circadian rhythms influence numerous physiological processes, including vascular regulation and skin microcirculation. However, evidence regarding diurnal variability in post-occlusive reactive hyperemia (PORH) parameters remains limited....

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
3 Citations
1,906 Views
11 Pages

Use Directional-Hemispherical Reflectance to Identify Female Skin Features in Response of Microdermabrasion Treatment

  • Anna Stolecka-Warzecha,
  • Aleksandra Brandys,
  • Małgorzata Bożek,
  • Agata Lebiedowska,
  • Barbara Błońska-Fajfrowska and
  • Sławomir Wilczyński

25 November 2022

Diamond microdermabrasion is one of the most popular cosmetological treatments in the field of mechanical, controlled abrasion of the stratum corneum corneocytes. In this study, the influence of micropeeling on the optical properties of the skin feat...

(This article belongs to the Section Applied Biosciences and Bioengineering)
  • Article
  • Open Access
3 Citations
2,493 Views
14 Pages

Non-Invasive Assessment of Skin Surface Proteins of Psoriasis Vulgaris Patients in Response to Biological Therapy

  • Kadri Orro,
  • Kristiina Salk,
  • Anna Merkulova,
  • Kristi Abram,
  • Maire Karelson,
  • Tanel Traks,
  • Toomas Neuman,
  • Pieter Spee and
  • Külli Kingo

13 November 2023

Measurements of skin surface biomarkers have enormous value for the detailed assessment of skin conditions, both for clinical application and in skin care. The main goals of the current study were to assess whether expression patterns of skin surface...

(This article belongs to the Special Issue Molecular Mechanisms of Treating Psoriasis)
  • Article
  • Open Access
17 Citations
5,304 Views
16 Pages

SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia

  • Hanna Karakula-Juchnowicz,
  • Joanna Rog,
  • Piotr Wolszczak,
  • Kamil Jonak,
  • Ewa Stelmach and
  • Paweł Krukow

13 June 2020

Schizophrenia has been considered a disorder linked with faulty lipid homeostasis, and the proposed tool for assessment of these disruptions is the niacin skin flush test. The aims of the study were: 1. Create a new tool to analyze results of the nia...

(This article belongs to the Section Mental Health)
  • Review
  • Open Access
28 Citations
10,596 Views
20 Pages

P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis

  • Carla Carvalho,
  • Rita Silva,
  • Teresa M. V. D. Pinho e Melo,
  • Alberto Inga and
  • Lucília Saraiva

27 November 2024

This review delves into the significant cellular and molecular responses triggered by UVR exposure in human skin, emphasizing the pivotal role of mutant p53 (mutp53) in the carcinogenic process elicited by radiation. By underlining the role of a func...

(This article belongs to the Special Issue Advances in Molecular Oncology and Therapeutics)
  • Article
  • Open Access
1,304 Views
19 Pages

A Rapid 3D Melanoma–Skin Organoid for High-Throughput Assessment of Tumor Dynamics and Drug Response

  • Gemma Nomdedeu-Sancho,
  • Nicholas Edenhoffer,
  • Anastasiya Gorkun-Roeder,
  • Ola A. Gaser,
  • Carlos Kengla,
  • Allie Benton,
  • David W. Mullins,
  • Anthony Atala and
  • Shay Soker

Melanoma is the most aggressive type of skin cancer, driven by early invasion, phenotypic plasticity, and frequent resistance to targeted therapies. Although genomic profiling informs treatment selection, genotype alone often fails to predict therape...

(This article belongs to the Section Molecular Oncology)
  • Review
  • Open Access
127 Citations
21,525 Views
20 Pages

16 May 2014

Staphylococcus aureus (S. aureus) is a widespread cutaneous pathogen responsible for the great majority of bacterial skin infections in humans. The incidence of skin infections by S. aureus reflects in part the competition between host cutaneous immu...

(This article belongs to the Special Issue Molecular Science for Drug Development and Biomedicine)
  • Article
  • Open Access
37 Citations
4,730 Views
12 Pages

21 November 2019

In order to determine the relationship between an exposure dose of Staphylococcus aureus (S. aureus) on the skin and the risk of infection, an understanding of the bacterial growth and decay kinetics is very important. Models are essential tools for...

(This article belongs to the Section Human Pathogens)
  • Article
  • Open Access
1 Citations
3,900 Views
14 Pages

Fish skin is a biological material with high flexibility and compliance and can provide good mechanical protection against sharp punctures. This unusual structural function makes fish skin a potential biomimetic design model for flexible, protective,...

(This article belongs to the Special Issue The Mechanical Properties of Biomaterials 2.0)
  • Article
  • Open Access
22 Citations
7,861 Views
13 Pages

The skin of an organism is affected by various environmental factors and fights against aging stress via mechanical and biochemical responses. Photoaging induced by ultraviolet B (UVB) irradiation is common and is the most vital factor in the senesce...

(This article belongs to the Special Issue Molecular Research of Aging Stress Response)
  • Review
  • Open Access
167 Citations
22,053 Views
31 Pages

Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis

  • César López-Camarillo,
  • Elena Aréchaga Ocampo,
  • Mavil López Casamichana,
  • Carlos Pérez-Plasencia,
  • Elizbeth Álvarez-Sánchez and
  • Laurence A. Marchat

23 December 2011

Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the specific signal transduction pathways and transcription factors involved...

(This article belongs to the Special Issue UV-Induced Cell Death)
  • Article
  • Open Access
6 Citations
3,235 Views
11 Pages

Local Response and Barrier Recovery in Elderly Skin Following the Application of High-Density Microarray Patches

  • Fredrik Iredahl,
  • David A. Muller,
  • Totte Togö,
  • Hanna Jonasson,
  • Ben Baker,
  • Chris D. Anderson and
  • Joakim Henricson

10 April 2022

The high-density microneedle array patch (HD-MAP) is a promising alternative vaccine delivery system device with broad application in disease, including SARS-CoV-2. Skin reactivity to HD-MAP applications has been extensively studied in young individu...

  • Article
  • Open Access
19 Citations
3,352 Views
20 Pages

14 November 2022

The skin is the largest organ on the surface of vertebrates, which not only acts as the first line of defense against pathogens but also harbors diverse symbiotic microorganisms. The complex interaction between skin immunity, pathogens, and commensal...

(This article belongs to the Section Molecular Immunology)
  • Article
  • Open Access
53 Citations
8,036 Views
16 Pages

Combined Effects of Carotenoids and Polyphenols in Balancing the Response of Skin Cells to UV Irradiation

  • Glenda Calniquer,
  • Marina Khanin,
  • Hilla Ovadia,
  • Karin Linnewiel-Hermoni,
  • David Stepensky,
  • Aviram Trachtenberg,
  • Tanya Sedlov,
  • Oleg Braverman,
  • Joseph Levy and
  • Yoav Sharoni

30 March 2021

Oral carotenoids and polyphenols have been suggested to induce photo-protective effects. The aim of the study was to test whether the combination of carotenoids and polyphenols produce greater protective effects from UV-induced damage to skin cells....

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
26 Citations
6,740 Views
16 Pages

Full-Thickness Perfused Skin-on-a-Chip with In Vivo-Like Drug Response for Drug and Cosmetics Testing

  • Stephen Rhee,
  • Chunguang Xia,
  • Aditya Chandra,
  • Morgan Hamon,
  • Geonhui Lee,
  • Chen Yang,
  • Zaixun Guo and
  • Bingjie Sun

In this study, we present a novel 3D perfused skin-on-a-chip model fabricated using micro-precision 3D printing, which offers a streamlined and reproducible approach for incorporating perfusion. Perfused skin models are well-regarded for their advant...

(This article belongs to the Section Biomedical Engineering and Biomaterials)
  • Article
  • Open Access
657 Views
20 Pages

Health-Promoting Phytobiotic-Based Feed Additive Improves Skin and Gill Proteome Response of Infected Fish

  • Elissavet A. Arapi,
  • Laura Fernández-Alacid,
  • Maria Mercè Isern-Subich,
  • Waldo G. Nuez-Ortín,
  • Antoni Ibarz and
  • Jo Cable

28 April 2026

Skin is a multifunctional organ essential for maintaining body homeostasis, regulating functions and providing protection from environmental stressors. In fish, skin is immune active, containing antimicrobial proteins acting as the first line of defe...

(This article belongs to the Section Aquatic Animals)
  • Article
  • Open Access
8 Citations
3,252 Views
16 Pages

In Vitro Prediction of Skin-Sensitizing Potency Using the GARDskin Dose–Response Assay: A Simple Regression Approach

  • Robin Gradin,
  • Fleur Tourneix,
  • Ulrika Mattson,
  • Johan Andersson,
  • Frédéric Amaral,
  • Andy Forreryd,
  • Nathalie Alépée and
  • Henrik Johansson

24 August 2024

Toxicological assessments of skin sensitizers have progressed towards a higher reliance on non-animal methods. Current technological trends aim to extend the utility of non-animal methods to accurately characterize skin-sensitizing potency. The GARDs...

(This article belongs to the Special Issue Skin Sensitization Testing Using New Approach Methodologies)

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