Next Article in Journal
In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways
Next Article in Special Issue
Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
Previous Article in Journal
Molecular Recognition of Agonist and Antagonist for Peroxisome Proliferator-Activated Receptor-α Studied by Molecular Dynamics Simulations
Previous Article in Special Issue
The Discovery of Potentially Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: A Combination of Pharmacophore Modelling, CoMFA, Virtual Screening and Molecular Docking Studies
Open AccessReview

Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides

1
Department of Biotechnology, Chosun University, Gwangju 501-759, Korea
2
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
3
Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(5), 8753-8772; https://doi.org/10.3390/ijms15058753
Received: 18 April 2014 / Revised: 2 May 2014 / Accepted: 7 May 2014 / Published: 16 May 2014
(This article belongs to the Special Issue Molecular Science for Drug Development and Biomedicine)
Staphylococcus aureus (S. aureus) is a widespread cutaneous pathogen responsible for the great majority of bacterial skin infections in humans. The incidence of skin infections by S. aureus reflects in part the competition between host cutaneous immune defenses and S. aureus virulence factors. As part of the innate immune system in the skin, cationic antimicrobial peptides (CAMPs) such as the β-defensins and cathelicidin contribute to host cutaneous defense, which prevents harmful microorganisms, like S. aureus, from crossing epithelial barriers. Conversely, S. aureus utilizes evasive mechanisms against host defenses to promote its colonization and infection of the skin. In this review, we focus on host-pathogen interactions during colonization and infection of the skin by S. aureus and methicillin-resistant Staphylococcus aureus (MRSA). We will discuss the peptides (defensins, cathelicidins, RNase7, dermcidin) and other mediators (toll-like receptor, IL-1 and IL-17) that comprise the host defense against S. aureus skin infection, as well as the various mechanisms by which S. aureus evades host defenses. It is anticipated that greater understanding of these mechanisms will enable development of more sustainable antimicrobial compounds and new therapeutic approaches to the treatment of S. aureus skin infection and colonization. View Full-Text
Keywords: Staphylococcus aureus; skin colonization; skin infection; immune system evasion; cationic antimicrobial peptides (CAMPs) Staphylococcus aureus; skin colonization; skin infection; immune system evasion; cationic antimicrobial peptides (CAMPs)
MDPI and ACS Style

Ryu, S.; Song, P.I.; Seo, C.H.; Cheong, H.; Park, Y. Colonization and Infection of the Skin by S. aureus: Immune System Evasion and the Response to Cationic Antimicrobial Peptides. Int. J. Mol. Sci. 2014, 15, 8753-8772.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop