The paper discusses possible consequences of A. D. Sakharov’s hypothesis of cosmological transitions with changes in the signature of the metric, based on the path integral approach. This hypothesis raises a number of mathematical and philosophical q...
Prior to the eighteenth century, cobalt was exclusively employed as a colouring agent for vitreous materials, and its use appears to be concurrent with the earliest large-scale production of glass during the Late Bronze Age (LBA). LBA cobalt deposits...
Morphine administration causes system-level metabolic changes. Here, we show that morphine-tolerant mice exhibited distinct plasma metabolic signatures upon acute and chronic administration. We utilized a mouse model of morphine tolerance by exposing...
Forest soils contain a large amount of organic carbon (OC); therefore, small changes in these ecosystems have effects on climate. In this study, variation in the quantity of C pools that occurred in one year in the soil of temperate forests managed b...
There is mounting evidence for the emerging role of gut microbiota (GM) and its metabolites in profoundly impacting allogenic hematopoietic stem cell transplantation (allo-HSCT) and its subsequent complications, mainly infections and graft versus hos...
The Earth’s geomagnetic field (GMF) is a fundamental environmental signal for plants, with its perception rooted in quantum biology. Specifically, the radical pair mechanism (RPM) explains how this weak force influences electron spin states in...
Urban agriculture is an emerging challenge. Identifying suitable agrosystems that allow for the multiple functions of urban agriculture represents a key issue for the reinforcement of the agricultural matrix in cities, with the aims of counteracting...
Mitochondrial dysfunction is an important mechanism contributing to the development and progression of diabetic kidney disease (DKD). Mitochondrial DNA (mtDNA) levels in blood and urine were evaluated in relation to podocyte injury and proximal tubul...
In this paper, I discuss the idea that the birth of our Universe may be a result of a quantum transition from a physical continuum with the Euclidean signature to a Lorentzian spacetime. A similar idea was expressed by Andrei D. Sakharov At the class...
The aim of this study was to determine the effect of progressive pig slurry (PS) rates, applied over a 12-year period, on the molecular composition of soil organic matter in a calcareous soil. Annual organic matter rates of PS ranged from 1.0 to 4.8...
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Endocrine disrupters include a broad spectrum of chemicals such as industrial chemicals, natural estrogens and androgens, synthetic estrogens and androgens. Phytoestrogens are widely present in diet and food supplements; mycoestrogens are frequently...
Runoff signatures (RS), a special set of runoff indexes reflecting the hydrological process, have an important influence on many fields of both human and natural systems by flooding, drought, and available water resources. However, the global RS chan...
Recent studies have provided evidence, based on analyses of instrumental measurements of the last seven decades, for a unidirectional, potentially causal link between temperature as the cause and carbon dioxide concentration ([CO2]) as the effect. In...
Background and Objectives. The prognostic role of adjacent nontumor tissue in patients with breast cancer (BC) is still unclear. The activity changes in immunologic and hallmark gene sets in normal tissues adjacent to BC may play a crucial role in pr...
In the last 50 years, hantaviruses have significantly affected public health worldwide, but the exact extent of the distribution of hantavirus diseases, species and lineages and the risk of their emergence into new geographic areas are still poorly k...
Increased choroid plexus (CP) volume has been recently implicated as a potential predictor of worse multiple sclerosis (MS) outcomes. The biomarker signature of CP changes in MS are currently unknown. To determine the blood-based biomarker characteri...
Using pan-cancer data from The Cancer Genome Atlas (TCGA), we investigated how patterns in copy number alterations in cancer cells vary both by tissue type and as a function of genetic alteration. We find that patterns in both chromosomal ploidy and...
Bone allografts are widely used as osteoconductive support to guide bone regrowth. Bone allografts are more than a scaffold for the immigrating cells as they maintain some bioactivity of the original bone matrix. Yet, it remains unclear how immigrati...
Despite decades of study, the factors that controlled the formation and evolution of the upper reaches of the Yellow River, including uplift of the northeastern Tibetan Plateau, Pliocene-Pleistocene climate change, and autogenetic processes are still...
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic factors as part of the senescence-associated secretory phenotyp...
Against the background of climate change, we studied the effects of a severe summer drought on buds of European beech (Fagus sylvatica L.) saplings and on leaves formed during the subsequent spring in trees attributed to different drought-damage clas...
From the physics point of view, time is now best described through General Relativity as part of space-time, which is a dynamical object encoding gravity. Time possesses also some intrinsic irreversibility due to thermodynamics and quantum mechanical...
The article presents a measurement system that captures two components of a motor vehicle’s magnetic profile, which are associated with the real and imaginary part of the impedance of a narrow inductive loop sensor. The proposed algorithm utili...
Classifying land cover is perhaps the most common application of remote sensing, yet classification at frequent temporal intervals remains a challenging task due to radiometric differences among scenes, time and budget constraints, and semantic diffe...
Individuals with Parkinson’s disease often face legal disputes over documents signed before the ongoing disease, since fine motor skill changes can lead to alterations in handwriting. Generally, rehabilitation programs focus on mobility in the...
A number of modern techniques for neural network training and recognition enhancement are based on their structures’ symmetry. Such approaches demonstrate impressive results, both for recognition practice, and for understanding of data transfor...
Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the addition of nitrog...
The occurrence of extreme windstorms and increasing heat and drought events induced by climate change leads to severe damage and stress in coniferous forests, making trees more vulnerable to spruce bark beetle infestations. The combination of abiotic...
Physical foundations for relativistic spacetimes are revisited in order to check at what extent Finsler spacetimes lie in their framework. Arguments based on inertial observers (as in the foundations of special relativity and classical mechanics) are...
Continuous monitoring of water resources is essential for ensuring sustainable urban water supply. Remote sensing techniques have proven to be valuable in monitoring certain qualitative parameters of water with optical characteristics. This survey wa...
Livestock expresses complex traits influenced by several factors. The response of animals to variations in climatic factors, such as increases in temperature, may induce heat stress conditions. In this study, animals living at different temperatures...
During the phase of proliferation needed for hematopoietic reconstitution following transplantation, hematopoietic stem/progenitor cells (HSPC) must express genes involved in stem cell self-renewal. We investigated the expression of genes relevant fo...
Proteins often exist in multiple conformational states, influenced by the binding of ligands or substrates. The study of these states, particularly the apo (unbound) and holo (ligand-bound) forms, is crucial for understanding protein function, dynami...
Obesity represents a major health concern, not just in the West but increasingly in low and middle income countries. In order to develop successful strategies for losing weight, it is essential to understand the molecular pathogenesis of weight chang...
Theoretical possibilities of models of gravity with dynamical signature are discussed. The different scenarios of the signature change are proposed in the framework of Einstein-Cartan gravity. We consider, subsequently, the dynamical signature in the...
This paper presents a novel algorithm for compensating the changes in conductance signatures of a piezo sensor due to the temperature variation employed in condition monitoring using the electro-mechanical impedance (EMI) approach. It is crucial to c...
The underwater electric potential (UEP) signature is an electric signal, which can be exploited by naval mines to be utilized as a possible trigger indicator and may cause severe damage to the vessel and the onboard crew. Hence, knowing the UEP signa...
Sarcoidosis is a multisystemic disease characterized by non-caseating granuloma infiltrating various organs. The form with symptomatic muscular involvement is called muscular sarcoidosis. The impact of immune cells composing the granuloma on the skel...
Microglia, the innate immune cells of the brain, are commonly perceived as resident macrophages of the central nervous system (CNS). This definition, however, requires further specification, as under healthy homeostatic conditions, neither morphologi...
As demonstrated in prior studies, InSAR holds great potential for land cover classification, especially considering its wide coverage and transparency to climatic conditions. In addition to features such as backscattering coefficient and phase cohere...
Triple-negative breast cancer (TNBC) has poor clinical prognosis. Lack of TNBC-specific biomarkers prevents active clinical intervention. We reasoned that TNBC must have its specific signature due to the lack of three key receptors to distinguish TNB...
Zooplankton is crucial for the transfer of matter, energy, and pollutants through aquatic food webs. Primary and secondary consumers contribute to the abundance and standing stock biomass, which both vary seasonally. By means of taxa- and size-specif...
Plants encrypt the perception of different pathogenic stimuli into specific intracellular calcium (Ca2+) signatures and subsequently decrypt the signatures into appropriate downstream responses through various Ca2+ sensors. Two microbe-associated mol...
Our understanding of how microbiome signatures are modulated in wild fish populations remains poorly developed and has, until now, mostly been inferred from studies in commercial and farmed fish populations. Here, for the first time, we have studied...
In this paper, a new fractal signature possessing the cardioid shape in the Mandelbrot set is presented in the Fourier space of a Fibonacci chain with two lengths, L and S, where L / S = ϕ . The corresponding pointwise dimension is 1.7. Variou...
We present the detection of the signatures of land use/land cover (LULC) changes on the regional climate of the US High Plains. We used the normalized difference vegetation index (NDVI) as a proxy of LULC changes and atmospheric CO2 concentrations as...
The purpose of this study is to develop a deep radiomic signature based on an artificial intelligence (AI) model. This radiomic signature identifies oocyte morphological changes corresponding to reproductive aging in bright field images captured by o...
Background: How the tumor microenvironment (TME) influences treatment response in HER2+ breast cancer following HER2-directed therapy is crucial for individualizing therapies and is currently understudied. The purpose of this exploratory analysis was...
Understanding the molecular signatures of colorectal cancer progression under chemotherapeutic treatment will be crucial for the success of future therapy improvements. Here, we used a xenograft-based mouse model to investigate, how whole transcripto...
Signatures of positive selection in the genome are a characteristic mark of adaptation that can reveal an ongoing, recent, or ancient response to environmental change throughout the evolution of a population. New sources of food, climate conditions,...
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