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Computational Methods for the Discovery of Metabolic Markers of Complex Traits
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The Metabolomic Signatures of Weight Change

1
Department of Twin Research, King’s College London, London SE1 7EH, UK
2
School of Medicine, University of Nottingham, Nottingham NG7 2TU, UK
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(4), 67; https://doi.org/10.3390/metabo9040067
Received: 30 January 2019 / Revised: 18 March 2019 / Accepted: 3 April 2019 / Published: 4 April 2019
(This article belongs to the Special Issue Metabolomics of Complex Traits)
Obesity represents a major health concern, not just in the West but increasingly in low and middle income countries. In order to develop successful strategies for losing weight, it is essential to understand the molecular pathogenesis of weight change. A number of pathways, implicating oxidative stress but also the fundamental regulatory of insulin, have been implicated in weight gain and in the regulation of energy expenditure. In addition, a considerable body of work has highlighted the role of metabolites generated by the gut microbiome, in particular short chain fatty acids, in both processes. The current review provides a brief understanding of the mechanisms underlying the associations of weight change with changes in lipid and amino acid metabolism, energy metabolism, dietary composition and insulin dynamics, as well as the influence of the gut microbiome. The changes in metabolomic profiles and the models outlined can be used as an accurate predictor for obesity and obesity related disorders. View Full-Text
Keywords: weight gain; oxidative stress; insulin theory weight gain; oxidative stress; insulin theory
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Vijay, A.; Valdes, A.M. The Metabolomic Signatures of Weight Change. Metabolites 2019, 9, 67.

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