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3,796 Results Found

  • Article
  • Open Access
4 Citations
2,770 Views
20 Pages

Biocomposites of Epoxidized Natural Rubber Modified with Natural Substances

  • Konrad Stefaniak,
  • Anna Masek and
  • Aleksandra Jastrzębska

15 November 2022

This research aimed to show the possible impact of natural antioxidants on epoxidized natural rubber (ENR) and poly(lactic acid) (PLA) green composites. Thus, the ENR/PLA blends were prepared with the addition of three selected phytochemicals (catech...

  • Review
  • Open Access
1 Citations
6,676 Views
29 Pages

Exploring the Antimicrobial Potential of Natural Substances and Their Applications in Cosmetic Formulations

  • Katarzyna Kulik-Siarek,
  • Marta Klimek-Szczykutowicz,
  • Ewelina Błońska-Sikora,
  • Emilia Zarembska and
  • Małgorzata Wrzosek

29 December 2024

The aim of this review is to analyze natural substances exhibiting antibacterial and antifungal activity against skin pathogens, along with their exemplary applications in cosmetic products. Growing concerns related to increasing infection rates and...

  • Review
  • Open Access
26 Citations
7,213 Views
18 Pages

Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases

  • Fan Liu,
  • Linkai Qu,
  • Hua Li,
  • Jiaxuan He,
  • Lei Wang,
  • Yimeng Fang,
  • Xiaoqing Yan,
  • Qinsi Yang,
  • Bo Peng and
  • Wei Wu
  • + 2 authors

Pigmentation diseases can lead to significant color differences between the affected part and the normal part, resulting in severe psychological and emotional distress among patients. The treatment of pigmentation diseases with good patient complianc...

  • Review
  • Open Access
25 Citations
6,031 Views
23 Pages

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

  • Kézia Cristine Barbosa Ferreira,
  • Ana Beatriz Caribé dos Santos Valle,
  • Camila Quinetti Paes,
  • Guilherme Diniz Tavares and
  • Frederico Pittella

The main function of the skin is to protect the body from the external environment. However, the skin can undergo inflammatory processes, due to genetic, hormonal, or environmental factors. When the defense system is overloaded, there is an increase...

  • Article
  • Open Access
9 Citations
2,950 Views
10 Pages

Growing pressure to reduce the environmental pesticide burden has the greatest impact on agriculture and crop protection. There is an enormous increase in the demand for research on new, effective, naturally based agents that do not pose an environme...

  • Review
  • Open Access
11 Citations
3,551 Views
17 Pages

Flavor is an important index to evaluate the sensory quality of tobacco. The process of fermentation is a key step in the production of aromatic substances in tobacco leaves and an important factor in improving their quality. Worldwide, reams of rese...

  • Article
  • Open Access
6 Citations
2,762 Views
15 Pages

6 December 2022

Natural Treatment Systems for Wastewater (NTSW) show great potential for economic, socially acceptable and environmentally friendly wastewater treatment, along with the renewal of water for its safe reuse. This article presents the reduction in nitro...

  • Review
  • Open Access
39 Citations
6,641 Views
34 Pages

Substances of Natural Origin in Medicine: Plants vs. Cancer

  • Adrianna Gielecińska,
  • Mateusz Kciuk,
  • Somdutt Mujwar,
  • Ismail Celik,
  • Damian Kołat,
  • Żaneta Kałuzińska-Kołat and
  • Renata Kontek

23 March 2023

Continuous monitoring of the population’s health is the main method of learning about disease prevalence. National and international data draw attention to the persistently high rates of cancer incidence. This necessitates the intensification o...

  • Review
  • Open Access
437 Views
19 Pages

20 October 2025

Malaria is one of the diseases that is a serious threat to global health, with millions of cases reported worldwide in recent years. The treatment of malaria is still a challenge due to its complex pathogenesis, resistance to many of the antimalarial...

  • Review
  • Open Access
3 Citations
2,302 Views
22 Pages

Nutrients and Natural Substances for Hypoglycemic Effects and Management in Diabetic Retinopathy

  • Francesco Cappellani,
  • Roberta Foti,
  • Giulia Malaguarnera,
  • Fabiana D’Esposito,
  • Carlo Musumeci,
  • Lorenzo Rapisarda,
  • Daniele Tognetto,
  • Caterina Gagliano and
  • Marco Zeppieri

30 March 2025

Diabetic retinopathy (DR) is a significant microvascular consequence of diabetes mellitus (DM), resulting in visual impairment and blindness. Controlling hyperglycemia is essential for avoiding and alleviating diabetic retinopathy. Nutrients and natu...

  • Review
  • Open Access
4 Citations
3,727 Views
22 Pages

The Application of Natural Phenolic Substances as Antimicrobial Agents in Agriculture and Food Industry

  • Katarzyna Dembińska,
  • Ambika H. Shinde,
  • Marcela Pejchalová,
  • Agnieszka Richert and
  • Maria Swiontek Brzezinska

26 May 2025

Natural phenolic substances have emerged as promising alternatives to synthetic antimicrobials in both agriculture and the food industry, where concerns over microbial resistance and chemical residues are rising. This review provides a comprehensive...

  • Review
  • Open Access
1 Citations
1,847 Views
26 Pages

21 September 2025

Humic substances, which include humic acid and fulvic acid, are natural biopolymers formed from the decomposition of organic matter. There is growing interest in them because of their diverse potential in the biomedical field. Their complex structure...

  • Review
  • Open Access
3 Citations
2,787 Views
17 Pages

The Equilibrium of Bacterial Microecosystem: Probiotics, Pathogenic Bacteria, and Natural Antimicrobial Substances in Semen

  • Xuelan Miao,
  • Yanhua Zhao,
  • Lingxi Zhu,
  • Yutian Zeng,
  • Cuiting Yang,
  • Run Zhang,
  • Arab Khan Lund and
  • Ming Zhang

Semen is a complex fluid that contains spermatozoa and also functions as a dynamic bacterial microecosystem, comprising probiotics, pathogenic bacteria, and natural antimicrobial substances. Probiotic bacteria, such as Lactobacillus and Bifidobacteri...

  • Article
  • Open Access
5,922 Views
14 Pages

17 December 2024

Topical formulations that include natural active compounds to treat inflamed and aching skin are favored by patients. Small local producers use commercial creams and gels to which they add compounds, often with criteria based more on trends than scie...

  • Review
  • Open Access
10 Citations
16,210 Views
24 Pages

Melasma is a fairly common condition that is the result of hyperpigmentation caused by increased melanin secretion. In the course of melasma, certain areas of the skin become darker than the rest of the epidermis. Although the pathogenesis remains in...

  • Article
  • Open Access
12 Citations
3,895 Views
14 Pages

Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

  • Micaela Machado Querido,
  • Ivo Paulo,
  • Sriram Hariharakrishnan,
  • Daniel Rocha,
  • Nuno Barbosa,
  • Rui Galhano dos Santos,
  • João Moura Bordado,
  • João Paulo Teixeira and
  • Cristiana Costa Pereira

5 November 2021

The risk of infection arising from indirect sources—namely, contaminated surfaces—has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces wit...

  • Review
  • Open Access
10 Citations
4,336 Views
12 Pages

Natural Substances, Probiotics, and Synthetic Agents in the Treatment and Prevention of Honeybee Nosemosis

  • Magdalena Kunat-Budzyńska,
  • Michał Budzyński,
  • Michał Schulz,
  • Aneta Strachecka,
  • Marek Gancarz,
  • Robert Rusinek and
  • Aneta A. Ptaszyńska

31 October 2022

Honeybees are important pollinators, but they are continuously exposed to a variety of fungal and bacterial diseases. One of the various diseases affecting honeybees is nosemosis caused by microsporidia from the Nosema genus. Honeybees are mainly inf...

  • Article
  • Open Access
10 Citations
3,472 Views
18 Pages

21 May 2021

The aim of this study is to present the possible influence of natural substances on the aging properties of epoxidized natural rubber (ENR) and poly(lactic acid) (PLA) eco-friendly elastic blends. Therefore, the ENR/PLA blends were filled with natura...

  • Review
  • Open Access
4,193 Views
25 Pages

20 August 2025

Photoaging is a multifactorial and progressive skin aging process primarily triggered by prolonged exposure to ultraviolet (UV) radiation. This condition leads to both structural and functional impairments in the skin, including the formation of wrin...

  • Feature Paper
  • Review
  • Open Access
31 Citations
10,893 Views
26 Pages

The consumption of new psychoactive substances (NPSs) has been increasing, and this problem affects several countries worldwide. There is a class of NPSs of natural origin, consisting of plants and fungi, which have a wide range of alkaloids, respons...

  • Review
  • Open Access
3 Citations
4,974 Views
22 Pages

Progress in the Study of Natural Antimicrobial Active Substances in Pseudomonas aeruginosa

  • Tianbo Si,
  • Anqi Wang,
  • Haowen Yan,
  • Lingcong Kong,
  • Lili Guan,
  • Chengguang He,
  • Yiyi Ma,
  • Haipeng Zhang and
  • Hongxia Ma

16 September 2024

The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in the prevention and treatment of infectious diseases caused by pathogens such as bacteria, fungi, and viruses. Microbial secondary metabolites have been rec...

  • Review
  • Open Access
2 Citations
2,015 Views
34 Pages

9 August 2024

Molds pose a severe challenge to agriculture because they cause very large crop losses. For this reason, synthetic fungicides have been used for a long time. Without adequate protection against pests and various pathogens, crop losses could be as hig...

  • Review
  • Open Access
11 Citations
7,417 Views
19 Pages

Natural Substances as Valuable Alternative for Improving Conventional Antifungal Chemotherapy: Lights and Shadows

  • Juan Carlos Argüelles,
  • Ruth Sánchez-Fresneda,
  • Alejandra Argüelles and
  • Francisco Solano

5 May 2024

Fungi are eukaryotic organisms with relatively few pathogenic members dangerous for humans, usually acting as opportunistic infections. In the last decades, several life-threatening fungal infections have risen mostly associated with the worldwide ex...

  • Review
  • Open Access
7 Citations
4,737 Views
16 Pages

Evidence for Ovarian and Testicular Toxicities of Cadmium and Detoxification by Natural Substances

  • Martin Massányi,
  • Soisungwan Satarug,
  • Roberto Madeddu,
  • Robert Stawarz and
  • Peter Massányi

22 December 2021

Cadmium (Cd) is an environmental toxicant, capable of reducing mitochondrial ATP production and promoting the formation of reactive oxygen species (ROS) with resultant oxidative stress conditions. The ovary and testis are the primary gonads in which...

  • Article
  • Open Access
2 Citations
2,357 Views
14 Pages

Antibiotics in animal production are widely used around the world for therapeutic and preventive purposes, and in some countries, they still serve as antibiotic growth stimulants. Regardless of the purpose of using antibiotics in livestock, they may...

  • Review
  • Open Access
30 Citations
7,408 Views
20 Pages

Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model

  • Adriana M. Ferreira,
  • Agerdânio A. de Souza,
  • Rosemary de Carvalho R. Koga,
  • Iracirema da S. Sena,
  • Mateus de Jesus S. Matos,
  • Rosana Tomazi,
  • Irlon M. Ferreira and
  • José Carlos T. Carvalho

20 January 2023

Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme in the process of pigmentation through melanin is tyrosinase, which catalyzes the first and only limiting step in melanogenesis. Since the di...

  • Article
  • Open Access
11 Citations
15,083 Views
11 Pages

The special issue “A Critical View on Natural Substances in Personal Care Products” is dedicated to addressing the multidisciplinary special challenges of natural ingredients in personal care products (PCP) and addresses also environmental exposure....

  • Review
  • Open Access
7 Citations
4,022 Views
22 Pages

Artificial Humic Substances as Biomimetics of Natural Analogues: Production, Characteristics and Preferences Regarding Their Use

  • Elena Efremenko,
  • Nikolay Stepanov,
  • Olga Senko,
  • Ilya Lyagin,
  • Olga Maslova and
  • Aysel Aslanli

Various processes designed for the humification (HF) of animal husbandry wastes, primarily bird droppings, reduce their volumes, solve environmental problems, and make it possible to obtain products with artificially formed humic substances (HSs) as...

  • Article
  • Open Access
1 Citations
2,788 Views
12 Pages

24 December 2022

Chemical diversification of substances present in natural product extracts can lead to a number of natural product-like compounds with a better chance of desirable bioactivities. The aim of this work was to discover unprecedented chemical conversion...

  • Article
  • Open Access
43 Citations
8,571 Views
16 Pages

Improvement of Sorghum Crop through Exogenous Application of Natural Growth-Promoting Substances under a Changing Climate

  • Wahid Ahmad,
  • Mehmood Ali Noor,
  • Irfan Afzal,
  • Muhammad Amir Bakhtavar,
  • Muhammad Mohsin Nawaz,
  • Xuefang Sun,
  • Baoyuan Zhou,
  • Wei Ma and
  • Ming Zhao

16 December 2016

High temperature during May to July is a major hurdle for production of sorghum as fodder in Pakistan, ultimately resulting in a deficit with respect to the demand of meat and milk for increasing population. A field study was conducted to investigate...

  • Review
  • Open Access
1,588 Views
14 Pages

Application of Antifreeze Substances in Food Cryopreservation

  • Mengxia Wu,
  • Qin Xu,
  • Han Ding,
  • Dumin Zhao,
  • Ying Wang and
  • Baocai Xu

13 June 2025

Freezing is a crucial technology for preserving food quality and extending shelf life. However, frozen storage often leads to protein oxidation, degradation, and cellular structural damage, compromising food palatability. To address these challenges,...

  • Review
  • Open Access
4 Citations
6,022 Views
29 Pages

Chemical Migration from Wine Contact Materials

  • Niki C. Maragou,
  • Alexandros Tzachristas,
  • Emmanouil D. Tsochatzis and
  • Nikolaos S. Thomaidis

25 July 2024

Wine quality and safety is affected by the food contact materials (FCMs) used. These materials are expected to protect the beverage from any chemical, physical, or biological hazard and preserve its composition stable throughout its shelf-life. Howev...

  • Review
  • Open Access
54 Citations
6,664 Views
27 Pages

Recent Progress in Antioxidant Active Substances from Marine Biota

  • Todorka Vladkova,
  • Nelly Georgieva,
  • Anna Staneva and
  • Dilyana Gospodinova

22 February 2022

Background: The well-recognized but not fully explored antioxidant activity of marine-biota-derived, biologically active substances has led to interest in their study as substitutes of antibiotics, antiaging agents, anticancer and antiviral drugs, an...

  • Review
  • Open Access
9 Citations
3,327 Views
37 Pages

Encapsulation of Active Substances in Natural Polymer Coatings

  • Emma Akpo,
  • Camille Colin,
  • Aurélie Perrin,
  • Julien Cambedouzou and
  • David Cornu

6 June 2024

Already used in the food, pharmaceutical, cosmetic, and agrochemical industries, encapsulation is a strategy used to protect active ingredients from external degradation factors and to control their release kinetics. Various encapsulation techniques...

  • Article
  • Open Access
15 Citations
3,587 Views
13 Pages

Functional Nanogel from Natural Substances for Delivery of Doxorubicin

  • Katya Kamenova,
  • Lyubomira Radeva,
  • Krassimira Yoncheva,
  • Filip Ublekov,
  • Martin A. Ravutsov,
  • Maya K. Marinova,
  • Svilen P. Simeonov,
  • Aleksander Forys,
  • Barbara Trzebicka and
  • Petar D. Petrov

5 September 2022

Nanogels (NGs) have attracted great attention because of their outstanding biocompatibility, biodegradability, very low toxicity, flexibility, and softness. NGs are characterized with a low and nonspecific interaction with blood proteins, meaning tha...

  • Review
  • Open Access

Marine-Derived Natural Substances with Anticholinesterase Activity

  • Daniela Dimitrova,
  • Gabriela Kehayova,
  • Simeonka Dimitrova and
  • Stela Dragomanova
Mar. Drugs2025, 23(11), 439;https://doi.org/10.3390/md23110439 
(registering DOI)

15 November 2025

Alzheimer’s disease continues to be one of the most urgent neurodegenerative conditions, with acetylcholinesterase (AChE) inhibitors serving as a fundamental component of contemporary treatment approaches. Growing evidence underscores that mari...

  • Review
  • Open Access
112 Citations
11,485 Views
16 Pages

Photoprotective Substances Derived from Marine Algae

  • Ratih Pangestuti,
  • Evi Amelia Siahaan and
  • Se-Kwon Kim

23 October 2018

Marine algae have received great attention as natural photoprotective agents due to their unique and exclusive bioactive substances which have been acquired as an adaptation to the extreme marine environment combine with a range of physical parameter...

  • Review
  • Open Access
412 Citations
22,016 Views
38 Pages

9 November 2018

This paper describes the substances of plant and marine origin that have anticancer properties. The chemical structure of the molecules of these substances, their properties, mechanisms of action, their structure–activity relationships, along with th...

  • Review
  • Open Access
44 Citations
5,385 Views
19 Pages

Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

  • Alexa-Maria Croitoru,
  • Denisa Ficai,
  • Anton Ficai,
  • Natalia Mihailescu,
  • Ecaterina Andronescu and
  • Stefan Claudiu Turculet

23 May 2020

The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as...

  • Article
  • Open Access
3 Citations
2,758 Views
21 Pages

Automated Detection of Substance-Use Status and Related Information from Clinical Text

  • Raid Alzubi,
  • Hadeel Alzoubi,
  • Stamos Katsigiannis,
  • Daune West and
  • Naeem Ramzan

8 December 2022

This study aims to develop and evaluate an automated system for extracting information related to patient substance use (smoking, alcohol, and drugs) from unstructured clinical text (medical discharge records). The authors propose a four-stage system...

  • Article
  • Open Access
13 Citations
6,964 Views
12 Pages

para-Menthane as a Stable Terpene Derived from Orange By-Products as a Novel Solvent for Green Extraction and Solubilization of Natural Substances

  • Sara Madji,
  • Soukaina Hilali,
  • Anne-Sylvie Fabiano-Tixier,
  • Mathieu Tenon,
  • Antoine Bily,
  • Mickaël Laguerre and
  • Farid Chemat

This study aims at investigating p-menthane, a novel bio-based solvent resulting from the hydrogenation of d-limonene, as a green alternative to n-hexane or toluene for the extraction and solubilization of natural substances. First, conductor-like co...

  • Review
  • Open Access
43 Citations
11,579 Views
19 Pages

Promising Strategies in Plant-Derived Treatments of Psoriasis-Update of In Vitro, In Vivo, and Clinical Trials Studies

  • Martyna Nowak-Perlak,
  • Krzysztof Szpadel,
  • Izabella Jabłońska,
  • Monika Pizon and
  • Marta Woźniak

18 January 2022

Psoriasis is a common, chronic systemic inflammatory disease affecting 125 million people worldwide. It is associated with several important conditions, including psoriatic arthritis, cardiometabolic syndrome, and depression, leading to a significant...

  • Systematic Review
  • Open Access
2,124 Views
22 Pages

Plant Protection Products to Control Alternaria Brown Spot Caused by Alternaria alternata in Citrus: A Systematic Review

  • Alfonso Garmendia,
  • María Ferriol,
  • Roberto Beltrán,
  • Francisco García-Breijo,
  • María Dolores Raigón,
  • María Del Carmen Parra and
  • Hugo Merle

30 May 2025

Alternaria Brown Spot (ABS) is one of the most critical diseases affecting susceptible mandarins worldwide, being a limiting factor in their cultivation. Although there are numerous reports on effective plant protection products against the disease,...

  • Review
  • Open Access
17 Citations
5,680 Views
28 Pages

28 January 2021

Plant diseases have been threatening food production. Controlling plant pathogens has become an important strategy to ensure food security. Although chemical control is an effective disease control strategy, its application is limited by many problem...

  • Review
  • Open Access
2 Citations
2,624 Views
25 Pages

Research Progress of Natural Active Substances with Immunosuppressive Activity

  • Fei Shao,
  • Qiying Shen,
  • Zhengfei Yang,
  • Wenqian Yang,
  • Zixiang Lu,
  • Jie Zheng,
  • Liming Zhang and
  • Hangying Li

The increasing prevalence of autoimmune diseases globally has prompted extensive research and the development of immunosuppressants. Currently, immunosuppressive drugs such as cyclosporine, rapamycin, and tacrolimus have been utilized in clinical pra...

  • Communication
  • Open Access
3 Citations
2,248 Views
7 Pages

Chloropinane and Chloromenthene as Novel Solvents for Solubilisation of Natural Substances

  • Mohamed Touaibia,
  • Anne-Sylvie Fabiano-Tixier and
  • Farid Chemat

24 April 2021

Chloropinane and chloromenthene, synthesized from pinene and limonene, respectively, were compared with their non-halogenated analogs and n-hexane for their ability to solubilize natural products of interest such as β-carotenoids, vanillin, and rosma...

  • Review
  • Open Access
11 Citations
5,276 Views
14 Pages

14 December 2021

Rates of intimate partner violence (IPV) and substance use have risen during the COVID-19 pandemic, with potentially enduring effects on women’s health. A rapid review was conducted on IPV and women’s substance use in the context of the C...

  • Article
  • Open Access
1,856 Views
11 Pages

Kinetic Model of Diclofenac Degradation Developed Using Multivariate Curve Resolution Method

  • Oxana Ye. Rodionova,
  • Alexey L. Pomerantsev and
  • Douglas N. Rutledge

15 November 2022

This study presents the kinetic modeling of the natural long-term aging of the pharmaceutical substance as well as the intact tablets of Diclofenac. Datasets are collections of near-infrared spectra acquired from the intact tablets packed in plastic...

  • Article
  • Open Access
4 Citations
2,574 Views
20 Pages

Micellar and Solvent Loan Chemical Extraction as a Tool for the Development of Natural Skin Care Cosmetics Containing Substances Isolated from Grapevine Buds

  • Zofia Hordyjewicz-Baran,
  • Tomasz Wasilewski,
  • Magdalena Zarębska,
  • Natalia Stanek-Wandzel,
  • Ewa Zajszły-Turko,
  • Magdalena Tomaka and
  • Martyna Zagórska-Dziok

8 February 2024

The present study aimed to evaluate the possibility of using micellar and solvent loan chemical extraction (LCE) to isolate valuable components from grapevine leaf buds, subsequently utilizing them to prepare functional and safe-to-use cosmetic prepa...

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