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Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Gh. Polizu St. 1-7, 011061 Bucharest, Romania
Academy of Romanian Scientists, Spl. Independentei 54, 050094 Bucharest, Romania
Laser Department, National Institute for Laser, Plasma & Radiation Physics, Atomistilor St. 409, 077125 Magurele, Romania
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari St. 8, 050474 Bucharest, Romania
Emergency Hospital Floreasca Bucharest, Calea Floreasca St. 8, 014461 Bucharest, Romania
Author to whom correspondence should be addressed.
Materials 2020, 13(10), 2407;
Received: 14 April 2020 / Revised: 11 May 2020 / Accepted: 21 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue Nanomaterials for Medical Application)
The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as a drug delivery system have been actively investigated and applied in medical and therapeutic applications. In recent decades, researchers have investigated the incorporation of natural or synthetic substances into novel bioactive electrospun nanofibrous architectures produced by the electrospinning method for skin substitutes. Therefore, the development of nanotechnology in the area of dressings that could provide higher performance and a synergistic effect for wound healing is needed. Natural compounds with antimicrobial, antibacterial, and anti-inflammatory activity in combination with nanostructured fibers represent a future approach due to the increased wound healing process and regeneration of the lost tissue. This paper presents different approaches in producing electrospun nanofibers, highlighting the electrospinning process used in fabricating innovative wound dressings that are able to release natural and/or synthetic substances in a controlled way, thus enhancing the healing process. View Full-Text
Keywords: electrospinning; electrospun nanofibers; wound dressing; natural/synthetic substances electrospinning; electrospun nanofibers; wound dressing; natural/synthetic substances
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MDPI and ACS Style

Croitoru, A.-M.; Ficai, D.; Ficai, A.; Mihailescu, N.; Andronescu, E.; Turculet, C.F. Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications. Materials 2020, 13, 2407.

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