Prostate cancer is a significant cause of morbidity and mortality in the USA. In this paper, we develop a computer-aided diagnostic (CAD) system for automated grade groups (GG) classification using digitized prostate biopsy specimens (PBSs). Our CAD...
Objective: To assess the risk of cancer-specific mortality (CSM) and other-cause mortality (OCM) using post-operative International Society of Urological Pathology Grade Group (GG) model in patients after radical prostatectomy (RP). Patients and Meth...
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Background/Objectives: International Society of Urological Pathology (ISUP) Grade Group discordance between prostate biopsy and radical prostatectomy (RP) affects 25–50% of men with localized prostate cancer and has direct implications for acti...
Background/Objectives: ISUP grade group discordance between prostate biopsy and radical prostatectomy (RP) impacts treatment decisions in over a third (~25–40%) of prostate cancer (PCa) patients. We aimed to identify ISUP grade migration predic...
Background and Objectives: Prostate cancer is the second most common cancer in men worldwide, with 1,466,680 new cases and 396,792 deaths reported in 2022. Accurate preoperative grading is critical, as the grade assessed on biopsy cores may be undere...
Selective depression of serpentine remains a major challenge in the flotation of low-grade nickel sulphide ores because serpentine slimes impair concentrate grade and recovery. In this study, four structurally related micromolecular depressants beari...
Digital technology plays a unique role in the cultivation of students’ creative thinking, which helps them solve poorly structured problems with effective and original solutions. This study applied collaborative learning in a digital-technology...
Background: Decision-making and selection of treatment modalities for newly diagnosed prostate cancer (PCa) are often determined by risk stratification using grade group (GG), prostate-specific antigen (PSA), and clinical stage. The discrepancies bet...
The aims of this study are: (1) to determine cause-specific survival by stage, grade, and molecular groups of breast cancer, (2) to identify factors which explain and predict the likelihood of survival and the risk of dying from this cancer; and (3)...
Programmed death-ligand 1 (PD-L1) expression in Grade Group 1 (GG1) prostate carcinoma biopsies has not been established as a marker of pathological upgrading at radical prostatectomy (RP). This two-center retrospective case–control study inclu...
Background/Objectives: Although the presence and diameter of the cribriform pattern (CP) are established prognostic factors in prostate cancer (PCa), the clinical impact of quantitative cribriform tumor burden (CTB) remains poorly characterized. This...
Purpose: The Ki67 index and the Gleason grade group (GGG) are vital prognostic indicators of prostate cancer (PCa). This study investigated the value of biparametric magnetic resonance imaging (bpMRI) radiomics feature-based machine learning (ML) mod...
Objective: Previous studies have demonstrated that prostate-specific antigen density (PSAD) may aid in predicting Gleason grade group (GG) upgrading and pathological upstaging in patients with prostate cancer (PCa). However, the differences and assoc...
This article develops a comprehensive theory of multiary graded polyadic algebras, extending the classical concept of group-graded algebras to higher-arity structures. We introduce the notion of grading by multiary groups and investigate various comp...
Introduction: Prostate biopsy results form the mainstay of patient care. However, there is often significant discordance between the biopsied histology and the ‘true’ histology shown on a radical prostatectomy (RP). Discordance in patholo...
Introduction: Prostate needle biopsy reporting is time-consuming because each case typically includes 12–18 cores that require detailed assessment before a final case-level diagnosis is issued. Reporting is also influenced by pathologist expert...
Gleason grading remains the strongest prognostic parameter in localized prostate adenocarcinoma. We have here outlined the evolution and contemporary practices in pathological evaluation of prostate tissue samples for Gleason score and Grade group. T...
The 2021 novelties in prognostic and therapeutic tissue markers in patients with prostate cancer (PCa) can be subdivided into two major groups. The first group is related to prognostic markers based on morphological and immunohistochemical evaluation...
An artificial intelligence (AI) algorithm for prostate cancer detection and grading was developed for clinical diagnostics on biopsies. The study cohort included 4221 scanned slides from 872 biopsy sessions at the HUS Helsinki University Hospital dur...
A research proposal on the algebraic structure, the representations and the possible applications of paraparticle algebras is structured in three modules: The first part stems from an attempt to classify the inequivalent gradings and braided group st...
Rice blast caused by Pyricularia oryzae progresses from symptom-free leaves to extensive tissue death, while neighboring severity grades often show similar spectra. This study developed XGBSVMRF-SA to integrate regional spectral-angle (SA) features w...
In this work, we introduced an automated diagnostic system for Gleason system grading and grade groups (GG) classification using whole slide images (WSIs) of digitized prostate biopsy specimens (PBSs). Our system first classifies the Gleason pattern...
High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >20 mitoses/10 HPF and Ki-67 &g...
(1) Background: Prognostic grade group (PGG) is an important prognostic parameter in prostate cancer that guides therapeutic decisions. The cribriform pattern and intraductal carcinoma (IDC) are two histological patterns, that have additional prognos...
8 November 2026
Cross-group comparisons require both adequate measurement-model estimation and a defensible procedure for expressing group-specific estimates on a common metric. This study presents a reproducible workflow for documenting the operational feasibility...
Age is a known prognostic factor for many sarcoma subtypes, however in the literature there are limited data on the different risk profiles of different age groups for osteosarcoma survival. This study aims to provide an overview of survival in patie...
In this article, we generalize the concept of group-graded modules by introducing the concept of
Collaboration with peers both inside and outside the classroom can be an invaluable tool for helping students learn physics. We investigated the impact of peer collaboration on learning physics by examining the characteristics of women and men who ty...
Background and Objectives: Prostate cancer (PC) has traditionally been regarded as a disease of older men, most commonly diagnosed after the age of 70 years. Recent epidemiological data indicate an increasing incidence of this malignancy among men yo...
Ion channels play ubiquitous roles in the maintenance of tumour cell homeostasis and hence are attractive targets in the molecular pathogenesis and progression of prostate cancer (PCa). This study aimed to investigate the roles of the potassium ion c...
27 March 2018
Storm surge has become an important factor restricting the economic and social development of China’s coastal regions. In order to improve the scientific judgment of future storm surge damage, a method of model groups is proposed to refine the evalua...
The goal of the present work was to study the recovery of copper, nickel, and platinum group metals (PGMs) (Pt and Pd) from low-grade copper–nickel ore containing pyrrhotite, pentlandite, and chalcopyrite by column bioleaching followed by cyani...
Background/Objectives: Compared to the general population in Germany, higher risks for depression, suicidal ideation and suicide risk have been reported for German veterinary students. This study assessed various demographic and study-related risk fa...
Water scarcity is compelling mining houses to not only recycle process water but to also identify alternative sources of make-up water in concentrators. South Africa has significant volumes of acid mine drainage (AMD) generated from vast mining opera...
Fat deposition is important to carcass value and some palatability characteristics. Carcasses with higher USDA quality grades produce more value for producers and processors in the US system and are more likely to have greater eating satisfaction. Us...
10 September 2024
We investigated associations between polysubstance use and behavioral problems among adolescents. Because substance use becomes more developmentally normative with age, we examined whether polysubstance use was less likely to co-occur with behavioral...
Background: Homologous recombination deficiency (HRD) has evolved into a major diagnostic marker in high-grade ovarian cancer (HGOC), predicting the response to poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) and also platinum-based...
Background/Objectives: The ratio of percentage of prostate cancer (PCa) biopsy-positive cores (BPC) to prostate volume as the index density factor (Id-BPC) was used to predict the risk of high tumour grades in the surgical specimens of European Assoc...
Despite its first recognition even longer ago, in the past nearly 20 years, intraductal carcinoma of the prostate has become a standard histopathologic reporting parameter conveying a strong negative prognostic factor for prostatic adenocarcinoma. Wh...
Background: Deep learning systems for Gleason grading are developed almost entirely on high-end clinical scanners and on cohorts from a small number of Western institutions, yet deployment increasingly involves other devices and other populations. Th...
Chromite is considered a strategic mineral in the global economy. It is mainly used as an essential raw material in the production of stainless steel and other metal alloys due to its corrosion and heat resistance properties. High-grade chromite reso...
Apomixis sensu stricto (agamospermy) is asexual reproduction by seed. In angiosperms it represents an easy byway of life cycle renewal through gamete-like cells that give rise to maternal embryos without ploidy reduction (meiosis) and ploidy restitut...
Cribriform glandular formations are characterized by a continuous proliferation of cells with intermingled lumina and can constitute a major or minor part of physiologic (normal central zone glands), benign (clear cell cribriform hyperplasia and basa...
A prostate-targeted biopsy (TB) core is usually collected from a site where magnetic resonance imaging (MRI) indicates possible cancer. However, the extent of the lesion is difficult to accurately predict using MRI or TB alone. Therefore, we performe...
This paper studies how a localized defect migrates through the
High-grade glioma (HGG) is associated with several external and internal stressors that may induce mood alterations at all stages of the disease. Symptoms of depression and anxiety in persons with glioma have multifactorial etiology and require activ...
Prostate adenocarcinoma (PCa) is a leading cause of mortality. Black males with high-risk PCa have a poorer prognosis compared to white males. Patients with International Society of Urological Pathology (ISUP) Grade Group (GG) 1 and 2 PCa have little...
The present research focuses on the machining of grade 2 titanium material using the Wire Electric Discharge Machining (WEDM) process by means of L16 Orthogonal Array (OA). This study investigates numerous process parameters, including pulse on time,...
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