Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cases
2.2. Immunohistochemistry
2.3. Statistical Analysis
3. Results
3.1. Patient Characteristics and Myeloid Profile
3.2. Clustering
3.3. Survival Analysis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Features | All Patients |
---|---|
Total | 45 (100) |
Gender | |
M | 28 (62.2) |
F | 17 (37.8) |
Years | |
Median (range) | 61 (33–78) |
Morphology | |
NET G3 | 6 (13.3) |
NEC-Ki67 <55 | 8 (17.8) |
NEC-Ki67 >55 | 31 (68.9) |
Stage | |
I-II | 3 (6.7) |
III | 14 (31.1) |
IV | 28 (62.2) |
Site | |
Colon | 8 (17.8) |
Ileum | 7 (15.6) |
Pancreas | 15 (33.3) |
Rectum | 10 (22.2) |
Stomach | 5 (11.1) |
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Centonze, G.; Lagano, V.; Sabella, G.; Mangogna, A.; Garzone, G.; Filugelli, M.; Belmonte, B.; Cattaneo, L.; Crisafulli, V.; Pellegrinelli, A.; et al. Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms. J. Clin. Med. 2021, 10, 1741. https://doi.org/10.3390/jcm10081741
Centonze G, Lagano V, Sabella G, Mangogna A, Garzone G, Filugelli M, Belmonte B, Cattaneo L, Crisafulli V, Pellegrinelli A, et al. Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms. Journal of Clinical Medicine. 2021; 10(8):1741. https://doi.org/10.3390/jcm10081741
Chicago/Turabian StyleCentonze, Giovanni, Vincenzo Lagano, Giovanna Sabella, Alessandro Mangogna, Giovanna Garzone, Martina Filugelli, Beatrice Belmonte, Laura Cattaneo, Valentina Crisafulli, Alessio Pellegrinelli, and et al. 2021. "Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms" Journal of Clinical Medicine 10, no. 8: 1741. https://doi.org/10.3390/jcm10081741