The study and development of the technological foundations for creating a textured surface using an electrode tool obtained by the method of additive manufacturing are the purpose of the work. Methods for obtaining textured surfaces and for creating...
Arbitrarily designed flat optics directly manipulate the light wavefront to reproduce complex optical functions, enabling more compact optical assemblies and microsystem integration. Phase-shifting micro-optical devices rely on locally tailoring the...
Accurate profiling of thread-milling cutters is one of the main prerequisites of high-precision internal thread production. Despite the accuracy of analytical methods, their complexity in most instances makes practical application an issue. The curre...
The Xiongpo fault-fold belt shows prominent NE, ENE- and ~N–S-trending relief, which resulted from multi-stage upper crustal shortening in the Longmen Shan piedmont during the eastward growth of the eastern Tibetan Plateau. Previous studies have dete...
The assessment of fire effects in Aleppo pine forests is crucial for guiding the recovery of burnt areas. This study presents a methodology using UAV-LiDAR data to quantify malleability and elasticity in four burnt areas (1970, 1995, 2008 and 2015) t...
Study of the deep structure of the White Sea region is relevant to active geodynamics, manifestations of kimberlite magmatism, and the prospects of oil and gas searches. The aim of this work was to model the velocity and density structure of the eart...
Chronic pain (CP), including pain related to cancer, affects approximately 2 billion people worldwide, significantly diminishing quality of life and imposing socio-economic burdens. Current treatments often provide limited relief and may cause advers...
We report the results of calculations of the Gibbs energy profiles of the guanosine triphosphate (GTP) hydrolysis by the Arl3-RP2 protein complex using molecular dynamics (MD) simulations with ab initio type QM/MM potentials. The chemical reaction of...
This research analyzes the relationships between “soil” and “organisms” within the framework of the Jenny equation, a fundamental expression in soil science that is the theoretical basis for modeling the complex occurrence of...
Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapie...
We review the results of Monte Carlo studies of chosen nonlinear optical effects in host-guest systems, using methods based on the bond-fluctuation model (BFM) for a polymer matrix. In particular, we simulate the inscription of various types of diffr...
Nutrition is being increasingly recognized as a modifiable adjuvant factor in symptom management, yet few studies have examined the direct contribution of fruit consumption to chronic disease outcomes. The existing research largely emphasizes broad d...
Triticale is a wheat–rye hybrid with a higher abiotic stress tolerance than wheat and is better adapted for cultivation in light-type soils, where aluminum ions are present as Al-complexes that are harmful to plants. The roots are the first pla...
As the search for modalities to cure Alzheimer’s disease (AD) has made slow progress, research has now turned to innovative pathways involving neural and peripheral inflammation and neuro-regeneration. Widely used AD treatments provide only sym...
Dry eye disease, a multifactorial and symptomatic disease characterized by tear film instability and ocular surface dysfunction, has emerged as an increasingly pressing global health concern—particularly against the backdrop of increasing digit...
Menopause is associated with health concerns including vasomotor symptoms, vulvar/vaginal atrophy (VVA), and osteoporosis. Estrogen therapy or combined estrogen-progestin therapy (EPT) are primary treatment options for menopausal symptom relief and o...
Introduction: Advances in pediatric oncology have transformed cancer into a condition with chronic and long-term developmental consequences. While survival rates have improved significantly, the literature on psychosocial outcomes remains fragmented...
Background/Objectives: Gabapentinoids are first-line treatments for neuropathic pain (NP); however, real-world evidence regarding their safety and effectiveness in complex clinical populations remains limited. This study aimed to evaluate the effecti...
Xueshan Jinluohan Pain-Relief Liniment (XJPL) is a Tibetan topical compound preparation composed of 11 medicinal materials. Its current quality standard relies mainly on thin-layer chromatographic identification, which is insufficient to comprehensiv...
Background/Objectives: Managing large midline olfactory groove meningiomas is especially difficult in elderly patients who have limited physiological reserves. Here we describe a unique and dangerous geriatric case where we used new quantifiable anat...
Treatment-resistant peripartum depression (TRPD) is a significant public health concern due to the dual imperative of maternal symptom relief and fetal/neonatal safety with complex therapeutic challenges, particularly among expecting mothers worldwid...
Background: Public catering is an underexplored One Health interface where structurally complex food-transport equipment may sustain reservoirs of antimicrobial-resistant bacteria. We investigated Escherichia coli from reusable institutional catering...
Background: Neurovascular compression syndromes (NVCS) represent a spectrum of disabling neurologic disorders caused by vascular or structural compression of cranial nerves, most commonly at the root entry zone. Conditions such as trigeminal neuralgi...
Due to atmospheric scattering, solar radiation, and other factors, the Ice, Cloud, and land Elevation Satellite-2 (ICESat-2) product data suffer from a substantial amount of background noise. This poses a significant challenge when attempting to dire...
One of the key parameters in radio link planning is the propagation path loss. Most of the existing methods for its prediction are not characterized by a good balance between accuracy, generality, and low computational complexity. To address this pro...
Alzheimer’s disease (AD) is a complex progressive neurodegenerative disorder affecting humans mainly through the deposition of Aβ-amyloid (Aβ) fibrils and accumulation of neurofibrillary tangles in the brain. Currently available AD treatments only ex...
In qualitative–quantitative assessment of geodiversity, geomorphology describes landscape forms suggesting specific locations as geosites. However, all digital elevation models (DEM) contain information only about altitude and coordinate systems, whi...
Dongxiang wild rice (DXWR, Oryza rufipogon Griff.), the northernmost known wild rice species, exhibits exceptional tolerance to combined low-temperature and anaerobic stress during seed germination, providing a unique model for understanding plant ad...
Background: Burning Mouth Syndrome (BMS) is a nociplastic pain condition characterized by altered central nervous system pain processing, significantly impacting patient quality of life. Pharmacological management often involves amitriptyline (monoth...
Lichen sclerosus (LS) is a chronic inflammatory dermatosis mostly localized in the genital area, characterized by vulvar alterations that can severely impact a patient’s quality of life. Current treatment modalities often provide incomplete rel...
Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and pharma...
Land suitability assessment, as an important process in modern agriculture, involves the evaluation of numerous aspects such as soil properties, climate, relief, hydrology and socio-economic aspects. The aim of this study was to evaluate the suitabil...
Chronic pain is a major cause of disability worldwide, impacting around 20% of adults globally. Conventional mu-opioid peptide (MOP) receptor agonists provide effective analgesia; however, their prolonged use is restricted by severe dose-limiting tox...