The Antimicrobial Resistance in the Food Chain

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 30 November 2025 | Viewed by 559

Special Issue Editor

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is a pressing global health concern, with the food chain presenting a significant conduit for the dissemination of resistant bacteria. Foodborne pathogens, including Campylobacter, Norovirus, Salmonella, Escherichia coli Listeria monocytogenes, Yersinia enterocolitica, Clostridium species, Staphylococcus aureus, and Bacillus cereus, are known to cause gastrointestinal illnesses (e.g., abdominal pain, nausea, diarrhea, and vomiting) and, in severe cases, respiratory difficulties and death. The transmission of disease-causing bacteria from food to consumers can occur through direct or indirect pathways. It is possible to trace the spread of infections through traditional epidemiological studies and molecular typing methods able to assess the structure (such as pulsed field gel electrophoresis (PFGE)) or sequence (like multilocus sequence typing (MLST)) of a microbe’s genetic material. These methods help determine the relationships between different isolates, establish whether they could be feasibly connected in the transmission of infections, and provide insights into the transmission dynamics of AMR within the food chain. Antimicrobial resistance is a natural process where microorganisms, which were once sensitive and could be treated with specific antibiotics, evolve to become resistant to these antibiotics. Food and food products can be tainted with antimicrobial-resistant bacteria (AMRB) at any stage in the farm-to-table process. Microbes utilize various strategies to combat antimicrobial agents, including the breakdown of antibiotics and antibacterial agents by enzymes, alteration of the targets of antibiotics, changes in cell wall permeability, and initiating alternative pathways. Understanding these mechanisms is crucial for developing strategies to mitigate the spread of AMR. This Special Issue collects research articles and reviews papers dealing with the occurrence and distribution of microbes responsible for food contamination, as well as the mechanisms involved in antibiotic resistance and strategic approaches.

In particular, the following topics are of interest:

  • The isolation and identification of AMRB in the food chain;
  • Antibiotic resistance genes;
  • Antimicrobial resistance profiles;
  • Antimicrobial strategies combatting foodborne pathogens.

Prof. Dr. Irene Dini
Guest Editor

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Keywords

  • food safety
  • foodborne pathogens
  • pathways of antimicrobial resistance
  • antibiotic resistance
  • phenotypic analyses
  • molecular analyses
  • regulatory guidelines
  • food chemistry

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Published Papers (1 paper)

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Research

12 pages, 585 KiB  
Article
Antimicrobial Resistance Profile and Biofilm Formation of Listeria monocytogenes Isolated from Meat
by Joana Paiva, Vanessa Silva, Patrícia Poeta and Cristina Saraiva
Antibiotics 2025, 14(5), 454; https://doi.org/10.3390/antibiotics14050454 - 30 Apr 2025
Viewed by 183
Abstract
Introduction: Listeria monocytogenes is the causative agent of listeriosis, a serious infectious disease with one of the highest case fatality rates among foodborne diseases affecting humans. Objectives: This study investigated the prevalence, antimicrobial resistance pattern and biofilm production capacity of L. monocytogenes isolated [...] Read more.
Introduction: Listeria monocytogenes is the causative agent of listeriosis, a serious infectious disease with one of the highest case fatality rates among foodborne diseases affecting humans. Objectives: This study investigated the prevalence, antimicrobial resistance pattern and biofilm production capacity of L. monocytogenes isolated in meats. Materials: A total of 75 samples were analyzed, including fresh meats and meat preparations, in Northern Portugal. Methods: The strains were identified using morphological and molecular methods. Antimicrobial resistance was determined using the Kirby–Bauer disk diffusion method, against a panel of 12 antibiotics and the presence of the respective antimicrobial resistance genes was investigated by polymerase chain reaction (PCR). The ability to form biofilms was evaluated by the microtiter biofilm assay. Results: The overall prevalence of L. monocytogenes among screened samples was 17.33%. The isolates were resistant to trimethoprim-sulfamethoxazole (85.71%), ciprofloxacin (38.10%), meropenem (33.33%), tetracycline and erythromycin (28.57%), rifampicin (23.81%), and kanamycin (14.29%). Six isolates (28.57%) exhibited a multidrug-resistance profile. All strains showed positive result for the virulence gene specific to listeriolysin O (hlyA). In the genotypic resistance analysis of the strains, the genes identified were tetK (23.81%), aadA, tetL, blaOXA-48 (14.29%), ermC, and msr(A/B) (4.76%). All isolates had the ability to form biofilms, with no significant differences in biofilm biomass production at 24 h and 48 h. Some of these strains showed a high capacity for biofilm production. Conclusions: These findings raise public health concerns due to resistance to first-line antibiotics and the biofilm-forming capacity of these isolates, which pose risks to the food industry. Enhanced monitoring and surveillance are essential to guide public health strategies in order to mitigate the threat posed by L. monocytogenes in food. Full article
(This article belongs to the Special Issue The Antimicrobial Resistance in the Food Chain)
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