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Interventional Pain Management: Current Evidence and Innovative Advances
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Interventional Pain Management: Current Evidence and Innovative Advances

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 24 November 2026 | Viewed by 876

Editor

Dr. Jamal Hasoon

E-Mail Website
Guest Editor
Department of Anesthesia, Critical Care, and Pain Medicine, McGovern Medical School, UTHealth, Houston, TX, USA
Interests: interventional pain procedures; neuromodulation; peripheral nerve interventions; spinal stenosis; minimally invasive surgery; injection techniques; education in pain medicine; standardization in pain medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic pain remains a leading cause of disability worldwide and represents a major clinical and socioeconomic challenge. As healthcare systems increasingly prioritize opioid sparing treatments, value-based care, and minimally invasive therapies, interventional pain management serves as a critical component of modern treatment strategies. Advances in imaging guidance, neuromodulation, and data-driven practice models are rapidly transforming the field. At the same time, clinicians face challenges related to the standardization of techniques and variability in evidence quality.

Interventional pain medicine is evolving beyond traditional injection-based procedures toward a more technology-integrated, multidisciplinary model. Innovations in spinal cord stimulation, dorsal root ganglion stimulation, peripheral nerve interventions, minimally invasive spine techniques, and artificial intelligence (AI)-assisted tools in medicine are expanding therapeutic possibilities. Simultaneously, there is a growing need for high-quality clinical research to ensure the safe implementation and reproducibility of therapies.

This Special Issue aims to present and disseminate the most recent advances related to interventional pain management by highlighting current evidence and innovations. We welcome original research and systematic reviews addressing contemporary developments in pain medicine.

Topics of interest include, but are not limited to, the following:

  • Image-guided injection techniques and interventional pain procedures;
  • Technical advancements and procedural techniques in interventional pain;
  • Physician perspectives and clinical decision-making in interventional pain practice;
  • Neuromodulation (spinal cord stimulation, dorsal root ganglion stimulation, and peripheral nerve stimulation);
  • Peripheral nerve blocks and radiofrequency ablation;
  • Minimally invasive interventions for spinal stenosis and degenerative spine disease;
  • Artificial intelligence and technological integration in pain practice;
  • Standardization, quality improvement, and outcome measures in interventional pain;
  • Clinical development in pain medicine.

Through this Special Issue, we aim to advance clinical practice, foster innovation, and support global collaboration in the evolving field of interventional pain management.

Dr. Jamal Hasoon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interventional pain management
  • chronic pain
  • image-guided procedures
  • injection techniques
  • neuromodulation
  • peripheral nerve blocks
  • radiofrequency ablation
  • minimally invasive spine interventions
  • artificial intelligence in medicine
  • quality improvement
  • clinical outcomes

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Published Papers (2 papers)

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Research

15 pages, 2038 KB  
Article
Intrathecal Drug Delivery as a Rescue Strategy in Patients with Spinal Cord Stimulation: A Single-Center Case Series
by Nicolás Cordero-Tous, Marcos Salmerón-Martín, Bernardino Alcazar-Navarrete, Manuel Cortiñas-Sáez, Rafael Gálvez-Mateos and Manuel Alejandro Sánchez-García
J. Clin. Med. 2026, 15(12), 4518; https://doi.org/10.3390/jcm15124518 - 11 Jun 2026
Viewed by 254
Abstract
Background: Chronic pain is the leading cause of years lived with disability worldwide, with low back pain representing the most prevalent and disabling condition. Spinal cord stimulation (SCS) and intrathecal drug delivery (IDD) systems are established neuromodulation techniques for refractory chronic pain. However, [...] Read more.
Background: Chronic pain is the leading cause of years lived with disability worldwide, with low back pain representing the most prevalent and disabling condition. Spinal cord stimulation (SCS) and intrathecal drug delivery (IDD) systems are established neuromodulation techniques for refractory chronic pain. However, a subset of patients experiences partial or declining benefit with either modality alone. In such cases, combined therapy may represent a rescue strategy. Methods: retrospective case series at a single center, including patients previously implanted with SCS who subsequently required IDD due to loss of efficacy or inadequate pain coverage. Pain intensity, opioid consumption, health-related quality of life, and patient satisfaction were assessed using validated instruments. Results: Twelve patients were included. Persistent low back pain with mixed nociceptive–neuropathic features was the most common indication. Combined therapy was observed in association with a mean reduction of 3.5 points on the Numeric Rating Scale, corresponding to an approximate 40% decrease in pain intensity. More than half of the patients discontinued systemic opioids. Complications occurred in seven patients (58.3%), mostly hardware-related and manageable with surgical revision; only one patient developed a device-related infection. Conclusions: In this case series, combined SCS and IDD therapy was observed in association with clinically meaningful pain reduction, decreased opioid use, and high patient-reported satisfaction. Although quality-of-life scores remained below population norms, patients consistently reported subjective improvement. Combined neuromodulation may represent a valid rescue option in selected patients with insufficient response to SCS alone. Full article
(This article belongs to the Special Issue Interventional Pain Management: Current Evidence and Innovative Advances)
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13 pages, 725 KB  
Article
Fluoroscopy- and Ultrasound-Guided Intra-Articular Pulsed Radiofrequency of the Atlanto-Occipital Joint for Chronic Post-Traumatic Neck Pain: A Retrospective Preliminary Case Series
by Paweł Gogol, Małgorzata Gierczak, Robert Szczepaniak, Rafał Pasztaleniec, Rafał Wiśniewski, Małgorzata Malec-Milewska, Rafał Staszkiewicz, Beniamin Oskar Grabarek and Michał Sobstyl
J. Clin. Med. 2026, 15(11), 4081; https://doi.org/10.3390/jcm15114081 - 25 May 2026
Viewed by 252
Abstract
Background/Objectives: To evaluate preliminary clinical outcomes, functional changes, and procedural safety associated with fluoroscopy- and ultrasound-guided intra-articular pulsed radiofrequency (PRF) of the atlanto-occipital joint in patients with chronic post-traumatic cervical pain. Methods: This retrospective preliminary case series included eight patients with [...] Read more.
Background/Objectives: To evaluate preliminary clinical outcomes, functional changes, and procedural safety associated with fluoroscopy- and ultrasound-guided intra-articular pulsed radiofrequency (PRF) of the atlanto-occipital joint in patients with chronic post-traumatic cervical pain. Methods: This retrospective preliminary case series included eight patients with chronic neck and/or head pain persisting for at least 6 months following whiplash injury or cervical hyperextension trauma. All patients underwent dual-guided intra-articular PRF of the atlanto-occipital joint. Pain intensity (Numeric Rating Scale, NRS), functional outcomes (Neck Disability Index, NDI; Patient-Specific Functional Scale, PSFS), and medication use were assessed at baseline and at 2, 3, and 6 months following the procedure. Results: Mean baseline NRS was 8.0 ± 0.76 and decreased to 2.38 ± 1.06 at 2 months, 3.38 ± 0.74 at 3 months, and 3.75 ± 1.16 at 6 months. A ≥ 50% reduction in pain intensity was observed in 87.5% of patients at 2 and 3 months and in 75.0% at 6 months. Functional outcome measures also showed improvement, with mean NDI scores decreasing from 60% at baseline to 25% at 2 months, with partial maintenance of improvement during follow-up. Mean PSFS scores increased from 3 at baseline to 7 at 2 months. Reduced use of analgesic and adjuvant medications was observed during follow-up. No serious procedure-related complications were identified. Conclusions: In this small retrospective case series, intra-articular PRF of the atlanto-occipital joint was associated with reductions in pain intensity, improvement in patient-reported functional outcomes, and reduced medication use in patients with chronic post-traumatic cervical pain. The procedure appeared technically feasible and well-tolerated. However, given the limited sample size and uncontrolled retrospective design, these findings should be interpreted cautiously and considered preliminary and hypothesis-generating rather than confirmatory. Prospective controlled studies are required to further evaluate potential efficacy, safety, and long-term outcomes. Full article
(This article belongs to the Special Issue Interventional Pain Management: Current Evidence and Innovative Advances)
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