1,674 Results Found

The post-synaptic density protein 95 (PSD95) is a crucial scaffolding protein participating in the organization and regulation of synapses. PSD95 interacts with numerous molecules, including neurotransmitter receptors and ion channels. The functional...

The N-methyl-D-aspartate receptor (NMDAR)-mediated structural plasticity of dendritic spines plays an important role in synaptic transmission in the brain during learning and memory formation. The Rho family of small GTPase RhoA and its downstream ef...

Therapies for stroke have remained elusive in the past despite the great relevance of this pathology. However, recent results have provided strong evidence that postsynaptic density protein-95 (PSD-95) can be exploited as an efficient target for stro...

A position sensitive detector (PSD) is frequently used for the measurement of a one-dimensional position along a line or a two-dimensional position on a plane, but is more often used for measuring static or quasi-static positions. Along with its quic...

The postsynaptic density (PSD) is a structural, electron-dense region of excitatory glutamatergic synapses, which is involved in a variety of cellular and signaling processes in neurons. The PSD is comprised of a large network of proteins, many of wh...

Here, we propose a mathematical model and a calibration procedure for a PSD (position sensitive device) sensor equipped with an optical system, to enable accurate measurement of the angle of arrival of one or more beams of light emitted by infrared (...

In order to obtain very precise measurements of the position of agents located at a considerable distance using a sensor system based on position sensitive detectors (PSD), it is necessary to analyze and mitigate the factors that generate substantial...

In this paper, a method of using a one-dimensional position-sensitive detector (PSD) by replacing charge-coupled device (CCD) to measure the movement of the interference fringes is presented first, and its feasibility is demonstrated through an ex...

The transport and fate of cohesive sediments in estuarine and coastal waters, including minerals, nutrients, and contaminants, are significantly influenced by flocculation processes involving particle aggregation and breakage. These dynamic flocculat...

Human serine racemase (hSR) is a pyridoxal-5′-phosphate (PLP)-dependent dimer that catalyzes the formation of D-serine from L-serine, as well as the dehydration of both L- and D-serine to pyruvate and ammonia. As D-serine is a co-agonist of N-m...

Differentiation of osteoclasts, which are specialized multinucleated macrophages capable of bone resorption, is driven primarily by receptor activator of NF-κB ligand (RANKL). Additional signaling from cell surface receptors, such as cell adhes...

PSD-95 (Dlg4) is an ionotropic glutamate receptor scaffolding protein essential in synapse stability and neurotransmission. PSD-95 levels are reduced during aging and in neurodegenerative diseases like Huntington’s disease (HD), and it is belie...

The non-Gaussian height distribution and power spectral density (PSD) characteristics of rough surfaces have significant effects on the real contact area, local pressure distribution, oil-film formation, and friction and wear behavior of lubricated c...

Osteoarthritis (OA) is a worldwide joint disease. However, the precise mechanism causing OA remains unclear. Our primary aim was to identify vital biomarkers associated with the mechano-inflammatory aspect of OA, providing potential diagnostic and th...

The security of internet of things (IoT) devices remains a major concern. These devices are very vulnerable because of some of their particularities (limited in both their memory and computing power, and available energy) that make it impossible to i...

Candidiasis is one of the most common fungal diseases that can pose a threat to life in immunodeficient individuals, particularly in its disseminated form. Not only fungal invasion but also fatal infection-related inflammation are common causes of sy...

Awareness of granulated soils’ internal instability is an important parameter when designing granulated filters, and the ability of a granulated soil’s internal stability can be verified using the soil PSD (Particle Size Distribution) cur...

Disruption of disease-relevant protein–protein interactions (PPIs) has emerged as a strategy to modulate pathological N-methyl-D-aspartate receptor (NMDAR) signaling while preserving essential physiological functions. A leading example is the i...

When related to a single and good contrast object or a laser spot, position sensing, or sensitive, detectors (PSDs) have a series of advantages over the classical camera sensors, including a good positioning accuracy for a fast response time and very...

In indoor localization there are applications in which the orientation of the agent to be located is as important as knowing the position. In this paper we present the results of the orientation estimation from a local positioning system based on pos...

Six degree-of-freedom (6-DOF) posture measurement is an important academic research topic which has been broadly applied in many fields. As a high-speed photoelectronic sensor with ultra-high resolution and precision, position sensitive detector (PSD...

The inherited metabolic disease phenylketonuria (PKU) is characterized by increased concentrations of phenylalanine in the blood and brain, and as a consequence neurotransmitter metabolism, white matter, and synapse functioning are affected. A specif...

Here, we present an indoor positioning system (IPS) for detecting mobile agents based on a single Position Sensitive Device sensor (PSD) sited in the environment and InfraRed Emitter Diode (IRED) located on mobile agents. The main goal of the work is...

Unmanned aerial vehicle (UAV) identification in edge environments requires both high classification accuracy and efficient real-time deployment on lightweight hardware. This study presents LUMEN, a Lightweight UAV Multi-Enhanced Network designed for...

(1) Background: The structural integrity of key components in unmanned aerial vehicle (UAV) mission systems is crucial for achieving performance goals. The installation environment of military and civilian UAV wing pylons is very complex, as they are...

Background/Objectives: Diagnostic metabolites measured in newborn screening, inherited metabolic disease, lysosomal storage disease, oncometabolite testing and routine clinical biochemistry are direct read-outs of human metabolic state. Their mechani...

There are several technologies and techniques available when developing indoor positioning systems (IPS). Recently, the development of positioning systems based on optical signals has aroused great interest, mainly those using visible light from the...

Accurate identification of dynamic parameters, specifically natural frequency and damping ratio, is critical for optimizing the disturbance rejection performance of laser level self-leveling mechanisms. However, traditional Finite Element Analysis (F...

Background/Objectives: BXOS110 is a first-in-class eicosapeptide designed to target the post-synaptic density protein 95 (PSD-95)-mediated signaling cascade, which plays a key role in ischemic brain injury. In this randomized, double-blind, placebo-c...

This study evaluates lead-free high-density polyethylene (HDPE) composites reinforced with high-Z oxides (Bi₂O₃, WO₃, Gd₂O₃, TeO₂, and a Bi₂O₃/WO₃ hybrid) as lightweight materials for gamma-ray and fast-neutron shielding. A hybrid computational frame...

Earthquakes cause severe damage to human beings and financial development, and they are commonly associated with a lot of uncertainties and stochastic factors regarding their frequency, intensity and duration. Thus, how to accurately select an earthq...

Schizophrenia is a complex mental disorder with a genetic component. The GRIK gene family encodes ionotropic glutamate receptors of the kainate subtype, which are considered candidate genes for schizophrenia. We screened for rare and pathogenic mutat...

Achieving accurate measurements of inflammation levels in tissues or thickness changes in biological membranes (e.g., amniotic sac, parietal pleura) and thin biological walls (e.g., blood vessels) from outside the human body, is a promising research...

Vinyl ester (VE) nanocomposites containing 0–20 wt.% ZrO₂ relative to the resin were produced to assess the effect of ZrO₂ loading on gamma-ray shielding. The crystalline structure and morphology of the ZrO₂ nanoparticles were examined by X-ray...

Most investigations of the gamma-shielding abilities of materials are often based on the Beer-Lambert law including recent studies on clay-polyethylene composites. The findings are usually silent on the secondary radiation effects that commonly occur...

A growing number of studies suggest that the perceived sensory dimensions (PSDs) of green space are associated with stress restoration offered by restorative environment. However, there is little known about PSDs and stress restoration as well as the...

Post-stroke depression (PSD) is a biopsychosocial disorder that affects individuals who have suffered a stroke at any point. PSD has a 20 to 60 percent reported prevalence among stroke survivors. Its effects are usually adverse, can lead to disabilit...

Mitochondrial dysfunctions are often associated with cellular aging as well as metabolic disorders. Therapeutic strategies for rewiring mitochondrial stress signaling in a disease context could be beneficial. New evidence indicates that mitochondrial...

The complex wind effects around platform screen doors (PSDs) caused by train-induced piston wind effect and positive micropressure waves in subway station platforms are investigated. Numerical modeling of the wind field around full-scale PSDs with re...

Vascular risk factors may predispose to post-stroke delirium (PSD). A systematic review and meta-analysis were performed by searching PubMed, Web of Science, and Scopus. The primary outcome was the prevalence of vascular risk factors in PSD vs. non-P...

Systems composed of piecewise smooth differential (PSD) mappings have quantitatively been searched for answers to a substantial issue of limit cycle (LC) bifurcations. In this paper, LC numbers (LCNs) of a PSD system (PSDS) consisting of four regions...

Objective: To investigate the relationship of lobar and deep brain regions with post-stroke dysphagia (PSD). Method: The databases of Medline, Embase, Web of Science, and Cochrane Library were searched from the establishment to May 2022. Studies that...

Particle size distribution (PSD) is an important parameter that is relevant to many aspects of marine ecosystems, such as phytoplankton functional types, optical absorption and scattering from particulates, sediment fluxes, and carbon export. However...

A multichannel speech enhancement system usually consists of spatial filters such as adaptive beamformers followed by postfilters, which suppress remaining noise. Accurate estimation of the power spectral density (PSD) of the residual noise is crucia...

In land battlefield environments, aerosol particles can cause laser beams to undergo attenuation, thus deteriorating the operational performance of military laser devices. The particle size distribution (PSD) and extinction coefficient are key optica...

Almost all recently built subway stations are equipped with Platform Screen Doors (PSDs) due to the numerous proven benefits of these systems. In addition, PSDs are now being introduced in existing subway stations, but their operation in conjunction...

This article presents a novel MPPT method for two stage PV inverters with a single phase connection to the power grid. The method takes advantage of the 100 Hz/120 Hz harmonic present on the DC-bus voltage to guide the MPP search. It consists of dete...

The decision-making process of China’s national forest park (NFP) system typically excludes the consideration of the public’s perceived benefits. In this regard, the objective of this study was to elucidate the type of cultural ecosystem...

University students face sustained academic demands that can compromise engagement and positive mental health, underscoring the need to identify modifiable everyday strategies that support health promotion in higher education. Drawing on Study Demand...

We investigated the alterations of hippocampal and reticulo-thalamic (RT) GABAergic parvalbumin (PV) interneurons and their synaptic re-organizations underlying the prodromal local sleep disorders in the distinct rat models of Parkinson’s disease (PD...