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Special Issue "Osteoclast Multinucleation Mechanisms"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2020.
Osteoclasts are specialized, multinucleated, and giant cells that resorb bone. Multinucleation is a hallmark of mature osteoclasts. The importance of multinucleation in osteoclast formation is demonstrated by the impaired bone-resorbing activity of osteoclasts that cannot achieve multinucleation. A functional defect in osteoclasts results in abnormal bone homeostasis. Therefore, it is important to understand the molecular signaling and genetic programs that control osteoclast multinucleation to improve our understanding of osteoclast biology and provide a molecular basis for designing therapeutic strategies for bone remodeling diseases.
Osteoclasts are hematopoietic in origin and are derived from myeloid precursors that also give rise to macrophages. In the past few decades, important advances have been made in molecular characterization of osteoclast multinucleation. To date, a number of molecules as well as cellular mechanisms (cell adhesion, the actin-based cytoskeleton, membrane-associated elements, irregular cell cycle, and cell fusion) have been revealed to be required for osteoclast multinucleation.
This Special Issue aims to cover a selection of recent research topics and current review articles related to osteoclast multinucleation. Since multinucleation is also observed in macrophages, and multinucleated macrophages have potential similarities to osteoclasts, we also welcome research and reviews characterizing the mechanisms of macrophage multinucleation, which will give us additional insights into the mechanisms underlying osteoclast multinucleation. Up-to-date review articles, commentaries, and experimental papers are all welcome.
Dr. Noriko Takegahara
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cell fusion
- bone metabolism