62,411 Results Found

This study aimed to elucidate the effects and underlying mechanisms of hepatitis B virus (HBV) preS mutations on hepatocarcinogenesis. The effect of the preS mutations on hepatocellular carcinoma (HCC) occurrence was evaluated using a prospective coh...

Posterior reversible encephalopathy syndrome (PRES) is a rare complication that the exact pathophysiological mechanism of which is still unclear. PRES most often occurs in connection with severe hypertension and autoimmune diseases. It can also appea...

In the modern era of HIV treatment, people co-infected with HIV and HBV still face poor liver outcomes, including liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. We investigated baseline characteristics and long-term liver function out...

Background: Chronic hepatitis B (CHB) remains being a major public health threat, and currently existing CHB therapies have limited efficacy and side effects. We have recently developed a vaccine termed VVX001 based on a recombinant fusion protein co...

The Heidenhain Variant of Creutzfeldt–Jakob disease (CJD) is an uncommon early clinical syndrome of the otherwise regular sporadic CJD, which belongs to the group of prion diseases caused by a transmissible agent, the misfolded form of the prio...

Background: Approximately 10–20% of subjects vaccinated with HBsAg-based hepatitis B virus (HBV) vaccines are non-responders. BM32 is a recombinant grass pollen allergy vaccine containing the HBV-derived preS surface antigen as an immunological...

Occult hepatitis B virus infection (HBV) is characterized by HBV DNA positivity but HBV surface antigen (HBsAg) negativity. Occult HBV infection is associated with a risk of HBV transmission through blood transfusion, hemodialysis, and liver transpla...

Hepatocellular carcinoma (HCC) is one of the most frequent and fatal human cancers worldwide and its development and prognosis are intimately associated with chronic infection with hepatitis B virus (HBV). The identification of genetic mutations and...

Inevitable long-term therapy with nucleos(t)ide analogs in patients with chronic hepatitis B virus (HBV) infection has selected reverse-transcriptase (rt) mutants in a substantial proportion of patients. Some of these mutants introduce premature stop...

Hepatocellular carcinoma (HCC) is among the most common and lethal human cancers worldwide and is closely associated with chronic hepatitis B virus (HBV) infection. Pre-S deleted proteins are naturally occurring mutant forms of HBV large surface prot...

Background and Objectives: The measurement of hepatitis B surface antigen (HBsAg) is essential for managing chronic hepatitis B virus infection (CHB). HBsAg consists of three different surface envelope proteins: large, middle, and small HB surface pr...

The preS1 region of the large hepatitis B virus (HBV) surface protein is a crucial component in HBV infection; however, its impact on the development of hepatocellular carcinoma (HCC) remains unknown. This study investigated the relationship between...

This article reports on the use of self-authorship as a pedagogical tool to develop pre-service teachers’ professional identities. Pre-professional identity is considered a dynamic, less mature version of professional identity. Such a notion of...

We report a novel electrostatic self-excited resonator driven by DC voltage that achieves variable velocity-position characteristics via applying the pre-tension/pre-compression constraint. The resonator consists of a simply supported micro-beam, two...

Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), the leading cause of cancer-related death worldwide. Despite progress in the prevention and therapy of HCC, high incidence and rec...

Mutations in the hepatitis B virus (HBV) genome can potentially lead to vaccination failure, diagnostic escape, and disease progression. However, there are no reports on viral gene expression and large hepatitis B surface antigen (HBsAg) antigenicity...

Hepatocellular carcinoma (HCC) is among the most common and lethal human cancers worldwide. Despite curative resection, high recurrence of HCC remains a big threat, leading to poor patient outcomes. Hepatitis B virus (HBV) pre-S mutants, which harbor...

Hepatitis B is a globally prevalent viral infectious disease caused by the hepatitis B virus (HBV). In this study, an immunochromatographic assay (ICA) for the rapid detection of hepatitis B preS2 antigen (preS2Ag) was established. The magnetic nanop...

Untargeted metabolomic studies generate information-rich, high-dimensional, and complex datasets that remain challenging to handle and fully exploit. Despite the remarkable progress in the development of tools and algorithms, the “exhaustive” extract...

For several years now, fruit-growers have increasingly often used pre-tensioned, pre-stressed concrete posts for supporting branches of fruit trees and suspending protective nets in order to limit damage to fruits caused by hail, wind, snow, heavy ra...

The effects of initial small-scale material nonlinearity on the pre-yield and pre-buckling response of externally pressurized metallic (plane strain) perfect rings (very long cylindrical shells) is investigated. The cylindrically curved 16-node eleme...

Hepatitis B virus (HBV) is a global health burden that causes acute and chronic hepatitis. To develop an HBV-neutralizing antibody that effectively prevents HBV infection, we previously generated a human anti-preS1 monoclonal antibody (1A8) that bind...

Hepatocellular carcinoma (HCC) is, globally, one of the most prevalent and deadly human cancers; despite curative surgical resection, its high recurrence rate after surgery remains a large threat, resulting in poor patient survival. The hepatitis B v...

This article investigates methane production, organic matter removal, and energy by comparing micro-aerobic pre-treatment and thermal pre-treatment of waste-activated sludge (WAS). For micro-aerobic pre-treatment, WAS was pre-treated at 0.35 vvm (vol...

Australia’s electricity networks are experiencing low demand during the day due to excessive residential solar export and high demand during the evening on days of extreme temperature due to high air conditioning use. Pre-cooling and solar pre-coolin...

It is common knowledge that fuzzy topology contributes to developing techniques to address real-life applications in various areas like information systems and optimal choices. The building blocks of fuzzy topology are fuzzy open sets, but other exte...

Hepatocellular carcinoma (HCC) is one of the most frequent and life-threatening human cancers worldwide. Despite curative resection surgery, the high recurrence rate of HCC leads to poor patient survival. Chronic hepatitis B virus (HBV) infection is...

Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), a class III histone deacetylase, is associated with the regulation of vario...

Background/Objectives: In chronic hepatitis B infection (CHB), the hepatitis B surface antigen (HBsAg) continuously exhausts the hepatitis B surface antibody (HBsAb), which leads to the formation of immune tolerance. Accordingly, the hepatitis B viru...

By using the contemporary theory of inequalities, this study is devoted to proposing a number of refinements inequalities for the Hermite-Hadamard’s type inequality and conclude explicit bounds for two new definitions of ( p 1 p 2 , q...

The goal of the present paper is to provide a cohomology theory and crossed modules of modified Rota–Baxter pre-Lie algebras. We introduce the notion of a modified Rota–Baxter pre-Lie algebra and its bimodule. We define a cohomology of mo...

Pre-eclampsia is a severe pregnancy-related complication that manifests as a syndrome with multisystem involvement and damage. It has significantly grown in frequency during the past 30 years and could be considered as one of the major causes of mate...

In the present work, different aging treatments were performed to investigate the pre-aging effect on the formation of Ω phase and mechanical properties in Al-Cu-Mg-Ag alloy. The results showed that pre-strain could inhibit the formation of &Om...

Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low-middle income countries. The aim of this project is to establish a pre-eclampsia biobank in South Africa to facilitate resear...

Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organ...

This study introduces the notions of BiHom-Poisson conformal algebra, BiHom-pre-Poisson conformal algebra, and their related structures. We show that many new BiHom-Poisson conformal algebras can be constructed from a BiHom-Poisson conformal algebra....

Although surgical resection is available as a potentially curative therapy for hepatocellular carcinoma (HCC), high recurrence of HCC after surgery remains a serious obstacle for long-term patient survival. Therefore, the discovery of valuable progno...

Mobile traffic classification serves as a fundamental component in network security systems. In recent years, pre-training methods have significantly advanced this field. However, as mobile traffic is typically mixed with third-party services, the de...

A pre-swirl fin (PSF), pre-swirl duct (PSD) and wake-equalizing duct (WED) energy-saving devices (ESD) are designed for the Duisburg Test Case (DTC). To this aim, a simulation-based design optimization method, combining RANSE analyses (ship resistanc...

Development of U-type pre-stressed girders has been attempted to increase the length of I-type girders in South Korea. However, a length of 30 m or less is common because the self-weight, according to the post-tension method, is large. In this study,...

Queuosine (Q) is a complex modification of the wobble base in tRNAs with GUN anticodons. The full Q biosynthesis pathway has been elucidated in Escherichia coli. FolE, QueD, QueE and QueC are involved in the conversion of guanosine triphosphate (GTP)...

We show that a PL∞-algebra V can be described by a nilpotent coderivation of degree −1 on coalgebra P*V. Based on this result, we can generalise the result of Lada to show that every A∞-algebra carries a PL∞-algebra structure...

In the future, ammonia is expected to become a carbon-free fuel for internal combustion engines. However, the flammability of ammonia is poorer compared to conventional fuels such as gasoline and diesel fuel. Pre-chamber jet ignition may be an effect...

Production of plants under artificial light conditions is an innovative and smart concept to grow food year-round in any location. However, pre-basic seed potato production in the greenhouse from LED pre-treated seedlings under an aeroponic system is...

In order to meet the sophisticated demands for large-scale applications such as electro-mobility, next generation energy storage technologies require advanced electrode active materials with enhanced gravimetric and volumetric capacities to achieve i...

Physical side-channel attacks utilize power, electromagnetic (EM), or timing signatures from cryptographic implementations during operation to retrieve sensitive information from security-critical devices. This paper provides a comprehensive review o...

We investigate analog and digital pre-emphasis for ultra-high-bit-rate coherent dual-polarization 64-QAM (DP-64QAM) transmission using OptiSystem. Two representative single-wavelength configurations are studied: 64 Gbaud (600 Gb/s payload, 768 Gb/s l...

This work shows the results of an experimental campaign carried out in two spark ignition engines, a small optical research engine and its commercial counterpart, using a turbulent ignition system (pre-chamber) specifically designed for small engines...

Metastasis, particularly brain metastasis, continues to puzzle researchers to this day, and exploring its molecular basis promises to break ground in developing new strategies for combatting this deadly cancer. In recent years, the research focus has...

The pre-release operation has the potential to enhance the ability of a reservoir to manage exceedance floods. However, the mechanisms for the initiation and termination of such operations are unclear, and a clear method for calculating the pre-relea...