Scaffolding molecules exert a critical role in orchestrating cellular response through the spatiotemporal assembly of effector proteins as signalosomes. By increasing the efficiency and selectivity of intracellular signaling, these molecules can exer...
We have developed MAGI-ACMG, a classification algorithm that allows the classification of sequencing variants (single nucleotide or small indels) according to the recommendations of the American College of Medical Genetics (ACMG) and the Association...
After his return from Italy in 1608, Peter Paul Rubens received a commission to depict an Adoration of the Magi for the Statenkamer in Antwerp’s Town Hall. It was the first, grand display of his stylistic and iconographic innovations. By buildi...
HPV 16 integration is crucial for the onset and progression of premalignant lesions to invasive squamous cell carcinoma (ISCC) because it promotes the amplification of proto-oncogenes and the silencing of tumor suppressor genes; some of these are pro...
MAGI1 acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer (BC), and its loss correlates with a more aggressive phenotype. To identify the pathways and events affected by MAGI1 loss, we deleted the MAGI1 gene in the ER+ MCF7 B...
Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent prot...
Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here...
High-Grade Serous Ovarian Carcinoma (HGSC) is the most incidental and lethal subtype of epithelial ovarian cancer (EOC) with a high mortality rate of nearly 65%. Recent findings aimed at understanding the pathogenesis of HGSC have attributed its prin...
Background: Hepatocellular carcinoma (HCC) is a very common neoplasm worldwide, and competitive endogenous RNA (ceRNA) plays an important role in the development of HCC. The purpose of this study is to investigate the molecular mechanisms of ceRNAs i...
The present exploratory study investigates the performance of a new, rapid, synthetic MRI method for diagnostic image quality assessment and measurement of relaxometry metric values in head and neck (HN) tumors and normal-appearing masseter muscle. T...
Introduction. Obesity exposes individuals to the risk of chronic inflammation of the prostate gland. Aim and design of the study. A longitudinal clinical study was conducted on selected overweight/obese patients with male accessory gland inflammation...
The Blaubeuren monastery (Germany) is home to one of the most beautiful religious artistic expressions of Swabian art from the end of the 15th century, a collaborative work of various artists and workshops, including Jörg Syrlin the Younger, Mic...
This contribution to the literature presents an in-depth analysis of the scene drawn by Leonardo da Vinci in the preparatory drawing, Adoration of the Magi, dated 1481, that is now housed at the Département des Arts Graphiques du Musée du Louvre in P...
Real-time vessel tracking and environmental assessment in developing regions face significant challenges due to the high cost and proprietary constraints of commercial Automatic Identification System (AIS) services. We introduce MAGI, an open-source,...
In the magical girl anime series Puella Magi Madoka Magica, middle-school girls receive the power and responsibility to fight witches in exchange for making a wish. The series has connections to many different genres and narrative traditions within t...
MAGI1 is a cytoplasmic scaffolding protein initially identified as a component of cell-to-cell contacts stabilizing cadherin-mediated cell–cell adhesion in epithelial and endothelial cells. Clinical-pathological and experimental evidence indicates th...
Traditional population-based metaheuristic algorithms are effective in solving complex real-world problems but require careful strategy selection and parameter tuning. Metaphorless population-based optimization algorithms have gained importance due t...
The analysis of dynamic scenes has been a challenging domain in eye tracking research. This study presents a framework, named MAGiC, for analyzing gaze contact and gaze aversion in face-to-face communication. MAGiC provides an environment that is abl...
Background: Differentiating pituitary adenoma (PA) from Rathke’s cleft cyst (RCC) on magnetic resonance imaging (MRI) remains challenging due to overlapping imaging features such as the cystic appearance, and location within the sellar region....
Human personality (i.e., temperament and character) is a complex trait related to mental health, influenced by genetic and environmental factors. Despite the efforts performed during the past decades, its genetic background is only just beginning to...
Microbial competition within plant tissues affects invading pathogens’ fitness. Metabolomics is a great tool for studying their biochemical interactions by identifying accumulated metabolites. Xylella fastidiosa, a Gram-negative bacterium causi...
High spatial resolution Earth observation imagery is considered desirable for many scientific and commercial applications. Given repeat multi-angle imagery, an imaging instrument with a specified spatial resolution, we can use image processing and de...
In recent years, small-scale drones have been used in heterogeneous tasks, such as border control, precision agriculture, and search and rescue. This is mainly due to their small size that allows for easy deployment, their low cost, and their increas...
The aim of this study was to explore the potential of magnetic resonance fingerprinting (MRF), an emerging quantitative MRI technique, in measuring relaxation values of female pelvic tissues compared to the conventional magnetic resonance image compi...
Male tract infections (MTIs) are a common clinical condition, often presenting without any signs nor symptoms of disease. As advised by the European Urology Guidelines dealing with this topic, patients are typically treated with antibiotics alone. Ne...
Alcohol consumption in young women is a widespread habit that may continue during pregnancy and induce alterations in the fetus. We aimed to characterize prevalence of alcohol consumption in parturient women and to assess fetal ethanol exposure in th...
In recent years, the consumption of energy drinks (EDs) has become increasingly popular, especially among adolescents. Caffeine, a psychostimulant, is the main compound of EDs which also contain other substances with pharmacological effects. This rev...
School personnel can struggle with meeting the daily physical activity recommendation; however, they are role models for students, and their attitudes towards physical activity can impact students’ physical activity habits. The aim was to assess scho...
The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50–200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone...
Polyelectrolyte–drug complexes are interesting alternatives to improve unfavorable drug properties. Vancomycin (VAN) is an antimicrobial used in the treatment of methicillin-resistant Staphylococcus aureus pulmonary infections in patients with...
The increasing availability of products generating burned area (BA) maps in recent years necessitates the creation of more accurate reference perimeters to validate these products and provide users with information about their accuracy. For this purp...
A trial was performed to investigate the effect of a proprietary guar protein concentrate, as a partial replacement of conventional protein sources, on the productive performances and gut health of rainbow trout through the growing phase. A total of...
Ficus drupacea is a fruit-bearing tree that is distributed in Southeast Asia and Australia. The objective of this research was to ascertain the following with regard to ripened fruits: (i) their nutritional value, (ii) their mineral status, (iii) the...
As zero-carbon fuels, hydrogen and ammonia are of great interest in the transition toward a climate-neutral transportation system. In order to use these fuels and their blends in reciprocating engines, a characterization of the combustion of NH3/H2/a...
Introduction: The recovery room (RR) is a hospital area where patients are monitored in the early postoperative period before being transferred to the surgical ward or other specialized units. The utilization of scores in the RR context facilitates t...
In this work, the influence of plenum and port geometry on the performance of the intake process in a four-stroke spark ignition engine for ultralight aircraft applications is analyzed. Three intake systems are considered: the so-called “standa...
Background: The differential diagnosis of atypical melanocytic skin lesions localized on palms and soles represents a diagnostic challenge: indeed, this spectrum encompasses atypical nevi (AN) and early-stage melanomas (EN) displaying overlapping cli...
Self-care plays a critical role in symptom recognition, management, and risk factor modification for patients with chronic illnesses. Despite its significance, self-care levels in this population are generally poor. Health literacy (HL) is pivotal fo...
Estimating daily continuous evapotranspiration (ET) can significantly enhance the monitoring of crop stress and drought on regional scales, as well as benefit the design of agricultural drought early warning systems. However, there is a need to verif...
“Harald Kittler” was not included as an author in the original publication [...]
Background: Hepatotoxicity, a significant complication of 5-fluorouracil (5-FU) treatment, is generally triggered by oxidative stress, liver damage, and apoptosis processes that take place in cancer patients. Methods: In this study, the protective ef...
The brown marmorated stink bug (BMSB), Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is a polyphagous pest native to East Asia and invasive in many countries. Various approaches have been used to control its spread, including IPM strategi...
Satellite data provide the spatial distributions of burned areas worldwide; assessing their accuracy and comparing burned area estimates from different products is relevant to gain insights into their reliability and sources of error. We compared BA...
Background: Synthetic cathinones (SCs) are the second most representative class of New Psychoactive Substances, with more than 100 analogues identified in the illicit drug market up to 2024. According to the United Nations Office on Drugs and Crimes,...
Background/Objectives: Pulmonary delivered tobramycin (TOB) is a standard treatment for Pseudomonas aeruginosa lung infections, that, along with Staphylococcus aureus, is one of the most common bacteria causing recurring infections in CF patients. Ho...
Cannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cann...
Background/Objectives: The prevalence of tattoos has risen globally in recent decades, ranging from 10% to 29%. Although rare, melanomas arising within tattoos are challenging for dermatologists due to the complexities in clinical and dermoscopic eva...
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particu...
Background and objective: Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreat...
In mid Adriatic Sea the common sea snail is the habitual snail eaten, but over the years fishermen started to capture also the long sea snail, a possible alternative for human consumption. This study aims to compare the quality traits of the edible f...
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