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Article

Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation

1
Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
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Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
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Department of Chemical Sciences, University of Catania, 95123 Catania, Italy
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Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, 00163 Rome, Italy
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Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy
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Section of Urology, Department of Surgery, University of Catania, 95123 Catania, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Silvia Savastano, Carla Lubrano, Giovanni Spera and Mikiko Watanabe
Nutrients 2022, 14(5), 1081; https://doi.org/10.3390/nu14051081
Received: 31 January 2022 / Revised: 27 February 2022 / Accepted: 2 March 2022 / Published: 4 March 2022
(This article belongs to the Special Issue The Role of Ketogenic Diet in Human Health and Diseases)
Introduction. Obesity exposes individuals to the risk of chronic inflammation of the prostate gland. Aim and design of the study. A longitudinal clinical study was conducted on selected overweight/obese patients with male accessory gland inflammation (MAGI) to evaluate the effects of body weight loss on their urogenital symptoms. Materials and methods. One hundred patients were selected and assigned to two groups undergoing two different nutritional programs. The first group (n = 50) started a Mediterranean diet (MedDiet) and the second (n = 50) a very-low-calorie ketogenic diet (VLCKD). Before and after three months on the diet, each patient was evaluated for body weight, waist circumference, and MAGI symptoms. The MAGI was assessed using the Structured Interview about MAGI (SI-MAGI), a questionnaire previously designed to assess the symptoms of MAGI. The questionnaire explores four domains, including urinary symptoms, ejaculatory pain or discomfort, sexual dysfunction, and impaired quality of life. Finally, in the two groups, the frequency of an α-blocker used to treat urinary tract symptoms was also evaluated. Results. Patients on MedDiet experienced significant amelioration in urinary symptoms and quality of life. Patients under VLCKD reported not only significant improvement of the same parameters, but also in ejaculatory pain/discomfort and sexual dysfunction. Finally, the percentage of patients on VLCKD taking the α-blocker decreased significantly. Moreover, patients under VLCKD showed a greater loss of body weight than those following the MedDiet. Discussion. The results of this study support the effectiveness of VLCKD in improving the symptoms of patients with MAGI. This improvement involved all of the domains of the SI-MAGI questionnaire and became manifest in a relatively short time. We suggest that a ketogenic nutritional approach can be used in overweight/obese patients with MAGI. View Full-Text
Keywords: VLCKD; very-low-calorie ketogenic diet; MAGI; male accessory gland infection; Mediterranean diet; urinary symptoms; quality of life; sexual dysfunction; ejaculatory pain VLCKD; very-low-calorie ketogenic diet; MAGI; male accessory gland infection; Mediterranean diet; urinary symptoms; quality of life; sexual dysfunction; ejaculatory pain
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MDPI and ACS Style

Condorelli, R.A.; Aversa, A.; Basile, L.; Cannarella, R.; Mongioì, L.M.; Cimino, L.; Perelli, S.; Caprio, M.; Cimino, S.; Calogero, A.E.; La Vignera, S. Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation. Nutrients 2022, 14, 1081. https://doi.org/10.3390/nu14051081

AMA Style

Condorelli RA, Aversa A, Basile L, Cannarella R, Mongioì LM, Cimino L, Perelli S, Caprio M, Cimino S, Calogero AE, La Vignera S. Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation. Nutrients. 2022; 14(5):1081. https://doi.org/10.3390/nu14051081

Chicago/Turabian Style

Condorelli, Rosita A., Antonio Aversa, Livia Basile, Rossella Cannarella, Laura M. Mongioì, Laura Cimino, Sarah Perelli, Massimiliano Caprio, Sebastiano Cimino, Aldo E. Calogero, and Sandro La Vignera. 2022. "Beneficial Effects of the Very-Low-Calorie Ketogenic Diet on the Symptoms of Male Accessory Gland Inflammation" Nutrients 14, no. 5: 1081. https://doi.org/10.3390/nu14051081

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