742 Results Found

The Helicobacter pylori Neutrophil Activating Protein (HP-NAP) is endowed with immunomodulatory properties that make it a potential candidate for anticancer therapeutic applications. By activating cytotoxic Th1 responses, HP-NAP inhibits the growth o...

It was demonstrated that the inactivation of high pressure (HP) treatment on Escherichia coli survival in sterile physiological saline (SPS) was influenced by the treatment conditions: unfrozen, frozen-thawed and fully frozen (phase transition). In o...

In this paper, a seven-parameter spectral/hp finite element model to obtain natural frequencies in shell type structures is presented. This model accounts for constant and variable thickness of shell structures. The finite element model is based on a...

This contribution presents a finite element shell model capable of performing linear vibration analyses of shell-type structures made of functionally graded material (FGM). The model is based on the seven-parameter spectral/hp finite element formulat...

The solubility and dissolution thermodynamics of new c-Met inhibitor, ABN401, were determined in eleven solvents and Transcutol^® HP–water mixture (TWM) from 298.15 to 318.15 K. The experimental solubilities were validated using five mathema...

It has been reported that Heteropodatoxin3 (HpTx3), a peptidic neurotoxin purified from the venom of the spider species Heteropoda venatoria, could inhibit K_v4.2 channels. Our present study newly found that HpTx3 also has potent and selective inhibit...

We introduce a Firefly-inspired algorithmic approach for protein structure prediction over two different lattice models in three-dimensional space. In particular, we consider three-dimensional cubic and three-dimensional face-centred-cubic (FCC) latt...

In this study, we used the hydrophobic-polar (HP) two-dimensional square and three-dimensional cubic lattice models for the problem of protein structure prediction (PSP). This kind of lattice reduces computational time and calculations, the conformat...

This paper proposes a structure for long-term energy demand forecasting. The proposed hybrid approach, called HPLLNF, uses the local linear neuro-fuzzy (LLNF) model as the forecaster and utilizes the Hodrick–Prescott (HP) filter for extraction of the...

This work presents the results of a study that used a model based on rough set theory (RST) to assess the brine temperature of vertical ground heat exchangers (VGHEs) to feed heat pumps (HP). The purpose of this research was to replace costly brine t...

We use a Species Distribution Modeling (SDM) approach along with Geographic Information Systems (GIS) techniques to examine the potential distribution of hantavirus pulmonary syndrome (HPS) caused by Andes virus (ANDV) in southern Argentina and, more...

The objective of the present study is to obtain linalool- cyclodextrin (CDs) solid complexes for possible applications in the food industry. For this purpose, a detailed study of linalool complexation was carried out at different pH values, to optimi...

Wind power plays an increasingly vital role in sustainable energy development. However, accurately simulating wind turbine aerodynamics, particularly in offshore wind farms, remains challenging due to complex environmental factors such as the marine...

The demand for electricity has been rising significantly over the past years and it is expected to rise further in the coming years due to economic and societal development. Smart grid technology is being developed in order to meet the rising electri...

(1) Background: Percutaneous microwave ablation (MWA) is an accepted treatment of non-operative liver cancer. This study compares the ablation zones of four commercially available 2.45 GHz MWA systems (Emprint, Eco, Neuwave, and Solero) in an ex vivo...

Harnessing the body’s intrinsic resources for wound healing is becoming a rapidly advancing field in regenerative medicine research. This study investigates the effects of the topical application of a novel porcine Hypoxia Preconditioned Serum...

Groundwater serves as an indispensable global resource, essential for agriculture, industry, and the urban water supply. Predicting the groundwater level in karst regions presents notable challenges due to the intricate geological structures and fluc...

Environmental sound classification (ESC) tasks are attracting more and more attention. Due to the complexity of the scene and personnel mobility, there are some difficulties in understanding and generating environmental sound models for ESC tasks. To...

Cone crushers have a central role in the processing of quarry rocks, besides coarser ore preparation in several mineral processing plants. This is particularly true in the case of Itabirite iron ore preparation plants in Brazil, so optimizing their p...

This paper concerns the algorithm of transition piezoelectric elements for adaptive analysis of electro-mechanical systems. In addition, effectivity of the proposed elements in such an analysis is presented. The elements under consideration are assig...

The heat capacity decomposition method, a well-established analytical approach in polymer thermodynamics for elucidating thermal transitions in homogeneous polymers, is extended here to heterogeneous systems. We demonstrate that the decomposition of...

A pyrazole derivative (CB1) was previously evaluated in vivo for various pharmacological activities (with the exception of antimicrobial effects), using DMSO as the administrative medium, mainly due to its water insolubility. Considering the global n...

The rising electricity costs, cost of space heating, and domestic hot water end up driving consumers toward reducing expenses by generating their electricity through devices like photovoltaic systems and efficient combined heat and power plants. When...

Metamorphic evolution of an accretionary wedge can be constrained by a reconstructed P–T conditions of the oceanic and continental margin fragments. This paper deals with the metamorphic overprinting of the Inner Western Carpathians (IWC) Melia...

The modelling of the trend component of economic time series has a long history, and the most primitive and popular model displays the trend as a linear function of time. However, the residuals of such a linear trend frequently exhibit long-period fl...

Background: Although the third most frequent interstitial lung disease, hypersensitivity pneumonitis (HP) remains an enigmatic disease without clear diagnostic and therapeutic guidelines. We assessed the effect of the commonly used therapeutic interv...

Background: Hepatopulmonary syndrome (HPS) is a pulmonary vasculature complication in the setting of liver disease that is characterized by pathological vasodilation resulting in arterial oxygenation defects. We investigated the role of extracellular...

Acute liver injury shares a common feature of hepatocytes death, immune system disorders, and cellular stress. Hepassocin (HPS) is a hepatokine that has ability to promote hepatocytes proliferation and to protect rats from D-galactose (D-Gal)- or car...

In this paper, the Kharrat–Toma transforms of the Prabhakar integral, a Hilfer–Prabhakar (HP) fractional derivative, and the regularized version of the HP fractional derivative are derived. Moreover, we also compute the solution of some C...

Nowadays, increasing the penetration of renewable heat technologies is an important approach to minimise global primary energy use and reduce CO₂ emissions for a sustainable future. Thermoelectric heat pumps, which have some unique characteristics in...

The purpose of this review is to comprehensively compare the developments and challenges in the energy performance of unconventional pneumatic suspension (PS) and hydropneumatic suspension (HPS), which have special applications in passenger cars, tru...

Cyclic dipeptides administered by both parenteral and oral routes are suggested as promising candidates for the treatment of neurodegeneration-related pathologies. In this study, we tested Cyclo (His-Pro) isomers (cHP1-4) for their anti-Alzheimer pot...

There is a growing need to develop anti-inflammatory drugs to regulate inflammatory responses. An extract of Huberia peruviana Cogn. had the best inhibitory effect on nitric oxide (NO) production in screening process undertaken in our laboratory. How...

Antimicrobial resistance is a global health threat, which has been worsened by the slow development of new antibiotics. The rational design of natural-derived antimicrobial peptides (AMPs) offers a promising alternative for enhancing the efficacy of...

Three-dimensional pharmacophore hypotheses were built from a set of 10 octopamine (OA) agonist 1-arylimidazole-2(3H)-thiones (AIHTs) and 1-arylimidazolidine-2-thiones (AITs). Among the ten common-featured models generated by program Catalyst/HipHop,...

Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, which is characterized by the accumulation of amyloid β (Aβ) plaques, oxidative stress, and neuronal loss. Therefore, clearing Aβ aggregates a...

Photovoltaic-thermal (PVT) collectors are hybrid solar collectors that convert solar and ambient energy into thermal and electrical energy. Integrated PVT-HP, in which PVT collectors are combined with a heat pump, offers an efficient and renewable op...

A hydronic pavement system (HPS) is an alternative method to clear snow and ice, which avoids the use of salt, sand, and fossil fuel in conventional snow clearance, and minimizes the risk of accidents. The aim is to analyze the performance of differe...

2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is widely used as an enabling excipient in pharmaceutical formulations. We previously demonstrated that HP-β-CyD disrupted cholesterol homeostasis, and inhibited the proliferation of leukemia cells by inducin...

Heat pipe heat exchangers (HPHEXs) are widely used in various industries. In this paper, a novel model of a liquid–liquid heat pipe heat exchanger in a countercurrent manner is established by considering the evaporation and condensation thermal...

The impact of high-pressure (HP) processing on the viability of two probiotic microorganisms (Bifidobacterium bifidum and Lactobacillus casei) at varying pressure (100−400 MPa), temperature (20−40 °C) and pH (6.5 vs. 4.8) conditions w...

Niemann–Pick disease type C (NPC) is an autosomal recessive disorder characterized by abnormal accumulation of free cholesterol and sphingolipids in lysosomes. The iminosugar miglustat, which inhibits hexosylceramide synthesis, is used for NPC...

Inhalable formulations with cyclodextrins (CDs) as solubility and absorption enhancers show promise for pulmonary delivery. Thiolated hydroxypropyl-β-cyclodextrin (HP-β-CD-SH) has mucoadhesive properties, enhancing drug absorption. Moreover...

For the first time, two poly-histidine-poly-glycine peptides (pHpG-H5 and pHpG-H7) were identified as promising candidates for matrix metalloproteinase inhibitors. cDNAs encoding pHpG-H5 and pHpG-H7 peptides were isolated from the Atheris squamigera...

Type 2 diabetes mellitus (T2DM) is associated with pancreatic β-cell dysfunction which can be induced by oxidative stress. Deuterohemin-βAla-His-Thr-Val-Glu-Lys (DhHP-6) is a microperoxidase mimetic that can scavenge reactive oxygen species...

Obesity, as a major risk factor of metabolic syndrome (MetS), represents a pandemic, especially in Western societies, and is considered a risk factor for malignancies. Helicobacter pylori (Hp), is a definite carcinogen with global distribution. We ai...

Nonalcoholic fatty liver disease (NAFLD) emerges as an important global burden and Helicobacter pylori infection (Hp-I) has been suggested as a risk factor of NAFLD, although controversy exists. This retrospective study aimed to investigate a potenti...

The ability to use the body’s resources to promote wound repair is increasingly becoming an interesting area of regenerative medicine research. Here, we tested the effect of topical application of blood-derived hypoxia preconditioned serum (HPS...

High-pressure abrasive water jet (HP-AWJ) cutting is a prominent technology for processing a wide variety of materials. The structural parameters of the nozzle are important for the cutting performance of the HP-AWJ. This paper combines an abrasive p...

Andes virus, ANDV, harbored by wild rodents, causes the highly lethal hantavirus pulmonary syndrome (HPS) upon transmission to humans resulting in death in 30% to 50% of the cases. As there is no treatment for this disease, we systematically tested t...