234 Results Found

Heart failure (HF) is a complex systemic syndrome for which the HLM staging system has been proposed to better capture disease complexity. This study investigated the prognostic role of HLM staging according to SGLT2i status and the impact of in-hosp...

A large number of studies have provided evidence regarding the factors that influence commuting time. However, few studies have explored such effects in the context of considering spatial heterogeneity across cities, which limits the generalizability...

Establishing the metabolism pathway of the drug undergoing the hepatic biotransformation pathway is one of the most important aspects in the preclinical discovery process since the presence of toxic or reactive metabolites may result in drug withdraw...

Background: Ischemic heart disease (IHD) represents the main cause of heart failure (HF). A prognostic stratification of HF patients with ischemic etiology, particularly those with acute coronary syndrome (ACS), may be challenging due the variability...

This research paper presents a new Latin hypercube sampling method, aimed at enhancing its performance in quantifying uncertainty and reducing computation time. The new Latin hypercube sampling (LHS) method serves as a tool in reliability-based desig...

High lithium and manganese oxides (HLMs), also known as lithium- and manganese-rich oxides (LMR), are an alternative to the state-of-the-art (SoA) cathode materials for Li-ion battery cells due to their high specific capacity, working potential, and...

Based on the China Migrants Dynamic Survey (CMDS) data from 2018 and the data from 58 large- and medium-sized cities in China, in this paper a hierarchical linear model was used to investigate the impact of demographic characteristics, social partici...

Macrophages are among the main actors in cancer immunoediting, with several functions, including recycling iron and packaging it in hemosiderin. Even though TAMs are widely studied in breast cancer and canine mammary tumors, hemosiderin-laden macroph...

The main objective of this study was to investigate the metabolism of miconazole, an azole antifungal drug. Miconazole was subjected to incubation with human liver microsomes (HLM) to mimic phase I metabolism reactions for the first time. Employing a...

The use of satellite remote sensing could effectively predict maize yield. However, many statistical prediction models using remote sensing data cannot extend to the regional scale without considering the regional climate. This paper first introduced...

This study examined the hollowing process of rural communities, which is caused by migration, and explored its influence factors based on Hierarchical Linear Model (HLM) analysis in an attempt to explore effect of regional characteristic. To capture...

: Identifying the fuzzy measures of the Choquet integral model is an important component in resolving complicated multi-criteria decision-making (MCDM) problems. Previous papers solved the above problem by using various mathematical programming model...

Mammary gland tumors are among the most common neoplasms in female dogs. Macrophages are believed to play an important role in tumor progression and metastasis. The aim of this study was to determine whether hemosiderin-laden macrophages (HLMs) may b...

This study is concerned with the central issues of community service engagement (CSE) in 21st century democratic societies around the world. To examine the factors influencing postsecondary education attainment’s relationship to CSE, this study utili...

This study examined the relationship between transformational leadership, learning orientation, creative self-efficacy, and employee creativity in manufacturing small and medium-sized enterprises (MSMEs) in China. A survey involving 742 employees was...

Numerous studies in different countries find evidence for high rates of teacher turnover, leading to shortages and potential quality issues. Job satisfaction is found to be an important antecedent of turnover. In this study, we investigate the impact...

In the context of the Healthy China 2030 Plan, the importance of the happiness of urban young returnees should not be underestimated. Based on a large-scale social survey of social practices in China, this paper applies a hierarchical linear regressi...

Understanding the metabolism of pharmaceutical compounds is a fundamental prerequisite for ensuring their safety and efficacy in clinical use. However, conventional methods for monitoring drug metabolism often come with the drawbacks of being time-co...

Background: Air pollution is an important factor affecting residents’ health. Methods: Based on the health data of 9959 residents from 28 provinces in China in the 2017 Chinese General Social Survey (CGSS), this paper uses a hierarchical linear...

The constant development in the area of medicinal substances on the market and their subsequent progress in the field of drug analysis has become one of the reasons for the search for alternative, cheaper, and faster methods to determine the metaboli...

3-Hydroxyeticyclidine (3-HO-PCE) is a ketamine derivative that produces dissociative, hallucinogenic, and euphoric effects when consumed, but little is known about its pharmacological properties, metabolism, and toxicity compared to other designer ke...

This study investigates the impact of human-like machines (HLMs) on the user experience (UX) of young adults during voice interactions between drivers and autonomous vehicles. A mixed-method approach was employed to evaluate three voice agents with v...

In the context of school learning and teaching, teachers are leaders who stimulate students’ learning outcomes through leadership styles. The teacher efficacy of this study is discussed by using multiple teaching and class management strategies...

Background: Sirolimus (SRL, rapamycin) is a clinically important mTOR inhibitor used in immunosuppression, oncology, and cardiovascular drug-eluting devices. Despite its long-standing FDA approval, the human metabolic profile of SRL remains incomplet...

The Corona Virus Disease 2019 (COVID-19) outbreak caused people to pay significant attention to urban public safety issues. The city’s public safety is an important part of the high-quality development and the construction of a liveable city. T...

Employees’ emotional-labor strategies, experienced affects, and emotional exhaustion in the workplace may vary over time within individuals, even within the same day. However, previous studies on these relationships have not highlighted their d...

In the context of achieving common prosperity, this article explores the implementation path of the new rural collective economic organization designed to alleviate relative poverty by improving the livelihood strategies of farmers from the perspecti...

Currently, coronavirus disease 2019 (COVID-19) remains a global pandemic, but the prevention and control of the disease in various countries have also entered the normalization stage. To achieve economic recovery and avoid a waste of resources, diffe...

Dubermatinib (DMB, TP-0903), a benzenesulfonamide, is an inhibitor of the tyrosine kinase AXL, which is a member of the TAM family and can prevent GAS6-mediated activation of AXL in cancer cells. Patients with previously treated chronic lymphocytic l...

Sunflower production is an excellent choice for both local and national agribusiness with significant potential in smallholder farming systems due to low input costs, consistent yields, and a short planting window. However, farmers are faced with int...

Ribociclib (Kisqali^®) is a pharmacological agent that has great selectivity as a cyclin-dependent kinase 4/6 inhibitor. It has received regulatory approval for its application in the treatment of breast cancer. The objective of the current study was...

Alectinib, also known as Alecensa^®, is prescribed for the therapeutic treatment of individuals diagnosed with metastatic non-small cell lung cancer (NSCLC) who have a specific genetic mutation referred to as anaplastic lymphoma kinase (ALK) posit...

This study investigated the effects of high-lipid diets (HLD) with methionine (Met) supplementations on golden pompano (Trachinotus ovatus). T. ovatus (initial weight 82 ± 0.04 g) were fed with a normal lipid control diet (11.30% crude lipid a...

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine highly expressed by epithelial cells and several innate and adaptive immune cells. TSLP exerts its biological effects by binding to a heterodimeric complex composed of TSLP receptor (TSLPR...

COVID-19 is a viral disease caused by SARS-CoV-2. This disease is characterized primarily, but not exclusively, by respiratory tract inflammation. SARS-CoV-2 infection relies on the binding of spike protein to ACE2 on the host cells. The virus uses t...

According to the United Nations Development Program, sustainable development goals are fundamental for attaining a better and more sustainable future for all of us, and are a primary concern today. New indicators, such as the Economic Complexity Inde...

Assessing vulnerability is key in the planning of climate change adaptation policies and, more importantly, in determining actions increasing resilience across different locations. This study presents the results of a hierarchical linear multilevel m...

Living in a world where we can expand our economic wealth and the richness of human life is the core of the human development concept. Greater well-being for all can be achieved by improving people’s capabilities and more importantly, by giving indiv...

Black soldier fly (Hermetia illucens) larvae meal have been used as feed protein supplements in fish feed, but few researches have investigated the metabolomic effects of Hermetia illucens larvae meal supplements. Therefore, the metabolic effects on...

Based on the data from the China Education Panel Survey 2013–2014, this study uses a two-level hierarchical linear model to explore the impact of student factors, teacher factors, and facility conditions on students’ cognitive scores and...

In this study, the phase I hepatic metabolism pathway of a cardiovascular drug nebivolol was proposed on the basis of a human liver microsomes assay with the use of LC-HR-MS coupled with the chemometric method. Six biotransformation products were fou...

Determination of the metabolism pathway of xenobiotics undergoing the hepatic pass is a crucial aspect in drug development since the presence of toxic biotransformation products may result in significant side effects during the therapy. In this study...

We investigated how students’ lunar phases learning outcomes were affected by student and teacher demographic characteristics (gender, race/ethnicity, spatial thinking ability, and content knowledge). The study identified moderately strong corr...

Based on the stimuli–organism–response framework, this study investigates how artistic stimuli (i.e., interior design) influence a person’s mental responses (i.e., situational satisfaction and stress). Prior to checking the main analysis, demographic...

This multi-national study hypothesized that higher levels of country-level gender equality would predict smaller differences in the frequency of women’s compared to men’s drinking in public (like bars and restaurants) settings and possibly private (h...

Resilience is widely accepted as the capacities implemented to manage climate change. Exploring how individual resilience can be enhanced to better prepare residents for natural disasters, such as urban flooding, is therefore necessary. Environmental...

Current resident lifestyles pose a significant threat to urban sustainable development. Therefore, low-carbon behavior is receiving increasing attention from scholars and policy makers. Ascertaining residential self-selection is essential in order to...

Advanced heart failure (AdHF) represents a challenging aspect of heart failure patients. Because of worsening clinical symptoms, high rates of re-hospitalization and mortality, AdHF represents an unstable condition where standard treatments are inade...

This mixed-method study investigated how primary school mathematics teachers in South Africa and Germany utilise educational technology. The perceptions of the principals and teachers regarding the use of educational technology and the obstacles to i...

The waste of electrical and electronic equipment (WEEE) is generally considered a secondary raw material for the recovery of valuable components. However, emerging issues regarding the impact of suspended particles arising from WEEE recycling operati...