Special Issue "Analysis of Xenobiotics and their Residues in Food, Biological and Environmental Samples by Chromatographic Techniques Coupled with Modern Detection Techniques"
Deadline for manuscript submissions: 31 October 2019
Dr. Tomasz Tuzimski (Ph.D., Adjunct Professor)
Medical University of Lublin, Faculty of Pharmacy with Medical Analytics Division, Chair of Chemistry, Department of Physical Chemistry, 4A Chodźki Street, PL-20093 Lublin, Poland
Interests: theory and application of liquid chromatography; modern extraction techniques (eg., QuEChERS); detection techniques (DAD, FLD, MS, MS/MS); method development and validation; optimisation of chromatographic systems for separation and quantitative analysis of xenobiotics and others (multicomponent mixtures) in food, environmental and biological samples
In their daily life, humans constantly encounter a huge amount of different substances, including xenobiotics, which are typically synthetic chemicals that are foreign to the body and/or to an ecological system. Xenobiotics can exert adverse effects on human health and increase the incidence of chronic diseases, including cancer, Parkinson’s, Alzheimer’s, multiple sclerosis, diabetes, cardiovascular, chronic kidney disease, and others. As a consequence, the development and validation of analytical methods for xenobiotics has become essential.
The choice of an appropriate extraction and analytical method for separation and final determination is closely related to the properties of the target compounds and matrices.
Common steps of sample treatment in most of the analytical methods reported for mixtures of xenobiotics and derivatives include sample pretreatment, extraction of analytes from the matrix, clean-up of the extracts to remove interferences, and concentration to achieve the desired sensitivity. Incontestable progress has been made during the past years regarding the development of techniques for the preparation of samples for analysis such as QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe), Solid Phase Extraction (SPE), Solid Phase Microextraction (SPME), Stir Bar Sorptive Extraction (SBSE), Hallow-Fiber Liquid Phase Microextraction (HFLPME), Dispersive Liquid–Liquid Microextraction (DLLME) or Focused Ultrasonic Solid-Liquid Extraction (FUSLE), and others.
The challenge for the analyst is to develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost. The most efficient approach to xenobiotic analysis involves the use of chromatographic methods. The following chromatographic methods are most frequently applied in environmental/biological samples and food analysis: high-performance liquid chromatography (HPLC), ultrahigh-performance liquid chromatography (UPLC), gas chromatography (GC) and multidimensional chromatographic techniques.
This Special Issue will present in a structured manner state-of-the-art information on the very important field of high-performance chromatographic techniques coupled with modern detection techniques, i.e., high resolution mass spectrometry (HRMS). It is a well-established fact that chromatographic techniques with high resolution mass spectrometry (HRMS) find broad application in the separation, identification, and quantification of important components such as xenobiotics (drugs and veterinary drugs, vitamins, dyes, mycotoxins, environmental bioindicators, allergens, and others).
I warmly invite our colleagues to submit their original contributions to this Special Issue in order to provide updates regarding chromatographic methods for xenobiotics analysis of food, biological and environmental samples that will be of interest to our readers.
I would be delighted if you could respond to confirm your contribution and the proposed title by 30 June 2019 to assist in planning the whole project. In the case of review articles, an additional brief (1–2 page) description of the topic including a draft index is required. This preliminary step is essential to avoid the overlapping of topics. The degree of novelty and the significance of the research will be scrutinized prior to the peer-review process.
Dr. Tomasz Tuzimski (Ph.D., Adjunct Professor)
Manuscript Submission Information
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- xenobiotics (drugs and veterinary drugs, vitamins, dyes, mycotoxins, environmental bioindicators, allergens, pesticides, and others)
- extraction techniques (QuEChERS/d-SPE, SPE, SPME, SBSE, HFLPME, DLLME, FUSLE, and others)
- chromatographic methods (HPLC, UPLC, GC, GC x GC, and others)
- detection techniques (DAD, FLD, MS, MS/MS, and others)