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85 Results Found

  • Article
  • Open Access
1 Citations
1,392 Views
27 Pages

Financial time-series data often exhibit statistically significant skewness and heavy tails, and numerous flexible distributions have been proposed to model them. In the context of the Log-linear Realized GARCH model with Skew-t (ST) distributions, o...

  • Article
  • Open Access
14 Citations
3,769 Views
20 Pages

Ginsenoside Rg5 Sensitizes Paclitaxel—Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel—And Enhances the Anticancer Effect of Paclitaxel

  • Janani Ramesh,
  • Rejani Chalikkaran Thilakan,
  • Raja Mohan Gopalakrishnan,
  • Singaravel Vijayapoopathi,
  • Arianna Dorschel and
  • Bhuvarahamurthy Venugopal

24 June 2022

In cervical cancer chemotherapy, paclitaxel (PTX) chemoresistance has become a major difficulty, and it also affects the survival rate of numerous tumor patients. Thus, for the reversal of chemoresistance, it is imperative to develop combinatory drug...

  • Article
  • Open Access
1 Citations
2,187 Views
15 Pages

Assessment of Gravity Deportment of Gold-Bearing Ores: Gravity Recoverable Gold Test

  • Oldřich Šigut,
  • Tomáš Široký,
  • Iva Janáková,
  • Radek Střelecký and
  • Vladimír Čablík

16 December 2024

This study investigated the potential of low-grade gold deposits in modern mining, particularly in the context of declining high-grade resources. The primary method for processing these ores was gravity separation with the Knelson concentrator. A GRG...

  • Article
  • Open Access
4 Citations
1,729 Views
11 Pages

Practical Approach for Determining Material Parameters When Predicting Austenite Grain Growth under Isothermal Heat Treatment

  • Mohd Kaswandee Razali,
  • Afaf Amera Abd Ghawi,
  • Missam Irani,
  • Suk Hwan Chung,
  • Jeong Muk Choi and
  • Man Soo Joun

6 October 2023

An investigation of austenite grain growth (AGG) during the isothermal heat treatment of low-alloy steel is conducted. The goal is to uncover the effect of time, temperature, and initial grain size on SA508-III steel grain growth. Understanding this...

  • Article
  • Open Access
824 Views
23 Pages

In recent days, aluminum-based hybrid composites have garnered more interest than monolithic alloys owing to their remarkable properties, encompassing a high strength-to-weight ratio, excellent corrosion resistance, and impressive wear durability. Th...

  • Article
  • Open Access
15 Citations
5,408 Views
20 Pages

15 August 2021

The application of fiber-reinforced plastic (FRP) composites as structural elements of air vehicles provides weight saving, which results in a reduction in fuel consumption, fuel cost, and air pollution, and a higher speed. The goal of this research...

  • Article
  • Open Access
12 Citations
3,347 Views
42 Pages

Multi-Objective and Multi-Variable Optimization Models of Hybrid Renewable Energy Solutions for Water–Energy Nexus

  • João S. T. Coelho,
  • Maaike van de Loo,
  • Juan Antonio Rodríguez Díaz,
  • Oscar E. Coronado-Hernández,
  • Modesto Perez-Sanchez and
  • Helena M. Ramos

23 August 2024

A new methodology, called HY4RES models, includes hybrid energy solutions (HESs) based on the availability of renewable sources, for 24 h of water allocation, using WaterGEMS 10.0 and PVGIS 5.2 as auxiliary calculations. The optimization design was a...

  • Communication
  • Open Access
27 Citations
6,140 Views
11 Pages

9 July 2013

In this communication our aim was to study the JK cell growth inhibitory and apoptosis-inducing effects of ginsenoside Rg6 (GRg6) from steamed notoginseng on human lymphocytoma. The CCK-8 method was used to observe the anti-proliferative effect of GR...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,054 Views
30 Pages

26 November 2024

Iron monosulfides and neoformed pyrite below the sulfate–methane transition zone (SMTZ) of rapidly accumulating turbiditic sediments from the Gaoping submarine canyon off southwestern Taiwan were examined by SEM-EDS-EBSD, HRTEM, and HAADF STEM...

  • Article
  • Open Access
11 Citations
3,629 Views
17 Pages

New Model for Analytical Predictions on the Bending Capacity of Concrete Elements Reinforced with FRP Bars

  • Kostiantyn Protchenko,
  • Przemysław Leśniak,
  • Elżbieta Szmigiera and
  • Marek Urbański

2 February 2021

Many studies on Fibre-Reinforced Polymers Reinforced Concrete (FRP-RC) beams tested in flexure have been performed by various researchers around the world. This work presents the results of statistical and mathematical analyses based on experimental...

  • Article
  • Open Access
8 Citations
2,062 Views
13 Pages

29 December 2023

In this study, we developed a unilateral knee actuated exoskeletal gait orthosis (KAEGO) for hemiplegic patients to conduct gait training in real-world environments without spatial limitations. For this purpose, it is crucial that the controller inte...

  • Article
  • Open Access
1,702 Views
14 Pages

22 January 2025

Numerical process modeling of continuous casting is increasingly applied to optimize production practices for higher product quality guarantees, in which real-time temperature prediction is the key factor that makes it possible to observe and optimiz...

  • Article
  • Open Access
32 Citations
8,006 Views
16 Pages

Ginsenoside Rg3 Improves Recovery from Spinal Cord Injury in Rats via Suppression of Neuronal Apoptosis, Pro-Inflammatory Mediators, and Microglial Activation

  • Dong-Kyu Kim,
  • Ki-Jung Kweon,
  • Pyungsoo Kim,
  • Hee-Jung Kim,
  • Sung-Soo Kim,
  • Nak-Won Sohn,
  • Sungho Maeng and
  • Jung-Won Shin

12 January 2017

Spinal cord injury (SCI) is one of the most devastating medical conditions; however, currently, there are no effective pharmacological interventions for SCI. Ginsenoside Rg3 (GRg3) is one of the protopanaxadiols that show anti-inflammatory, anti-oxid...

  • Article
  • Open Access
31 Citations
4,632 Views
14 Pages

20(S)-Ginsenoside Rg3 Promotes HeLa Cell Apoptosis by Regulating Autophagy

  • Shuai Bian,
  • Yue Zhao,
  • Fangyu Li,
  • Shuyan Lu,
  • Siming Wang,
  • Xueyuan Bai,
  • Meichen Liu,
  • Daqing Zhao,
  • Jiawen Wang and
  • Dean Guo

10 October 2019

20(S)-Ginsenoside Rg3 (GRg3) has various bioactivities including anti-cancer effects and inhibition of autophagy. However, no reports have investigated the appearance of autophagy or the connection between autophagy and apoptosis in HeLa cells treate...

  • Article
  • Open Access
1 Citations
1,290 Views
14 Pages

This study investigated whether ginsenoside Rg1 (G-Rg1) alleviated acute gouty arthritis (AGA) in rats by modulating the TLR4/NLRP3 pathway and neutrophil extracellular trap (NET) formation. Rats were orally administered G-Rg1 or colchicine (Col) for...

  • Article
  • Open Access
41 Citations
4,788 Views
14 Pages

27 June 2021

Ginsenoside Rk1 and Rg5 are minor ginseng saponins that have received more attention recently because of their high oral bioavailability. Each of them can effectively inhibit the survival and proliferation of human liver cancer cells, but the underly...

  • Article
  • Open Access
12 Citations
2,573 Views
26 Pages

Hybrid Artificial Intelligence Models with Multi Objective Optimization for Prediction of Tribological Behavior of Polytetrafluoroethylene Matrix Composites

  • Musa Alhaji Ibrahim,
  • Hüseyin Çamur,
  • Mahmut A. Savaş,
  • Alhassan Kawu Sabo,
  • Mamunu Mustapha and
  • Sani I. Abba

30 August 2022

This study presents multi-response optimization and prediction tribological behaviors polytetrafluoroethylene (PTFE) matrix composites. For multi-response optimization, the Taguchi model was hybridized with grey relational analysis to produce grey re...

  • Article
  • Open Access
24 Citations
3,316 Views
22 Pages

8 February 2020

As an essentially multi-input multi-output process, determination of optimal conditions for laser cladding normally requires multi-objective optimization. To understand multi-response coupling, the effects of processing parameters on the morphology q...

  • Article
  • Open Access
15 Citations
3,833 Views
14 Pages

Surface Characteristics and Color Stability of Gingiva-Colored Resin Composites

  • Aikaterini Petropoulou,
  • Maria Dimitriadi,
  • Spiros Zinelis,
  • Aspasia Sarafianou and
  • George Eliades

3 June 2020

The purpose of this study was to investigate the surface characteristics and color stability of gingiva-colored composite restorative materials (Anaxgum—ANG, Ceramage—CMG and Gradia Gum—GRG). The microstructure, composition, degree...

  • Article
  • Open Access
10 Citations
3,345 Views
12 Pages

The combination of Carthamus tinctorius extract (CTE) and notoginseng total saponins (NGTS), namely, CNP, presents a synergistic effect on myocardial ischemia protection. Herein, comparative pharmacokinetic studies between CNP and CTE/NGTS were condu...

  • Article
  • Open Access
728 Views
21 Pages

14 November 2025

STRange and Odd Morphology Extragalactic Radio Sources (STROMERSs) is a new category of radio galaxies that shows extremely peculiar anatomy. A purely manual visual search is carried out for the identification of such interesting sources. We reported...

  • Article
  • Open Access
29 Citations
2,330 Views
13 Pages

Multi-Objective Optimization of Machining Parameters for Drilling LM5/ZrO2 Composites Using Grey Relational Analysis

  • Sunder Jebarose Juliyana,
  • Jayavelu Udaya Prakash,
  • Robert Čep and
  • Krishnasamy Karthik

9 May 2023

In today’s world, engineering materials have changed dramatically. Traditional materials are failing to satisfy the demands of present applications, so several composites are being used to address these issues. Drilling is the most vital manufa...

  • Article
  • Open Access
1 Citations
1,624 Views
14 Pages

Simultaneous Quantification of Main Saponins in Panax vietnamensis by HPLC-PDA/ELSD Using the Quantitative Analysis of Multi-Components by Single-Marker Method

  • Thi-My-Duyen Ngo,
  • Thi Kim Ngan Tran,
  • Thi Minh Thu Le,
  • Mong Kha Tran,
  • Huu Son Nguyen,
  • Huy Truong Nguyen and
  • Kim Long Vu-Huynh

Background: The Quantitative Analysis of Multi-components by Single-marker (QAMS) method has been developed as an alternative to the External Standards Method (ESM) for the quality control of medicinal herbs. Objectives: In this study, QAMS was devel...

  • Article
  • Open Access
25 Citations
3,631 Views
18 Pages

Optimization of Wire EDM Process Parameters for Machining Hybrid Composites Using Grey Relational Analysis

  • Sunder Jebarose Juliyana,
  • Jayavelu Udaya Prakash,
  • Charles Sarala Rubi,
  • Sachin Salunkhe,
  • Sharad Ramdas Gawade,
  • Emad S. Abouel Nasr and
  • Ali K. Kamrani

28 October 2023

The materials used in engineering have seen a significant transformation in the contemporary world. Numerous composites are employed to overcome these problems because conventional materials are unable to meet the needs of current applications. For q...

  • Article
  • Open Access
5 Citations
3,051 Views
13 Pages

Application of Gamma Ray-Responsive Genes for Transcriptome-Based Phytodosimetry in Rice

  • Jin-Hong Kim,
  • Kwon Hwangbo,
  • Eujin Lee,
  • Shubham Kumar Dubey,
  • Moon-Soo Chung,
  • Byung-Yeoup Chung and
  • Sungbeom Lee

13 May 2021

Transcriptome-based dose–response curves were recently applied to the phytodosimetry of gamma radiation in a dicot plant, Arabidopsis thaliana, as an alternative biological assessment of genotoxicity using DNA damage response (DDR) genes. In the pres...

  • Article
  • Open Access
8 Citations
2,558 Views
15 Pages

Ameliorative Effect of Ginsenoside Rg6 in Periodontal Tissue Inflammation and Recovering Damaged Alveolar Bone

  • Won-Jin Lee,
  • Eun-Nam Kim,
  • Nguyen Minh Trang,
  • Jee-Hyun Lee,
  • Soo-Hyun Cho,
  • Hui-Ji Choi,
  • Gyu-Yong Song and
  • Gil-Saeng Jeong

20 December 2023

Periodontal disease is a chronic disease with a high prevalence, and in order to secure natural materials to prevent oral diseases, new materials that protect periodontal tissue from inflammation are being sought. Genes were identified using real-tim...

  • Article
  • Open Access
16 Citations
6,867 Views
12 Pages

Accumulation of Saponins in Underground Parts of Panax vietnamensis at Different Ages Analyzed by HPLC-UV/ELSD

  • Kim Long Vu-Huynh,
  • Huy Truong Nguyen,
  • Thi Hong Van Le,
  • Chi Thanh Ma,
  • Gwang Jin Lee,
  • Sung Won Kwon,
  • Jeong Hill Park and
  • Minh Duc Nguyen

Panax vietnamensis (PV), a wild Panax species discovered in Vietnam in 1973, has been increasingly overexploited due to its economic value and therapeutic uses. This resulted in the development of PV cultivation to meet the market demand. There is li...

  • Article
  • Open Access
11 Citations
2,821 Views
22 Pages

28 July 2021

The present Global Navigation Satellite System (GNSS) can provide at least double-frequency observations, and especially the Galileo Navigation Satellite System (Galileo) can provide five-frequency observations for all constellation satellites. In th...

  • Article
  • Open Access
18 Citations
2,681 Views
20 Pages

27 May 2024

Efficiently managing multiple process parameters is critical for achieving optimal performance in additive manufacturing. This study investigates the relationship between eight key parameters in fused deposition modeling (FDM) and their impact on res...

  • Article
  • Open Access
16 Citations
5,533 Views
14 Pages

29 April 2022

Pulsed electric field (PEF) processing is an emerging non-thermal technology that shows the potential to improve food quality and maintain stability. However, the attributes and retrogradation properties of food products made of PEF-treated rice grai...

  • Article
  • Open Access
13 Citations
3,329 Views
16 Pages

17 December 2022

With the increased frequency of red ginseng extract (RGE) and lactic acid bacteria (LAB) co-administration, we aimed to investigate the interactions between RGE and LAB with regard to in vitro and in vivo deglycosylation metabolism and the pharmacoki...

  • Article
  • Open Access
26 Citations
4,468 Views
23 Pages

Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice

  • Ji-Hyeon Jeon,
  • Jaehyeok Lee,
  • Jin-Hyang Park,
  • Chul-Haeng Lee,
  • Min-Koo Choi and
  • Im-Sook Song

This study aims to investigate the effect of lactic acid bacteria (LAB) on in vitro and in vivo metabolism and the pharmacokinetics of ginsenosides in mice. When the in vitro fermentation test of RGE with LAB was carried out, protopanaxadiol (PPD) an...

  • Article
  • Open Access
2 Citations
1,523 Views
15 Pages

15 November 2024

Solar air heaters play a crucial role in distributing heated air at low to medium temperatures. The heart of these systems lies in the absorber plate, which directly absorbs solar heat energy and then efficiently transfers it to the flowing air. Howe...

  • Article
  • Open Access
22 Citations
1,719 Views
12 Pages

1 January 2014

Response Surface Methodology (RSM) is a method that uses a combination of statistical techniques and experimental design for modelling and optimization problems. Many researchers have studied the integration of heuristic methods and RSM in recent yea...

  • Article
  • Open Access
317 Views
25 Pages

Integrative Single-Cell and Machine Learning Analysis Develops a Glutamine Metabolism–Based Prognostic Model and Identifies MSMO1 as a Therapeutic Target in Osteosarcoma

  • Hui Ma,
  • Haiyang Zhang,
  • Johny Bajgai,
  • Md. Habibur Rahman,
  • Thu Thao Pham,
  • Chaodeng Mo,
  • Buchan Cao,
  • Yeong-eun Choi,
  • Cheol-Su Kim and
  • Kyu-Jae Lee

28 November 2025

Although metabolic pathways profoundly influence disease behavior, osteosarcoma (OS) still lacks a glutamine metabolism–based framework for patient stratification. By integrating single-cell RNA sequencing with bulk cohorts, we delineated a glu...

  • Article
  • Open Access
8 Citations
3,993 Views
16 Pages

12 August 2020

This paper aims to provide a novel construct that is based on data envelopment analysis (DEA) range adjusted measure (RAM) of efficiency and demonstrate its practical implementation by evaluating the financial performance of a sample of three upper-c...

  • Article
  • Open Access
15 Citations
2,987 Views
12 Pages

Parametric Analysis of Epoxy/Crumb Rubber Composite by Using Taguchi—GRA Hybrid Technique

  • Kiran Shahapurkar,
  • Venkatesh Chenrayan,
  • Belay Brehane Tesfamarium,
  • Manzoore Elahi M. Soudagar,
  • Nazia Hossain,
  • Ali A. Rajhi,
  • Sagr Alamri,
  • Ibrahim M. Alarifi,
  • Pavan Shahapurkar and
  • M. A. Mujtaba
  • + 2 authors

7 October 2021

Effect of parameters affecting solid particle erosion of crumb rubber epoxy composite is investigated. Five important process parameters—impact velocity, impingement angle, standoff distance, erodent size, and crumb rubber content—are taken into cons...

  • Proceeding Paper
  • Open Access
1,224 Views
8 Pages

CO2 Emissions Projections of the North American Cement Industry

  • Ángel Francisco Galaviz Román,
  • Seyedmehdi Mirmohammadsadeghi and
  • Golam Kabir

17 October 2024

Forecasting carbon dioxide (CO2) emissions has become a relevant issue. International organizations have emphasized the necessity of generating a plan to gradually reduce the concentrations of this pollutant to combat climate change. Cement industrie...

  • Article
  • Open Access
12 Citations
4,104 Views
14 Pages

23 November 2018

Due to the increasing environmental pressures, one of the most direct and effective way to achieve emission reduction is to reduce the CO2 emissions of the blast furnace process in the iron and steel industry. Based on the substance conservation and...

  • Article
  • Open Access
4 Citations
3,193 Views
20 Pages

25 April 2021

Petri nets are widely used to model concurrent software systems. Currently, there are many different kinds of Petri net tools that can analyze system properties such as deadlocks, reachability and liveness. However, most tools are not suitable to ana...

  • Article
  • Open Access
17 Citations
2,185 Views
15 Pages

12 July 2022

The objective of this investigational analysis was to study the influence of process variables on the response during the drilling of LM6/B4C composite materials. Stir casting was employed to produce the LM6/B4C composites. A Vertical Machining Cente...

  • Article
  • Open Access
6 Citations
5,423 Views
19 Pages

Analysis and Optimization of Atmospheric Drain Tank of Lng Carrier Steam Power Plant

  • Igor Poljak,
  • Toni Bielić,
  • Vedran Mrzljak and
  • Josip Orović

The atmospheric drain condensate system of a marine steam power plant is described and evaluated from the energetic and exergetic point of view at a conventional liquefied natural gas (LNG) carrier. Energy loss and exergy destruction rate were calcul...

  • Article
  • Open Access
11 Citations
4,265 Views
19 Pages

Cost-Based Optimization of Isolated Footing in Cohesive Soils Using Generalized Reduced Gradient Method

  • Muhammad Naqeeb Nawaz,
  • Agha Shah Ali,
  • Syed Taseer Abbas Jaffar,
  • Turab H. Jafri,
  • Tae-Min Oh,
  • Mirvat Abdallah,
  • Steve Karam and
  • Marc Azab

10 October 2022

This study presents a cost-based optimization model for the design of isolated foundations in cohesive soils. The optimization algorithm not only incorporates safety requirements in the form of ultimate limit state (ULS) and serviceability limit stat...

  • Article
  • Open Access
38 Citations
5,910 Views
15 Pages

Optimal Design for Compliant Mechanism Flexure Hinges: Bridge-Type

  • Chia-Nan Wang,
  • Fu-Chiang Yang,
  • Van Thanh Tien Nguyen,
  • Quoc Manh Nguyen,
  • Ngoc Thai Huynh and
  • Thanh Thuong Huynh

23 October 2021

Compliant mechanisms’ design aims to create a larger workspace and simple structural shapes because these mechanical systems usually have small dimensions, reduced friction, and less bending. From that request, we designed optimal bridge-type complia...

  • Article
  • Open Access
9 Citations
10,504 Views
12 Pages

9 July 2010

This paper presents an optimum design of a lightweight vehicle levitation electromagnet, which also provides a passive guide force in a magnetic levitation system for contactless delivery applications. The split alignment of C-shaped electromagnets a...

  • Article
  • Open Access
13 Citations
2,654 Views
18 Pages

The Impact of Hydrogen on a Stationary Gasoline-Based Engine through Multi-Response Optimization: A Desirability Function Approach

  • Jesus M. Padilla-Atondo,
  • Jorge Limon-Romero,
  • Armando Perez-Sanchez,
  • Diego Tlapa,
  • Yolanda Baez-Lopez,
  • Cesar Puente and
  • Sinue Ontiveros

28 January 2021

Several studies have been conducted on alternatives to fossil fuels in internal combustion engines. In this work, we present an analysis of the optimization of a spark ignition engine (SIE), which operates with a mix of gasoline and hydrogen. Thus, t...

  • Article
  • Open Access
11 Citations
5,093 Views
20 Pages

Modelling Forward Osmosis Treatment of Automobile Wastewaters

  • Anita Haupt,
  • Christian Marx and
  • André Lerch

22 August 2019

Forward osmosis (FO) has rarely been investigated as a treatment technology for industrial wastewaters. Within this study, common FO model equations were applied to simulate forward osmosis treatment of industrial wastewaters from the automobile indu...

  • Article
  • Open Access
19 Citations
6,592 Views
12 Pages

Increase in Protective Effect of Panax vietnamensis by Heat Processing on Cisplatin-Induced Kidney Cell Toxicity

  • Kim Long Vu-Huynh,
  • Thi Hong Van Le,
  • Huy Truong Nguyen,
  • Hyung Min Kim,
  • Ki Sung Kang,
  • Jeong Hill Park and
  • Minh Duc Nguyen

17 December 2019

Cisplatin is a platinum-based anticancer agent used for treating a wide range of solid cancers. One of the side effects of this drug is its severe nephrotoxicity, limiting the safe dose of cisplatin. Therefore, many natural products have been studied...

  • Article
  • Open Access
24 Citations
5,133 Views
15 Pages

Quantifying Temperature and Osmotic Stress Impact on Seed Germination Rate and Seedling Growth of Eruca sativa Mill. via Hydrothermal Time Model

  • Sheharyar Khan,
  • Abd Ullah,
  • Sami Ullah,
  • Muhammad Hamzah Saleem,
  • Mohammad K. Okla,
  • Abdulrahman Al-Hashimi,
  • Yinglong Chen and
  • Shafaqat Ali

9 March 2022

Germination models are quite helpful in predicting emergence times, dormancy periods, and their applications in crop management. This study investigated the germination behaviors of Eruca sativa Mill. in response to fluctuations in temperatures (Ts)...

  • Article
  • Open Access
3 Citations
3,048 Views
20 Pages

16 October 2023

The design of turbines used to convert thermal energy into electrical energy in an organic Rankine cycle (ORC) is crucial. A high-speed turbine requires high-performance bearings, which increases turbine manufacturing costs. In this study, a high-eff...

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