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  • Article
  • Open Access
14 Citations
10,559 Views
10 Pages

A Novel Biosurfactant, 2-Acyloxyethylphosphonate, Isolated from Waterblooms of Aphanizomenon flos-aquae

  • Kunimitsu Kaya,
  • Louise F. Morrison,
  • Geoffrey A. Codd,
  • James S. Metcalf,
  • Tomoharu Sano,
  • Hiroo Takagi and
  • Takuya Kubo

22 July 2006

A novel biosurfactant, 2-acyloxyethylphosphonate, was isolated from waterblooms of Aphanizomenon flos-aquae. Its structure was elucidated by chemical degradation and HRFABMS, GC/EI-MS and 1D- and 2D-NMR spectral analyses. The surfactant contained one...

  • Article
  • Open Access
11 Citations
5,645 Views
14 Pages

Molecular Verification of Bloom-forming Aphanizomenon flos-aquae and Their Secondary Metabolites in the Nakdong River

  • Hae-Kyung Park,
  • Mi-Ae Kwon,
  • Hae-Jin Lee,
  • Jonghee Oh,
  • Su-Heon Lee and
  • In-Soo Kim

Aphanizomenon spp. have formed harmful cyanobacterial blooms in the Nakdong River during spring, autumn, and now in winter, and the expansion of blooming period and area, associated with the global warming is predicted. The genus Aphanizomenon has be...

(This article belongs to the Special Issue Innovative Methods for Monitoring and Assessment of Contaminants in Aquatic Ecosystems)
  • Article
  • Open Access
4 Citations
4,056 Views
24 Pages

Aphanizomenon flos-aquae: A Biorefinery for Health and Energy—Unleashing Phycocyanin’s Power and Biogas Potential

  • Pilar Águila-Carricondo,
  • Raquel García-García,
  • Juan Pablo de la Roche,
  • Pedro Luis Galán,
  • Luis Fernando Bautista,
  • Juan J. Espada and
  • Gemma Vicente

24 May 2025

This study presents a biorefinery approach for Aphanizomenon flos-aquae, demonstrating its potential as a dual source for phycocyanin and biogas. The antioxidant capacity of the extract was evaluated using the ABTS•+ assay, while flow cytometry...

(This article belongs to the Section Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals)
  • Article
  • Open Access
16 Citations
7,178 Views
16 Pages

AphaMax®, an Aphanizomenon Flos-Aquae Aqueous Extract, Exerts Intestinal Protective Effects in Experimental Colitis in Rats

  • Maria Grazia Zizzo,
  • Gaetano Caldara,
  • Annalisa Bellanca,
  • Domenico Nuzzo,
  • Marta Di Carlo,
  • Stefano Scoglio and
  • Rosa Serio

26 November 2020

Background: Aphanizomenon flos-aquae (AFA) is a unicellular cyanobacterium considered to be a “superfood” for its complete nutritional profile and beneficial properties. We investigated possible beneficial effects of an AFA extract, comme...

(This article belongs to the Special Issue New Research in Dietary Supplements and Healthy Foods)
  • Review
  • Open Access
44 Citations
10,726 Views
18 Pages

21 June 2018

Previous studies of recreational waters and blue-green algae supplements (BGAS) demonstrated co-occurrence of Aphanizomenon flos-aquae (AFA) and cyanotoxins, presenting exposure risk. The authors conducted a systematic literature review using a GRADE...

(This article belongs to the Special Issue Cyanobacteria and Cyanotoxins: New Advances and Future Challenges)
  • Article
  • Open Access
37 Citations
5,479 Views
23 Pages

In recent years, the key role of oxidative stress in pathogenesis of oral diseases has been emphasized and the use of antioxidant agents has been encouraged. Aphanizomenon flos-aquae (AFA) is a unicellular blue-green alga with antioxidant and anti-in...

(This article belongs to the Special Issue Buccal Drug Delivery)
  • Article
  • Open Access
5 Citations
2,636 Views
11 Pages

Aphanizomenon flos-aquae can form extensive blooms from freshwater to the brackish environment and, being a diazotrophic species, contribute significantly to the nitrogen and carbon cycle. It occurs as single filaments or aggregates and could be...

(This article belongs to the Special Issue The Phenomenon of Toxin-Producing Cyanobacterial Blooms and Their Impact on Aquatic Organisms, Ecosystems, and Human Health)
  • Article
  • Open Access
4 Citations
3,139 Views
13 Pages

Evaluation of Genotoxic and Hemolytic Effects of Aphanizomenon flos-aquae and Microcystis aeruginosa Biomass Extracts on Human Blood Cells In Vitro

  • Nevena B. Đorđević,
  • Jovana Tubić Vukajlović,
  • Olivera Milošević-Đorđević,
  • Vladimir B. Mihailović,
  • Nikola Z. Srećković,
  • Aleksandra B. Rakonjac and
  • Snežana B. Simić

This study explores the in vitro effects of cyanotoxins from the methanolic extract of the cyanobacteria Aphanizomenon flos-aquae and Microcystis aeruginosa on human blood cells, with samples drawn from the Gruža reservoir in Serbia. These cyano...

(This article belongs to the Special Issue Advances in Research on Cyanobacteria)
  • Article
  • Open Access
11 Citations
6,521 Views
16 Pages

Aphanizomenon flos-aquae (AFA) Extract Prevents Neurodegeneration in the HFD Mouse Model by Modulating Astrocytes and Microglia Activation

  • Giacoma Galizzi,
  • Irene Deidda,
  • Antonella Amato,
  • Pasquale Calvi,
  • Simona Terzo,
  • Luca Caruana,
  • Stefano Scoglio,
  • Flavia Mulè and
  • Marta Di Carlo

Obesity and related metabolic dysfunctions are associated with neurodegenerative diseases, such as Alzheimer’s disease. Aphanizomenon flos-aquae (AFA) is a cyanobacterium considered a suitable supplement for its nutritional profile and benefici...

(This article belongs to the Section Molecular Biology)
  • Article
  • Open Access
103 Citations
10,042 Views
14 Pages

Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria

  • Lisa Spoof,
  • Agata Błaszczyk,
  • Jussi Meriluoto,
  • Marta Cegłowska and
  • Hanna Mazur-Marzec

30 December 2015

Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-a...

(This article belongs to the Special Issue Compounds from Cyanobacteria)
  • Article
  • Open Access
10 Citations
5,315 Views
12 Pages

Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility

  • Antonella Amato,
  • Simona Terzo,
  • Pierenrico Marchesa,
  • Angela Maffongelli,
  • Martina Martorana,
  • Stefano Scoglio and
  • Flavia Mulè

28 September 2021

The blue-green algae Aphanizomenon flos aquae (AFA), rich in beneficial nutrients, exerts various beneficial effects, acting in different organs including the gut. Klamin® is an AFA extract particularly rich in β-PEA, a trace-amine considered a neuro...

(This article belongs to the Section Phytochemicals and Human Health)
  • Article
  • Open Access
5 Citations
690 Views
10 Pages
Limnol. Rev.2017, 17(2), 79-88;https://doi.org/10.1515/limre-2017-0008 
(registering DOI)

19 December 2017

The first studies of phytoplankton of the River Warta in Poznań (Poland) were carried out in the 20th century (in 1922–23 and 1950–57). In the growing seasons the dominant groups were diatoms and green algae. Cyanobacteria were noted, but they did no...

  • Article
  • Open Access
5 Citations
6,244 Views
18 Pages

Positive Impacts of Aphanizomenon Flos Aquae Extract on Obesity-Related Dysmetabolism in Mice with Diet-Induced Obesity

  • Simona Terzo,
  • Pasquale Calvi,
  • Marta Giardina,
  • Giacoma Gallizzi,
  • Marta Di Carlo,
  • Domenico Nuzzo,
  • Pasquale Picone,
  • Roberto Puleio,
  • Flavia Mulè and
  • Antonella Amato
  • + 1 author

25 November 2023

The present study evaluated the ability of KlamExtra®, an Aphanizomenon flos aquae (AFA) extract, to counteract metabolic dysfunctions due to a high fat diet (HFD) or to accelerate their reversion induced by switching an HFD to a normocaloric die...

  • Review
  • Open Access
101 Citations
7,892 Views
16 Pages

30 November 2019

The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs. In particular, diets enriched with natural compounds have become an increasingly attractive, no...

(This article belongs to the Special Issue Redox Regulation of Metabolic Syndrome: From Biochemical Mechanisms to Nutritional Interventions)
  • Article
  • Open Access
5 Citations
11,307 Views
19 Pages

Several active principles from plants could trigger the release of stem cells from the bone marrow. Stem cell mobilizers have shown side effects in patients. Thus, the purpose of this paper is to find the natural products from plants (curcuminoids, g...

  • Article
  • Open Access
13 Citations
4,923 Views
14 Pages

Occurrence of Mycosporine-like Amino Acids (MAAs) from the Bloom-Forming Cyanobacteria Aphanizomenon Strains

  • Hang Zhang,
  • Yongguang Jiang,
  • Chi Zhou,
  • Youxin Chen,
  • Gongliang Yu,
  • Liping Zheng,
  • Honglin Guan and
  • Renhui Li

Mycosporine-like amino acids (MAAs) are widespread in various microbes and protect them against harsh environments. Here, four different Aphanizomenon species were isolated from severely eutrophic waterbodies, Lake Dianchi and the Guanqiao fishpond....

(This article belongs to the Collection Microalgae and Their Bioactive Molecules: From Basic Research to Applications)
  • Article
  • Open Access
5 Citations
3,000 Views
13 Pages

6 November 2021

Cyanobacteria bloom caused by water eutrophication has threatened human health and become a global environmental problem. To develop green algicides with strong specificity and high efficiency, three series of ester and amide derivatives from parent...

  • Article
  • Open Access
11 Citations
3,911 Views
13 Pages

4 November 2022

Bioactive peptides may exert beneficial activities in living organisms such as the regulation of glucose metabolism through the inhibition of alpha amylases. Algae and cyanobacteria are gaining a growing interest for their health-promoting properties...

(This article belongs to the Collection Bioactive Peptides: Challenges and Opportunities)
  • Article
  • Open Access
65 Citations
8,746 Views
23 Pages

Variability in Macro- and Micronutrients of 15 Commercially Available Microalgae Powders

  • Fabian Sandgruber,
  • Annekathrin Gielsdorf,
  • Anja C. Baur,
  • Benjamin Schenz,
  • Sandra Marie Müller,
  • Tanja Schwerdtle,
  • Gabriele I. Stangl,
  • Carola Griehl,
  • Stefan Lorkowski and
  • Christine Dawczynski

27 May 2021

The nutrient composition of 15 commercially available microalgae powders of Arthrospira platensis, Chlorella pyrenoidosa and vulgaris, Dunaliella salina, Haematococcus pluvialis, Tetraselmis chuii, and Aphanizomenon flos-aquae was analyzed. The Dunal...

  • Article
  • Open Access
10 Citations
6,181 Views
16 Pages

Determination of Heavy Metal Content: Arsenic, Cadmium, Mercury, and Lead in Cyano-Phycocyanin Isolated from the Cyanobacterial Biomass

  • Daiva Galinytė,
  • Gabrielė Balčiūnaitė-Murzienė,
  • Jūratė Karosienė,
  • Dmitrij Morudov,
  • Rima Naginienė,
  • Dalė Baranauskienė,
  • Jurgita Šulinskienė,
  • Ieva Kudlinskienė,
  • Arūnas Savickas and
  • Nijolė Savickienė

1 September 2023

Cyano-phycocyanin (C-PC) is a light-absorbing biliprotein found in cyanobacteria, commonly known as blue-green algae. Due to its antioxidative, anti-inflammatory, and anticancer properties, this protein is a promising substance in medicine and pharma...

(This article belongs to the Special Issue Phytochemical Profiles of Plant Materials: From Extracts to Added Value Ingredients)
  • Abstract
  • Open Access
1,326 Views
2 Pages

Viral Effect on Carbon and Nitrogen Cycling in Bloom-Forming Cyanobacteria

  • Sigitas Šulčius,
  • Jolita Kuznecova,
  • Adam Antosiak,
  • Gediminas Alzbutas,
  • Valiantsin Lukashevich and
  • Dariusz Dziga

Viruses can significantly influence the biogeochemical cycling of major nutrients through the infection and lysis of cyanobacteria, a globally important primary producer [...]

(This article belongs to the Proceedings of International Conference EcoBalt 2023 "Chemicals & Environment")
  • Review
  • Open Access
2 Citations
1,650 Views
20 Pages

15 September 2025

HCBs (Harmful Cyanobacterial Blooms) are increasing in freshwaters across the globe, particularly at lower latitudes. In Southern Europe, a decrease in annual precipitation and an increase in drought periods have enhanced the occurrence of HCBs, impa...

  • Article
  • Open Access
25 Citations
7,909 Views
20 Pages

Presence of Potential Toxin-Producing Cyanobacteria in an Oligo-Mesotrophic Lake in Baltic Lake District, Germany: An Ecological, Genetic and Toxicological Survey

  • Pawan K. Dadheech,
  • Géza B. Selmeczy,
  • Gábor Vasas,
  • Judit Padisák,
  • Wolfgang Arp,
  • Kálmán Tapolczai,
  • Peter Casper and
  • Lothar Krienitz

29 September 2014

Massive developments of potentially toxic cyanobacteria in Lake Stechlin, an oligo-mesotrophic lake in the Baltic Lake District of Germany raised concerns about toxic contamination of these important ecosystems. Field samples in the phase of mass de...

(This article belongs to the Section Marine and Freshwater Toxins)
  • Article
  • Open Access
1 Citations
1,971 Views
37 Pages

Floodplain lakes play a significant role in maintaining biological diversity and providing a food base for aquatic organisms. In 2023–2024, for the first time, we studied phytoplankton of five floodplain lakes of the transboundary Irtysh River...

(This article belongs to the Special Issue Environmental Risk Assessment of Aquatic Environments)
  • Article
  • Open Access
56 Citations
6,622 Views
18 Pages

Antioxidant and Cytoprotective Properties of Cyanobacteria: Potential for Biotechnological Applications

  • Adriana Guerreiro,
  • Mariana A. Andrade,
  • Carina Menezes,
  • Fernanda Vilarinho and
  • Elsa Dias

26 August 2020

Antioxidant compounds from cyanobacteria may constitute a natural alternative to current synthetic antioxidants, which contain preservatives and suspected toxicity. In this work, we evaluate the antioxidant potential of cyanobacterial strains of dist...

(This article belongs to the Special Issue Selected Papers from the 6th Iberian and 2nd Ibero-American Cyanotoxin Congress CIC2019)
  • Article
  • Open Access
11 Citations
10,279 Views
12 Pages

Effect of Rainfall and pH on Musty Odor Produced in the Sanbe Reservoir

  • Sangyeob Kim,
  • Shohei Hayashi,
  • Shingo Masuki,
  • Kazuhiro Ayukawa,
  • Shuji Ohtani and
  • Yasushi Seike

15 December 2021

Harmful cyanobacterial blooms are continuously formed in water systems such as reservoirs and lakes around the world. Geosmin and 2-methylisoborneol (2-MIB) produced by some species of cyanobacteria have caused odor problems in the drinking water of...

(This article belongs to the Section Water Quality and Contamination)
  • Article
  • Open Access
26 Citations
9,345 Views
13 Pages

28 August 2020

Food supplements with microalgae are becoming increasingly abundant and can be easily found anywhere. The most popular products are based on cyanophytes, such as Aphanizomenon flos-aquae, Arthrospira platensis and Limnospira maxima, or on chlorophyte...

(This article belongs to the Special Issue Selected Papers from the 6th Iberian and 2nd Ibero-American Cyanotoxin Congress CIC2019)
  • Article
  • Open Access
1 Citations
2,788 Views
17 Pages

Application of Targeted and Suspect Screening Workflows for Cyclic Peptide Cyanotoxin Profiling in Spirulina- and Klamath-Based Food Supplements

  • Laura Carbonell-Rozas,
  • M. Mar Aparicio-Muriana,
  • Roberto Romero-González,
  • Antonia Garrido Frenich,
  • Ana M. García-Campaña and
  • Monsalud del Olmo-Iruela

26 August 2025

Spirulina (Arthrospira spp.) and klamath (Aphanizomenon flos-aquae) are widely consumed cyanobacteria-based food supplements valued for their nutritional and health-promoting properties. However, these products are susceptible to contamination by cya...

(This article belongs to the Section Food Toxicology)
  • Article
  • Open Access
6 Citations
2,940 Views
13 Pages

Blue-Green Algae as Stimulating and Attractive Feeding Substrates for a Mediterranean Commercial Sea Urchin Species, Paracentrotus lividus

  • Paolo Solari,
  • Giorgia Sollai,
  • Viviana Pasquini,
  • Angelica Giglioli,
  • Roberto Crnjar and
  • Piero Addis

5 July 2023

Sea urchins rely on chemical senses to localize suitable food resources, therefore representing model species for chemosensory studies. In the present study, we investigated the chemical sensitivity of the Mediterranean sea urchin Paracentrotus livid...

(This article belongs to the Special Issue Algae—a Step Forward in the Sustainability of Resources)
  • Article
  • Open Access
27 Citations
4,867 Views
16 Pages

The Effect of a Combined Hydrogen Peroxide-MlrA Treatment on the Phytoplankton Community and Microcystin Concentrations in a Mesocosm Experiment in Lake Ludoš

  • Dariusz Dziga,
  • Nada Tokodi,
  • Damjana Drobac,
  • Mikołaj Kokociński,
  • Adam Antosiak,
  • Jakub Puchalski,
  • Wojciech Strzałka,
  • Mariusz Madej,
  • Zorica Svirčev and
  • Jussi Meriluoto

11 December 2019

Harmful cyanobacteria and their toxic metabolites constitute a big challenge for the production of safe drinking water. Microcystins (MC), chemically stable hepatotoxic heptapeptides, have often been involved in cyanobacterial poisoning incidents. A...

(This article belongs to the Section Marine and Freshwater Toxins)
  • Article
  • Open Access
3 Citations
2,185 Views
12 Pages

Non-Nitrogen-Fixers or Nitrogen-Fixers? Factors Distinguishing the Dominance of Chroococcal and Diazotrophic Cyanobacterial Species

  • Elżbieta Wilk-Woźniak,
  • Ewa Szarek-Gwiazda,
  • Edward Walusiak,
  • Joanna Kosiba and
  • Wojciech Krztoń

Global warming and eutrophication are the main factors driving the development of cyanobacterial dominance in aquatic ecosystems. We used a model linking water temperature, oxygen saturation, concentrations of PO43−, NO3−, NH4+, total dis...

(This article belongs to the Special Issue The Phenomenon of Toxin-Producing Cyanobacterial Blooms and Their Impact on Aquatic Organisms, Ecosystems, and Human Health)
  • Article
  • Open Access
122 Citations
16,168 Views
17 Pages

Detection of Cyanotoxins in Algae Dietary Supplements

  • Audrey Roy-Lachapelle,
  • Morgan Solliec,
  • Maryse F. Bouchard and
  • Sébastien Sauvé

25 February 2017

Algae dietary supplements are marketed worldwide as natural health products. Although their proprieties have been claimed as beneficial to improve overall health, there have been several previous reports of contamination by cyanotoxins. These product...

(This article belongs to the Section Marine and Freshwater Toxins)
  • Article
  • Open Access
31 Citations
6,874 Views
17 Pages

Cyanobacteria synthesize various harmful materials, including off-flavor substances and toxins, that are regarded as potential socio-economic and environmental hazards in freshwater systems, however, their production is still not well understood. In...

(This article belongs to the Section Environmental Science and Engineering)
  • Article
  • Open Access
1 Citations
1,544 Views
16 Pages

10 August 2025

Gehu Lake in the lower reaches of the Taihu Lake Basin has experienced water quality degradation due to increasing human activities, pollutant discharge, and non-point source pollution, which requires ecosystem restoration. Currently, the community s...

(This article belongs to the Special Issue NBS for Watershed Management: From Ecological Health Assessment to Ecosystem Restoration)
  • Article
  • Open Access
6 Citations
3,318 Views
11 Pages

13 October 2023

Cyanobacteria harmful algal blooms (cyanoHABs) can have impacts on human health, aquatic ecosystems, and the economy. Nutrient management is an important mitigation and even remediation strategy. In this work, the paralytic shellfish toxin (PST)-prod...

(This article belongs to the Section Marine and Freshwater Toxins)
  • Abstract
  • Open Access
2,123 Views
2 Pages

Climate change enhances the occurrence of HCBs (Harmful Cyanobacterial Blooms) worldwide, particularly in freshwater ecosystems, posing increased risks for local populations. The present work intends to conduct a spatiotemporal historical overview on...

(This article belongs to the Proceedings of The 7th Iberian Congress on Cyanotoxins/3rd Iberoamerican Congress on Cyanotoxins)
  • Article
  • Open Access
1,378 Views
15 Pages

Screening of Bioactive Microalgae from Freshwaters, Collected in Hue, Vietnam: Cytotoxic Constituents from Dolichospermum smithii HU04

  • Nguyen Thi Minh Hang,
  • Nguyen Thi Thu Ha,
  • Hoang Duc Manh,
  • Duong Thi Thuy,
  • Hoang Thi Quynh,
  • Nguyen Thi Thu Lien,
  • Nguyen Thi Tu Oanh,
  • Tran Huu Giap,
  • Buu Huu Tai and
  • Nguyen Xuan Nhiem
  • + 2 authors

1 January 2026

Background/Objectives: Microalgae are recognized as prolific producers of bioactive metabolites with pharmaceutical potential. This study aimed to isolate and characterize cytotoxic constituents from selected cytotoxic microalgae, collected in Hue ci...

(This article belongs to the Special Issue Functional Evaluation of Bioactive Compounds from Natural Sources, 2nd Edition)