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Open AccessArticle

Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria

1
Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6 A, 20520 Turku, Finland
2
Department of Marine Biotechnology, University of Gdańsk, Al. Marszałka Piłsudskiego 46, 81-378 Gdynia, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2016, 14(1), 8; https://doi.org/10.3390/md14010008
Received: 22 October 2015 / Revised: 22 December 2015 / Accepted: 23 December 2015 / Published: 30 December 2015
(This article belongs to the Special Issue Compounds from Cyanobacteria)
Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-aquae (40%) and Dolichospermum spp. (10%). Five new anabaenopeptins and nine previously known anabaenopeptins were isolated, and their putative structures were determined by tandem mass spectrometry. The activity of the peptides against carboxypeptidase A and protein phosphatase 1 as well as chymotrypsin, trypsin and thrombin was tested. All anabaenopeptins inhibited carboxypeptidase A (apart from one anabaenopeptin variant) and protein phosphatase 1 with varying potency, but no inhibition against chymotrypsin, trypsin and thrombin was observed. View Full-Text
Keywords: Anabaenopeptins; nodulapeptins; Baltic Sea; cyanobacteria; Nodularia spumigena; Aphanizomenon flos-aquae; Dolichospermum spp.; carboxypeptidase A; protein phosphatase 1 Anabaenopeptins; nodulapeptins; Baltic Sea; cyanobacteria; Nodularia spumigena; Aphanizomenon flos-aquae; Dolichospermum spp.; carboxypeptidase A; protein phosphatase 1
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Spoof, L.; Błaszczyk, A.; Meriluoto, J.; Cegłowska, M.; Mazur-Marzec, H. Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria. Mar. Drugs 2016, 14, 8.

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