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Molecules, Volume 30, Issue 22

November-2 2025 - 168 articles

Cover Story: Saffron (Crocus sativus L.) is rich in bioactive apocarotenoids with antioxidant, neuroprotective, and anticancer properties. To enhance its therapeutic efficacy, stigmas were extracted and purified via solid-phase extraction to enrich crocin and picrocrocin fractions. These extracts were included in liposomes prepared by the reverse-phase evaporation method, with saturated or unsaturated lipids used to enhance their bioavailability and gastrointestinal absorption by oral administration while protecting them from the harsh gastric environment and to promote their release in the gastrointestinal tract. Results indicate that liposomes show greater encapsulation capacity for hydrophilic apocarotenoids, supporting their use in improving the stability and bioavailability of saffron extracts for nutraceutical and pharmaceutical applications. View this paper
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Articles (168)

  • Article
  • Open Access
1,023 Views
15 Pages

Assessment of ADC Higher Order Structure Through 2D NMR Analysis

  • Emily M. Grasso,
  • Angela N. Marquard,
  • Zachary Sparta,
  • David Fry and
  • Nareshkumar Jain

20 November 2025

Antibody–drug conjugates (ADCs) represent a growing class of important chemotherapeutic molecules. Our understanding of the physical properties of the antibody, linker, and payload is still quite limited, but a better understanding may lead to...

  • Article
  • Open Access
654 Views
24 Pages

20 November 2025

Background: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation. Ganoderma lucidum glycoprotein (Gl-Gp) exhibits potent anti...

  • Article
  • Open Access
365 Views
18 Pages

Adaptive Serum Biochemistry Responses to Ethanol Administration in a Mouse Model: Implications for Metabolic Regulation Under Analgesia

  • Bożena Witek,
  • Krzysztof Wróbel,
  • Grażyna Świderska-Kołacz,
  • Szymon Zmorzyński,
  • Anna Wojciechowska and
  • Joanna Czerwik-Marcinkowska

20 November 2025

Analgesia, or reduced pain sensitivity, can result from pharmacological or stress-induced mechanisms, but human studies are limited by complex physiological and psychological variables. This study aimed to evaluate the impact of ethanol consumption o...

  • Review
  • Open Access
763 Views
30 Pages

20 November 2025

Biomimetic cell membrane-coated nanoparticles (BMCNPs) are an attractive drug delivery platform that combines the advantages of an inorganic core with the biological functionality of a natural cell membrane. This hybrid design merges the versatility...

  • Review
  • Open Access
739 Views
23 Pages

20 November 2025

Paired electrolysis represents a paradigm shift in overcoming the energy intensity of conventional CO2 electrolysis. By supplanting the oxygen evolution reaction with value-added anodic oxidations, this technology simultaneously slashes energy demand...

  • Article
  • Open Access
462 Views
15 Pages

Theoretical-Experimental Analysis to Elucidate the Mechanism of Action of Novel Anabolic Agents

  • Israel Quiroga,
  • Maura Cardenas-Garcia,
  • María Guadalupe Hernández-Linares,
  • Gabriel Guerrero-Luna and
  • Fermín Flores-Manuel

20 November 2025

Research into muscle tissue pathologies offers great opportunities for new pharmaceutical agents. Current therapies, including corticosteroids and immunosuppressants, have limited efficacy and significant adverse effects. In this context, steroidal h...

  • Article
  • Open Access
587 Views
17 Pages

Physicochemical Profiling, Bioactive Properties, and Spectroscopic Fingerprinting of Cow’s Milk from the Pampas Valley (Tayacaja, Peru): A Chemometric Approach to Geographical Differentiation

  • Eudes Villanueva,
  • Harold P. J. Ore-Quiroz,
  • Gino P. Prieto-Rosales,
  • Raquel N. Veliz-Sagarvinaga,
  • Yaser M. Chavez-Solano,
  • Elza Aguirre,
  • Gustavo Puma-Isuiza and
  • Beetthssy Z. Hurtado-Soria

20 November 2025

This study aimed to characterize the physicochemical and functional properties of bovine milk from four districts (Acraquia, Ahuaycha, Pampas, and Daniel Hernández) of the Pampas Valley, Tayacaja province, Huancavelica (Peru), and assess its g...

  • Article
  • Open Access
332 Views
10 Pages

Cytotoxic Cytochalasans from Sponge-Derived Aspergillus sp. SCSIO 41044

  • Xiaoyan Pang,
  • Ini Wong,
  • Qinlin Cao,
  • Junfeng Wang,
  • Xuefeng Zhou,
  • Bin Yang,
  • Junjian Wang,
  • Hong Wang and
  • Yonghong Liu

20 November 2025

Two new cytochalasans (1–2), along with eight known ones (3–10) were isolated from sponge-derived Aspergillus sp. SCSIO 41044. The planar structures of 1–2 were elucidated through extensive spectroscopic analyses and their absolute...

  • Article
  • Open Access
396 Views
10 Pages

Electrically Controlled Structures in Cholesteric Droplets with Planar Anchoring

  • Oxana O. Prishchepa,
  • Mikhail N. Krakhalev and
  • Anna P. Gardymova

20 November 2025

Structure transformations in cholesteric droplets with planar anchoring induced by an electric field are studied experimentally. The radial spherical structure is formed initially, then it transforms into the quasi-nematic untwisting state under the...

  • Article
  • Open Access
1 Citations
511 Views
19 Pages

20 November 2025

The presence of heavy metals in soils poses a serious threat due to these harmful elements being transported into the food chain. The aim of the presented research was to evaluate the effect of the extraction of selected heavy metals from soil with a...

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Molecules - ISSN 1420-3049