2025 November-2 - 168 articles
Antibody–drug conjugates (ADCs) represent a growing class of important chemotherapeutic molecules. Our understanding of the physical properties of the antibody, linker, and payload is still quite limited, but a better understanding may lead to...
Background: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation. Ganoderma lucidum glycoprotein (Gl-Gp) exhibits potent anti...
Analgesia, or reduced pain sensitivity, can result from pharmacological or stress-induced mechanisms, but human studies are limited by complex physiological and psychological variables. This study aimed to evaluate the impact of ethanol consumption o...
Biomimetic cell membrane-coated nanoparticles (BMCNPs) are an attractive drug delivery platform that combines the advantages of an inorganic core with the biological functionality of a natural cell membrane. This hybrid design merges the versatility...
Paired electrolysis represents a paradigm shift in overcoming the energy intensity of conventional CO2 electrolysis. By supplanting the oxygen evolution reaction with value-added anodic oxidations, this technology simultaneously slashes energy demand...
Research into muscle tissue pathologies offers great opportunities for new pharmaceutical agents. Current therapies, including corticosteroids and immunosuppressants, have limited efficacy and significant adverse effects. In this context, steroidal h...
This study aimed to characterize the physicochemical and functional properties of bovine milk from four districts (Acraquia, Ahuaycha, Pampas, and Daniel Hernández) of the Pampas Valley, Tayacaja province, Huancavelica (Peru), and assess its g...
Two new cytochalasans (1–2), along with eight known ones (3–10) were isolated from sponge-derived Aspergillus sp. SCSIO 41044. The planar structures of 1–2 were elucidated through extensive spectroscopic analyses and their absolute...
Structure transformations in cholesteric droplets with planar anchoring induced by an electric field are studied experimentally. The radial spherical structure is formed initially, then it transforms into the quasi-nematic untwisting state under the...
The presence of heavy metals in soils poses a serious threat due to these harmful elements being transported into the food chain. The aim of the presented research was to evaluate the effect of the extraction of selected heavy metals from soil with a...
The development of environmentally friendly materials for forensic applications is a growing area of interest. Traditional forensic methods often rely on resource-intensive processes and hazardous materials, and thus a demand for sustainable efficien...
In recent years, the marked increase in the abuse of fentanyl and its analogues has emphasized the importance of developing highly sensitive and selective analytical methods for their detection in biological matrices. Oral fluid (OF) has emerged as a...
Materials of the 2D zeolite class retain local catalytically active sites and the stability of traditional zeolites but with layered structures. Synthetic and naturally occurring single- and multilayer apophyllite-related compounds are prototypes of...
This study presents new findings on the conformational mobility of the nonsteroidal antiandrogen blocker, bicalutamide, in deuterated chloroform. Based on NOE NMR spectral analysis, quantitative information was obtained regarding the distribution of...
To apply molecular dynamics (MD) simulations in the study of virgin asphalt binder, researchers have relied on basis sets of representative model structures from the SARA categories of saturated aliphatics (S), naphthenic aromatics (A), polar aromati...
For a family of 24-atom triazine macrocycles, a single intramolecular hydrogen bond (IMHB) network leads to a conserved, hinge-like motif in solution. Modifications to the backbone of these macrocycles preserve this motif. Modifications to peripheral...
Acne is a common skin condition that causes pimples, redness and inflammation. Benzoyl peroxide (BENZ), salicylic acid (SAL), curcumin (CUR), rosmarinic acid (ROS) and resveratrol (RESV) exhibit antimicrobial, anti-inflammatory and antioxidant proper...
In this research, we studied the synthesis and characterization of a novel amidine derivative of benzoperimidine derived from 1-aminoanthraquinone, focusing on its emission properties and potential applications in confocal laser scanning microscopy....
Cycloplatinated complexes incorporating pyrene chromophores of the formulae (C^C*)Pt(acac) (3, 4), (C^C* = Pyrenyl-NHC, acac = acetylacetonate) were prepared and fully characterized. For comparison, two regioisomeric complexes were prepared following...
Accurate and sensitive determination of hormones in biological matrices is essential for clinical diagnostics, therapeutic monitoring, and endocrine research. However, hormone determination presents significant challenges due to their typically low c...
Background: Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow. (ZS) is a valuable plant with diverse economic applications, as all its organs contain bioactive secondary metabolites. The seeds, known as Suanzaoren in traditional Chinese med...
The development of efficient and cost-effective catalysts is crucial for modern catalytic processes, especially in oxidation reactions. In this study, a sol–gel method was successfully adapted for the synthesis of NiO-Fe2O3-SiO2/Al2O3 catalysts...
The lack of complex schemes and proper kinetic studies for asphaltenes pyrolysis is a significant problem for understanding the reaction mechanisms. Therefore, this study evaluates various parameter estimation approaches (focusing on reaction rate co...
This study examines the impact of metal coordination on the antioxidant and pro-oxidant properties of 3,4-dihydroxybenzoic acid (3,4-DHBA) and caffeic acid (CA). Their Na(I), K(I) salts and Cr(III) complexes were evaluated in vitro using radical scav...
The recalcitrance and biological toxicity of phenolic pollutants pose a serious threat to the safety of aquatic environments, and developing efficient and stable catalytic degradation technologies is a key research focus in the current environmental...
This study investigates all-solid-state batteries employing multifunctional metallic current collectors/electrodes that remain electrochemically inert toward an alkali-based Na ion solid electrolyte. Inconel 625 was evaluated as the positive current...
The present study explores novel alternatives for the exploitation of sugarcane bagasse ash by obtaining and modifying SiO2 nanoparticles through a green synthesis method. The hydrophilic nature of the nanoparticles was modified using oleic acid. The...
Accumulation of plastic debris in marine environments has become a critical global issue, with microplastics (MPs) posing persistent ecological risks. This review synthesizes current knowledge on the formation mechanisms of MPs from polyolefins such...
Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp3)-H bond formation with N-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp3)–S bonds under...
Triarylmethyl radicals (TAMs) have recently emerged as highly effective polarizing agents in dynamic nuclear polarization (DNP) under viscous conditions, enabling substantial hyperpolarization via the solid-effect (SE) DNP mechanism even at room temp...
Capsaicin, a natural bioactive compound, has attracted wide interest for its potential health benefits. However, its rapid metabolism and strong irritancy upon oral administration have greatly limited its further application. To address these issues,...
Propolis is a well-known sticky, resinous substance collected by honeybees (Apis mellifera) from the buds of trees and other plants, then mixed with beeswax and their own glandular secretions. Its chemical composition varies widely depending on the b...
A polymethacrylate matrix (PMM) is proposed for the solid-phase extraction and determination of tetracycline (TC). The study of the influence of medium acidity, temperature, and contact time on the extraction of tetracycline by PMM showed that tetrac...
Stimuli-responsive microgels, smart polymeric particles at a micro- to sub-micro scale that are capable of undergoing reversible changes in response to external triggers, have emerged as versatile tools in the field of biomedical research. The review...
Cognitive decline associated with healthy ageing and pathological conditions is driven by multifactorial processes, including oxidative stress, mitochondrial dysfunction and chronic neuroinflammation. Alzheimer’s Disease (AD), a progressive neu...
Chiral mesoporous silica nanostructures (MSNs) have emerged as a cutting-edge material in nanotechnology. These nanostructures not only retain the tunable physicochemical properties of traditional MSNs—such as adjustable pore size, high surface...
Cancer remains a significant global public health concern. Numerous challenges still remain in its treatment. Recently, a novel two-dimensional material—violet phosphorene nanosheets (VPNS)—has shown considerable application potential in...
Cu-modified ferrites, prepared by solvothermal syntheses, at up to 200 °C, show the presence of copper metal particles, embedded in ferrite nanocrystalline particle agglomerates. Notably, these metallic copper micron-sized crystallites were drama...
The dysregulation of CK1 isoforms is linked to various types of diseases, including neurodegeneration and different types of neoplasia such as colon, pancreatic, breast, and ovarian cancer. For CK1 isoforms, a plethora of effective small molecule inh...
This study assesses the phytochemicals and bioactivity of four plant species: Polypodium vulgare, Chamaemelum nobile, Ocimum forsskaolii Benth, and Lavandula stoechas. Plant chemical composition was determined. Antioxidant activity was assessed using...
This is the first report on the electrochemical simulation of phase I metabolism of 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe), a relatively new psychoactive substance available on the illicit drug market. The e...
Protein tyrosine phosphatases (PTPs) are prominent enzymes which play pivotal roles in the regulation of multifarious cellular functions. Dysregulations of several PTPs have well-documented implications in the pathogenesis of various human diseases,...
According to the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC), type 2 diabetes mellitus (T2DM) remains a major public health issue with a considerable impact on human life, affecting over 38 mil...
The extra-heavy oil in the Tahe Oilfield of China has extremely high viscosity, as it is rich in the heavy components asphaltene and resin, creating significant difficulties in its exploitation and transportation. Therefore, it is important to effect...
We studied the impact of some magnetic nanoparticles on two wastewater models of Rhodamine B dye, with 5 µM and 10 µM concentrations. The magnetite nanoparticles, synthesized by the co-precipitation technique, having less than 20 nm diame...
Activated carbon beads, some of which contain Fe3O4 nanoparticles or graphene oxide, were synthesized by thermal activation (700 °C) of chitosan hydrogel beads. Materials showed a multiporous scale (micro/meso/macro) and BET specific surface area...
CCR8 chemokine receptor is a selective marker of tumor-infiltrating regulatory T cells (ti-Tregs) which interfere with the efficacy of checkpoint inhibitor immunotherapy (ICI) in many types of cancer. Eliminating CCR8+ ti-Tregs dramatically improves...
Predicting the solubility of active pharmaceutical ingredients (APIs) in binary solvent mixtures is a major challenge in formulation science, as physics-based models often fail to capture complex, non-additive mixing effects. This study presents a ro...
Quercetin, a dietary flavonoid, has demonstrated antioxidant, anti-inflammatory, and anti-tumor activities. Increasing evidence highlights that its metabolites contribute to these health benefits. This review summarizes current knowledge on the molec...
Using molecular dynamics simulations, we explore the impact of correlated monomer activity and star topology on the structure and dynamics of active polymers. Unlike uncorrelated active Brownian particle (ABP) stars, correlated activity induces a rat...
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