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Bioactive Compounds from Roots, Stems, Leaves, Flowers, Fruits, and Seeds: 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1274

Special Issue Editors


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Guest Editor
Department of Chemistry and Nano Science, College of Natural Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea
Interests: marine natural products; structure elucidation of natural products; antibacterial and anti-cancer natural products
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea
Interests: natural products; isolation and structure determination of natural compounds; standardization of traditional medine; analysis of compounds; pharmacognosy; traditional medicine; dietary supplement; food ingredients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to announce the 2nd edition of our Special Issue on bioactive compounds derived from medicinal plants. Building on the success of the first edition (Bioactive Compounds from Roots, Stems, Leaves, Flowers, Fruits, and Seeds in Molecules), which garnered significant interest and high-quality submissions, this new edition will continue to focus on the isolation and characterization of active constituents from various plant parts. In the present Special Issue, the isolation of bioactive compounds from roots, stems, leaves, flowers, fruits, and seeds of any medicinal plant and traditional medicine will be predominately covered. However, other relevant topics can be included, such as the following:

  • New bioactive compounds from any plant part, including roots, stems, leaves, flowers, fruits, and seeds;
  • Bioactive compounds from plants identified via a mechanism study;
  • Analysis of bioactive compounds from plants using a QNMR or MS-MS study, including a metabolomic study;
  • Isolation techniques for bioactive compounds from plants;
  • Standardization methods for active natural medicine or plants using active compounds.

We encourage a diverse range of submissions centered on the identification of bioactive compounds, while studies focused solely on bioassays or mechanisms using plant extracts will be excluded. We look forward to receiving your contributions as we continue to advance the research field of natural products.

Dr. Sang-Jip Nam
Prof. Dr. Eun Kyoung Seo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • roots, stems, leaves, flowers, fruits, and seeds
  • natural products
  • natural medicine
  • medicinal plants

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Related Special Issue

Published Papers (2 papers)

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Research

22 pages, 2210 KiB  
Article
Berberine and Palmatine Distribution Across Plant Organs in Berberis darwinii: Basis for Selecting Superior-Producing Accessions
by Manuel Chacón-Fuentes, César Burgos-Díaz, Mauricio Opazo-Navarrete, Alan Mercado and Fernando Westermeyer
Molecules 2025, 30(8), 1849; https://doi.org/10.3390/molecules30081849 - 20 Apr 2025
Viewed by 143
Abstract
Berberis darwinii, known for its bioactive alkaloids like berberine and palmatine, has gained attention for its medicinal properties. However, comprehensive studies on the specific bioactive molecules of Michay are lacking, as previous research has primarily focused on wild plants. Therefore, this study [...] Read more.
Berberis darwinii, known for its bioactive alkaloids like berberine and palmatine, has gained attention for its medicinal properties. However, comprehensive studies on the specific bioactive molecules of Michay are lacking, as previous research has primarily focused on wild plants. Therefore, this study proposes to evaluate the alkaloid content in various tissues of B. darwinii collected from different locations, aiming to identify high-yielding accessions suitable for consistent bioactive alkaloid production. This research focuses on plants from a cultivated Michay orchard established five years ago. Leaves, stems, roots, and fruits from 96 accessions of Michay were collected to obtain an alkaloidal extract used for the characterization and comprehensive analysis of bioactive alkaloids through high-performance liquid chromatography. Based on these results, a search for the main outliers was conducted to identify the accessions with the highest alkaloid production. The results showed that roots had the highest concentrations of both berberine and palmatine, followed by stems, while leaves and seeds had lower levels, and the pulp from fruits had no detectable alkaloids. Notably, alkaloid concentrations reached up to 30,806 µg/g in roots, with accession C2P18 standing out for its combined total of 20,827.74 µg/g of berberine and 9978.27 µg/g of palmatine. Accession C3P26 showed the highest berberine concentration at 26,482.20 µg/g. These values underscore the wide variation in alkaloid accumulation and highlight the potential for selecting elite accessions with exceptionally high yields. These findings highlight the importance of plant selection for optimal alkaloid extraction. Choosing high-yielding accessions and standardizing cultivation practices will ensure a stable supply of berberine and palmatine for pharmaceutical, nutraceutical, and food industry applications. Full article
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17 pages, 4435 KiB  
Article
Bioassay-Guided Isolation and Identification of Antibacterial Compounds from Invasive Tree of Heaven Stem and Trunk Bark
by Anna Cselőtey, Márton Baglyas, Nóra Király, Péter G. Ott, Vesna Glavnik, Irena Vovk and Ágnes M. Móricz
Molecules 2024, 29(24), 5846; https://doi.org/10.3390/molecules29245846 - 11 Dec 2024
Viewed by 952
Abstract
Flash column chromatographic fractionation of tree of heaven (Ailanthus altissima) stem and trunk bark extracts, guided by thin-layer chromatography (TLC)–Bacillus subtilis assay and TLC–heated electrospray high-resolution tandem mass spectrometry (HESI-HRMS/MS), lead to the isolation of six known compounds: (9Z [...] Read more.
Flash column chromatographic fractionation of tree of heaven (Ailanthus altissima) stem and trunk bark extracts, guided by thin-layer chromatography (TLC)–Bacillus subtilis assay and TLC–heated electrospray high-resolution tandem mass spectrometry (HESI-HRMS/MS), lead to the isolation of six known compounds: (9Z,11E)-13-hydroxy-9,11-octadecadienoic acid (13-HODE, A1), (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (9-HODE, A2), hexadecanedioic acid (thapsic acid, A3), 16-hydroxyhexadecanoic acid (juniperic acid, A4), 16-feruloyloxypalmitic acid (alpinagalanate, A5), and canthin-6-one (A6). Their structures were elucidated by HESI-HRMS/MS and one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy. This is the first study identifying A1A5 in A. altissima tree. Except for A5, all isolated compounds exhibited antibacterial activity against B. subtilis in microdilution assays. A6 showed the strongest effect with a minimum inhibitory concentration (MIC) value of 8.3 µg/mL. The antibacterial activity of A3 and A4 is newly described. Full article
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