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A Themed Issue in Honor of the 20th Anniversary of the Mexican Academy of Organic Chemistry (AMQO)

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1647

Special Issue Editors


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Guest Editor
CONAHCYT-Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca, Morelos 62209, Mexico
Interests: peptides; amino acids α-aminophosphonates; cancer; anti-inflammatory; antimicrobial; green chemistry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209 Cuernavaca, Morelos, Mexico
Interests: α-aminophosphonates; aminophosphonic acids; stereoselective synthesis; anti-inflammatory; multicomponent reaction; stereodivergent synthesis
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, 38206 La Laguna, Tenerife, Spain
Interests: peptides; amino acids; antimicrobial; proteins; phytosanitary; site-selective modification of peptides; fluorescent; cancer

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Guest Editor
Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, Mexico
Interests: enzymatic catalysts; synthesis of chiral compounds; anti-inflammatory activities; anticancer activities; antimicrobial activities; potential applications; plasticizers

Special Issue Information

Dear Colleagues,

Since its foundation, the Mexican Academy of Organic Chemistry (AMQO) has organized annual meetings at various universities across Mexico. These events bring together students, researchers, and industry professionals to share and discuss the latest trends and advancements in organic chemistry and related fields, fostering collaboration and knowledge exchange.

This Special Issue celebrates the 20th anniversary of AMQO, featuring contributions from leading research groups that have played a key role in the academy’s development and growth over the years.

Although AMQO primarily focuses on organic chemistry, this special edition takes a multidisciplinary approach, encompassing various branches of chemistry sciences, including natural products, organometallic chemistry, supramolecular, inorganic, theoretical, analytical, environmental chemistry, materials science, biochemistry and chemical engineering, among others.

This anniversary not only marks two decades of scientific progress but also reaffirms AMQO’s commitment to strengthening research and education in Chemistry, solidifying its role as a cornerstone of Mexico’s scientific and technological development. 

Dr. Ivan Romero-Estudillo
Prof. Dr. Mario Orodnez
Prof. Dr. Alicia Boto
Dr. David Chávez-Flores
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic chemistry
  • chemistry process
  • chemistry
  • chemical science
  • science in Mexico

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Published Papers (2 papers)

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Research

15 pages, 1210 KB  
Article
Theoretical-Experimental Analysis to Elucidate the Mechanism of Action of Novel Anabolic Agents
by Israel Quiroga, Maura Cardenas-Garcia, María Guadalupe Hernández-Linares, Gabriel Guerrero-Luna and Fermín Flores-Manuel
Molecules 2025, 30(22), 4486; https://doi.org/10.3390/molecules30224486 - 20 Nov 2025
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Abstract
Research into muscle tissue pathologies offers great opportunities for new pharmaceutical agents. Current therapies, including corticosteroids and immunosuppressants, have limited efficacy and significant adverse effects. In this context, steroidal hydrazone compound 4d was investigated for its ability to promote muscle growth and regeneration [...] Read more.
Research into muscle tissue pathologies offers great opportunities for new pharmaceutical agents. Current therapies, including corticosteroids and immunosuppressants, have limited efficacy and significant adverse effects. In this context, steroidal hydrazone compound 4d was investigated for its ability to promote muscle growth and regeneration as a potential anabolic and regenerative modulator. Flow cytometry analysis showed that 4d significantly increases cell populations in S phase, indicating a strong proliferative stimulus in pathways regulated by TNF-α, AKT, MAFbX, and SMAD2/3. Molecular docking studies showed that 4d shares strong interactions with the known MasR agonist (EP-2825), exhibiting a higher predicted binding affinity. Furthermore, 4d demonstrated the ability to interact with ACVR1/2A receptors, mimicking the binding profiles of known antagonists and potentially inhibiting myostatin/SMAD signaling. Taken together, experimental and computational evidence supports a dual-mechanistic model in which 4d promotes muscle proliferation and regeneration by (1) activating the MasR–PI3K/AKT/mTOR axis and (2) inhibiting the ACVR1/2A–SMAD pathway, counteracting the action of myostatin. These findings position compound 4d as a promising therapeutic candidate against muscle wasting disorders, including cancer-related cachexia, by inducing a robust and multifactorial anabolic response. Full article
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21 pages, 1414 KB  
Article
Practical and Efficient Synthesis of (E)-α,β-Unsaturated Amides Incorporating α-Aminophosphonates via the Horner–Wadsworth–Emmons Reaction
by Sindy Anahi Perez-Aniceto, Erica Cano-Tapia, Mario Ordoñez, José Luis Viveros-Ceballos and Ivan Romero-Estudillo
Molecules 2025, 30(18), 3730; https://doi.org/10.3390/molecules30183730 - 13 Sep 2025
Viewed by 900
Abstract
An efficient and practical procedure for the synthesis of (E)-α,β-unsaturated amides incorporating α-aminophosphonates, derived from readily accessible phosphonoacetamides, via the Horner–Wadsworth–Emmons (HWE) reaction was developed. The influence of reaction parameters, including base, solvent, and temperature, as well as the scope of [...] Read more.
An efficient and practical procedure for the synthesis of (E)-α,β-unsaturated amides incorporating α-aminophosphonates, derived from readily accessible phosphonoacetamides, via the Horner–Wadsworth–Emmons (HWE) reaction was developed. The influence of reaction parameters, including base, solvent, and temperature, as well as the scope of the method with different aldehydes, was examined, affording the target compounds in good yields and with high (E)-selectivity. The required phosphonoacetamides were conveniently prepared through a Kabachnik–Fields reaction of aldehydes, benzylamine and dimethyl phosphite followed by hydrogenolytic cleavage of the N-Bn bond, acylation with bromoacetyl bromide, and a subsequent Arbuzov reaction. This HWE protocol provides straightforward access to a broad range of (E)-α,β-unsaturated amides incorporating α-aminophosphonates under mild conditions, offering valuable scaffolds with potential pharmacological relevance as anticancer agents. Full article
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