Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.6
4.6
Journals
Molecules
Special Issues
A Themed Issue in Honor of the 20th Anniversary of...
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

A Themed Issue in Honor of the 20th Anniversary of the Mexican Academy of Organic Chemistry (AMQO)

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 4425

Special Issue Editors

Dr. Ivan Romero-Estudillo

E-Mail Website
Guest Editor
CONAHCYT-Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca, Morelos 62209, Mexico
Interests: peptides; amino acids α-aminophosphonates; cancer; anti-inflammatory; antimicrobial; green chemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mario Orodnez

E-Mail Website
Guest Editor
Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62209 Cuernavaca, Morelos, Mexico
Interests: α-aminophosphonates; aminophosphonic acids; stereoselective synthesis; anti-inflammatory; multicomponent reaction; stereodivergent synthesis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Alicia Boto

E-Mail Website
Guest Editor
Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Fco. Sánchez, 3, 38206 La Laguna, Tenerife, Spain
Interests: peptides; amino acids; antimicrobial; proteins; phytosanitary; site-selective modification of peptides; fluorescent; cancer
Dr. David Chávez-Flores

E-Mail Website
Guest Editor
Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, Mexico
Interests: enzymatic catalysts; synthesis of chiral compounds; anti-inflammatory activities; anticancer activities; antimicrobial activities; potential applications; plasticizers

Special Issue Information

Dear Colleagues,

Since its foundation, the Mexican Academy of Organic Chemistry (AMQO) has organized annual meetings at various universities across Mexico. These events bring together students, researchers, and industry professionals to share and discuss the latest trends and advancements in organic chemistry and related fields, fostering collaboration and knowledge exchange.

This Special Issue celebrates the 20th anniversary of AMQO, featuring contributions from leading research groups that have played a key role in the academy’s development and growth over the years.

Although AMQO primarily focuses on organic chemistry, this special edition takes a multidisciplinary approach, encompassing various branches of chemistry sciences, including natural products, organometallic chemistry, supramolecular, inorganic, theoretical, analytical, environmental chemistry, materials science, biochemistry and chemical engineering, among others.

This anniversary not only marks two decades of scientific progress but also reaffirms AMQO’s commitment to strengthening research and education in Chemistry, solidifying its role as a cornerstone of Mexico’s scientific and technological development. 

Dr. Ivan Romero-Estudillo
Prof. Dr. Mario Orodnez
Prof. Dr. Alicia Boto
Dr. David Chávez-Flores
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic chemistry
  • chemistry process
  • chemistry
  • chemical science
  • science in Mexico

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

19 pages, 2776 KB  
Article
Heteroditopic Bis-Urea and Bis-Thiourea Receptors on Merrifield and Wang Resins: Solid-Phase Synthesis and Ion-Pair Recognition
by Pedro Jancarlo Gomez-Vega, Octavio Juárez-Sánchez, Juan Carlos Gálvez-Ruiz, Enrique de la Re Vega, Judas Vargas-Durazo, Hisila Santacruz-Ortega and Karen Ochoa Lara
Molecules 2026, 31(7), 1126; https://doi.org/10.3390/molecules31071126 - 29 Mar 2026
Viewed by 421
Abstract
A library of twelve heteroditopic bis-urea and bis-thiourea receptors supported on Merrifield and Wang resins was prepared by solid-phase synthesis. The receptors incorporate dual hydrogen-bond-donor units for anion binding and a polyether spacer that simultaneously functions as a cation-binding site, enabling ion-pair recognition [...] Read more.
A library of twelve heteroditopic bis-urea and bis-thiourea receptors supported on Merrifield and Wang resins was prepared by solid-phase synthesis. The receptors incorporate dual hydrogen-bond-donor units for anion binding and a polyether spacer that simultaneously functions as a cation-binding site, enabling ion-pair recognition at the solid–liquid interface. Molecular recognition studies were performed using several inorganic and tetraalkylammonium salts, and fluorescence changes were monitored by microplate measurements in DMSO and DMSO/H2O (95:5, v/v). Univariate and factorial statistical analyses revealed statistically significant fluorescence changes and identified the structural variables governing guest recognition in each medium. Under the conditions examined, several systems exhibited reproducible ion-pair-induced fluorescence responses, highlighting the influence of receptor type and spacer architecture. These findings provide a basis for the rational optimization of supported receptors for sensing and extraction applications. Full article
(This article belongs to the Special Issue A Themed Issue in Honor of the 20th Anniversary of the Mexican Academy of Organic Chemistry (AMQO))
►▼ Show Figures

Figure 1

23 pages, 1747 KB  
Article
The Use of Benzoin as a Privileged Structure: Synthesis, Characterization, Crystalline Form and an In Vitro Biological Evaluation of 1,2-Diphenyl-2-[1,2,3]triazol-1-yl-ethanol Derivatives
by Noé Martínez-Romero, Mario Valle-Sánchez, Marco A. García-Eleno, Carlos A. González-González, David Corona-Becerril, Lizbeth Triana-Cruz, Diego Martínez-Otero, María Teresa Ramírez-Apan, David Morales-Morales, Jorge Andrés Ornelas-Guillén and Erick Cuevas-Yañez
Molecules 2026, 31(1), 170; https://doi.org/10.3390/molecules31010170 - 1 Jan 2026
Viewed by 920
Abstract
A collection of 40 derivatives of 1,2-diphenyl-2-[1,2,3]triazol-1-yl-ethanol was obtained through a sequence of reactions, starting with benzoin as the initial raw material and using the CuAAC reaction as the key step in this process. The structure of a pair of these compounds was [...] Read more.
A collection of 40 derivatives of 1,2-diphenyl-2-[1,2,3]triazol-1-yl-ethanol was obtained through a sequence of reactions, starting with benzoin as the initial raw material and using the CuAAC reaction as the key step in this process. The structure of a pair of these compounds was ultimately corroborated by single-crystal X-ray diffraction studies, which also reveals important O-H···N interactions. The antimicrobial activity of synthesized 1,2,3-triazoles was assessed against strains that include Candida albicans and Staphylococcus aureus. The antiproliferative properties of some of these novel compounds were also tested using a variety of tumor cell lines, including U251 (human glioblastoma), PC-3 (human prostate cancer cell line), K562 (human leukemia), HCT-15 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), and SKLU (human lung adenocarcinoma). Full article
(This article belongs to the Special Issue A Themed Issue in Honor of the 20th Anniversary of the Mexican Academy of Organic Chemistry (AMQO))
►▼ Show Figures

Figure 1

15 pages, 1210 KB  
Article
Theoretical-Experimental Analysis to Elucidate the Mechanism of Action of Novel Anabolic Agents
by Israel Quiroga, Maura Cardenas-Garcia, María Guadalupe Hernández-Linares, Gabriel Guerrero-Luna and Fermín Flores-Manuel
Molecules 2025, 30(22), 4486; https://doi.org/10.3390/molecules30224486 - 20 Nov 2025
Viewed by 1028
Abstract
Research into muscle tissue pathologies offers great opportunities for new pharmaceutical agents. Current therapies, including corticosteroids and immunosuppressants, have limited efficacy and significant adverse effects. In this context, steroidal hydrazone compound 4d was investigated for its ability to promote muscle growth and regeneration [...] Read more.
Research into muscle tissue pathologies offers great opportunities for new pharmaceutical agents. Current therapies, including corticosteroids and immunosuppressants, have limited efficacy and significant adverse effects. In this context, steroidal hydrazone compound 4d was investigated for its ability to promote muscle growth and regeneration as a potential anabolic and regenerative modulator. Flow cytometry analysis showed that 4d significantly increases cell populations in S phase, indicating a strong proliferative stimulus in pathways regulated by TNF-α, AKT, MAFbX, and SMAD2/3. Molecular docking studies showed that 4d shares strong interactions with the known MasR agonist (EP-2825), exhibiting a higher predicted binding affinity. Furthermore, 4d demonstrated the ability to interact with ACVR1/2A receptors, mimicking the binding profiles of known antagonists and potentially inhibiting myostatin/SMAD signaling. Taken together, experimental and computational evidence supports a dual-mechanistic model in which 4d promotes muscle proliferation and regeneration by (1) activating the MasR–PI3K/AKT/mTOR axis and (2) inhibiting the ACVR1/2A–SMAD pathway, counteracting the action of myostatin. These findings position compound 4d as a promising therapeutic candidate against muscle wasting disorders, including cancer-related cachexia, by inducing a robust and multifactorial anabolic response. Full article
(This article belongs to the Special Issue A Themed Issue in Honor of the 20th Anniversary of the Mexican Academy of Organic Chemistry (AMQO))
►▼ Show Figures

Graphical abstract

21 pages, 1414 KB  
Article
Practical and Efficient Synthesis of (E)-α,β-Unsaturated Amides Incorporating α-Aminophosphonates via the Horner–Wadsworth–Emmons Reaction
by Sindy Anahi Perez-Aniceto, Erica Cano-Tapia, Mario Ordoñez, José Luis Viveros-Ceballos and Ivan Romero-Estudillo
Molecules 2025, 30(18), 3730; https://doi.org/10.3390/molecules30183730 - 13 Sep 2025
Viewed by 1366
Abstract
An efficient and practical procedure for the synthesis of (E)-α,β-unsaturated amides incorporating α-aminophosphonates, derived from readily accessible phosphonoacetamides, via the Horner–Wadsworth–Emmons (HWE) reaction was developed. The influence of reaction parameters, including base, solvent, and temperature, as well as the scope of [...] Read more.
An efficient and practical procedure for the synthesis of (E)-α,β-unsaturated amides incorporating α-aminophosphonates, derived from readily accessible phosphonoacetamides, via the Horner–Wadsworth–Emmons (HWE) reaction was developed. The influence of reaction parameters, including base, solvent, and temperature, as well as the scope of the method with different aldehydes, was examined, affording the target compounds in good yields and with high (E)-selectivity. The required phosphonoacetamides were conveniently prepared through a Kabachnik–Fields reaction of aldehydes, benzylamine and dimethyl phosphite followed by hydrogenolytic cleavage of the N-Bn bond, acylation with bromoacetyl bromide, and a subsequent Arbuzov reaction. This HWE protocol provides straightforward access to a broad range of (E)-α,β-unsaturated amides incorporating α-aminophosphonates under mild conditions, offering valuable scaffolds with potential pharmacological relevance as anticancer agents. Full article
(This article belongs to the Special Issue A Themed Issue in Honor of the 20th Anniversary of the Mexican Academy of Organic Chemistry (AMQO))
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop