2026 October-1 - 219 articles
The simultaneous separation of therapeutic insulin analogues by capillary electrophoresis (CE) remains challenging because of their high structural similarity and their tendency to adsorb onto the capillary surface. This study investigated the applic...
Salidroside is a bioactive compound extracted from the traditional Chinese medicinal plant Rhodiola rosea that exerts differential regulatory effects on cell viability depending on cell type and physiological state. Sertoli cells are important testic...
Helichrysum italicum (Roth) G. Don subsp. italicum is one of the most valuable Mediterranean aromatic species owing to its essential oil, which is widely used in pharmaceutical, cosmetic, and nutraceutical applications. However, comparative phytochem...
Understanding the molecular organization of surfactants at the sc-CO2/water interface is essential for the rational design of CO2-philic interfacial formulations with reduced fluorine content. In this work, three low-fluorinated anionic surfactants (...
Sacha inchi oil is a highly unsaturated edible oil with considerable nutritional value but high susceptibility to oxidative deterioration. This study evaluated the effects of matico (Piper aduncum L.), real lemon (Citrus limon (L.) Burm. f.), and spe...
Pyrazine (1,4-diazine) and its annulated derivatives are promising platforms for colorimetric and fluorescent chemosensors of biologically and environmentally relevant metal cations, including Hg2+, Cu2+, Zn2+, Pb2+, Fe3+, Al3+, Co2+, Ni2+, Ag+ and C...
Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid with promising anticancer activity, although its limited selectivity toward malignant over non-cancerous cells restricts its therapeutic potential. A series of mono- and bis-N-substituted tetrandr...
Chemicals are widely used to protect humans from biological threats. Ticks are among the most dangerous biological species, as they transmit dangerous diseases such as Q-fever, Crimean–Congo hemorrhagic fever, tick-borne encephalitis, and other...
This study aimed to obtain crude, purified, and fractionated anthocyanin-rich extracts of three black bean cultivars from the South Pacific Region of Mexico (Chiapas, Guerrero, and Oaxaca). The extracts were obtained using an Amberlite XAD-7HP column...
The use of herbal medicinal products and dietary supplements has increased significantly in recent years. Insufficient knowledge regarding the effects of herbal raw materials, as well as their potential adverse effects and interactions with medicatio...
In this study, thiazole derivatives 13–23 were synthesized as novel cholinesterase inhibitors. Their structures were elucidated using 1H-NMR, 13C-NMR, and elemental analysis techniques. The binding positions and efficiencies of the designed com...
Polyimide (PI) films serving as high-temperature dielectric and structural materials are increasingly required to combine mechanical robustness, thermal stability, and low dielectric properties for advanced electronic packaging. Herein, PI composite...
The present study describes the development and validation of a simple, rapid, and reliable RP-HPLC method for the simultaneous estimation of acyclovir and doxepin hydrochloride in bulk and topical cream formulation using an Analytical Quality by Des...
The occurrence of antimicrobial resistance (AMR) and chemoresistance (CMR) during bacterial infections and cancer progression, respectively, has become a serious threat leading to increased mortality rates and putting significant pressure on healthca...
Oxidative stress, mitochondrial dysfunction, and chronic neuroinflammation are closely interconnected processes involved in the pathogenesis and progression of neurodegenerative diseases. Bee-derived products, including honey, propolis, royal jelly,...
Ficus species are recognized for their nutritional and phytochemical diversity; however, the infructescences of Ficus benjamina and Ficus mathewsii remain underutilized. This study aimed to evaluate the nutritional composition, volatile and phenolic...
Optimizing the morphology and structure of noble metal nanomaterials is critical for the design of high-performance surface-enhanced Raman scattering (SERS) substrates for trace analyte detection. A plasmon-tunable SERS platform consisting of AuAg al...
The Gibbs equation describes the relationship between the enthalpy (∆H), entropy (∆S), and Gibbs energy (∆G) changes in physicochemical processes: ∆G = ∆H − T∆S. It remains a cornerstone of chemical thermodyn...
Njangsa seed oil (NSO) is rich in polyunsaturated fatty acids and represents an underexplored plant source for producing conjugated linoleic acid (CLA). This study explored the production of CLA from NSO via alkali isomerization, as well as and its s...
Ionic liquids (ILs) are often described as designer solvents. However, a single cation–anion pair rarely optimizes phase stability, transport properties, and task-specific functions simultaneously. Mixing introduces composition as a continuous...
Longitudinal bone growth is primarily regulated by the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis. However, non-hormonal and orally administered strategies for promoting longitudinal growth remain limited. Here, we investigated the...
Tm3+, Yb3+: GdxBi2−xWO6 series upconversion luminescent materials were synthesized via a solid-state method. Calculations and XRD analysis reveal that Gd3+ in the lattice exhibits both substitutional and interstitial doping. Compared with the N...
Ziziphus seeds, an abundant and low-cost lignocellulosic residue generated across the value chains of Z. mauritiana, Z. spina-christi, and Z. jujuba in arid and semi-arid regions, have emerged as a promising but under-synthesized feedstock for adsorp...
Cannabigerol (CBG) exerts vasorelaxant effects in human pulmonary arteries and lowers blood pressure (BP) in normotensive mice. However, data on the cardiovascular effects of CBG in hypertension and platelet function remain limited. Consequently, the...
Xenon (Xe) is an inert noble gas receiving increasing attention in medical research due to its anesthetic properties, ability to regulate metabolic processes, and broad organoprotective effects. Due to its small size and non-covalent intermolecular i...
The presence of organic pollutants in soil represents one of the main remediation challenges of the 21st century, and in this regard, peroxymonosulfate- (PMS) and persulfate (PS)-based advanced oxidation processes (AOPs) are among the most promising...
Ruta chalepensis L. var. angustifolia (Pers.) Willk. (Rutaceae) has been traditionally associated with hypocholesterolemic effects, although the bioactive metabolites responsible for this activity remain largely unknown. This study aimed to fractiona...
Background: DNase I inhibitors may be useful as biochemical tools and as potential leads for investigating pathological processes associated with excessive DNA degradation. Squaramides represent attractive scaffolds for drug discovery owing to their...
Layered transition-metal oxides (NaxTMO2) are among the most promising cathode candidates for sodium-ion batteries, yet their interfacial degradation under high voltage, deep desodiation, and humid environments remains the central bottleneck to comme...
Civilizational development, which depends on the availability of raw materials, has accelerated tremendously in recent decades. This is due to globalization and the growth of emerging markets. It represents a huge opportunity for an innovative approa...
Dietary polyphenols, abundant in fruits, vegetables, tea, coffee, cocoa, and wine, have been widely investigated for their potential relevance to cardiovascular health. Their proposed protective effects extend beyond classical antioxidant activity, e...
The rational design and fabrication of semiconductor photocatalysts possessing high intrinsic activity are pivotal for the remediation of tetracycline (TC)-contaminated aqueous streams. Herein, we synthesized a LaVO4/Bi2O2S heterostructure and compre...
Holy basil (Ocimum tenuiflorum) is well known for its bioactive properties, including antioxidant and anti-inflammatory effects. Leaves samples from Costa Rica were extracted and analyzed in composition and in antioxidant and cytotoxic activities. Th...
Different plants containing isoquinoline alkaloids are known to exhibit various biological activities such as anti-inflammatory, antimicrobial, antiviral, antioxidant, antihyperglycemic, cholesterol-lowering, antifungal and anticancer behaviors. Dise...
Chlorogenic acid (CA), the principal bioactive constituent of honeysuckle, is conventionally extracted by time-consuming methods using toxic organic solvents, which carry the risk of thermal degradation. This study provides a rapid and efficient micr...
Lonicera japonica Thunb. (L. japonica), an edible medicinal plant that has been widely consumed in East Asian countries, including China, Japan, and Korea, for centuries, has long been regarded as a superior herb in traditional Chinese medicine and i...
Water-soluble C60 derivatives functionalized with phenylacetic acid (PhAA) and benzylmalonic acid (BnMA), together with their di- and tetrahydroxylated derivatives, were investigated using density functional theory, molecular docking, and molecular d...
Polygonatum cyrtonema Hua in Jiuhua Mountain (JHPCH) is a nationally recognized geographically indicated medicinal plant known for its bioactive polysaccharides with diverse pharmacological activities. This study isolated a homogeneous polysaccharide...
The rapid expansion of the lithium industry has generated large quantities of lithium refinery residue (LRR), whose stockpiling and landfilling cause environmental risks and the loss of potentially recoverable resources. This review critically examin...
A triethanolamine (TEOA)-catalyzed, one-pot, three-component reaction of 4-hydroxycoumarin, aldehydes, and malononitrile was developed as a highly atom-economic domino protocol for the synthesis of biologically significant 4H-pyrano[3,2-c]coumarins....
Nickel is a widespread environmental pollutant originating from industrial activities, and its pollution problem persists globally. Currently, research on nickel ion metabolism and detoxification mechanisms primarily focuses on prokaryotes, while the...
Orthopedic site infections remain a growing concern in implantology, particularly in light of rising antibiotic resistance. Identifying optimal, standardized antimicrobial treatments is increasingly challenging. Beyond the design and functional prope...
Silver nanoparticles (AgNPs) have emerged as a promising nanoplatform for oncological intervention, yet their clinical translation is severely hampered by systemic toxicities associated with high effective doses, while the underlying mechanisms gover...
The intrinsic brittleness and poor crack resistance of OPC-based materials severely limit their service durability under complex environments. In this study, a composite latex polymer was fabricated via an ambient-temperature APS/STS redox initiation...
Colorectal cancer (CRC) remains a major global health burden, while conventional systemic therapies are limited by toxicity, drug resistance, suboptimal tumour exposure, and pharmacokinetic constraints. Recent advances in nanotechnology have produced...
Pleurotus djamor is cultivated on diverse lignocellulosic residues, but the relationship between progressive substrate formulation, mushroom productivity, and metabolomic responses remains insufficiently characterized. This study evaluated the effect...
Growing herbicide resistance and concerns regarding the environmental and health impacts of synthetic herbicides have intensified interest in plant-derived weed-management products. This review assesses the phytotoxic, herbicidal, and allelopathic po...
Anthraquinone-fused enediynes (AFEs) are a class of microbial natural products with remarkable cytotoxicity and exhibit promising application prospects in tumor therapy. Taking tiancimycins (TNMs) as an example, this class of compounds holds great po...
Dietitians routinely recommend refined high polyunsaturated fatty acid (PUFA) content culinary oils such as soybean, corn, canola, rapeseed and sunflower oils to pregnant women. Unfortunately, these PUFAs readily undergo peroxidation (especially at h...
Pyridine derivatives are prepared via the dehydrogenative aromatization of 1,4-dihydropyridines (1,4-DHPs). Among these methods, stoichiometric catalysis with high waste and electrochemical oxidation with less productivity are limited in their use. N...
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