Search Results (273)

This paper addresses the challenge of fostering cooperation among virtual power plant (VPP) operators in competitive electricity markets, focusing on the application of evolutionary game theory (EGT) and static reward–punishment mechanisms. This investigation resolves four critical questions: the minimum reward–punishment thresholds triggering stable cooperation, the influence of initial market composition on equilibrium selection, the sufficiency of static versus dynamic mechanisms, and the quantitative mapping between regulatory parameters and market outcomes. The study establishes the mathematical conditions under which static reward–punishment mechanisms transform competitive VPP markets into stable cooperative systems, quantifying efficiency improvements of 15–23% and renewable integration gains of 18–31%. Through rigorous evolutionary game-theoretic analysis, we identify critical parameter thresholds that guarantee cooperation emergence, resolving longstanding market coordination failures documented across multiple jurisdictions. Numerical simulations and sensitivity analysis demonstrate that static reward–punishment systems enhance cooperation, optimize resources, and increase renewable energy utilization. Key findings include: (1) Reward–punishment mechanisms effectively promote cooperation and system performance; (2) A critical region exists where cooperation dominates, enhancing market outcomes; and (3) Parameter adjustments significantly impact VPP performance and market behavior. The theoretical contributions of this research address documented market failures observed across operational VPP implementations. Our findings provide quantitative foundations for regulatory frameworks currently under development in seven national energy markets, including the European Union’s proposed Digital Single Market for Energy and Japan’s emerging VPP aggregation standards. The model’s predictions align with successful cooperation rates achieved by established VPP operators, suggesting practical applicability for scaled implementations. Overall, through evolutionary game-theoretic analysis of 156 VPP implementations, we establish precise conditions under which static mechanisms achieve 85%+ cooperation rates. Based on this, future work could explore dynamic adjustments, uncertainty modeling, and technologies like blockchain to further improve VPP resilience. Full article

Phosphatidylinositol 3-kinase alpha (PI3Kα) is frequently mutated in head and neck squamous cell carcinoma (HNSCC), leading to the constitutive activation of the PI3K/Akt pathway, which promotes tumor cell proliferation, survival, and metastasis. PI3Kα allosteric inhibitors demonstrate therapeutic potential as both monotherapy and combination therapy, particularly in patients with PIK3CA mutations or resistance to immunotherapy, through the precise targeting of mutant PI3Kα. Compared to ATP-competitive PI3Kα inhibitors such as Alpelisib, the allosteric inhibitor RLY-2608 exhibits enhanced selectivity for mutant PI3Kα while minimizing the inhibition of wild-type PI3Kα, thereby reducing side effects such as hyperglycemia. To date, no allosteric PI3Kα inhibitors have been approved for clinical use. To develop novel PI3Kα inhibitors with improved safety and efficacy, we employed a scaffold hopping approach to structurally modify RLY-2608 and constructed a compound library. Based on the structural information of the PI3Kα allosteric site, we conducted the systematic virtual screening of 11,550 molecules from databases to identify lead compounds. Through integrated approaches, including molecular docking studies, target validation, druggability evaluation, molecular dynamics simulations, and metabolic pathway and metabolite analyses, we successfully identified a promising novel allosteric PI3Kα inhibitor, H-18 (3-(2-chloro-5-fluorophenyl)isoindolin-1-one). H-18 has not been previously reported as a PI3Kα inhibitor, and provides an excellent foundation for subsequent lead optimization, offering a significant starting point for the development of more potent PI3Kα allosteric inhibitors. Full article

This research addresses the optimization and deployment of convolutional neural networks for eyeglasses detection on low-power edge devices. Multiple convolutional neural network architectures were trained and evaluated using the FFHQ dataset, which contains annotated eyeglasses in the context of faces with diverse facial features and eyewear styles. Several post-training quantization techniques, including Float16, dynamic range, and full integer quantization, were applied to reduce model size and computational demand while preserving detection accuracy. The impact of model architecture and quantization methods on detection accuracy and inference latency was systematically evaluated. The optimized models were deployed and benchmarked on Raspberry Pi 5 and NVIDIA Jetson Orin Nano platforms. Experimental results show that full integer quantization reduces model size by up to 75% while maintaining competitive detection accuracy. Among the evaluated models, MobileNet architectures achieved the most favorable balance between inference speed and accuracy, demonstrating their suitability for real-time eyeglasses detection in resource-constrained environments. These findings enable efficient on-device eyeglasses detection, supporting applications such as virtual try-ons and IoT-based facial analysis systems. Full article

Lactate dehydrogenase (LDH) catalyzes the reversible interconversion of pyruvate and lactate, coupled with the redox cycling of NADH and NAD⁺. While LDHA has been extensively studied as a therapeutic target, particularly in cancer, due to its role in the Warburg effect, LDHB remains underexplored, despite its involvement in the metabolic reprogramming of specific cancer types, including breast and lung cancers. Most known LDH inhibitors are designed against the LDHA isoform and act competitively at the active site. In contrast, LDHB exhibits distinct kinetic properties, substrate preferences, and structural features, warranting isoform-specific screening strategies. In this study, 115 natural compounds previously reported as LDHA inhibitors were systematically evaluated for LDHB inhibition using an integrated in silico and in vitro approach. Virtual screening identified 16 lead phytochemicals, among which luteolin and quercetin exhibited uncompetitive inhibition of LDHB, as demonstrated by enzyme kinetic assays. These findings were strongly supported by molecular docking analyses, which revealed that both compounds bind at an allosteric site located at the dimer interface, closely resembling the binding mode of the established LDHB uncompetitive inhibitor AXKO-0046. In contrast, comparative docking against LDHA confirmed their active-site binding and competitive inhibition, underscoring their isoform-specific behavior. Our findings highlight the necessity of assay conditions tailored to LDHB’s physiological role and demonstrate the application of a previously validated colorimetric assay for high-throughput screening. This work lays the foundation for the rational design of selective LDHB inhibitors from natural product libraries. Full article

Effective energy management in microgrids is essential for integrating renewable energy sources and maintaining operational stability. Machine learning (ML) techniques offer significant potential for optimizing microgrid performance. This study provides a comprehensive comparative performance evaluation of four ML-based control strategies: deep Q-networks (DQNs), proximal policy optimization (PPO), Q-learning, and advantage actor–critic (A2C). These strategies were rigorously tested using simulation data from a representative islanded microgrid model, with metrics evaluated across diverse seasonal conditions (autumn, spring, summer, winter). Key performance indicators included overall episodic reward, unmet load, excess generation, energy storage system (ESS) state-of-charge (SoC) imbalance, ESS utilization, and computational runtime. Results from the simulation indicate that the DQN-based agent consistently achieved superior performance across all evaluated seasons, effectively balancing economic rewards, reliability, and battery health while maintaining competitive computational runtimes. Specifically, DQN delivered near-optimal rewards by significantly reducing unmet load, minimizing excess renewable energy curtailment, and virtually eliminating ESS SoC imbalance, thereby prolonging battery life. Although the tabular Q-learning method showed the lowest computational latency, it was constrained by limited adaptability in more complex scenarios. PPO and A2C, while offering robust performance, incurred higher computational costs without additional performance advantages over DQN. This evaluation clearly demonstrates the capability and adaptability of the DQN approach for intelligent and autonomous microgrid management, providing valuable insights into the relative advantages and limitations of various ML strategies in complex energy management scenarios. Full article

Understanding user interaction patterns during technology-triggered public discourse provides critical insights into how emerging technologies gain social meaning. This study develops an intelligent digital twin framework for modeling discourse dynamics around DeepSeek, an indigenous large language model that generated approximately 250,000 social media interactions during a 13-day period. By integrating LLM-enhanced semantic analysis with agent-based modeling, we create a comprehensive virtual representation that captures both content characteristics and behavioral dynamics. Our analysis identifies six distinct thematic domains that structure public engagement: Technological Competition, Technological Breakthrough, User Feedback, Financial Market, Social Influence, and Information Security. The agent-based simulation reveals distinctive participation and sentiment patterns across different user segments, with general users expressing stronger positive sentiments than domain experts and institutional accounts. Network analysis demonstrates the evolution from random-like initial connection patterns to scale-free structures with pronounced influence hubs. The simulation results illuminate how individual behaviors aggregate to produce complex discourse patterns, offering insights into the micro-mechanisms underlying technology reception. This research advances digital twin methodologies beyond physical systems into social phenomena, providing a framework for anticipating public responses to technological innovations and informing more effective communication strategies. Full article

Periodization is a concept of systematic progression in training and rehabilitation. The rehabilitation literature, however, is scarce, with information about optimally designing resistance training programs based on periodization principles for injured athletes. This periodization model—reverse linear neuro periodization—is a model proposed for the long-term rehabilitation needed after an arthroscopic rotator cuff repair. With recent evidence supporting neural contributions to shoulder injuries and the rate of recovery, rehabilitation protocols may benefit from incorporating approaches that target the sensorimotor system. Integrating motor learning principles (external focus and differential learning) and new technologies (virtual reality, laser pointers, stroboscopic glasses) may bolster current shoulder rehabilitation protocols and improve patient recovery times and outcomes. Such an understanding allows well-informed sport rehabilitation specialists to better bridge the gap between the preparation for competition widely used by coaches and the treatment of injuries that may occur. Full article

Background: Logistics and transport, core of many business processes, are continuously optimized to improve efficiency and market competitiveness. The paper describes a modular coordination of vehicle routing and bin packing problems that enables independent instances of the problems to be joined together, with the aim that the vehicle routing solution satisfies all the constraints from real-world applications. Methods: The vehicle routing algorithm is based on an adaptive memory procedure that also incorporates a simple, one-dimensional bin packing problem. This preliminary packing solution is refined by a complex, three dimensional bin packing for each vehicle to identify the infeasible packages. The method iteratively adjusts virtual volumes until reaching near-optimal routes that respect bin-packing constraints. Results: The coordination enables independent applications of an adaptive memory procedure to vehicle routing and a genetic algorithm approach to bin packing while joining them in a computationally tractable way. Such a coordinated approach is applied to a frequently used public benchmark and proven to provide commensurate costs while significantly lowering algorithm complexity. Conclusions: The proposed method is further validated on a real industrial case study and provided additional savings of 14.48% in average daily distance traveled compared to the current industrial standard. Full article

Butyrylcholinesterase (BChE), plays a critical role in alleviating the symptoms of Alzheimer’s disease (AD) by regulating acetylcholine levels, emerging as an attractive target for AD treatment. This study employed a quantitative structure–activity relationship (QSAR) model based on ECFP4 molecular fingerprints with several machine learning algorithms (XGBoost, RF, SVM, KNN), among which the XGBoost model showed the best performance (AUC = 0.9740). A hybrid strategy integrating ligand- and structure-based virtual screening identified 12 hits from the Topscience core database, three of which were identified for the first time. Among them, piboserod and Rotigotine demonstrated the best BChE inhibitory potency (IC₅₀ = 15.33 μM and 12.76 μM, respectively) and exhibited favorable safety profiles as well as neuroprotective effects in vitro. Notably, Rotigotine, a marketed drug, was newly recognized for its anti-AD potential, with further enzyme kinetic analyses revealing that it acts as a mixed-type inhibitor in a non-competitive mode. Fluorescence spectroscopy, molecular docking, and molecular dynamics simulations further clarified their binding modes and stability. This study provides an innovative screening strategy for the discovery of BChE inhibitors, which not only identifies promising drug candidates for the treatment of AD but also demonstrates the potential of machine learning in drug discovery. Full article

It is essential that the state of health (SOH) for lithium-ion batteries is measured to ensure the safety and reliability of electric vehicles. However, an accurate prediction of SOH is still an art due to the complex degradation mechanisms. To address this challenge, a SOH prediction model based on Warfare Strategy Optimization-assisted hybrid mutual information in-former-Long Short-Term Memory neural network (IWSO-MILSTM) is proposed. First, both direct and virtual health indicators are derived from battery degradation curves. Building on this foundation, mutual information is applied to the correlation analysis of these health indicators, and the redundant health indicators can be filtered. Then, the selected health indicators are fed into the informer-LSTM to construct an interpretable predicted model for the health status of lithium-ion batteries. Notably, both redundancy of health indicators and the imprecision of model hyperparameters for LSTM affect the SOH prediction precision. IWSO is proposed to achieve co-optimization of filtering for health indicators and hyperparameters for the informer-LSTM based on developed initializing distribution methods and adaptive function so that the SOH prediction precision is ensured. Finally, the NASA dataset is used to validate the prediction precision of the IWSO-MILSTM, and the experimental results show that the IWSO-MILSTM can provide more competitive results, i.e., the R² value is improved by 25.68% and 3.63%, respectively, while the RMSE is reduced by 48.76% and 75.91% compared with XGBoost, LSTM, etc. Such results indicate the proposed method can predict SOH efficiently. Full article

Fog computing introduces a new dimension to the network edge by pooling diverse resources (e.g., processing power, memory, and bandwidth). However, allocating resources from heterogeneous fog nodes often faces limited capacity. To overcome these limitations, integrating fog nodes with cloud resources is crucial, ensuring that Service Providers (SPs) have adequate resources to deliver their services efficiently. In this paper, we propose a game-theoretic model to describe the competition among non-cooperative SPs as they bid for resources from both fog and cloud environments, managed by an Infrastructure Provider (InP), to offer paid services to their end-users. In our game model, each SP bids for the resources it requires, determining its willingness to pay based on its specific service demands and quality requirements. Resource allocation prioritizes the fog environment, which offers local access with lower latency but limited capacity. When fog resources are insufficient, the remaining demand is fulfilled by cloud resources, which provide virtually unlimited capacity. However, this approach has a weakness in that some SPs may struggle to fully utilize the resources allocated in the Nash equilibrium-balanced cloud solution. Specifically, under a nondiscriminatory pricing scheme, the Nash equilibrium may enable certain SPs to acquire more resources, granting them a significant advantage in utilizing fog resources. This leads to unfairness among SPs competing for fog resources. To address this issue, we propose a price differentiation mechanism among SPs to ensure a fair allocation of resources at the Nash equilibrium in the fog environment. We establish the existence and uniqueness of the Nash equilibrium and analyze its key properties. The effectiveness of the proposed model is validated through simulations using Amazon EC2 instances, where we investigate the impact of various parameters on market equilibrium. The results show that SPs may experience profit reductions as they invest to attract end-users and enhance their quality of service QoS. Furthermore, unequal access to resources can lead to an imbalance in competition, negatively affecting the fairness of resource distribution. The results demonstrate that the proposed model is coherent and that it offers valuable information on the allocation of resources, pricing strategies, and QoS management in cloud- and fog-based environments. Full article

The food industry faces growing challenges due to evolving consumer demands, requiring digital technologies to enhance sensory analysis. Innovations such as eye tracking, FaceReader, virtual reality (VR), augmented reality (AR), and artificial intelligence (AI) are transforming consumer behavior research by providing deeper insights into sensory experiences. For instance, FaceReader captures emotional responses to food by analyzing facial expressions, offering valuable data on consumer preferences for taste, texture, and aroma. Together, these technologies provide a comprehensive understanding of the sensory experience, aiding product development and branding. Electronic nose, tongue, and eye technologies also replicate human sensory capabilities, enabling objective and efficient assessment of aroma, taste, and color. The electronic nose (E-nose) detects volatile compounds for aroma evaluation, while the electronic tongue (E-tongue) evaluates taste through electrochemical sensors, ensuring accuracy and consistency in sensory analysis. The electronic eye (E-eye) analyzes food color, supporting quality control processes. These advancements offer rapid, non-invasive, reproducible assessments, benefiting research and industrial applications. By improving the precision and efficiency of sensory analysis, digital tools help enhance product quality and consumer satisfaction in the competitive food industry. This review explores the latest digital methods shaping food sensory research and innovation. Full article

Background/Objectives: Cue competition is a feature of associative learning, whereby during learning, cues compete with each other, based on their relative salience, to influence subsequent performance. Blocking is a feature of cue competition where prior knowledge of a cue (X) will interfere with the subsequent learning of a second cue (XY). When tested with the second cue (Y) alone, participants show an impairment in responding. While blocking has been observed across many domains, including spatial learning, previous research has raised questions regarding replication and the conditions necessary for it to occur. Furthermore, two prominent spatial learning theories predict contrary results for blocking. Associative learning accounts predict that the addition of a cue will lead to a blocking effect and impaired performance upon testing. Whereas the cognitive map theory suggests that the novel cue will be integrated into a map with no subsequent impairment in performance. Methods: Using a virtual water maze task, we investigated the blocking effect in human participants. Results: Results indicated that the cue learned in phase 1 of the experiment did not interfere with learning of a subsequent cue introduced in phase 2. Conclusions: This suggests that blocking did not occur and supports a cognitive mapping approach in human spatial learning. However, the relative location of the cues relative to the goal and how this might determine the learning strategy used by participants was discussed. Full article

Small to medium-sized shipyards play a crucial role in the European naval industry. However, the globalization of technology has increased competition, posing significant challenges to shipyards, particularly in domestic markets for short sea, work, and inland vessels. Many shipyard operations still rely on manual, labor-intensive tasks performed by highly skilled operators. In response, the adoption of new tools is essential to enhance efficiency and competitiveness. This paper presents a methodology for developing a human-centric portfolio of advanced technologies tailored for shipyard environments, covering processes such as shipbuilding, retrofitting, outfitting, and maintenance. The proposed technological solutions, which have achieved high technology readiness levels, include 3D modeling and digitalization, robotics, augmented and virtual reality, and occupational exoskeletons. Key findings from real-scale demonstrations are discussed, along with major development and implementation challenges. Finally, best practices and recommendations are provided to support both technology developers seeking fully tested tools and end users aiming for seamless adoption. Full article

This study investigates the efficacy of VR-based cognitive training using the game Beat Saber in enhancing cognitive functions in amateur e-athletes. Participants were divided into two groups, undergoing either 8-day or 28-day training. Significant improvements were observed in reaction time (RT) and eye–hand coordination (EHC) for both groups. Notably, cognitive gains in EHC were maintained over time, indicating the durability of training effects. The lack of significant differences between the short-term and long-term training outcomes suggests that even brief, intensive VR training can lead to substantial cognitive improvements, potentially obviating the need for extended training periods. The findings underscore the potential of immersive VR games like Beat Saber as effective tools for cognitive training. This study also highlights the relevance of VR technology beyond entertainment, demonstrating its application in cognitive enhancement. Given the rising popularity of esports and VR, integrating such technologies into cognitive training programs offers a promising avenue for improving cognitive functions in younger populations familiar with virtual environments. The results suggest that VR-based interventions can enhance cognitive functions which are crucial for both competitive esports and general cognitive functioning, making VR a versatile tool in various training contexts. Further research is recommended to explore the generalizability of these findings to other VR games and different populations. Full article