MMCS 2019 2019 - 117 articles
Barcelona, Spain | 15–17 May 2019
Volume Editor:
Diego Muñoz-Torrero, University of Barcelona, Spain
F. Javier Luque, University of Barcelona, Spain
Target-guided synthesis has emerged as an elegant and efficient lead- and drug-discovery strategy. [...]
Fbw7 is an important E3 ligase and one of the most commonly deregulated proteins in human cancers. [...]
Bivalent degrader molecules (also termed PROTACs) target proteins for degradation through recruitment to E3 ligases. PROTACs are a revolutionary new modality class with therapeutic potential. Formation of a ternary complex between the degrader, the l...
Phospholipid-hydrolyzing enzymes, such as phospholipases A2 (PLA2s) and autotaxin (ATX), have attracted medicinal interest because they are involved in the generation of various inflammatory mediators. PLA2s hydrolyze membrane phospholipids initiatin...
At present, drug abuse has developed into a social problem. [...]
Quorum Sensing (QS) is a bacterial communication system. [...]
Today, drug abuse has developed into a social problem and begun to demand specific measures from different social sectors and government agencies all over the world. Despite significant efforts made toward relevant mechanistic targets, such as the do...
Enzymes are increasingly used as biocatalysts for the production of Active Pharmaceutical [...]
Fragment-based drug discovery has been established as a powerful method for the assembly of optimized protein ligands [...]
SCF (SKP1, Cullins, and F-box proteins) E3 ligase, also known. [...]
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