2,202 Results Found

Switching to bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) from other antiretroviral regimens is safe and effective for virologically suppressed people living with HIV (PLWH). The term virological suppression includes both low b...

Increasing evidence shows that many infections of COVID-19 are asymptomatic, becoming a global challenge, since asymptomatic infections have the same infectivity as symptomatic infections. We developed a probabilistic model for estimating the proport...

We study the probability of an undetected error for general q-ary codes. We give upper and lower bounds on this quantity, by the Linear Programming and the Polynomial methods, as a function of the length, size, and minimum distance. Sharper bounds ar...

In some settings, systems may not fail completely but instead undergo performance degradation, leading to reduced efficiency. A significant concern arises when a system transitions into a degraded state without immediate detection, with the degradati...

Background/Objectives: Ageing is a continuous process of physiological changes that occur over time and affect both ability and function, including vision. A major health issue for older people is visual impairment, which affects both daily activitie...

The Undetectable = Untransmittable (U=U) message is a cornerstone of HIV-related public health communication, yet global levels of awareness and acceptance remain unclear across key populations. This study aimed to assess the global prevalence of awa...

Increased access to highly active antiretroviral therapy (HAART) by human immunodeficiency virus postive (HIV⁺) individuals has become a reality worldwide. In Brazil, HAART currently reaches over half of HIV-infected subjects. In the context of a rem...

The finite-set statistics (FISST) foundational approach to multitarget tracking and information fusion has inspired work by dozens of research groups in at least 20 nations; and FISST publications have been cited tens of thousands of times. This revi...

The coronavirus disease 2019 (COVID-19) pandemic has caused a significant disruption to cancer diagnosis, treatment and prevention worldwide that could have serious consequences in the near future. We intend to evaluate the weight of this backlog on...

Hepatitis B Core antibody (HBcAb) positivity is the surrogate marker of hepatitis B occult infection. This condition is not a contraindication for switching to two-drug (2DR) antiretroviral therapy; however, the removal of tenofovir may contribute to...

Background and Objectives: The aim of this study was to report the characteristics of macular neovascularization (MNV) with undetectable flow on optical coherence tomography angiography (OCTA) in neovascular age related macular degeneration (nAMD), a...

Background: Vertical transmission of HIV infection may occur during pregnancy, at childbirth or through breastfeeding. Recommendations on the safety of breastfeeding of HIV-infected women on effective antiretroviral treatment are not univocal among i...

Chikungunya and dengue are arboviral diseases transmitted by mosquitoes that have been increasingly recognized as public health concerns in Sub-Saharan Africa. Several studies conducted in Nigeria and other West African countries have revealed the se...

Introduction: We hypothesized that an endovascular electroencephalogram (eEEG) can detect subdural electrode (SDE)-detectable, scalp EEG-undetectable epileptiform discharges. The purpose of this study is, therefore, to measure SDE-detectable, scalp E...

Background: Septic pulmonary embolism (SPE) may be a frequently undetected complication of central venous catheter (CVC)-related bloodstream infections (CRBSIs). Materials and Methods: The incidence of SPE was evaluated in a cohort of non-oncological...

In the last decade, reliable scientific evidence has emerged to support the concept that undetectable viral loads prevent human immunodeficiency virus (HIV). Undetectable equals untransmissible (U = U) is a simple message that everyone can understand...

Cervical cancer tumors with undetectable HPV (HPV^U) have been underappreciated in clinical decision making. In this study, two independent CC datasets were used to characterize the largest cohort of HPV^U tumors to date (HPV^U = 35, HPV⁺ = 430). Genomi...

Background: Mechanisms and causes of death in older patients with SARS-CoV-2 infection are still poorly understood. Methods: We conducted in a retrospective monocentric study, a clinical chart review and post-mortem examination of patients aged 75 ye...

Background/Objectives: The impact of virion maturation on neutralizing antibody responses in HIV treatment is not fully understood. This study examines whether antiretroviral regimens (ART) with boosted protease inhibitors (b-PI), which increase expo...

Broadly neutralizing antibodies (bnAbs) bind and neutralize diverse HIV isolates and demonstrate protective effects in primate models and humans against specific isolates. To develop an effective HIV vaccine, it is widely believed that inducing these...

Worldwide, large-scale biodiversity monitoring schemes are developing and involve many non-specialist volunteers. If the opening of schemes to non-specialists allows for the gathering of huge amounts of data, their quality represents a controversial...

The paper presents a method of creating a hidden channel using a signals’ superposition. According to this idea, a transmitter simultaneously sends overt and covert (secret) signals, whereby the overt signal is a carrier for the covert one. Due...

In this short communication, we investigate whether the intensity of the second wave of infection from SARS-CoV-2 that hit Italy in October–November–December 2020 is related to the intensity of the first wave, which took place in March&nd...

Modern telecommunications systems require the use of various transmission techniques, which are either open or hidden. The open transmission system uses various security techniques against its unauthorized reception, and cryptographic solutions ensur...

The gain in the identification capacity afforded by a rate-limited description of the noise sequence corrupting a modulo-additive noise channel is studied. Both the classical Ahlswede–Dueck version and the Ahlswede–Cai–Ning–Zh...

We propose a two-step procedure for atomic decomposition of multichannel EEGs, based upon multivariate matching pursuit and dipolar inverse solution, from which atoms representing relevant EEG structures are selected according to prior knowledge. We...

The Yuanjiang River, situated in the upper reaches of the Red River, is a crucial component of a biodiversity hotspot in the mountains of southwestern China, supporting a high diversity of fish species. Nevertheless, systematic research on fish diver...

This article examines the impact of an undetected Instrument Landing System (ILS) failure on crew situational awareness. A literature review of similar aviation accidents is presented, highlighting the recurring challenge of misleading instrument ind...

When a minor DNA component to a binary mixture is present at a weight ratio of approximately 1:50 or less, the presence of this minor donor is undetectable (or barely detectable) by standard mixture deconvolution approaches. In an attempt to retrieve...

One of the most striking features of KCTD proteins is their involvement in apparently unrelated yet fundamental physio-pathological processes. Unfortunately, comprehensive structure–function relationships for this protein family have been hampe...

Background/Objectives: A decrease in serum AMH is generally associated with low ovarian response in assisted reproductive procedures, whether or not in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) is performed. Methods: We r...

The oral cavity is thought to be one of the portals for SARS-CoV-2 entry, although there is limited evidence of active oral infection by SARS-CoV-2 viruses. We assessed the capacity of SARS-CoV-2 to infect and replicate in oral epithelial cells. Oral...

Cannabinoid type 1 receptor (CB₁R) is expressed and participates in several aspects of cerebral cortex embryonic development as demonstrated with whole-transcriptome mRNA sequencing and other contemporary methods. However, the cellular location of CB...

One of the most significant innovations in HIV prevention is the use of HIV treatment to prevent HIV transmission. This information has been disseminated as the “Undetectable = Untransmittable” (U = U) message. Despite evidence of effecti...

Alphaviruses are mosquito-transmitted RNA viruses which generally cause acute disease including mild febrile illness, rash, arthralgia, myalgia and more severely, encephalitis. In the mouse, peripheral infection with Semliki Forest virus (SFV) result...

Objectives: Primary objective was to report the feasibility, safety and efficacy of percutaneous ablation of hepatic malignant tumors that are undetectable or inconspicuous in non-enhanced computed tomography (CT) scans using an electromagnetic navig...

Background: Gaps remain in the detection of nucleic acid test (NAT) yield and occult hepatitis B virus (HBV) infection (OBI) by current HBV surface antigen (HBsAg) assays. The lack of detection may be due to HBsAg levels below current assay detection...

(1) Heart transplantation (HTX) improves the overall survival and functional status of end-stage heart failure patients with cardiomyopathies (CMPs). The majority of CMPs have genetic causes, and the overlap between CMPs and inherited myopathies is w...

Fluoropyrimidines, the mainstay agents for the treatment of colorectal cancer, alone or as a part of combination therapies, cause severe adverse reactions in about 10%–30% of patients. Dihydropyrimidine dehydrogenase (DPD), a key enzyme in the cat...

This paper proposes a modified sensor measurement expression for a moving target defense (MTD) strategy to detect coordinated cyber-physical attacks (CCPAs). Essentially, the MTD defense characteristics for detecting false data injection attacks (FDI...

Wireless covert communication is an emerging communication technique that prevents eavesdroppers. This paper presents a novel approach to wireless covert communication based on polar codes with dirty constellation polarization. The feasibility of dir...

Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latenc...

Plastically deformed low-carbon steel has been analyzed by nondestructive three-dimensional orientation and strain mapping using scanning three-dimensional X-ray diffraction microscopy (S3DXRD). However, the application of S3DXRD is limited to single...

Metachronous oligo-metastatic disease is variably defined as one to five metastases detected after a disease-free interval and treatment of the primary tumour with curative intent. Oligo-metastases in non-small cell lung cancer (NSCLC) are often trea...

The ergothioneine transporter ETT (formerly OCTN1; human gene symbol SLC22A4) is a powerful and highly specific transporter for the uptake of ergothioneine (ET). Recently, Sparreboom et al. reported that the ETT would transport nucleosides and nucleo...

From a cancer-centric perspective, radiotherapy has been primarily viewed as a localised treatment modality, targeting cancer tissues with ionising radiation to induce DNA damage and cell death [...]

Untreated vitamin B12 (B12) deficiency may cause delayed development in infants. Several newborn screening (NBS) programs have reported an increased detection rate of B12 deficiency when second-tier dried blood spot (DBS) analyses of total homocystei...

Reports of the prevalence of antibodies to infliximab (anti-drug antibodies, ADA) are inconsistent due in part to the various assay formats used to monitor immunogenicity in the clinic and under clinical trial settings. This study aimed to determine...

Modern safety-critical systems depend heavily on communication networks while operating in increasingly polluted electromagnetic environments. Forward Error Correction codes are increasingly being used in safety-critical applications; however, vulner...

Breast cancer is the most common cancer in women, a leading cause of morbidity and mortality, and a significant health issue worldwide. According to the World Health Organization’s cancer awareness recommendations, mammographic screening should...