Brown adipose tissue (BAT), a uniquely thermogenic tissue that plays an important role in metabolism and energy expenditure, has recently become a revived target in the fight against metabolic diseases, such as obesity, diabetes, and non-alcoholic fa...
Non-invasive diagnostics play a crucial role in medicine, and they ensure both contamination safety and patient comfort. The proposed study integrates hyperspectral imaging with advanced image fusion, enabling non-invasive, diagnostic procedure withi...
Recent advances in optical clearing techniques have dramatically improved deep tissue imaging by reducing the obscuring effects of light scattering and absorption. However, these optical clearing methods require specialized equipment or a lengthy und...
Epicardial adipose tissue (EAT), strategically located between the myocardium and the visceral pericardial layer, is increasingly recognized as an active player in cardiovascular health rather than a passive fat depot. EAT secretes a notable array of...
Developing algorithms for analyzing hyperspectral images as an intraoperative tool for margin assessment during breast-conserving surgery requires a dataset with reliable histopathologic labels. The feasibility of using tissue slices hyperspectral da...
Background: Skin lesions associated with head and neck carcinomas present a diagnostic challenge. Conventional imaging methods, such as dermoscopy and RGB imaging, often face limitations in providing detailed information about skin lesions and accura...
To overcome the limitations of brown adipose tissue (BAT) imaging with MRI and PET/CT, near-infrared (NIR) fluorescence imaging has been utilized in living animals because it is highly sensitive, noninvasive, nonradioactive, and cost-effective. To da...
The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal flu...
The expression abundance of transcripts in nondiseased breast tissue varies among individuals. The association study of genotypes and imaging phenotypes may help us to understand this individual variation. Since existing reports mainly focus on tumor...
Soft tissue masses are predominantly benign, with a benign-to-malignant ratio exceeding 100:1, often located around joints. They may be contiguous or adjacent to joints or reflect systemic diseases or distant organ involvement. Clinically, they typic...
Postoperative imaging of musculoskeletal tumors poses a significant diagnostic challenge for radiologists. The complexity arises from the need to differentiate between expected postoperative changes, potential complications, and local recurrence. The...
In shallow tissues of the human body, pathological changes often occur, and there are several kinds of scattering media, such as mucosa, fat, and blood, present on the surface of these tissues. In such scattering environments, it is difficult to dist...
Tissue-engineered scaffolds, particularly composite scaffolds composed of polymers combined with ceramics, bioactive glasses, or nanomaterials, play a vital role in regenerative medicine by providing structural and biological support for tissue repai...
Novel profiling methodologies are redefining the diagnostic capabilities and therapeutic approaches towards more precise and personalized healthcare. Complementary information can be obtained from different omic approaches in combination with the tra...
The ability to respond to injury with tissue repair is a fundamental property of all multicellular organisms. The extracellular matrix (ECM), composed of fibrillar collagens as well as a number of other components is dis-regulated during repair in ma...
Breast cancer is one of the leading causes of cancer death among women; to decrease the death rate for this disease, early detection plays a key role. Recently, microwave imaging systems have been proposed as an alternative to the current techniques,...
This study aimed to evaluate the accuracy of the Digital Imaging software in the prediction of soft tissue changes following three types of orthodontic interventions: non-extraction, extraction, and orthognathic surgery treatments. Ninety-six patient...
Obtaining adequate resection margins in small intestinal necrotic tissue remains challenging due to the lack of intraoperative feedback. Here, we used hyperspectral imaging (HSI), an imaging technique for objective identification, combined with deep...
Accurate and detailed tissue characterization is a central goal in medical diagnostics, often requiring the combination of multiple imaging modalities. This study presents a multimodal imaging system that integrates mid-infrared (MIR) scanning with f...
Various methods have been proposed to estimate the tissue speed of sound (SOS) of propagating medium using the curvature of received channel waveform or the analysis of resultant image quality. In our previous study, baseband delay-multiply-and-sum (...
Musculoskeletal soft-tissue infections include a wide range of clinical conditions that are commonly encountered in both emergency departments and non-emergency clinical settings. Since clinical signs, symptoms, and even laboratory tests can be unrem...
The Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the...
Knowing the precise location of analytes in the tissue has the potential to provide information about the organs’ function and predict its behavior. It is especially powerful when used in diagnosis and prognosis prediction of pathologies, such as can...
Mueller matrix polarimetry has great potential for tissue detection and clinical diagnosis due to its ability to provide rich microstructural information accurately. However, in practical in vivo tissue imaging based on backscattering Mueller matrix...
Background/Objectives: Since the initial approach towards the clinical presentation of soft-tissue masses is challenging for frontline physicians, some countries use clinical practice guidelines. Proper imaging work-up is crucial to differentiate bet...
Background and Aims: Neurovascular abnormalities, such as aberrant nerve migration in Hirschsprung’s disease and reduced vascular density in necrotizing enterocolitis, are frequently observed in intestinal diseases. Traditional 2-dimensional (2...
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial information is lost during the extraction and elucidation of a drugs biodistr...
Tissue imaging is crucial in oral cancer diagnostics. Imaging techniques such as X-ray imaging, magnetic resonance imaging, optical coherence tomography (OCT) and computed tomography (CT) enable the visualization and analysis of tissues, aiding in th...
This paper proposes a full-automatic high-efficiency Mueller matrix microscopic imaging (MMMI) system based on the tissue microarray (TMA) for cancer inspection for the first time. By performing a polar decomposition on the sample’s Mueller mat...
This paper presents a combined optical imaging/artificial intelligence (OI/AI) technique for the real-time analysis of tissue morphology at the tip of the biopsy needle, prior to collecting a biopsy specimen. This is an important clinical problem as...
The characterization and evaluation of skin tissue structures are crucial for dermatological applications. Recently, Mueller matrix polarimetry and second harmonic generation microscopy have been widely used in skin tissue imaging due to their unique...
Surgery is the mainstay of treatment for localized soft tissue sarcomas (STS). The curative treatment highly depends on complete tumor resection, as positive margins are associated with local recurrence (LR) and prognosis. However, determining the tu...
The superharmonic imaging of tissue has the potential for high spatial and contrast resolutions, compared to the fundamental and second harmonic imaging. For this technique, the spectral bandwidth of an ultrasound transducer is divided for transmissi...
The dysregulation of fatty acid (FA) metabolism is linked to various brain diseases, including Alzheimer’s disease (AD). Mass spectrometry imaging (MSI) allows for the visualization of FA distribution in brain tissues but is often limited by lo...
High-speed, optical-sectioning imaging is highly desired in biomedical studies, as most bio-structures and bio-dynamics are in three-dimensions. Compared to point-scanning techniques, line scanning temporal focusing microscopy (LSTFM) is a promising...
The development of nanomaterials with special optical window is critical for clinical applications and the optoelectronic industry. In this work, eight kinds of samarium-based metal organic compound nanoparticles (Sm–Fe, Sm–Ga, Sm–M...
Background: Respiratory Syncytial Virus (RSV) is the major cause of severe acute respiratory tract illness in young children worldwide and a main pathogen for the elderly and immune-compromised people. In the absence of vaccines or effective treatmen...
Breast tissue-mimicking phantoms are essential tools for validating microwave imaging systems designed for early breast cancer detection. In this work, we report the fabrication and comprehensive characterization of oil-in-gelatin phantoms emulating...
Prepubertal boys with cancer may suffer from reduced fertility and maturity following gonadotoxic chemoradiotherapy. Thus, a viable method of immature testicular tissue (ITT) preservation is required in this cohort. In this study, we used poly-L-lact...
Isocitrate dehydrogenase 1 (IDH1) mutations in gliomas, fibrosarcoma, and other cancers leads to a novel metabolite, D-2-hydroxyglutarate, which is proposed to cause tumorigenesis. The production of this metabolite also causes vulnerabilities in cell...
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an advanced technique that uses minimum fragmented ions from complex molecules for mass spectrometry (MS) analysis (tissue profiling by mass spectrometry). It is able to anal...
The preservation of kidneys using normothermic machine perfusion (NMP) prior to transplantation has the potential for predictive evaluation of organ quality. Investigations concerning the quantitative assessment of physiological tissue parameters and...
Background: Right ventricular thrombosis (RVT) is rarely detected in clinical practice. Depending on its aetiology, RVT may originate from a deep venous thrombosis (type A) or in situ (type B). Type A is characterized by increased mobility and freque...
Background and Objectives: The introduction of portable ultrasound devices has transformed clinical practice in emergency medicine. Diagnostic accuracy and patient safety have been enhanced by point-of-care ultrasonography (POCUS), which has become a...
Background: Dirofilaria immitis is a nematode that produces proliferative pulmonary endarteritis in dogs due to direct contact of the adult parasites with the intima layer of the pulmonary arteries, leading to irreversible severe structural damage an...
Kidney and renal pelvic cancer are a significant cause of cancer-related deaths, with the most common malignant kidney tumor being renal cell carcinoma (RCC). Chromophobe renal cell carcinoma is a rarer form of RCC that poses significant challenges t...
Cardiac magnetic resonance (CMR) has emerged as a useful tool in the diagnostic work-up of patients with clinically suspected acute myocarditis (AM), yet the diagnosis remains challenging. The purpose of this proof-of-concept study was to evaluate if...
The aim of the study was to develop a semi-automated, computer-aided imaging technique to quantify the amount and distribution of perivascular fat at the level of the iliac arteries (periiliac adipose tissue—PIAT), and to investigate the associ...
Background: The necessity of a pre-therapeutic biopsy for soft tissue tumors is assessed differently depending on imaging. We examined the concordance of histopathological and radiological imaging-based diagnoses of soft tissue tumors in a monocentri...
In this paper, the oil-in-gelatin based tissue-mimicking materials (TMMs) doped with carbon based materials including carbon nanotube, graphene ink or lignin were prepared. The volume percent for gelatin based mixtures and oil based mixtures were bot...
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