This paper presents a design synthesis method for robust controllers of active vehicle suspensions (AVSs). Various control techniques have been applied to the design of AVSs for enhancing ride comfort and handling performance of ground vehicles. Howe...
Designing new mechatronic systems for vehicle applications is a complex and time-consuming process. The increasing computational power allows us to generate automatically novel and new mechatronic discrete-topology concepts in an efficient manner. Us...
Magnetic graphene composites have emerged as a frontier material platform, offering designable properties and multifunctional integration across environmental, biomedical, electromagnetic, and energy applications. Despite extensive research, a cohere...
Green synthesis of silver nanoparticles (AgNPs) involves a reduction reaction of a metal salt solution mixed with a plant extract. The reaction yield can be controlled using several independent factors, such as extract and metal concentration, temper...
Generative models such as generative adversarial networks and variational autoencoders are widely used for design synthesis. A diffusion model is another generative model that outperforms GANs and VAEs in image processing. It has also been applied in...
This review was devoted to outlining the use and potential increasing application of the Design of Experiment (DoE) approach to the rational and planned synthesis of inorganic nanomaterials, with a particular focus on polycrystalline nanostructures (...
Continuous introduction of advanced optimization algorithms promotes the development of electromagnetic (EM) technology in radar and communication systems. Wideband antenna design within a given space and wideband array pattern synthesis, especially...
Nanoparticles (NPs) of noble metals such as gold have garnered significant attention due to their novel optical and catalytic properties, their theranostic properties, as they are biocompatible, and they attract considerable interest in a range of ap...
In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software MODDE® Pro 13 (Sartorius) was used to develop a full-factorial design of experi...
In this study, we present a fractional factorial design approach for exploring the effects and interactions of key synthesis and electrochemical transfer parameters on the roughness and wettability of hexagonal boron nitride (h-BN) coatings, due to t...
Magnetite nanocrystal clusters are being investigated for their potential applications in catalysis, magnetic separation, and drug delivery. Controlling their size and size distribution is of paramount importance and often requires tedious trial-and-...
Parallel-kinematic machines or parallel robots have only been established in a few applications where their advantage over serial kinematics due to their high payload capacity, stiffness, or dynamics with their limited workspace-to-installation-space...
The pursuit of efficient approaches for the production of promising antiviral and cytostatic pharmaceuticals is a crucial direction in medical biotechnology, especially after the COVID-19 pandemic. Modified nucleosides and nucleotides represent a hig...
A major limitation preventing the use of surface-enhanced Raman scattering (SERS) in routine analyses is the signal variability due to the heterogeneity of metallic nanoparticles used as SERS substrates. This study aimed to robustly optimise a synthe...
We report herein the design and synthesis of a series of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis (MTB) H37...
This study aims to develop and systematically evaluate a data-driven inverse-design framework for determining silver nanoparticle (AgNP) synthesis conditions that achieve a prescribed particle size. To this end, a forward surrogate model is first dev...
Alternaria alternata is a global fungal pathogen that causes symptoms such as leaf blight and seed rot resulting in economically significant yield losses in different varieties of crops. Green synthesis of nanoparticles is preferred over other method...
Fuel expenses constitute the largest part of the operating cost of a merchant ship. Integrated energy systems that cover all energy loads with low fuel consumption, while being economically feasible, are increasingly studied and installed. Due to the...
The production of ammonia, consuming up to 5% of natural gas global production, accounts for about 2% of world energy. Worldwide, the Haber–Bosch process is the mainly used method of ammonia catalytic synthesis, involving temperatures up to 600...
Petrochemical tail gases have various components and many separation methods, thus there are many possible design schemes, making it difficult to determine the optimal scheme. In this work, a graphic synthesis method was used to design a hybrid multi...
The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to de...
The design of a semiconductor or a composite semiconductor system—with applications in materials science—is complex because its morphology and structure depend on several parameters. These parameters are the precursor type, solvent, pH of the solutio...
(1) Background: Startups operate in highly uncertain environments where ineffective risk management increases the likelihood of failure. While several risk management frameworks have been developed specifically for startups and SMEs, they typically l...
Reward functions determine what reinforcement learning agents ultimately optimize, yet reward design for complex tasks has traditionally relied on extensive domain expertise and iterative engineering. Recent large language models and vision–lan...
Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains (BET) are involved in viral r...
Synthetic ammonia produced from fossil fuels is essential for agriculture. However, the emissions-intensive nature of the Haber–Bosch process, as well as a depleting supply of these fossil fuels have motivated the production of ammonia using re...
Exposure to ultraviolet (UV) light is known to cause skin aging, skin damage, cancer, and eye diseases, as well as polymer material aging. Therefore, significant attention has been devoted to the research and development of UV absorbers. Considering...
Two series of novel 2-substituted-4-amino-6-halogenquinolines 8a–l and 13a–h were designed, synthesized and evaluated for their antiproliferative activity against H-460, HT-29, HepG2 and SGC-7901 cancer cell lines in vitro. The pharmacological result...
Histone deacetylases (HDACs) are important epigenetic regulatory enzymes contributing to cancer proliferation, which could be critical targets in cancer therapy. The structural similarities of the existing HDAC inhibitors have resulted in an increase...
Harsh modern industrial working conditions require high-performance lubricants, but traditional additives are limited by single functionality and poor compatibility, driving the development of multifunctional alternatives. Two novel hindered phenolic...
Hybrid molecules, integrating multiple pharmacophores within a single scaffold, represent a modern strategy in drug discovery, offering improved selectivity and safety. Anthranilic acid is a versatile building block with diverse biological activities...
Background/Objectives: Angiogenesis plays a crucial role in tumor development and is a driving force for the aggressiveness of several types of cancer. Our team developed a novel series of thiosemicarbazone-containing quinazoline derivatives, TSC1-TS...
Oxime derivatives of dehydrocholic acid and its esters were designed for anti-hepatitis B virus (HBV) drugs according to principles of assembling active chemical fragments. Twelve compounds were synthesized from dehydrocholic acid by esterification a...
A series of novel potential DNA bis-intercalators were designed and synthesized, in which two glucuronic acids were linked by ethylenediamine, and the glucuronic acid was coupled with various chromophores, including quinoline, acridine, indole and pu...
A novel series of N-sulfonyl homoserine lactone derivatives 5a–l has been designed, synthesized and evaluated for quorum sensing inhibitory activities towards violacein production. Of the compounds synthesized, compound 5h was found to possess an exc...
In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfu...
A systematic approach to the design of electrical machines is implemented by solving problems of analysis and synthesis in various combinations at different stages and stages of design. The questions of the formulation and implementation of synthesis...
A series of oxime Cyclohexyl (E)-4-(hydroxyimino)-4-phenylbutanoates and their ethers were designed, synthesized, and evaluated for anti-hepatitis B virus (HBV) activities with HepG 2.2.15 cell line in vitro. Most of these compounds possessed anti-HB...
MDA-9/Syntenin, a key scaffolding protein and a molecular hub involved in a diverse range of cell signaling responses, has proved to be a challenging target for the design and discovery of small molecule probes. In this paper, we report on the design...
A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase...
The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegat...
Seven novel N-arylsulfonyl-3-(2-yl-ethanone)-6-methylindole derivatives 4a–f and 6 were readily synthesized and have been identified as inhibitors of human immunodeficiency virus type-1 (HIV-1) replication. Initial biological studies indicated that a...
Recent advances in the design and synthesis of five-membered heterocycles containing both sulfur and selenium atoms—1,3-thiaselenolane and 1,3-thiaselenole derivatives—are discussed in this review. These heterocyclic systems are of intere...
The field of electric vehicles and electric mobility, like other modern engineering practice, not only requires deep analytical skills but increasingly demands the ability to synthesise and integrate knowledge across multiple disciplines (e.g., elect...
A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as...
New quinazoline-sulfonylurea hybrids were prepared and examined for their in vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as a reference drug. Compounds VI-6-a, V, IV-4, VI-4-c, IV-6, VI-2-a, IV-1, and IV-2...
Aromatic polymers such as poly(ether sulfone), poly(ether ketone), and polyimide have been widely used in industry due to their thermal, mechanical, and chemical stabilities. Although their application to catalysis has been limited, the introduction...
The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired size, morphology, chemical...
Additive manufacturing (AM) is a process that creates a three-dimensional (3D) physical object from a digital design by building layers of material directly from a computer-aided design (CAD) file, allowing for precise and rapid production of parts o...
In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido-Dihy...
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