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142 Results Found

  • Article
  • Open Access
746 Views
14 Pages

Leveraging In Silico Data for the Development and Implementation of Multivariate Statistical Process Monitoring Models in Monoclonal Antibody Manufacturing

  • Sushrut Marathe,
  • Samira Beyramysoltan,
  • Giulia Marchese,
  • Elaheh Ardalani,
  • Nathaniel Berendson,
  • Theodore Vu,
  • Gabriele Bano and
  • Sayantan Chattoraj

The design and development of a robust and consistent manufacturing process for monoclonal antibodies (mAbs), augmented by advanced process analytics capabilities, is a key current focus area in the pharmaceutical industry. In this work, we describe...

  • Feature Paper
  • Article
  • Open Access
18 Citations
5,325 Views
14 Pages

25 June 2021

Froth image analysis has been considered widely in the identification of operational regimes in flotation circuits, the characterisation of froths in terms of bubble size distributions, froth stability and local froth velocity patterns, or as a basis...

  • Review
  • Open Access
10 Citations
4,945 Views
18 Pages

8 November 2024

The exploration and development of resources and energy are fundamental to human survival and development, and geological drilling is a key method for deep resource and energy exploration. Intelligent monitoring technology can achieve anomaly detecti...

  • Review
  • Open Access
49 Citations
14,725 Views
75 Pages

Data-Driven Process Monitoring and Fault Diagnosis: A Comprehensive Survey

  • Afrânio Melo,
  • Maurício Melo Câmara and
  • José Carlos Pinto

24 January 2024

This paper presents a comprehensive review of the historical development, the current state of the art, and prospects of data-driven approaches for industrial process monitoring. The subject covers a vast and diverse range of works, which are compile...

  • Article
  • Open Access
18 Citations
5,751 Views
22 Pages

4 June 2019

In Italy, it has always been difficult to collect reliable data on real estate given the opacity of the information available. Keeping into consideration the actual availability of data and information, the possibility to have a structure for permane...

  • Article
  • Open Access
7 Citations
2,208 Views
26 Pages

Construction Tasks Electronic Process Monitoring: Laboratory Circuit-Based Simulation Deployment

  • Diego Calvetti,
  • Luís Sanhudo,
  • Pedro Mêda,
  • João Poças Martins,
  • Miguel Chichorro Gonçalves and
  • Hipólito Sousa

6 August 2022

The domain of data processing is essential to accelerate the delivery of information based on electronic performance monitoring (EPM). The classification of the activities conducted by craft workers can enhance the mechanisation and productivity of a...

  • Article
  • Open Access
9 Citations
2,849 Views
19 Pages

A Framework for Multivariate Statistical Quality Monitoring of Additive Manufacturing: Fused Filament Fabrication Process

  • Moath Alatefi,
  • Abdulrahman M. Al-Ahmari,
  • Abdullah Yahia AlFaify and
  • Mustafa Saleh

14 April 2023

Advances in additive manufacturing (AM) processes have increased the number of relevant applications in various industries. To keep up with this development, the process stability of AM processes should be monitored, which is conducted through the as...

  • Article
  • Open Access
3 Citations
2,425 Views
11 Pages

9 December 2020

This article developed an improved statistical pattern analysis (SPA) monitoring strategy for fault detection of complex multivariate processes using empirical likelihood. The technique based on statistical pattern analysis performs fault detection b...

  • Feature Paper
  • Article
  • Open Access
45 Citations
14,399 Views
18 Pages

Principal Component Analysis of Process Datasets with Missing Values

  • Kristen A. Severson,
  • Mark C. Molaro and
  • Richard D. Braatz

6 July 2017

Datasets with missing values arising from causes such as sensor failure, inconsistent sampling rates, and merging data from different systems are common in the process industry. Methods for handling missing data typically operate during data pre-proc...

  • Article
  • Open Access
6 Citations
2,914 Views
16 Pages

16 December 2023

This paper introduces a novel method for enhancing fault classification and diagnosis in dynamic nonlinear processes. The method focuses on dynamic feature extraction within multivariate time series data and utilizes dynamic reconstruction errors to...

  • Article
  • Open Access
12 Citations
3,310 Views
15 Pages

A Multiblock Approach to Fuse Process and Near-Infrared Sensors for On-Line Prediction of Polymer Properties

  • Lorenzo Strani,
  • Raffaele Vitale,
  • Daniele Tanzilli,
  • Francesco Bonacini,
  • Andrea Perolo,
  • Erik Mantovani,
  • Angelo Ferrando and
  • Marina Cocchi

13 February 2022

Petrochemical companies aim at assessing final product quality in real time, in order to rapidly deal with possible plant faults and to reduce chemical wastes and staff effort resulting from the many laboratory analyses performed every day. In order...

  • Proceeding Paper
  • Open Access
5 Citations
2,586 Views
5 Pages

26 December 2018

In this paper, the deterioration of statistical fault classification of a hydraulic system and an electromechanical cylinder EMC due to reduced sampling rates of sensor nets is shown. As a result, two types of faults can be distinguished: On the one...

  • Article
  • Open Access
28 Citations
6,165 Views
14 Pages

13 October 2019

With the rapid development of advanced sensor technologies, it has become popular to monitor multiple quality variables for a manufacturing process. Consequently, multivariate statistical process control (MSPC) charts have been commonly used for moni...

  • Article
  • Open Access
2 Citations
2,520 Views
19 Pages

A New EWMA Control Chart for Monitoring Multinomial Proportions

  • Shengjin Gan,
  • Su-Fen Yang and
  • Li-Pang Chen

31 July 2023

Control charts have been widely used for monitoring process quality in manufacturing and have played an important role in triggering a signal in time when detecting a change in process quality. Many control charts in literature assume that the in-con...

  • Article
  • Open Access
2 Citations
2,480 Views
12 Pages

Stable and Unstable Pattern Recognition Using D2 and SVM: A Multivariate Approach

  • Pamela Chiñas-Sanchez,
  • Ismael Lopez-Juarez,
  • Jose Antonio Vazquez-Lopez,
  • Abdelkader El Kamel and
  • Jose Luis Navarro-Gonzalez

23 December 2020

Control charts are used to visually identify the signals that define the behavior of industrial processes in univariate cases. However, whenever the statistical quality of more than one critical variable needs to be monitored simultaneously, the proc...

  • Article
  • Open Access
14 Citations
3,712 Views
20 Pages

2 December 2022

With the continuous expansion of industrial production scale, most of the chemical process variables are nonlinear, multi-modal and dynamic. For some traditional multivariate statistical monitoring and fault diagnosis algorithms, such as principal co...

  • Feature Paper
  • Article
  • Open Access
4 Citations
2,945 Views
18 Pages

8 January 2024

Reliable monitoring of mineral process systems is key to more efficient plant operation. Multivariate statistical process control based on principal component analysis is well-established in industry but may not be effective when dealing with dynamic...

  • Article
  • Open Access
4 Citations
5,393 Views
16 Pages

Multivariate Monitoring Workflow for Formulation, Fill and Finish Processes

  • Barbara Pretzner,
  • Christopher Taylor,
  • Filip Dorozinski,
  • Michael Dekner,
  • Andreas Liebminger and
  • Christoph Herwig

Process monitoring is a critical task in ensuring the consistent quality of the final drug product in biopharmaceutical formulation, fill, and finish (FFF) processes. Data generated during FFF monitoring includes multiple time series and high-dimensi...

  • Article
  • Open Access
17 Citations
3,651 Views
25 Pages

15 March 2022

Fault monitoring is often employed for the secure functioning of industrial systems. To assess performance and enhance product quality, statistical process control (SPC) charts such as Shewhart, CUSUM, and EWMA statistics have historically been utili...

  • Article
  • Open Access
415 Views
19 Pages

4 November 2025

With the increasing demands for process safety and manufacturing efficiency, process monitoring has garnered significant attention from both academia and industry over the past few decades. Process monitoring aims to detect deviations from normal ope...

  • Article
  • Open Access
7 Citations
3,729 Views
26 Pages

26 July 2023

Statistical process control (SPC) charts are commonly used to monitor quality characteristics in manufacturing processes. When monitoring two or more related quality characteristics simultaneously, multivariate T2 control charts are often employed. L...

  • Article
  • Open Access
3 Citations
2,414 Views
11 Pages

18 November 2022

An in-line monitoring method for the elution process of Ginkgo biloba L. leaves using visible and near-infrared spectroscopy in conjunction with multivariate statistical process control (MSPC) was established. Experiments, including normal operating...

  • Article
  • Open Access
3 Citations
1,862 Views
17 Pages

This paper proposes a parallel monitoring method for plant-wide processes by integrating mutual information and Bayesian inference into a global-local preserving projections (GLPP)-based multi-block framework. Unlike traditional multivariate statisti...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,270 Views
17 Pages

4 October 2022

Traditional multivariate statistical methods, which are often used to monitor stationary processes, are not applicable to nonstationary processes. Cointegration analysis (CA) is considered an effective method to deal with nonstationary variables. If...

  • Article
  • Open Access
7 Citations
1,877 Views
20 Pages

9 December 2024

In this work, we introduce MOLA, a multi-block orthogonal long short-term memory autoencoder paradigm, to conduct accurate, reliable fault detection of industrial processes. To achieve this, MOLA effectively extracts dynamic orthogonal features by in...

  • Article
  • Open Access
2 Citations
2,785 Views
19 Pages

Monitoring and Interpretation of Process Variability Generated from the Integration of the Multivariate Cumulative Sum Control Chart and Artificial Intelligence

  • Edgar Augusto Ruelas-Santoyo,
  • Vicente Figueroa-Fernández,
  • Moisés Tapia-Esquivias,
  • Yaquelin Verenice Pantoja-Pacheco,
  • Edgar Bravo-Santibáñez and
  • Javier Cruz-Salgado

24 October 2024

Variability in manufacturing processes must be properly monitored and controlled to avoid incurring quality problems; otherwise, the probability of manufacturing defective products increases, and, consequently, production costs rise. This paper prese...

  • Article
  • Open Access
420 Views
17 Pages

Ambiguity-Informed Modifications to Multivariate Process Analysis Using Binance Market Data

  • Atef F. Hashem,
  • Abdulrahman Obaid Alshammari,
  • Ishfaq Ahmad and
  • Nasir Ali

5 November 2025

The growing complexity of the contemporary financial systems requires the emergence of sophisticated computational and statistical methods that are capable of managing uncertainty, lack of normality and structural variability of multivariate data. Th...

  • Article
  • Open Access
6 Citations
3,523 Views
18 Pages

Multivariate Pattern Recognition in MSPC Using Bayesian Inference

  • Jose Ruiz-Tamayo,
  • Jose Antonio Vazquez-Lopez,
  • Edgar Augusto Ruelas-Santoyo,
  • Aidee Hernandez-Lopez,
  • Ismael Lopez-Juarez and
  • Armando Javier Rios-Lira

4 February 2021

Multivariate Statistical Process Control (MSPC) seeks to monitor several quality characteristics simultaneously. However, it has limitations derived from its inability to identify the source of special variation in the process. In this research, a pr...

  • Review
  • Open Access
10 Citations
4,607 Views
15 Pages

9 July 2022

Achieving beer quality and stability remains the main challenge for the brewing industry. Despite all the technologies available, to obtain a high-quality product, it is important to know and control every step of the beer production process. Since t...

  • Article
  • Open Access
7 Citations
3,531 Views
17 Pages

Performance Assessment of Natural Wastewater Treatment Plants by Multivariate Statistical Models: A Case Study

  • Mahmoud Gad,
  • Sayeda M. Abdo,
  • Anyi Hu,
  • Mohamed Azab El-Liethy,
  • Mohamed S. Hellal,
  • Hala S. Doma and
  • Gamila H. Ali

23 June 2022

Waste stabilization ponds (WSPs) as natural wastewater treatment plants are commonly utilized for wastewater treatment due to their simple design, low cost, and low-skilled operator requirements. Large-scale studies assessing the performance of WSPs...

  • Article
  • Open Access
924 Views
23 Pages

6 August 2025

Multivariate space–time datasets are often collected at discrete, regularly monitored time intervals and are typically treated as components of time series in environmental science and other applied fields. To effectively characterize such data...

  • Article
  • Open Access
6 Citations
4,530 Views
11 Pages

5 January 2019

Fault detection and isolation are important tasks in statistical process control. A real-time contrasts (RTC) control chart converts the statistical process-monitoring problem to the real-time classification problem, thus outperforming traditional mo...

  • Article
  • Open Access
16 Citations
3,385 Views
27 Pages

An Adaptive EWMA Control Chart Based on Principal Component Method to Monitor Process Mean Vector

  • Muhammad Riaz,
  • Babar Zaman,
  • Ishaq Adeyanju Raji,
  • M. Hafidz Omar,
  • Rashid Mehmood and
  • Nasir Abbas

11 June 2022

The special causes of variations, which is also known as a shift, can occur in a single or more than one related process characteristics. Statistical process control tools such as control charts are useful to monitor shifts in the process parameters...

  • Article
  • Open Access
2 Citations
3,263 Views
20 Pages

Accurate monitoring of complex industrial plants is crucial for ensuring safe operations and reliable management of desired quality. Early detection of abnormal events is essential to preempt serious consequences, enhance system performance, and redu...

  • Article
  • Open Access
13 Citations
4,349 Views
14 Pages

Causal Plot: Causal-Based Fault Diagnosis Method Based on Causal Analysis

  • Yoshiaki Uchida,
  • Koichi Fujiwara,
  • Tatsuki Saito and
  • Taketsugu Osaka

3 November 2022

Fault diagnosis is crucial for realizing safe process operation when a fault occurs. Multivariate statistical process control (MSPC) has widely been adopted for fault detection in real processes, and contribution plots based on MSPC are a well-known...

  • Article
  • Open Access
30 Citations
3,848 Views
19 Pages

28 September 2020

Pumps are one of the most critical machines in the petrochemical process. Condition monitoring of such parts and detecting faults at an early stage are crucial for reducing downtime in the production line and improving plant safety, efficiency and re...

  • Article
  • Open Access
1,349 Views
14 Pages

1 July 2025

This paper introduces a groundbreaking decentralized approach for real-time bus monitoring and geo-location, leveraging advanced geo-statistical and multivariate statistical methods. The proposed long short-term memory (LSTM) model predicts bus arriv...

  • Article
  • Open Access
2 Citations
3,665 Views
18 Pages

Background: Growing disparities in development, governance, and logistics performance across countries pose challenges for global policymaking and Sustainable Development Goal (SDG) monitoring. This study proposes a classification of 137 countries ba...

  • Article
  • Open Access
15 Citations
3,130 Views
31 Pages

17 August 2023

Simultaneous monitoring of the process parameters in a multivariate normal process has caught researchers’ attention during the last two decades. However, only statistical control charts have been developed so far for this purpose. On the other...

  • Review
  • Open Access
818 Views
24 Pages

25 November 2025

Artificial intelligence (AI) has emerged as an innovative approach to the computer modeling and optimization of anaerobic digestion (AD) and anaerobic co-digestion (AcoD) processes. AI-based algorithms are ideally suited to capture the complex nonlin...

  • Article
  • Open Access
12 Citations
3,764 Views
27 Pages

Robust Fault Detection in Monitoring Chemical Processes Using Multi-Scale PCA with KD Approach

  • K. Ramakrishna Kini,
  • Muddu Madakyaru,
  • Fouzi Harrou,
  • Anoop Kishore Vatti and
  • Ying Sun

Effective fault detection in chemical processes is of utmost importance to ensure operational safety, minimize environmental impact, and optimize production efficiency. To enhance the monitoring of chemical processes under noisy conditions, an innova...

  • Review
  • Open Access
121 Citations
19,223 Views
45 Pages

Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that...

  • Article
  • Open Access
12 Citations
8,074 Views
8 Pages

From Mini to Micro Scale—Feasibility of Raman Spectroscopy as a Process Analytical Tool (PAT)

  • Markus Wirges,
  • Joshua Müller,
  • Péter Kása,
  • Géza Regdon,
  • Klára Pintye-Hódi,
  • Klaus Knop and
  • Peter Kleinebudde

14 October 2011

Background: Active coating is an important unit operation in the pharmaceutical industry. The quality, stability, safety and performance of the final product largely depend on the amount and uniformity of coating applied. Active coating is challengin...

  • Article
  • Open Access
11 Citations
3,006 Views
13 Pages

A Feasibility Study towards the On-Line Quality Assessment of Pesto Sauce Production by NIR and Chemometrics

  • Daniele Tanzilli,
  • Alessandro D’Alessandro,
  • Samuele Tamelli,
  • Caterina Durante,
  • Marina Cocchi and
  • Lorenzo Strani

18 April 2023

The food industry needs tools to improve the efficiency of their production processes by minimizing waste, detecting timely potential process issues, as well as reducing the efforts and workforce devoted to laboratory analysis while, at the same time...

  • Article
  • Open Access
8 Citations
3,576 Views
24 Pages

2 January 2022

The analysis of the Earth system and interactions among its spheres is increasingly important to improve the understanding of global environmental change. In this regard, Earth observation (EO) is a valuable tool for monitoring of long term changes o...

  • Article
  • Open Access
12 Citations
2,597 Views
23 Pages

28 May 2022

This paper develops an incipient fault detection and isolation method using the Wasserstein distance, which measures the difference between the probability distributions of normal and faulty data sets from the aspect of optimal transport. For fault d...

  • Article
  • Open Access
12 Citations
3,923 Views
17 Pages

3 April 2019

This paper presents an experimental study on detecting and monitoring of evolution of fatigue damage in composites under cyclic loads by using guided waves. Composite specimens fabricated by glass fiber/epoxy laminates and surface mounted with piezoe...

  • Article
  • Open Access
15 Citations
5,048 Views
12 Pages

A FT-NIR Process Analytical Technology Approach for Milk Renneting Control

  • Silvia Grassi,
  • Lorenzo Strani,
  • Cristina Alamprese,
  • Nicolò Pricca,
  • Ernestina Casiraghi and
  • Giovanni Cabassi

23 December 2021

The study proposes a process analytical technology (PAT) approach for the control of milk coagulation through near infrared spectroscopy (NIRS), computing multivariate statistical process control (MSPC) charts, based on principal component analysis (...

  • Article
  • Open Access
1 Citations
2,054 Views
15 Pages

22 September 2023

Significant efforts have been spent in the modern era towards implementing environmentally friendly procedures like composting to mitigate the negative effects of intensive agricultural practices. In this context, a novel fertilizer was produced via...

  • Article
  • Open Access
468 Views
17 Pages

Raman Spectroscopy Coupled with Multivariate Statistical Process Control for Detecting Anomalies During Milk Coagulation

  • Leonardo Sibono,
  • Stefania Tronci,
  • Martin Aage Barsøe Hedegaard,
  • Massimiliano Errico and
  • Massimiliano Grosso

3 November 2025

This study explores the potential of Raman spectroscopy as a screening tool for fault detection in dairy processing, focusing its application on milk rennet coagulation. Multivariate Statistical Process Control techniques were employed to analyze spe...

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