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6,664 Results Found

  • Article
  • Open Access
11 Citations
5,524 Views
15 Pages

7 August 2022

In this research, a microfluid-based extended gate field-effect transistor (EGFET) biosensor with an on-chip sensing window (OCSW) was fabricated. The detection window was composed of six metal layers, and a ruthenium dioxide (RuO2) film was spattere...

(This article belongs to the Special Issue Advanced Field-Effect Sensors)
  • Article
  • Open Access
38 Citations
7,693 Views
22 Pages

Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation

  • Enrica Chiesa,
  • Antonietta Greco,
  • Federica Riva,
  • Elena Maria Tosca and ,
  • Rossella Dorati,
  • Silvia Pisani,
  • Tiziana Modena,
  • Bice Conti and
  • Ida Genta
  • + 4 authors+ 0 author

9 December 2019

Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge...

(This article belongs to the Special Issue Chitosan Functionalizations, Formulations and Composites)
  • Article
  • Open Access
22 Citations
5,535 Views
16 Pages

25 June 2021

Lubricating oil monitoring technology is a commonly used method in aeroengine condition monitoring, which includes particle counting technology, as well as spectral and ferrography technology in offline monitoring. However, these technologies only an...

  • Article
  • Open Access
918 Views
18 Pages

23 October 2025

Hundred-micron-sized microdroplets are widely used in microbial culture, chemical investigations and industrial processes. The size, velocity and frequency of microdroplets significantly affect the cultivation and processing effects. The detections o...

(This article belongs to the Topic Advances in Microfluidics and Lab on a Chip Technology, 2nd Edition)
  • Article
  • Open Access
17 Citations
5,700 Views
23 Pages

21 March 2022

The microfluid jet polishing (MFJP) process is a manufacturing technology in which small abrasive particles (such as diamond, alumina, and ceria) are premixed with a carrier fluid (typically water) to form a liquid suspension that is pressurized and...

  • Article
  • Open Access
5 Citations
2,744 Views
27 Pages

Dynamic post-buckling behavior of microscale cylindrical shells reinforced with functionally graded carbon nanotubes (FG-CNTs) and conveying microfluid is discussed for the first time. The microshell is embedded in a Kerr foundation and subjected to...

  • Review
  • Open Access
13 Citations
4,304 Views
16 Pages

Microfluidics: Insights into Intestinal Microorganisms

  • Ping Qi,
  • Jin Lv,
  • Xiangdong Yan,
  • Liuhui Bai and
  • Lei Zhang

Microfluidics is a system involving the treatment or manipulation of microscale (10−9 to 10−18 L) fluids using microchannels (10 to 100 μm) contained on a microfluidic chip. Among the different methodologies used to study intestinal mi...

(This article belongs to the Special Issue Novel Strategies in the Study of the Human Gut Microbiota)
  • Review
  • Open Access
208 Citations
16,942 Views
26 Pages

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

  • Hedieh Fallahi,
  • Jun Zhang,
  • Hoang-Phuong Phan and
  • Nam-Trung Nguyen

29 November 2019

Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing techno...

(This article belongs to the Special Issue 10th Anniversary of Micromachines)
  • Review
  • Open Access
18 Citations
5,570 Views
17 Pages

28 November 2024

This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidi...

(This article belongs to the Section B: Biology and Biomedicine)
  • Review
  • Open Access
50 Citations
14,914 Views
13 Pages

Microfluidic Devices for Drug Assays

  • Clément Regnault,
  • Dharmendra S. Dheeman and
  • Axel Hochstetter

In this review, we give an overview of the current state of microfluidic-based high-throughput drug assays. In this highly interdisciplinary research field, various approaches have been applied to high-throughput drug screening, including microtiter...

  • Article
  • Open Access
4 Citations
4,458 Views
11 Pages

Microfabrication of Nonplanar Polymeric Microfluidics

  • Pin-Chuan Chen,
  • Chung-Ying Lee and
  • Lynh Huyen Duong

25 September 2018

For four decades, microfluidics technology has been used in exciting, state-of-the-art applications. This paper reports on a novel fabrication approach in which micromachining is used to create nonplanar, three-dimensional microfluidic chips for expe...

(This article belongs to the Section B: Biology and Biomedicine)
  • Review
  • Open Access
171 Citations
20,847 Views
20 Pages

Recent Advances and Future Perspectives on Microfluidic Liquid Handling

  • Nam-Trung Nguyen,
  • Majid Hejazian,
  • Chin Hong Ooi and
  • Navid Kashaninejad

12 June 2017

The interdisciplinary research field of microfluidics has the potential to revolutionize current technologies that require the handling of a small amount of fluid, a fast response, low costs and automation. Microfluidic platforms that handle small am...

(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
  • Review
  • Open Access
14 Citations
9,244 Views
37 Pages

Cellulose, a linear polysaccharide, is the most common and renewable biopolymer in nature. Because this natural polymer cannot be melted (heated) or dissolved (in typical organic solvents), making complicated structures from it necessitates specializ...

  • Feature Paper
  • Article
  • Open Access
26 Citations
8,180 Views
11 Pages

PDMS-Parylene Hybrid, Flexible Microfluidics for Real-Time Modulation of 3D Helical Inertial Microfluidics

  • Bum-Joon Jung,
  • Jihye Kim,
  • Jeong-ah Kim,
  • Hansol Jang and ,
  • Sumin Seo and
  • Wonhee Lee
  • + 1 author+ 0 author

Inertial microfluidics has drawn much attention for its applications for circulating tumor cell separations from blood. The fluid flows and the inertial particle focusing in inertial microfluidic systems are highly dependent on the channel geometry a...

(This article belongs to the Special Issue Liquid Biopsy in a Microfluidic Chip for Rapid and Non-Invasive Point-of-Care Diagnostics)
  • Feature Paper
  • Review
  • Open Access
79 Citations
17,824 Views
30 Pages

20 March 2022

Microfluidics is a multidisciplinary technology with applications in various fields, such as biomedical, energy, chemicals and environment. Thermoplastic is one of the most prominent materials for polymer microfluidics. Properties such as good mechan...

(This article belongs to the Special Issue Feature Papers of Micromachines in Biology and Biomedicine 2022)
  • Article
  • Open Access
12 Citations
4,065 Views
13 Pages

A New Direction in Microfluidics: Printed Porous Materials

  • Hanno Evard,
  • Hans Priks,
  • Indrek Saar,
  • Heili Aavola and ,
  • Tarmo Tamm and
  • Ivo Leito
  • + 1 author+ 0 author

In this work, the feasibility of a novel direction for microfluidics is studied by demonstrating a set of new methods to fabricate microfluidic systems. Similarly to microfluidic paper-based analytical devices, porous materials are being used. Howeve...

(This article belongs to the Section D: Materials and Processing)
  • Review
  • Open Access
50 Citations
16,281 Views
23 Pages

18 May 2011

A review of research activities on opto-microfluidic sensors carried out by the research groups in Canada is presented. After a brief introduction of this exciting research field, detailed discussion is focused on different techniques for the fabrica...

(This article belongs to the Special Issue State-of-the-Art Sensors in Canada)
  • Perspective
  • Open Access
11 Citations
4,459 Views
13 Pages

Two-Phase Biocatalysis in Microfluidic Droplets

  • Lanting Xiang,
  • Felix Kaspar,
  • Anett Schallmey and
  • Iordania Constantinou

21 October 2021

This Perspective discusses the literature related to two-phase biocatalysis in microfluidic droplets. Enzymes used as catalysts in biocatalysis are generally less stable in organic media than in their native aqueous environments; however, chemical an...

(This article belongs to the Special Issue Microfluidics for Biosensing)
  • Review
  • Open Access
78 Citations
14,617 Views
25 Pages

Programmable Paper-Based Microfluidic Devices for Biomarker Detections

  • Veasna Soum,
  • Sooyong Park,
  • Albertus Ivan Brilian,
  • Oh-Sun Kwon and
  • Kwanwoo Shin

2 August 2019

Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide...

(This article belongs to the Special Issue Micro- and Nanofluidics for Bionanoparticle Analysis)
  • Review
  • Open Access
100 Citations
11,898 Views
32 Pages

A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis

  • Adelina-Gabriela Niculescu,
  • Dan Eduard Mihaiescu and
  • Alexandru Mihai Grumezescu

Microfluidics is defined as emerging science and technology based on precisely manipulating fluids through miniaturized devices with micro-scale channels and chambers. Such microfluidic systems can be used for numerous applications, including reactio...

(This article belongs to the Special Issue Multidisciplinary Investigations of Nanoparticle Synthesis and Analysis for Possible Biomedical and Food Technology Applications 2.0)
  • Editorial
  • Open Access
9 Citations
5,095 Views
7 Pages

25 July 2017

Microfluidics is quickly becoming a key technology in an expanding range of fields, such as medical sciences, biosensing, bioactuation, chemical synthesis, and more. This is helping its transformation from a promising R&D tool to commercially via...

(This article belongs to the Special Issue Microfluidics-Based Microsystem Integration Research)
  • Review
  • Open Access
51 Citations
11,314 Views
38 Pages

Microfluidic Devices and Microfluidics-Integrated Electrochemical and Optical (Bio)Sensors for Pollution Analysis: A Review

  • Badriyah Alhalaili,
  • Ileana Nicoleta Popescu,
  • Carmen Otilia Rusanescu and
  • Ruxandra Vidu

9 October 2022

An overview of the recent research works and trends in the design and fabrication of microfluidic devices and microfluidics-integrated biosensors for pollution analysis and monitoring of environmental contaminants is presented in this paper. In align...

(This article belongs to the Section Sustainable Materials)
  • Article
  • Open Access
10 Citations
3,903 Views
12 Pages

6 July 2023

Simple and rapid fabrication of microfluidic devices can enable widespread implementation of lab-on-chip devices in resource-limited environments. However, currently most of the microfluidic devices are fabricated in cleanroom facilities that are wel...

  • Review
  • Open Access
24 Citations
7,995 Views
33 Pages

The rapid development of microfluidics has driven innovations in material engineering, particularly through its ability to precisely manipulate fluids and cells at microscopic scales. Microfluidic biomaterials, a cutting-edge interdisciplinary field...

(This article belongs to the Section Biomaterials and Devices for Healthcare Applications)
  • Review
  • Open Access
160 Citations
25,828 Views
34 Pages

Microfluidic Production of Multiple Emulsions

  • Goran T. Vladisavljević,
  • Ruqaya Al Nuumani and
  • Seyed Ali Nabavi

Microfluidic devices are promising tools for the production of monodispersed tuneable complex emulsions. This review highlights the advantages of microfluidics for the fabrication of emulsions and presents an overview of the microfluidic emulsificati...

(This article belongs to the Special Issue Droplet Microfluidics: Techniques and Technologies, Volume II)
  • Review
  • Open Access
14 Citations
4,863 Views
33 Pages

Microfluidic Systems for Neural Cell Studies

  • Eleftheria Babaliari,
  • Anthi Ranella and
  • Emmanuel Stratakis

Whereas the axons of the peripheral nervous system (PNS) spontaneously regenerate after an injury, the occurring regeneration is rarely successful because axons are usually directed by inappropriate cues. Therefore, finding successful ways to guide n...

(This article belongs to the Section Nanobiotechnology and Biofabrication)
  • Review
  • Open Access
45 Citations
7,454 Views
19 Pages

Role of Polymers in Microfluidic Devices

  • Laila A. Damiati,
  • Marwa El-Yaagoubi,
  • Safa A. Damiati,
  • Rimantas Kodzius and ,
  • Farshid Sefat and
  • Samar Damiati
  • + 1 author+ 0 author

25 November 2022

Polymers are sustainable and renewable materials that are in high demand due to their excellent properties. Natural and synthetic polymers with high flexibility, good biocompatibility, good degradation rate, and stiffness are widely used for various...

(This article belongs to the Special Issue Sustainable Biopolymer-Based Composites: Processing, Characterization, and Application)
  • Review
  • Open Access
7 Citations
4,107 Views
8 Pages

The purpose of the present review is to try to highlight recent advances in the application of microfluidic technology on non-invasive prenatal diagnosis (NIPD). The immunoaffinity based microfluidic technology is the most common approach for NIPD, f...

(This article belongs to the Special Issue Circulating Tumor Cells, Liquid Biopsies, and Precision Oncology)
  • Review
  • Open Access
7 Citations
11,307 Views
19 Pages

Mobile Microfluidics

  • Mirela Alistar

Microfluidics platforms can program small amounts of fluids to execute a bio-protocol, and thus, can automate the work of a technician and also integrate a large part of laboratory equipment. Although most microfluidic systems have considerably reduc...

(This article belongs to the Special Issue Frontiers of Microfluidics in Biology)
  • Review
  • Open Access
79 Citations
9,997 Views
18 Pages

16 May 2022

Microfluidic platform technology has presented a new strategy to detect and analyze analytes and biological entities thanks to its reduced dimensions, which results in lower reagent consumption, fast reaction, multiplex, simplified procedure, and hig...

(This article belongs to the Special Issue Polymer Micro/Nanofabrication and Manufacturing)
  • Review
  • Open Access
145 Citations
16,253 Views
26 Pages

Progress of Inertial Microfluidics in Principle and Application

  • Yixing Gou,
  • Yixuan Jia,
  • Peng Wang and
  • Changku Sun

1 June 2018

Inertial microfluidics has become a popular topic in microfluidics research for its good performance in particle manipulation and its advantages of simple structure, high throughput, and freedom from an external field. Compared with traditional micro...

(This article belongs to the Special Issue Sensors and Lab-on-a-Chip)
  • Review
  • Open Access
59 Citations
8,987 Views
22 Pages

Modular Microfluidics: Current Status and Future Prospects

  • Xiaochen Lai,
  • Mingpeng Yang,
  • Hao Wu and
  • Dachao Li

22 August 2022

This review mainly studies the development status, limitations, and future directions of modular microfluidic systems. Microfluidic technology is an important tool platform for scientific research and plays an important role in various fields. With t...

(This article belongs to the Special Issue Physics in Micro/Nano Devices: From Fundamental to Application)
  • Review
  • Open Access
142 Citations
23,848 Views
23 Pages

Droplet Microfluidics for the Production of Microparticles and Nanoparticles

  • Jianmei Wang,
  • Yan Li,
  • Xueying Wang,
  • Jianchun Wang and ,
  • Hanmei Tian,
  • Pei Zhao,
  • Ye Tian,
  • Yeming Gu,
  • Liqiu Wang and
  • Chengyang Wang
  • + 5 authors+ 0 author

14 January 2017

Droplet microfluidics technology is recently a highly interesting platform in material fabrication. Droplets can precisely monitor and control entire material fabrication processes and are superior to conventional bulk techniques. Droplet production...

(This article belongs to the Special Issue Insights and Advancements in Microfluidics)
  • Article
  • Open Access
4 Citations
4,314 Views
14 Pages

Microfabrication Bonding Process Optimization for a 3D Multi-Layer PDMS Suspended Microfluidics

  • Mostapha Marzban,
  • Ehsan Yazdanpanah Moghadam,
  • Javad Dargahi and
  • Muthukumaran Packirisamy

4 May 2022

Microfluidic systems have received increased attention due to their wide variety of applications, from chemical sensing to biological detection to medical analysis. Microfluidics used to be fabricated by using etching techniques that required cleanro...

(This article belongs to the Special Issue Microfluidics in Biomedical Engineering)
  • Review
  • Open Access
156 Citations
11,326 Views
28 Pages

Nanomaterials Synthesis through Microfluidic Methods: An Updated Overview

  • Adelina-Gabriela Niculescu,
  • Cristina Chircov,
  • Alexandra Cătălina Bîrcă and
  • Alexandru Mihai Grumezescu

28 March 2021

Microfluidic devices emerged due to an interdisciplinary “collision” between chemistry, physics, biology, fluid dynamics, microelectronics, and material science. Such devices can act as reaction vessels for many chemical and biological processes, red...

(This article belongs to the Special Issue Synthesis, Characterization and Biomedical Applications of Nanomaterials)
  • Article
  • Open Access
53 Citations
9,863 Views
32 Pages

Microfluidic Techniques for Analytes Concentration

  • Cunlu Zhao,
  • Zhengwei Ge and
  • Chun Yang

22 January 2017

Microfluidics has been undergoing fast development in the past two decades due to its promising applications in biotechnology, medicine, and chemistry. Towards these applications, enhancing concentration sensitivity and detection resolution are indis...

(This article belongs to the Special Issue Micro/Nano-Chip Electrokinetics)
  • Perspective
  • Open Access
44 Citations
8,533 Views
12 Pages

24 December 2018

Materials science is a fast-evolving area that aims to uncover functional materials with ever more sophisticated properties and functions. For this to happen, new methodologies for materials synthesis, optimization, and preparation are desired. In th...

  • Review
  • Open Access
44 Citations
9,795 Views
40 Pages

Microfluidic Systems for Blood and Blood Cell Characterization

  • Hojin Kim,
  • Alexander Zhbanov and
  • Sung Yang

22 December 2022

A laboratory blood test is vital for assessing a patient’s health and disease status. Advances in microfluidic technology have opened the door for on-chip blood analysis. Currently, microfluidic devices can reproduce myriad routine laboratory b...

(This article belongs to the Section Nano- and Micro-Technologies in Biosensors)
  • Proceeding Paper
  • Open Access
2,143 Views
5 Pages

26 November 2018

This work reports for the first-time integration of continuous microfluidic channels to the paper-based electro-osmotic pumps (EOPs) with liquid bridges. In addition, 0.2 μm pore sized cellulose acetate (CA) membrane filter is used to eliminate pr...

(This article belongs to the Proceedings of EUROSENSORS 2018)
  • Review
  • Open Access
88 Citations
17,835 Views
25 Pages

20 June 2019

Recently, droplet-based microfluidic systems have been widely used in various biochemical and molecular biological assays. Since this platform technique allows manipulation of large amounts of data and also provides absolute accuracy in comparison to...

(This article belongs to the Special Issue Microfluidics for Soft Matter and Mechanobiology, Volume I)
  • Review
  • Open Access
65 Citations
8,693 Views
33 Pages

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

  • Rui Vitorino,
  • Sofia Guedes,
  • João Pinto da Costa and
  • Václav Kašička

26 April 2021

Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control che...

(This article belongs to the Section Biology and Medicines)
  • Review
  • Open Access
66 Citations
7,829 Views
15 Pages

Microfluidic Systems for Cancer Diagnosis and Applications

  • Semra Akgönüllü,
  • Monireh Bakhshpour,
  • Ayşe Kevser Pişkin and
  • Adil Denizli

31 October 2021

Microfluidic devices have led to novel biological advances through the improvement of micro systems that can mimic and measure. Microsystems easily handle sub-microliter volumes, obviously with guidance presumably through laminated fluid flows. Micro...

(This article belongs to the Section B4: Point-of-Care Devices)
  • Feature Paper
  • Review
  • Open Access
69 Citations
12,885 Views
30 Pages

Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review

  • Mariana Ferreira,
  • Violeta Carvalho,
  • João Ribeiro,
  • Rui A. Lima and ,
  • Senhorinha Teixeira and
  • Diana Pinho
  • + 1 author+ 0 author

30 June 2024

The evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing...

(This article belongs to the Section B: Biology and Biomedicine)
  • Review
  • Open Access
33 Citations
9,313 Views
22 Pages

This is a literature teaching resource review for biologically inspired microfluidics courses or exploring the diverse applications of microfluidics. The structure is around key papers and model organisms. While courses gradually change over time, a...

(This article belongs to the Special Issue Frontiers of Microfluidics in Biology)
  • Review
  • Open Access
1,036 Citations
50,667 Views
25 Pages

Microfluidic Mixing: A Review

  • Chia-Yen Lee,
  • Chin-Lung Chang,
  • Yao-Nan Wang and
  • Lung-Ming Fu

18 May 2011

The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly...

(This article belongs to the Special Issue Microfluidics)
  • Review
  • Open Access
14 Citations
12,502 Views
41 Pages

Microfluidic Bioreactors for Cellular Microarrays

  • Ronnie G. Willaert and
  • Katty Goossens

Living cell microarrays have been combined with microfluidic bioreactors, which provide multiple advantages for multiplex dynamic analyses and high-throughput screening. In the last decade, many developments in this new field have been introduced. Th...

  • Article
  • Open Access
22 Citations
7,185 Views
13 Pages

3D-Printed Microfluidic One-Way Valves and Pumps

  • Hunter Hinnen,
  • Matthew Viglione,
  • Troy R. Munro,
  • Adam T. Woolley and
  • Gregory P. Nordin

23 June 2023

New microfluidic lab-on-a-chip capabilities are enabled by broadening the toolkit of devices that can be created using microfabrication processes. For example, complex geometries made possible by 3D printing can be used to approach microfluidic desig...

(This article belongs to the Special Issue 3D Printing of MEMS Technology, Volume II)
  • Communication
  • Open Access
6 Citations
3,204 Views
14 Pages

The Importance of Dimensional Traceability in Microfluidic Systems

  • Elsa Batista,
  • João Alves e Sousa,
  • Fernanda Saraiva,
  • André Lopes and ,
  • Vania Silverio,
  • Rui F. Martins and
  • Luis Martins
  • + 2 authors+ 0 author

6 May 2024

Dimensional measurements are fundamental in microfluidic device manufacturing and performance. The main focus of this study is the measurement of the connection port sizes in microfluidic devices and components and, accordingly, the possible existenc...

(This article belongs to the Topic Measurement Strategies and Standardization in Manufacturing)
  • Review
  • Open Access
101 Citations
8,407 Views
23 Pages

The Microfluidic Technique and the Manufacturing of Polysaccharide Nanoparticles

  • Enrica Chiesa,
  • Rossella Dorati,
  • Silvia Pisani,
  • Bice Conti and ,
  • Gloria Bergamini,
  • Tiziana Modena and
  • Ida Genta
  • + 2 authors+ 0 author

The microfluidic technique has emerged as a promising tool to accelerate the clinical translation of nanoparticles, and its application affects several aspects, such as the production of nanoparticles and the in vitro characterization in the microenv...

(This article belongs to the Special Issue Micro and Nano Encapsulation Techniques)
  • Review
  • Open Access
99 Citations
12,651 Views
34 Pages

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

  • Roozbeh Abedini-Nassab,
  • Mahrad Pouryosef Miandoab and
  • Merivan Şaşmaz

29 June 2021

Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriat...

(This article belongs to the Special Issue MEMS Devices for Nanomanufacturing)

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