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Micromachines 2017, 8(1), 28;

Microfluidic Techniques for Analytes Concentration

1,†,* , 2,†
Key Laboratory of Thermo-Fluid Science and Engineering of MOE, School of Energy and Power Engineering, Xi’an Jiaotong University, Xi’an 710049, China
School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editors: Xiangchun Xuan and Shizhi Qian
Received: 6 November 2016 / Revised: 1 January 2017 / Accepted: 16 January 2017 / Published: 22 January 2017
(This article belongs to the Special Issue Micro/Nano-Chip Electrokinetics)
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Microfluidics has been undergoing fast development in the past two decades due to its promising applications in biotechnology, medicine, and chemistry. Towards these applications, enhancing concentration sensitivity and detection resolution are indispensable to meet the detection limits because of the dilute sample concentrations, ultra-small sample volumes and short detection lengths in microfluidic devices. A variety of microfluidic techniques for concentrating analytes have been developed. This article presents an overview of analyte concentration techniques in microfluidics. We focus on discussing the physical mechanism of each concentration technique with its representative advancements and applications. Finally, the article is concluded by highlighting and discussing advantages and disadvantages of the reviewed techniques. View Full-Text
Keywords: microfluidics; sample preconcentration; stacking; field gradient focusing; electrokinetic trapping; immunocapture based trapping microfluidics; sample preconcentration; stacking; field gradient focusing; electrokinetic trapping; immunocapture based trapping

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Zhao, C.; Ge, Z.; Yang, C. Microfluidic Techniques for Analytes Concentration. Micromachines 2017, 8, 28.

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